{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:45:19Z","timestamp":1790189119838,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.theisn.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.kint.2017.04.009","type":"journal-article","created":{"date-parts":[[2017,7,6]],"date-time":"2017-07-06T05:15:19Z","timestamp":1499318119000},"page":"864-875","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Net K + secretion in the thick ascending limb of mice on a low-Na, high-K diet"],"prefix":"10.1016","volume":"92","author":[{"given":"Bangchen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghai","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang-France","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven C.","family":"Sansom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2017.04.009_bib1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1475-2840-8-35","article-title":"Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study","volume":"8","author":"J\u00f6nsson","year":"2009","journal-title":"Cardiovasc Diabetol"},{"key":"10.1016\/j.kint.2017.04.009_bib2","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MOL.0000000000000044","article-title":"Dietary patterns, Mediterranean diet, and cardiovascular disease","volume":"25","author":"Martinez-Gonzalez","year":"2014","journal-title":"Curr Opin Lipidol"},{"key":"10.1016\/j.kint.2017.04.009_bib3","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/ejcn.2014.243","article-title":"Effects of Mediterranean-style diet on glycemic control, weight loss and cardiovascular risk factors among type 2 diabetes individuals: a meta-analysis","volume":"69","author":"Huo","year":"2015","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.kint.2017.04.009_bib4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/ajh\/hpu195","article-title":"Mediterranean-style diet is associated with reduced blood pressure variability and subsequent stroke risk in patients with coronary artery disease","volume":"28","author":"Lau","year":"2015","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.kint.2017.04.009_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.amjmed.2014.10.014","article-title":"The Mediterranean diet, its components, and cardiovascular disease","volume":"128","author":"Widmer","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.kint.2017.04.009_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.CIR.52.1.146","article-title":"Blood pressure, sodium intake, and sodium related hormones in the Yanomamo Indians, a \u201cno-salt\u201d culture","volume":"52","author":"Oliver","year":"1975","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2017.04.009_bib7","doi-asserted-by":"crossref","first-page":"F581","DOI":"10.1152\/ajprenal.00330.2015","article-title":"Maintaining K balance on the low Na, high K diet","volume":"310","author":"Cornelius","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib8","doi-asserted-by":"crossref","first-page":"e0115515","DOI":"10.1371\/journal.pone.0115515","article-title":"Low Na, high K diet and the role of aldosterone in BK-mediated K excretion","volume":"10","author":"Cornelius","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2017.04.009_bib9","doi-asserted-by":"crossref","first-page":"F1563","DOI":"10.1152\/ajprenal.00490.2012","article-title":"Bicarbonate promotes BK-alpha\/beta4-mediated K excretion in the renal distal nephron","volume":"303","author":"Cornelius","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coph.2013.11.001","article-title":"Interacting influence of diuretics and diet on BK channel-regulated K homeostasis","volume":"15","author":"Wen","year":"2014","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.kint.2017.04.009_bib11","doi-asserted-by":"crossref","first-page":"F517","DOI":"10.1152\/ajprenal.00118.2006","article-title":"BK channels in the kidney: role in K(+) secretion and localization of molecular components","volume":"291","author":"Pluznick","year":"2006","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib12","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/sj.ki.5002438","article-title":"Two channels for one job","volume":"72","author":"Sansom","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.04.009_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.semnephrol.2013.04.002","article-title":"Regulation of renal potassium secretion: molecular mechanisms","volume":"33","author":"Welling","year":"2013","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2017.04.009_bib14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/ki.2014.14","article-title":"Relation between BK-alpha\/beta4-mediated potassium secretion and ENaC-mediated sodium reabsorption","volume":"86","author":"Wen","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.04.009_bib15","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1172\/JCI109215","article-title":"Effect of chronic potassium loading on potassium secretion by the pars recta or descending limb of the juxtamedullary nephron in the rat","volume":"62","author":"Battilana","year":"1978","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.04.009_bib16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1172\/JCI110609","article-title":"Consequences of potassium recycling in the renal medulla. Effects of ion transport by the medullary thick ascending limb of Henle's loop","volume":"70","author":"Stokes","year":"1982","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.04.009_bib17","first-page":"F297","article-title":"New pathways for potassium transport in