{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:46:51Z","timestamp":1790725611704,"version":"4.1.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.kint.2017.03.010","type":"journal-article","created":{"date-parts":[[2017,5,6]],"date-time":"2017-05-06T00:45:19Z","timestamp":1494031519000},"page":"349-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":79,"title":["Rac1 activation in podocytes induces the spectrum\u00a0of nephrotic syndrome"],"prefix":"10.1016","volume":"92","author":[{"given":"Richard","family":"Robins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Baldwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamine","family":"Aoudjit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indra R.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoko","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2017.03.010_bib1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00041552-200405000-00006","article-title":"A\u00a0podocentric view of nephrology","volume":"13","author":"Ly","year":"2004","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2017.03.010_bib2","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ajpath.2012.11.002","article-title":"Light microscopic visualization of podocyte ultrastructure demonstrates oscillating glomerular contractions","volume":"182","author":"H\u00f6hne","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2017.03.010_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.mnh.0000447018.28852.b6","article-title":"Advances in slit diaphragm signaling","volume":"23","author":"New","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2017.03.010_bib4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1681\/ASN.2011121206","article-title":"Podocyte-specific loss of cdc42 leads to congenital nephropathy","volume":"23","author":"Scott","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib5","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1155\/2014\/903158","article-title":"Rho-GTPase Signalling in the pathogenesis of nephrotic syndrome","volume":"2014","author":"Robins","year":"2014","journal-title":"Advances in Nephrology"},{"key":"10.1016\/j.kint.2017.03.010_bib6","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ki.2013.175","article-title":"Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury","volume":"84","author":"Blattner","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.03.010_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(04)00003-0","article-title":"Rho and Rac take center stage","volume":"116","author":"Burridge","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.kint.2017.03.010_bib8","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/ki.2011.472","article-title":"Mechanisms of the proteinuria induced by Rho GTPases","volume":"81","author":"Wang","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.03.010_bib9","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1681\/ASN.2010111146","article-title":"Activation of RhoA in podocytes induces focal segmental glomerulosclerosis","volume":"22","author":"Zhu","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib10","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1172\/JCI46458","article-title":"Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis","volume":"121","author":"Akilesh","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.03.010_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/21541248.2015.1113353","article-title":"Disease-causing mutations of RhoGDIalpha induce Rac1 hyperactivation in podocytes","volume":"7","author":"Auguste","year":"2016","journal-title":"Small GTPases"},{"key":"10.1016\/j.kint.2017.03.010_bib12","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1172\/JCI69134","article-title":"ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling","volume":"123","author":"Gee","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.03.010_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/jmedgenet-2012-101442","article-title":"ARHGDIA: a novel gene implicated in nephrotic syndrome","volume":"50","author":"Gupta","year":"2013","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.kint.2017.03.010_bib14","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/MCB.00730-13","article-title":"Rac1 activation in podocytes induces rapid foot process effacement and proteinuria","volume":"33","author":"Yu","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2017.03.010_bib15","doi-asserted-by":"crossref","first-page":"F1207","DOI":"10.1152\/ajprenal.00225.2014","article-title":"Loss of Rho-GDI\u03b1 sensitizes podocytes to lipopolysaccharide-mediated injury","volume":"308","author":"Robins","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.03.010_bib16","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ajpath.2014.05.005","article-title":"Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria","volume":"184","author":"Kumagai","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2017.03.010_bib17","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1046\/j.1523-1755.2001.060003957.x","article-title":"Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat","volume":"60","author":"Kim","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.03.010_bib18","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1681\/ASN.2005010055","article-title":"Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene","volume":"16","author":"Wharram","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib19","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1681\/ASN.2013080859","article-title":"Estimating podocyte number and density using a single histologic section","volume":"25","author":"Venkatareddy","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1074-7613(00)80154-5","article-title":"RAC1\/P38 MAPK signaling pathway controls beta1 integrin-induced interleukin-8 production in human natural killer cells","volume":"12","author":"Mainiero","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2017.03.010_bib21","doi-asserted-by":"crossref","first-page":"27634","DOI":"10.1074\/jbc.M003170200","article-title":"The Rac1\/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins","volume":"275","author":"Uddin","year":"2000","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.03.010_bib22","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1681\/ASN.2004121084","article-title":"Role of p38 mitogen-activated protein kinase activation in podocyte injury and proteinuria in experimental nephrotic syndrome","volume":"16","author":"Koshikawa","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib23","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ajpath.2012.06.018","article-title":"Glycogen synthase kinase 3\u03b2 inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation","volume":"181","author":"Rom","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2017.03.010_bib24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/nrneph.2012.291","article-title":"Cell-matrix adhesion of podocytes in physiology and