{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:14:31Z","timestamp":1790525671757,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.kint.2016.09.028","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T02:31:22Z","timestamp":1480905082000},"page":"616-627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease"],"prefix":"10.1016","volume":"91","author":[{"given":"Isabel N.","family":"Schellinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Cordasic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Panesar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Hartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Klanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Jakubiczka-Smorag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Burzlaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Warnecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Raaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Willam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai-Uwe","family":"Eckardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Amann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl F.","family":"Hilgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2016.09.028_bib1","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","article-title":"Prevalence of chronic kidney disease in the United States","volume":"298","author":"Coresh","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2016.09.028_bib2","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1093\/ndt\/gfq062","article-title":"Trends in the prevalence of chronic kidney disease and its risk factors in a general Japanese population: the Hisayama Study","volume":"25","author":"Nagata","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2016.09.028_bib3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0140-6736(13)60439-0","article-title":"Evolving importance of kidney disease: from subspecialty to global health burden","volume":"382","author":"Eckardt","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2016.09.028_bib4","doi-asserted-by":"crossref","first-page":"c4986","DOI":"10.1136\/bmj.c4986","article-title":"Chronic kidney disease and risk of major cardiovascular disease and non-vascular mortality: prospective population based cohort study","volume":"341","author":"Di Angelantonio","year":"2010","journal-title":"BMJ"},{"key":"10.1016\/j.kint.2016.09.028_bib5","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2005111204","article-title":"Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) Study","volume":"18","author":"Wattanakit","year":"2007","journal-title":"J\u00a0Amer Soc Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib6","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/jcb.21523","article-title":"Vasculogenesis, angiogenesis, and arteriogenesis: mechanisms of blood vessel formation and remodeling","volume":"102","author":"Semenza","year":"2007","journal-title":"J\u00a0Cell Biochem"},{"key":"10.1016\/j.kint.2016.09.028_bib7","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1161\/01.ATV.0000133488.56221.4a","article-title":"Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure","volume":"24","author":"Choi","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2016.09.028_bib8","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1681\/ASN.2009010061","article-title":"The soluble VEGF receptor sFlt1 contributes to endothelial dysfunction in CKD","volume":"20","author":"Di Marco","year":"2009","journal-title":"J\u00a0Amer Soc Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/scdb.2001.0287","article-title":"Oxygen sensors and angiogenesis","volume":"13","author":"Maxwell","year":"2002","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.kint.2016.09.028_bib10","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1074\/jbc.272.9.5375","article-title":"Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia","volume":"272","author":"Lee","year":"1997","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2016.09.028_bib11","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1172\/JCI117858","article-title":"Increased gene expression for VEGF and the VEGF receptors KDR\/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide","volume":"95","author":"Tuder","year":"1995","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2016.09.028_bib12","first-page":"858","article-title":"Complex role of heme oxygenase-1 in angiogenesis","volume":"6","author":"Dulak","year":"2004","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.kint.2016.09.028_bib13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1159\/000339706","article-title":"Decreased hypoxia-inducible factor-1alpha in gastrocnemius muscle in rats with chronic kidney disease","volume":"35","author":"Flisinski","year":"2012","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.kint.2016.09.028_bib14","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/labinvest.2011.114","article-title":"Indoxyl sulfate, a representative uremic toxin, suppresses erythropoietin production in a HIF-dependent manner","volume":"91","author":"Chiang","year":"2011","journal-title":"Lab Invest"},{"key":"10.1016\/j.kint.2016.09.028_bib15","doi-asserted-by":"crossref","first-page":"C142","DOI":"10.1152\/ajpcell.00172.2015","article-title":"Activation of aryl hydrocarbon receptor mediates suppression of hypoxia inducible factor-dependent erythropoietin expression by indoxyl sulfate","volume":"310","author":"Asai","year":"2016","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.kint.2016.09.028_bib16","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1038\/sj.ki.5000448","article-title":"Subtotal nephrectomy impairs ischemia-induced angiogenesis and hindlimb re-perfusion in rats","volume":"69","author":"Jacobi","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2016.09.028_bib17","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/08860220701813335","article-title":"A\u00a0defective angiogenesis in chronic kidney disease","volume":"30","author":"Futrakul","year":"2008","journal-title":"Ren Fail"},{"key":"10.1016\/j.kint.2016.09.028_bib18","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.jacc.2005.08.045","article-title":"Hypoxia-inducible factor 1-alpha reduces\u00a0infarction and attenuates progression of cardiac dysfunction after myocardial infarction in the mouse","volume":"46","author":"Kido","year":"2005","journal-title":"J\u00a0Am Coll Cardiol"},{"key":"10.1016\/j.kint.2016.09.028_bib19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cardiores.2005.05.002","article-title":"Constitutively active HIF-1alpha improves perfusion and arterial remodeling in an endovascular model of limb ischemia","volume":"68","author":"Patel","year":"2005","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.kint.2016.09.028_bib20","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1096\/fj.05-3720fje","article-title":"Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer","volume":"19","author":"Pajusola","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2016.09.028_bib21","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1681\/ASN.2014111139","article-title":"Four-week