{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:03:04Z","timestamp":1791820984429,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.kint.2017.11.024","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T20:10:30Z","timestamp":1517602230000},"page":"1198-1206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":105,"title":["Markers of early progressive renal decline in type\u00a02\u00a0diabetes suggest different implications for\u00a0etiological studies and prognostic tests\u00a0development"],"prefix":"10.1016","volume":"93","author":[{"given":"Natalia","family":"Nowak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Skupien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Smiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamanouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika A.","family":"Niewczas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej T.","family":"Galecki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Duffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Breyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Pullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Bonventre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej S.","family":"Krolewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1 Suppl","key":"10.1016\/j.kint.2017.11.024_bib1","doi-asserted-by":"crossref","first-page":"A8","DOI":"10.1053\/j.ajkd.2010.10.007","article-title":"US renal data system 2010 annual data report","volume":"57","author":"Collins","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2017.11.024_bib2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrneph.2015.173","article-title":"Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease","volume":"12","author":"Thomas","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib3","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.kint.2016.10.046","article-title":"Fast renal decline to end-stage renal disease: an unrecognized feature of nephropathy in diabetes","volume":"91","author":"Krolewski","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ki.2012.189","article-title":"The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease","volume":"82","author":"Skupien","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib5","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.2337\/dc16-0950","article-title":"Patterns of Estimated Glomerular Filtration Rate Decline Leading to End-Stage Renal Disease in Type 1 Diabetes","volume":"39","author":"Skupien","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2017.11.024_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1681\/ASN.2011060627","article-title":"Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes","volume":"23","author":"Niewczas","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib7","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1038\/ki.2013.497","article-title":"Uremic solutes and risk of end-stage renal disease in type 2 diabetes: metabolomic study","volume":"85","author":"Niewczas","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.kint.2017.02.010","article-title":"Improved clinical trial enrollment criterion to identify patients with diabetes at risk of end-stage renal disease","volume":"92","author":"Yamanouchi","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib9","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/ki.2015.199","article-title":"Biomarkers of rapid chronic kidney disease progression in type 2 diabetes","volume":"88","author":"Looker","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib10","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2337\/dc16-1571","article-title":"Association of Circulating Biomarkers (Adrenomedullin, TNFR1, and NT-proBNP) With Renal Function Decline in Patients With Type 2 Diabetes: A French Prospective Cohort","volume":"40","author":"Saulnier","year":"2017","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2017.11.024_bib11","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1681\/ASN.2006080872","article-title":"Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes","volume":"18","author":"Perkins","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib12","doi-asserted-by":"crossref","first-page":"226","DOI":"10.2337\/dc13-0985","article-title":"Early Progressive Renal Decline Precedes the Onset of Microalbuminuria and Its Progression to Macroalbuminuria","volume":"37","author":"Krolewski","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2017.11.024_bib13","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2337\/dc15-0184","article-title":"Progressive renal decline: the new paradigm of diabetic nephropathy in type 1 diabetes","volume":"38","author":"Krolewski","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2017.11.024_bib14","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.2014.6634","article-title":"Decline in estimated glomerular filtration rate and subsequent risk of end-stage renal disease and mortality","volume":"311","author":"Coresh","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2017.11.024_bib15","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1681\/ASN.2013070758","article-title":"Kidney Injury Molecule-1 is a Biomarker of Acute and Chronic Kidney Injury and Predicts Progression to ESRD","volume":"25","author":"Sabbisetti","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/ki.2015.314","article-title":"Increased plasma kidney injury molecule-1 suggests early progressive renal decline in non-proteinuric patients with type 1 diabetes","volume":"89","author":"Nowak","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib17","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI34487","article-title":"Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells","volume":"118","author":"Ichimura","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.11.024_bib18","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1097\/01.ASN.0000015609.31253.7F","article-title":"MCP-1 induces inflammatory activation of human tubular epithelial cells: involvement of the transcription factors, nuclear factor-kappaB and activating protein-1","volume":"13","author":"Viedt","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib19","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1172\/JCI114359","article-title":"Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure","volume":"84","author":"Humes","year":"1989","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.11.024_bib20","doi-asserted-by":"crossref","first-page":"944","DOI":"10.2741\/2734","article-title":"The role of chemokines and chemokine receptors in diabetic nephropathy","volume":"13","author":"Ruster","year":"2008","journal-title":"Front Biosci"},{"key":"10.1016\/j.kint.2017.11.024_bib21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ki.2014.285","article-title":"TNF receptors: signaling pathways and contribution to renal dysfunction","volume":"87","author":"Al-Lamki","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/303298","article-title":"Emerging Urinary Markers of Renal Injury in Obstructive Nephropathy","author":"Lucarelli","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.kint.2017.11.024_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000416503","article-title":"Kidney function and protein excretion in relation to pathomorphology of glomerular diseases","volume":"68","author":"Ackle","year":"1988","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ki.1997.2","article-title":"Understanding the nature of renal disease progression","volume":"51","author":"Remuzzi","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib25","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1681\/ASN.2006080936","article-title":"Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study","volume":"18","author":"Fliser","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib26","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00365510802150158","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease","volume":"241","author":"Devarajan","year":"2008","journal-title":"Scand