{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:23:19Z","timestamp":1791274999857,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["JP26461235"],"award-info":[{"award-number":["JP26461235"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.kint.2017.11.016","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T23:33:33Z","timestamp":1517528013000},"page":"1108-1117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6"],"prefix":"10.1016","volume":"93","author":[{"given":"Yoshiro","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kiyonari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Mukumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiko","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2017.11.016_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00467-010-1585-z","article-title":"Nephronophthisis","volume":"26","author":"Wolf","year":"2011","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2017.11.016_bib2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/MOP.0000000000000194","article-title":"Nephronophthisis and related syndromes","volume":"27","author":"Wolf","year":"2015","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.kint.2017.11.016_bib3","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1681\/ASN.2006121344","article-title":"Nephronophthisis-associated ciliopathies","volume":"18","author":"Hildebrandt","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.016_bib4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/jmedgenet-2015-103304","article-title":"Large-scale targeted sequencing comparison highlights extreme genetic heterogeneity in nephronophthisis-related ciliopathies","volume":"53","author":"Schueler","year":"2016","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.kint.2017.11.016_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12565-015-0302-1","article-title":"Ciliary subcompartments and cysto-proteins","volume":"92","author":"Yokoyama","year":"2017","journal-title":"Anat Sci Int"},{"key":"10.1016\/j.kint.2017.11.016_bib6","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2011.04.019","article-title":"Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways","volume":"145","author":"Sang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.kint.2017.11.016_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/cm.21264","article-title":"Structural basis of the Inv compartment and ciliary abnormalities in Inv\/nphp2 mutant mice","volume":"73","author":"Tsuji","year":"2016","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.kint.2017.11.016_bib8","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1126\/science.8480178","article-title":"Reversal of left-right asymmetry: a situs inversus mutation","volume":"260","author":"Yokoyama","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.kint.2017.11.016_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/26006","article-title":"Cloning of inv, a gene that controls left\/right asymmetry and kidney development","volume":"395","author":"Mochizuki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.kint.2017.11.016_bib10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1242\/jcs.037408","article-title":"Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region","volume":"122","author":"Shiba","year":"2009","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2017.11.016_bib11","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/cm.20428","article-title":"Inv acts as a molecular anchor for Nphp3 and Nek8 in the proximal segment of primary cilia","volume":"67","author":"Shiba","year":"2010","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.kint.2017.11.016_bib12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/ng.2681","article-title":"ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3","volume":"45","author":"Hoff","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2017.11.016_bib13","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1038\/ncomms7023","article-title":"ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning","volume":"6","author":"Czarnecki","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2017.11.016_bib14","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1681\/ASN.2005080824","article-title":"NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes","volume":"16","author":"Mahjoub","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.016_bib15","doi-asserted-by":"crossref","first-page":"a028134","DOI":"10.1101\/cshperspect.a028134","article-title":"Open Sesame: How transition fibers and the transition zone control ciliary composition","volume":"9","author":"Garcia-Gonzalo","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.kint.2017.11.016_bib16","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.febslet.2012.05.064","article-title":"The ciliary protein Nek8\/Nphp9 acts downstream of Inv\/Nphp2 during pronephros morphogenesis and left\u2013right establishment in zebrafish","volume":"586","author":"Fukui","year":"2012","journal-title":"FEBS Lett"},{"key":"10.1016\/j.kint.2017.11.016_bib17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.ajhg.2008.02.017","article-title":"Loss of nephrocystin-3 function can cause embryonic lethality, Meckel-Gruber-like syndrome, situs inversus, and renal-hepatic-pancreatic dysplasia","volume":"82","author":"Bergmann","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.kint.2017.11.016_bib18","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1681\/ASN.2012050490","article-title":"Loss of the ciliary kinase Nek8 cause left-right asymmetry defects","volume":"24","author":"Manning","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.016_bib19","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1101\/gad.173443.111","article-title":"An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium","volume":"25","author":"Wright","year":"2011","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2017.11.016_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/cm.21014","article-title":"Targeting of Nphp3 to the primary cilia is controlled by an N-terminal myristoylation site and coiled-coil domains","volume":"69","author":"Nakata","year":"2012","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.kint.2017.11.016_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1681\/ASN.V121107","article-title":"Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice","volume":"12","author":"Omran","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.016_bib22","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ki.2008.662","article-title":"Mutations of NPHP2 and NPHP3 in infantile nephronophthisis","volume":"75","author":"Tory","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.016_bib23","doi-asserted-by":"crossref","first-page":"20766","DOI":"10.1074\/jbc.M116.741827","article-title":"Novel biochemical and structural insights into the interaction of myristoylated cargo with Unc119 protein and their release by Arl2\/3","volume":"291","author":"Jaiswai","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2017.11.016_bib24","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1242\/dev.00407","article-title":"The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia","volume":"130","author":"Watanabe","year":"2003","journal-title":"Development"},{"key":"10.1016\/j.kint.2017.11.016_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ki.2015.122","article-title":"The SAM domain of ANKS6 has different interacting partners and mutations can induce different cysticphenotypes","volume":"88","author":"Bakey","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.016_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1472-6807-14-17","article-title":"Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3","volume":"14","author":"Leettola","year":"2014","journal-title":"BMC Struct Biol"},{"key":"10.1016\/j.kint.2017.11.016_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbrc.2009.03.113","article-title":"The polycystic kidney disease-related proteins Bicc1 and SamCystin interact","volume":"383","author":"Stagner","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2017.11.016_bib28","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1242\/dev.038174","article-title":"Bicaudal C, a novel regulator of Dvl signaling abutting RNA-processing bodies, controls cilia orientation and leftward flow","volume":"136","author":"Maisonneuve","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.kint.2017.11.016_bib29","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1007\/s00335-002-2241-0","article-title":"Positional cloning of jcpk\/bpk locus of the mouse","volume":"14","author":"Cogswell","year":"2003","journal-title":"Mamm Genome"},{"key":"10.1016\/j.kint.2017.11.016_bib30","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/ki.2015.17","article-title":"Anks3 interacts with nephronophthisis proteins and is required for normal renal development","volume":"87","author":"Yakulov","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.016_bib31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/dvg.20614","article-title":"Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL\/6N mouse strain with high efficiency and stability","volume":"48","author":"Kiyonari","year":"2010","journal-title":"Genesis"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817308529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253817308529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T19:50:37Z","timestamp":1720036237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253817308529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0085253817308529"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2017.11.016","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Inv compartment of renal cilia is an intraciliary signal-activating center to phosphorylate ANKS6","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2017.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}