the kidney","volume":"242","author":"Jamison","year":"1982","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib18","doi-asserted-by":"crossref","first-page":"F1139","DOI":"10.1152\/ajprenal.00259.2013","article-title":"Dietary salt intake modulates differential splicing of the Na-K-2Cl cotransporter NKCC2","volume":"305","author":"Schiessl","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib19","doi-asserted-by":"crossref","first-page":"F679","DOI":"10.1152\/ajprenal.00407.2012","article-title":"AMPK couples plasma renin to cellular metabolism by phosphorylation of ACC1","volume":"305","author":"Fraser","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib20","first-page":"F121","article-title":"Axial heterogeneity of potassium transport across hamster thick ascending limb of Henle's loop","volume":"267","author":"Tsuruoka","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib21","first-page":"F1224","article-title":"Isoproterenol increases Ca, Mg, and NaCl reabsorption in mouse thick ascending limb","volume":"258","author":"Bailly","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0002-9343(84)80004-2","article-title":"Diuretic-induced hypokalemia","volume":"77","author":"Knochel","year":"1984","journal-title":"Am J Med"},{"key":"10.1016\/j.kint.2017.04.009_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.1985.154","article-title":"Tubular action of diuretics: distal effects on electrolyte transport and acidification","volume":"28","author":"Hropot","year":"1985","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.04.009_bib24","first-page":"F395","article-title":"Potassium secretion by cortical collecting tubule: relation to sodium absorption, luminal sodium concentration, and transepithelial voltage","volume":"241","author":"Stokes","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib25","doi-asserted-by":"crossref","first-page":"37881","DOI":"10.1074\/jbc.M206644200","article-title":"Absence of small conductance K+ channel (SK) activity in apical membranes of thick ascending limb and cortical collecting duct in ROMK (Bartter's) knockout mice","volume":"277","author":"Lu","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.04.009_bib26","doi-asserted-by":"crossref","first-page":"F490","DOI":"10.1152\/ajprenal.00305.2003","article-title":"ROMK is required for expression of the 70-pS K channel in the thick ascending limb","volume":"286","author":"Lu","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib27","doi-asserted-by":"crossref","first-page":"37871","DOI":"10.1074\/jbc.M205627200","article-title":"Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter's syndrome","volume":"277","author":"Lorenz","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.04.009_bib28","doi-asserted-by":"crossref","first-page":"F849","DOI":"10.1152\/ajprenal.00181.2009","article-title":"A\u00a0comprehensive guide to the ROMK potassium channel: form and function in health and disease","volume":"297","author":"Welling","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib29","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/BF00374924","article-title":"Ca2+, Mg2+ and K+ transport in the cortical and medullary thick ascending limb of the rat nephron: influence of transepithelial voltage","volume":"424","author":"Mandon","year":"1993","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2017.04.009_bib30","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/BF00582129","article-title":"Effects of glucagon on Na+, Cl-, K+, Mg2+ and Ca2+ transports in cortical and medullary thick ascending limbs of mouse kidney","volume":"414","author":"Di Stefano","year":"1989","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2017.04.009_bib31","first-page":"381","article-title":"Furosemide (frusemide). A pharmacokinetic\/pharmacodynamic review (Part I)","volume":"18","author":"Ponto","year":"1990","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.kint.2017.04.009_bib32","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1751-7176.2011.00512.x","article-title":"Thiazide and loop diuretics","volume":"13","author":"Sica","year":"2011","journal-title":"J\u00a0Clin Hypertens (Greenwich)"},{"key":"10.1016\/j.kint.2017.04.009_bib33","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1001\/archinte.160.16.2429","article-title":"New guidelines for potassium replacement in clinical practice: a contemporary review by the National Council on Potassium in Clinical Practice","volume":"160","author":"Cohn","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.kint.2017.04.009_bib34","first-page":"F257","article-title":"Extrarenal potassium homeostasis","volume":"240","author":"Bia","year":"1981","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib35","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MNH.0b013e328332bda4","article-title":"Regulation of sodium transport by ENaC in the kidney","volume":"19","author":"Hamm","year":"2010","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2017.04.009_bib36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1042\/cs0980481","article-title":"Localization of diuretic effects along the loop of Henle: an in\u00a0vivo microperfusion study in rats","volume":"98","author":"Unwin","year":"2000","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.kint.2017.04.009_bib37","doi-asserted-by":"crossref","first-page":"F280","DOI":"10.1152\/ajprenal.00093.2015","article-title":"Vasopressin regulation of sodium transport in the distal nephron and collecting