J Clin Lab Invest Suppl"},{"key":"10.1016\/j.kint.2017.11.024_bib27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000151665","article-title":"Pathological and prognostic value of urinary neutrophil gelatinase-associated lipocalin in macroproteinuric patients with worsening renal function","volume":"31","author":"Bolignano","year":"2008","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.kint.2017.11.024_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cyto.2009.04.001","article-title":"Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy","volume":"47","author":"Tam","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.kint.2017.11.024_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac7071","article-title":"Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker","volume":"7","author":"Ju","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.kint.2017.11.024_bib30","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.kint.2016.01.015","article-title":"Urinary peptidomics in a rodent model of diabetic nephropathy highlights epidermal growth factor as a biomarker for renal deterioration in patients with type 2 diabetes","volume":"89","author":"Betz","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib31","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/sj.ki.5002621","article-title":"The ratio of epidermal growth factor to monocyte chemotactic peptide-1 in the urine predicts renal prognosis in IgA nephropathy","volume":"73","author":"Torres","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib32","series-title":"Brenner and Rector\u2019s the Kidney","first-page":"1777","article-title":"Diabetic nephropathy","author":"Parving","year":"2004"},{"key":"10.1016\/j.kint.2017.11.024_bib33","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1172\/JCI45361","article-title":"Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis","volume":"123","author":"Humphreys","year":"2013","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2017.11.024_bib34","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1038\/ki.1996.521","article-title":"Urinary IL-6\/EGF ratio: a useful prognostic marker for the progression of renal damage in IgA nephropathy","volume":"50","author":"Ranieri","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib35","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0302-2838(03)00190-8","article-title":"Epidermal growth factor and monocyte chemotactic peptide-1 expression in reflux nephropathy","volume":"44","author":"Chertin","year":"2003","journal-title":"Eur Urol"},{"key":"10.1016\/j.kint.2017.11.024_bib36","first-page":"4886","article-title":"Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1)","volume":"48","author":"Mullin","year":"1988","journal-title":"Cancer Res"},{"key":"10.1016\/j.kint.2017.11.024_bib37","doi-asserted-by":"crossref","first-page":"F365","DOI":"10.1152\/ajprenal.00035.2004","article-title":"Requirement of the epidermal 422 growth factor receptor in renal epithelial cell proliferation and migration","volume":"287","author":"Zhuang","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.11.024_bib38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ki.2012.43","article-title":"Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury","volume":"82","author":"Chen","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib39","doi-asserted-by":"crossref","first-page":"F697","DOI":"10.1152\/ajprenal.00016.2008","article-title":"MCP-1\/CCL2: a new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy","volume":"294","author":"Tesch","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2017.11.024_bib40","first-page":"1496","article-title":"Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria","volume":"14","author":"Mizu","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib41","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1097\/01.ASN.0000089563.63641.A8","article-title":"CCR2 signaling contributes to ischemia-reperfusion injury in kidney","volume":"14","author":"Furuichi","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib42","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/01.ASN.0000120371.09769.80","article-title":"Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis","volume":"15","author":"Wada","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib43","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.ajpath.2011.11.011","article-title":"Chemokine receptor CCR1 disruption limits renal damage in a murine model of hemolytic uremic syndrome","volume":"180","author":"Ramos","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2017.11.024_bib44","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ki.2011.102","article-title":"An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes","volume":"80","author":"Sayyed","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib45","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1038\/ki.2012.195","article-title":"NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease","volume":"82","author":"Nickolas","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2017.11.024_bib46","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1681\/ASN.V76930","article-title":"Effect of duration of type I diabetes on the prevalence of stages of diabetic nephropathy defined by urinary albumin\/creatinine ratio","volume":"7","author":"Warram","year":"1996","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2017.11.024_bib47","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.kint.2017.11.024_bib48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","article-title":"Estimation of failure probabilities in the presence of competing risks: new representations of old estimators","volume":"18","author":"Gooley","year":"1999","journal-title":"Stat Med"},{"key":"10.1016\/j.kint.2017.11.024_bib49","unstructured":"Bergstralh E. SAS Macro That Performs Cumulative Incidence in Presence of Completing Risks. Available at: https:\/\/github.com\/Jiangtang\/Programming-SAS\/blob\/master\/UserMacros\/mayo\/comprisk.sas. Accessed February 3, 2010."},{"key":"10.1016\/j.kint.2017.11.024_bib50","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A\u00a0new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J\u00a0Chronic Dis"},{"key":"10.1016\/j.kint.2017.11.024_bib51","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jclinepi.2016.03.031","article-title":"Regression coefficient-based scoring system should be used to assign weights to the risk index","volume":"79","author":"Mehta","year":"2016","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.kint.2017.11.024_bib52","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1001\/jama.2016.5951","article-title":"Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease","volume":"315","author":"Ganz","year":"2016","journal-title":"JAMA"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381730892X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525381730892X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:49:05Z","timestamp":1758761345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525381730892X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S008525381730892X"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2017.11.024","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Markers of early progressive renal decline in type\u00a02\u00a0diabetes suggest different implications for\u00a0etiological studies and prognostic tests\u00a0development","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2017.11.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}