studies of oral hypoxia-inducible factor-prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia","volume":"27","author":"Holdstock","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib22","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1681\/ASN.2015030241","article-title":"Roxadustat (FG-4592): correction of anemia in incident dialysis patients","volume":"27","author":"Besarab","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib23","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1681\/ASN.2010010116","article-title":"Inhibition of prolyl hydroxylases increases erythropoietin production in ESRD","volume":"21","author":"Bernhardt","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib24","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrneph.2015.193","article-title":"HIF prolyl hydroxylase inhibitors for the treatment of renal anaemia and beyond","volume":"12","author":"Maxwell","year":"2016","journal-title":"Na Rev Nephrol"},{"key":"10.1016\/j.kint.2016.09.028_bib25","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1161\/ATVBAHA.107.148551","article-title":"A\u00a0novel class of prolyl hydroxylase inhibitors induces angiogenesis and exerts organ protection against ischemia","volume":"27","author":"Nangaku","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2016.09.028_bib26","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1096\/fj.02-1062fje","article-title":"Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors","volume":"17","author":"Warnecke","year":"2003","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2016.09.028_bib27","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s00424-014-1667-z","article-title":"Pre- and post-conditional inhibition of prolyl-4-hydroxylase domain enzymes protects the heart from an ischemic insult","volume":"467","author":"Vogler","year":"2015","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2016.09.028_bib28","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng.2007.62","article-title":"Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism","volume":"40","author":"Aragones","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2016.09.028_bib29","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ajpath.2012.07.010","article-title":"Selective stabilization of HIF-1alpha in renal tubular cells by 2-oxoglutarate analogues","volume":"181","author":"Schley","year":"2012","journal-title":"Amer J Pathol"},{"key":"10.1016\/j.kint.2016.09.028_bib30","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1152\/physiolgenomics.00110.2002","article-title":"Time course of skeletal muscle repair and gene expression following acute hind limb ischemia in mice","volume":"11","author":"Paoni","year":"2002","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.kint.2016.09.028_bib31","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jacc.2003.09.033","article-title":"Temporal patterns of gene expression after acute hindlimb ischemia in mice: insights into the genomic program for collateral vessel development","volume":"43","author":"Lee","year":"2004","journal-title":"J\u00a0Amer Coll Cardiol"},{"key":"10.1016\/j.kint.2016.09.028_bib32","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/BF02631017","article-title":"SK HEP-1: a human cell line of endothelial origin","volume":"28A","author":"Heffelfinger","year":"1992","journal-title":"In\u00a0Vitro Cell Dev Biol"},{"key":"10.1016\/j.kint.2016.09.028_bib33","doi-asserted-by":"crossref","first-page":"14379","DOI":"10.1074\/jbc.M609857200","article-title":"Hypoxia-inducible factor-1 (HIF-1) is a transcriptional activator of the TrkB neurotrophin receptor gene","volume":"282","author":"Martens","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2016.09.028_bib34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1080\/10408440490503143","article-title":"Toxicity of dipyridyl compounds and related compounds","volume":"34","author":"Li","year":"2004","journal-title":"Crit Rev Toxicol"},{"key":"10.1016\/j.kint.2016.09.028_bib35","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0272-6386(97)90283-3","article-title":"Rats with moderate renal failure show capillary deficit in heart but not skeletal muscle","volume":"30","author":"Amann","year":"1997","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2016.09.028_bib36","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/08860220801985694","article-title":"Influence of different stages of experimental chronic kidney disease on rats locomotor and postural skeletal muscles microcirculation","volume":"30","author":"Flisinski","year":"2008","journal-title":"Ren Fail"},{"key":"10.1016\/j.kint.2016.09.028_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.etp.2005.09.005","article-title":"Suitability of 5\/6 nephrectomy (5\/6NX) for the induction of interstitial renal fibrosis in rats\u2013influence of\u00a0sex, strain, and surgical procedure","volume":"57","author":"Fleck","year":"2006","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.kint.2016.09.028_bib38","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1113\/jphysiol.2004.069757","article-title":"Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice","volume":"560","author":"Milkiewicz","year":"2004","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.kint.2016.09.028_bib39","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0008-6363(02)00259-6","article-title":"Intramyocardial injection of naked DNA encoding HIF-1alpha\/VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat","volume":"54","author":"Shyu","year":"2002","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.kint.2016.09.028_bib40","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1161\/01.CIR.102.18.2255","article-title":"Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1alpha\/VP16 hybrid transcription factor","volume":"102","author":"Vincent","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2016.09.028_bib41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.atherosclerosis.2004.01.015","article-title":"HIF-VEGF-VEGFR-2, TNF-alpha and IGF pathways are upregulated in critical human skeletal muscle ischemia as studied with DNA array","volume":"174","author":"Tuomisto","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.kint.2016.09.028_bib42","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1096\/fj.04-1605fje","article-title":"Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium","volume":"18","author":"Jurgensen","year":"2004","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2016.09.028_bib43","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ejheart.2005.10.009","article-title":"Stabilization of hypoxia inducible factor rather than modulation of collagen