{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T21:49:32Z","timestamp":1766180972916,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.kint.2017.03.021","type":"journal-article","created":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T05:31:00Z","timestamp":1495258260000},"page":"703-709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease"],"prefix":"10.1016","volume":"92","author":[{"given":"Tai-Shuan","family":"Lai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Hsuan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwai-I.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Lin","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng-Nan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"L\u2019Italien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo-Liong","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-Jen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2017.03.021_bib1","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2215\/CJN.06840712","article-title":"The USRDS: what you need to know about what it can and can't tell us about ESRD","volume":"8","author":"Foley","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrneph.2009.173","article-title":"Emerging risk factors and markers of chronic kidney disease progression","volume":"5","author":"Kronenberg","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib3","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1056\/NEJM199302183280703","article-title":"Membranoproliferative glomerulonephritis associated with hepatitis C virus infection","volume":"328","author":"Johnson","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2017.03.021_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1056\/NEJM200107053450107","article-title":"Hepatitis C virus infection","volume":"345","author":"Lauer","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2017.03.021_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2215\/CJN.03710708","article-title":"Hepatitis C infection and chronic renal diseases","volume":"4","author":"Perico","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1053\/j.ajkd.2004.12.014","article-title":"Hepatitis C infection is acquired pre-ESRD","volume":"45","author":"Bergman","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib7","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10157-007-0005-6","article-title":"Patterns in the prevalence of hepatitis C virus infection at the start of hemodialysis in Japan","volume":"12","author":"Iwasa","year":"2008","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib8","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1681\/ASN.2005091006","article-title":"Relationship between hepatitis C and chronic kidney disease: results from the Third National Health and Nutrition Examination Survey","volume":"17","author":"Tsui","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib9","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2215\/CJN.00470107","article-title":"Hepatitis C virus infection and the prevalence of renal insufficiency","volume":"2","author":"Dalrymple","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib10","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1872-034X.2008.00334.x","article-title":"Association between hepatitis B\/C viral infection, chronic kidney disease and insulin resistance in individuals undergoing general health screening","volume":"38","author":"Ishizaka","year":"2008","journal-title":"Hepatol Res"},{"key":"10.1016\/j.kint.2017.03.021_bib11","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1053\/j.ajkd.2008.03.009","article-title":"Association of hepatitis C virus infection with prevalence and development of kidney disease","volume":"51","author":"Moe","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1053\/j.ajkd.2010.01.015","article-title":"Association of hepatitis C and B virus infection with CKD in an endemic area in Taiwan: a cross-sectional study","volume":"56","author":"Lee","year":"2010","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib13","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cgh.2009.08.031","article-title":"Lack of association between hepatitis C infection and chronic kidney disease","volume":"8","author":"Asrani","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.kint.2017.03.021_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.ajkd.2010.09.023","article-title":"HCV infection and the incidence of CKD","volume":"57","author":"Butt","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib15","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2215\/CJN.06920711","article-title":"Hepatitis C virus infection and kidney disease: a meta-analysis","volume":"7","author":"Fabrizi","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.03.021_bib16","unstructured":"United States Renal Data System. USRDS Annual Data Report, vol. 2: 2013 Atlas of End-Stage Renal Disease. Available at: http:\/\/www.usrds.org\/2013\/pdf\/v2_ch1_13.pdf."},{"key":"10.1016\/j.kint.2017.03.021_bib17","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1200\/JCO.2010.29.1500","article-title":"Hepatitis C virus seromarkers and subsequent risk of hepatocellular carcinoma: long-term predictors from a community-based cohort study","volume":"28","author":"Lee","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.kint.2017.03.021_bib18","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/STROKEAHA.110.598136","article-title":"Hepatitis C virus infection and increased risk of cerebrovascular disease","volume":"41","author":"Lee","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.kint.2017.03.021_bib19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/infdis\/jis385","article-title":"Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study","volume":"206","author":"Lee","year":"2012","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<290::AID-JMV5>3.0.CO;2-R","article-title":"Transmission of hepatitis C virus in Taiwan: prevalence and risk factors based on a nationwide survey","volume":"59","author":"Sun","year":"1999","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.kint.2017.03.021_bib21","first-page":"9270","article-title":"Epidemiology and natural history of hepatitis C virus infection","volume":"20","author":"Lee","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.kint.2017.03.021_bib22","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1056\/NEJM199908193410802","article-title":"The prevalence of hepatitis C virus infection in the United States, 1988 through 1994","volume":"341","author":"Alter","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2017.03.021_bib23","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1053\/jhep.2003.50157","article-title":"Hepatitis C virus infection in the general population: a community-based study in West Bengal, India","volume":"37","author":"Chowdhury","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.kint.2017.03.021_bib24","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/hep.20046","article-title":"Epidemiology and risk factors for hepatitis C in Alaska Natives","volume":"39","author":"McMahon","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.kint.2017.03.021_bib25","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/QAD.0b013e3283574e71","article-title":"Hepatitis C virus viremia increases the incidence of chronic kidney disease in HIV-infected patients","volume":"26","author":"Peters","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.kint.2017.03.021_bib26","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1093\/infdis\/jit373","article-title":"Hepatitis C viremia and the risk of chronic kidney disease in HIV-infected individuals","volume":"208","author":"Lucas","year":"2013","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib27","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.trstmh.2005.10.008","article-title":"Hepatitis C virus genotypes in southern Taiwan: prevalence and clinical implications","volume":"100","author":"Lee","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.kint.2017.03.021_bib28","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1093\/ndt\/gfm205","article-title":"Hepatitis C virus: from entry to renal injury\u2013facts and potentials","volume":"22","author":"Barsoum","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2017.03.021_bib29","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/jmv.20527","article-title":"Transmission in\u00a0vitro of hepatitis C virus from persistently infected human B-cells to hepatoma cells by cell-to-cell contact","volume":"78","author":"Valli","year":"2006","journal-title":"J\u00a0Med Virol"},{"key":"10.1016\/j.kint.2017.03.021_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2893.2000.00194.x","article-title":"Hepatitis C virus RNA in kidney biopsies from infected patients with renal diseases","volume":"7","author":"Rodriguez-Inigo","year":"2000","journal-title":"J\u00a0Viral Hepat"},{"key":"10.1016\/j.kint.2017.03.021_bib31","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1016\/S0168-8278(12)60007-5","article-title":"The interaction of metabolic factors with HCV infection: does it matter?","volume":"56 Suppl 1","author":"Bugianesi","year":"2012","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.kint.2017.03.021_bib32","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2003.11.056","article-title":"Hepatitis C virus infection and diabetes: direct involvement of the virus in the development of insulin resistance","volume":"126","author":"Shintani","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.kint.2017.03.021_bib33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level","volume":"295","author":"Chen","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2017.03.021_bib34","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.03.021_bib35","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Int Med"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302168?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302168?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:50:14Z","timestamp":1758761414000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253817302168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0085253817302168"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2017.03.021","relation":{},"ISSN":["0085-2538"],"issn-type":[{"type":"print","value":"0085-2538"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High hepatitis C viral load and genotype 2 are strong predictors of chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2017.03.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}