duct","volume":"309","author":"Kortenoeven","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib38","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.2012050449","article-title":"Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity","volume":"24","author":"Roos","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.04.009_bib39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1113\/jphysiol.2006.118315","article-title":"Role of vasopressin in rat distal colon function","volume":"578","author":"Cristia","year":"2007","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib40","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1161\/01.HYP.3.2.174","article-title":"Does vasopressin contribute to salt-induced hypertension in the Dahl strain?","volume":"3","author":"Matsuguchi","year":"1981","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2017.04.009_bib41","doi-asserted-by":"crossref","first-page":"F301","DOI":"10.1152\/ajprenal.00129.2001","article-title":"Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT(1) receptors","volume":"282","author":"Kovacs","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib42","doi-asserted-by":"crossref","first-page":"F1177","DOI":"10.1152\/ajprenal.00201.2013","article-title":"K+-induced natriuresis is preserved during Na+ depletion and accompanied by inhibition of the Na+-Cl- cotransporter","volume":"305","author":"van der Lubbe","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib43","first-page":"600","article-title":"Membrane stretch: a physiological stimulator of Ca2+-activated K+ channels in thick ascending limb","volume":"408","author":"Taniguchi","year":"1989","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib44","first-page":"F805","article-title":"Regulation of apical K channels in rat cortical collecting tubule during changes in dietary K intake","volume":"277","author":"Palmer","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib45","doi-asserted-by":"crossref","first-page":"23066","DOI":"10.1074\/jbc.M212301200","article-title":"Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A","volume":"278","author":"Yoo","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.04.009_bib46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1152\/physrev.00051.2003","article-title":"Molecular diversity and regulation of renal potassium channels","volume":"85","author":"Hebert","year":"2005","journal-title":"Physiol Rev"},{"key":"10.1016\/j.kint.2017.04.009_bib47","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1074\/jbc.M115.707877","article-title":"Romk1 knockout mice do not produce bartter phenotype but exhibit impaired K excretion","volume":"291","author":"Dong","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.04.009_bib48","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1681\/ASN.V981347","article-title":"11Beta-hydroxysteroid dehydrogenase, mineralocorticoid receptor, and thiazide-sensitive Na-Cl cotransporter expression by distal tubules","volume":"9","author":"Bostanjoglo","year":"1998","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.04.009_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-physiol-021115-105423","article-title":"Roles and regulation of renal K channels","volume":"78","author":"Welling","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib50","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1085\/jgp.108.6.537","article-title":"Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney","volume":"108","author":"Lu","year":"1996","journal-title":"J\u00a0Gen Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib51","first-page":"F494","article-title":"Regulation of small-conductance K+ channel in apical membrane of rat cortical collecting tubule","volume":"259","author":"Wang","year":"1990","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib52","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1161\/HYPERTENSIONAHA.115.05394","article-title":"Increased epithelial sodium channel activity contributes to hypertension caused by Na+-HCO3- cotransporter electrogenic 2 deficiency","volume":"66","author":"Wen","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2017.04.009_bib53","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00424-008-0581-7","article-title":"Micropuncturing the nephron","volume":"458","author":"Vallon","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2017.04.009_bib54","first-page":"F658","article-title":"Arachidonic acid potentiates the feedback response of mesangial BKCa channels to angiotensin II","volume":"274","author":"Stockand","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib55","doi-asserted-by":"crossref","first-page":"F1465","DOI":"10.1152\/ajprenal.00012.2008","article-title":"Insulin increases the activity of mesangial BK channels through MAPK signaling","volume":"294","author":"Foutz","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.04.009_bib56","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1681\/ASN.2009080817","article-title":"Intercalated cell BK-alpha\/beta4 channels modulate sodium and potassium handling during potassium adaptation","volume":"21","author":"Holtzclaw","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817302818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T13:59:24Z","timestamp":1659189564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253817302818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0085253817302818"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2017.04.009","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2017.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}