{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:19:33Z","timestamp":1790133573393,"version":"4.0.1"},"reference-count":82,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.kint.2018.01.025","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T10:55:39Z","timestamp":1524308139000},"page":"259-267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Are Pax proteins potential therapeutic targets in kidney disease and cancer?"],"prefix":"10.1016","volume":"94","author":[{"given":"Edward","family":"Grimley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R.","family":"Dressler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2018.01.025_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/j.ajkd.2003.09.004","article-title":"USRDS: the United States Renal Data System","volume":"42","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2018.01.025_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.kint.2017.07.030","article-title":"Cellular and molecular pathways of renal repair after acute kidney injury","volume":"93","author":"Kumar","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.01.025_bib3","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1681\/ASN.2005010055","article-title":"Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene","volume":"16","author":"Wharram","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nrneph.2016.127","article-title":"Podocyte-actin dynamics in health and disease","volume":"12","author":"Perico","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib5","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/nep.13161","article-title":"The endothelial glycocalyx in health and kidney disease: rising star or false dawn?","volume":"22","author":"Liew","year":"2017","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.kint.2018.01.025_bib6","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0959-437X(93)90095-7","article-title":"Evolution and role of Pax genes","volume":"3","author":"Noll","year":"1993","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.kint.2018.01.025_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/0888-7543(91)90151-4","article-title":"Pax: a murine multigene family of paired box-containing genes","volume":"11","author":"Walther","year":"1991","journal-title":"Genomics"},{"key":"10.1016\/j.kint.2018.01.025_bib8","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1073\/pnas.89.4.1179","article-title":"Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor","volume":"89","author":"Dressler","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.01.025_bib9","first-page":"6024","article-title":"Alternative splicing of Pax-8 gene transcripts is developmentally regulated and generates isoforms with different transactivation properties","volume":"13","author":"Kozmik","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib10","doi-asserted-by":"crossref","first-page":"12745","DOI":"10.1073\/pnas.91.26.12745","article-title":"Pax-3 contains domains for transcription activation and transcription inhibition","volume":"91","author":"Chalepakis","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.01.025_bib11","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1128\/MCB.15.5.2858","article-title":"DNA-binding and transactivation properties of Pax-6: three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5)","volume":"15","author":"Czerny","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib12","doi-asserted-by":"crossref","first-page":"8281","DOI":"10.1128\/MCB.19.12.8281","article-title":"Identification of a portable repression domain and an E1A-responsive activation domain in Pax4: a possible role of Pax4 as a transcriptional repressor in the pancreas","volume":"19","author":"Fujitani","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1006\/bbrc.1999.0809","article-title":"DNA binding and transactivating properties of the paired and homeobox protein Pax4","volume":"259","author":"Kalousova","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2018.01.025_bib14","doi-asserted-by":"crossref","first-page":"21088","DOI":"10.1074\/jbc.271.35.21088","article-title":"Mapping of Pax-2 transcription activation domains","volume":"271","author":"Lechner","year":"1996","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.01.025_bib15","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1093\/nar\/28.14.2741","article-title":"PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin","volume":"28","author":"Lechner","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2018.01.025_bib16","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1242\/dev.122.10.3141","article-title":"A\u00a0conserved region of engrailed, shared among all en-, gsc-, Nk1-, Nk2- and msh-class homeoproteins, mediates active transcriptional repression in\u00a0vivo","volume":"122","author":"Smith","year":"1996","journal-title":"Development"},{"key":"10.1016\/j.kint.2018.01.025_bib17","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/MCB.18.5.2804","article-title":"Two distinct types of repression domain in engrailed: one interacts with the groucho corepressor and is preferentially active on integrated target genes","volume":"18","author":"Tolkunova","year":"1998","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib18","doi-asserted-by":"crossref","first-page":"3863","DOI":"10.1242\/dev.034876","article-title":"Advances in early kidney specification, development and