metabolism improves cardiac function after acute myocardial infarction in rats","volume":"8","author":"Philipp","year":"2006","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.kint.2016.09.028_bib44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1089\/hum.2013.110","article-title":"Short hairpin RNA gene silencing of prolyl hydroxylase-2 with a minicircle vector improves neovascularization of hindlimb ischemia","volume":"25","author":"Lijkwan","year":"2014","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.kint.2016.09.028_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1161\/CIRCULATIONAHA.108.813303","article-title":"Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization","volume":"120","author":"Loinard","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2016.09.028_bib46","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ndt\/gfr379","article-title":"The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment","volume":"27","author":"Wang","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2016.09.028_bib47","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ndt\/gfp454","article-title":"Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney","volume":"25","author":"Song","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2016.09.028_bib48","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1038\/labinvest.3700328","article-title":"Cobalt promotes angiogenesis via hypoxia-inducible factor and protects tubulointerstitium in the remnant kidney model","volume":"85","author":"Tanaka","year":"2005","journal-title":"Lab Invest"},{"key":"10.1016\/j.kint.2016.09.028_bib49","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1093\/ndt\/gfr754","article-title":"The balance of beneficial and deleterious effects of hypoxia-inducible factor activation by prolyl hydroxylase inhibitor in rat remnant kidney depends on the timing of administration","volume":"27","author":"Yu","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2016.09.028_bib50","first-page":"B80","article-title":"FG-2216, a novel oral HIF-PHI, stimulates erythropoiesis and increases hemoglobin concentration in patients with non-dialysis CKD","volume":"51","author":"Provenzano","year":"2008","journal-title":"AJKD"},{"key":"10.1016\/j.kint.2016.09.028_bib51","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1159\/000049071","article-title":"Elevated plasma vascular endothelial growth factor levels in non-diabetic predialysis uraemia","volume":"90","author":"Harper","year":"2002","journal-title":"Nephron"},{"key":"10.1016\/j.kint.2016.09.028_bib52","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1096\/fj.13-233874","article-title":"High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1alpha","volume":"28","author":"Tan","year":"2014","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2016.09.028_bib53","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1124\/mol.107.034041","article-title":"Quercetin activates an angiogenic pathway, hypoxia inducible factor (HIF)-1-vascular endothelial growth factor, by inhibiting HIF-prolyl hydroxylase: a structural analysis of quercetin for inhibiting HIF-prolyl hydroxylase","volume":"71","author":"Jeon","year":"2007","journal-title":"Mol Pharmacol"},{"key":"10.1016\/j.kint.2016.09.028_bib54","doi-asserted-by":"crossref","first-page":"F1314","DOI":"10.1152\/ajprenal.90755.2008","article-title":"Endothelial progenitor cell dysfunction in patients with progressive chronic kidney disease","volume":"296","author":"Krenning","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2016.09.028_bib55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/01.LAB.0000050761.67879.E4","article-title":"Hypoxic preconditioning augments efficacy of human endothelial progenitor cells for therapeutic neovascularization","volume":"83","author":"Akita","year":"2003","journal-title":"Lab Invest"},{"key":"10.1016\/j.kint.2016.09.028_bib56","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/ndt\/gfp749","article-title":"Progenitor cells and vascular function are impaired in patients with chronic kidney disease","volume":"25","author":"Jie","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2016.09.028_bib57","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ki.2015.21","article-title":"Inflammation and hypoxia linked to renal injury by CCAAT\/enhancer-binding protein delta","volume":"88","author":"Yamaguchi","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2016.09.028_bib58","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/01.RES.80.6.829","article-title":"Monocyte chemotactic protein-1 increases collateral and peripheral conductance after femoral artery occlusion","volume":"80","author":"Ito","year":"1997","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2016.09.028_bib59","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/SHK.0b013e318225ad7e","article-title":"The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells","volume":"36","author":"Hams","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.kint.2016.09.028_bib60","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.4049\/jimmunol.0903617","article-title":"Hypoxia-inducible factor-1alpha-dependent protection from intestinal ischemia\/reperfusion injury involves ecto-5\u2032-nucleotidase (CD73) and the A2B adenosine receptor","volume":"186","author":"Hart","year":"2011","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2016.09.028_bib61","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/nature10507","article-title":"Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis","volume":"479","author":"Takeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.kint.2016.09.028_bib62","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/1358863X14557151","article-title":"Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease","volume":"19","author":"Olson","year":"2014","journal-title":"Vasc Med"},{"key":"10.1016\/j.kint.2016.09.028_bib63","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ki.2015.214","article-title":"Hypoxia inhibits nephrogenesis through paracrine Vegfa despite the ability to enhance tubulogenesis","volume":"88","author":"Schley","year":"2015","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253816305610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253816305610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T01:30:14Z","timestamp":1614562214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253816305610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0085253816305610"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2016.09.028","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoxia inducible factor stabilization improves defective ischemia-induced angiogenesis in a rodent model of chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2016.09.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016, International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}