disease","volume":"9","author":"Sachs","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib25","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMc1202500","article-title":"Resolution of recurrent focal segmental glomerulosclerosis after retransplantation","volume":"366","author":"Gallon","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2017.03.010_bib26","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1093\/ndt\/gfu355","article-title":"Permeability factors in idiopathic nephrotic syndrome: historical perspectives and lessons for the future","volume":"29","author":"Maas","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2017.03.010_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ki.1978.23","article-title":"Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report from the International Study of Kidney Disease in Children","volume":"13","year":"1978","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.03.010_bib28","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1681\/ASN.2015121303","article-title":"Intravital and kidney slice imaging of podocyte membrane dynamics","volume":"27","author":"Br\u00e4hler","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib29","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0140-6736(14)60541-9","article-title":"Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial","volume":"384","author":"Iijima","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2017.03.010_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/sj.cr.7290257","article-title":"Activation and signaling of the p38 MAP kinase pathway","volume":"15","author":"Zarubin","year":"2005","journal-title":"Cell Res"},{"key":"10.1016\/j.kint.2017.03.010_bib31","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1128\/MCB.26.6.2118-2129.2006","article-title":"p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells","volume":"26","author":"Farley","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2017.03.010_bib32","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1091\/mbc.e02-10-0653","article-title":"p38 Mitogen-activated protein kinase mediates cell death and p21-activated kinase mediates cell survival during chemotherapeutic drug-induced mitotic arrest","volume":"14","author":"Deacon","year":"2003","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.kint.2017.03.010_bib33","doi-asserted-by":"crossref","first-page":"F765","DOI":"10.1152\/ajprenal.00100.2003","article-title":"p38 mitogen-activated protein kinase protects glomerular epithelial cells from complement-mediated cell injury","volume":"285","author":"Aoudjit","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.03.010_bib34","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1681\/ASN.2006010050","article-title":"Inhibition of p38 mitogen-activated protein kinase is effective in the treatment of experimental crescentic glomerulonephritis and suppresses monocyte chemoattractant protein-1 but not IL-1beta or IL-6","volume":"18","author":"Sheryanna","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1097\/01.ASN.0000048715.12315.FD","article-title":"Blockade of p38alpha MAPK ameliorates acute inflammatory renal injury in rat anti-GBM glomerulonephritis","volume":"14","author":"Stambe","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib36","doi-asserted-by":"crossref","first-page":"46707","DOI":"10.1074\/jbc.M106176200","article-title":"Integrin beta 1 signaling is necessary for transforming growth factor-beta activation of p38MAPK and epithelial plasticity","volume":"276","author":"Bhowmick","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.03.010_bib37","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0006-291X(02)02033-8","article-title":"Hypoxia activates beta(1)-integrin via ERK 1\/2 and p38 MAP kinase in human vascular smooth muscle cells","volume":"296","author":"Blaschke","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2017.03.010_bib38","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1248\/bpb.32.1795","article-title":"Tenascin-X induces cell detachment through p38 mitogen-activated protein kinase activation","volume":"32","author":"Fujie","year":"2009","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.kint.2017.03.010_bib39","doi-asserted-by":"crossref","first-page":"e17179","DOI":"10.1371\/journal.pone.0017179","article-title":"HAMLET binding to alpha-actinin facilitates tumor cell detachment","volume":"6","author":"Trulsson","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2017.03.010_bib40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nm1696","article-title":"Modification of kidney barrier function by the urokinase receptor","volume":"14","author":"Wei","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2017.03.010_bib41","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.2411","article-title":"Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis","volume":"17","author":"Wei","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2017.03.010_bib42","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1681\/ASN.V1481998","article-title":"Inducible podocyte-specific gene expression in transgenic mice","volume":"14","author":"Shigehara","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2144\/000112913","article-title":"Real-time PCR to determine transgene copy number and to quantitate the biolocalization of adoptively transferred cells from EGFP-transgenic mice","volume":"45","author":"Joshi","year":"2008","journal-title":"Biotechniques"},{"key":"10.1016\/j.kint.2017.03.010_bib44","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.4161\/cc.28401","article-title":"Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events","volume":"13","author":"McCloy","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.kint.2017.03.010_bib45","doi-asserted-by":"crossref","first-page":"12564","DOI":"10.1073\/pnas.0914191107","article-title":"Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2\/PP2A balance","volume":"107","author":"Burgess","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2017.03.010_bib46","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A\u00a0conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.010_bib47","doi-asserted-by":"crossref","first-page":"F148","DOI":"10.1152\/ajprenal.00294.2006","article-title":"Role of Rho-GTPases in complement-mediated glomerular epithelial cell injury","volume":"293","author":"Zhang","year":"2007","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T23:14:57Z","timestamp":1627773297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253817302004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["S0085253817302004"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2017.03.010","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727592619.793566375","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rac1 activation in podocytes induces the spectrum\u00a0of nephrotic syndrome","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2017.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}