patterning","volume":"136","author":"Dressler","year":"2009","journal-title":"Development"},{"key":"10.1016\/j.kint.2018.01.025_bib19","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/dev.109.4.787","article-title":"Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system","volume":"109","author":"Dressler","year":"1990","journal-title":"Development"},{"key":"10.1016\/j.kint.2018.01.025_bib20","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1073\/pnas.0408840102","article-title":"Pax2 expression occurs in renal medullary epithelial cells in\u00a0vivo and in cell culture, is osmoregulated, and promotes osmotic tolerance","volume":"102","author":"Cai","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.01.025_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1097\/PAI.0b013e3181d712ef","article-title":"PAX-2 expression in non-neoplastic, primary neoplastic, and metastatic neoplastic tissue: a comprehensive immunohistochemical study","volume":"18","author":"Zhai","year":"2010","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1016\/j.kint.2018.01.025_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1681\/ASN.2008070709","article-title":"Regeneration of glomerular podocytes by human renal progenitors","volume":"20","author":"Ronconi","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib23","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/MNH.0b013e32835fefd4","article-title":"Glomerular parietal epithelial cells in kidney physiology, pathology, and repair","volume":"22","author":"Shankland","year":"2013","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2018.01.025_bib24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ydbio.2012.02.032","article-title":"Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys","volume":"365","author":"Soofi","year":"2012","journal-title":"Dev Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib25","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1242\/dev.121.12.4057","article-title":"Pax-2 controls multiple steps of urogenital development","volume":"121","author":"Torres","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.kint.2018.01.025_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ng0495-358","article-title":"Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux","volume":"9","author":"Sanyanusin","year":"1995","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2018.01.025_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/humu.22020","article-title":"Update of PAX2 mutations in renal coloboma syndrome and establishment of a locus-specific database","volume":"33","author":"Bower","year":"2012","journal-title":"Hum Mutat"},{"key":"10.1016\/j.kint.2018.01.025_bib28","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1101\/gad.240102","article-title":"Nephric lineage specification by Pax2 and Pax8","volume":"16","author":"Bouchard","year":"2002","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2018.01.025_bib29","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1681\/ASN.2006070739","article-title":"Pax2 and pax8 regulate branching morphogenesis and nephron differentiation in the developing kidney","volume":"18","author":"Narlis","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib30","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1242\/dev.110.2.643","article-title":"Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland","volume":"110","author":"Plachov","year":"1990","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/j.kint.2018.01.025_bib31","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"Traykova-Brauch","year":"2008","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2018.01.025_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.eururo.2011.06.049","article-title":"The epidemiology of renal cell carcinoma","volume":"60","author":"Ljungberg","year":"2011","journal-title":"European Urology"},{"key":"10.1016\/j.kint.2018.01.025_bib33","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.7935.1","article-title":"Recent advances in the management of renal cell carcinoma","volume":"5","author":"Molina","year":"2016","journal-title":"F1000Research"},{"key":"10.1016\/j.kint.2018.01.025_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/ng0594-85","article-title":"Mutations of the VHL tumour suppressor gene in renal carcinoma","volume":"7","author":"Gnarra","year":"1994","journal-title":"Nature Genetics"},{"key":"10.1016\/j.kint.2018.01.025_bib35","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.eururo.2015.01.005","article-title":"EAU guidelines on renal cell carcinoma: 2014 update","volume":"67","author":"Ljungberg","year":"2015","journal-title":"European Urology"},{"key":"10.1016\/j.kint.2018.01.025_bib36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/modpathol.3800535","article-title":"PAX2: a reliable marker for nephrogenic adenoma","volume":"19","author":"Tong","year":"2006","journal-title":"Mod Pathol"},{"key":"10.1016\/j.kint.2018.01.025_bib37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/hupa.2001.22753","article-title":"Pax-2 expression in adult renal tumors","volume":"32","author":"Daniel","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1016\/j.kint.2018.01.025_bib38","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/modpathol.3800320","article-title":"Expression of aquaporins and PAX-2 compared to CD10 and cytokeratin 7 in renal neoplasms: a tissue microarray study","volume":"18","author":"Mazal","year":"2005","journal-title":"Mod Pathol"},{"key":"10.1016\/j.kint.2018.01.025_bib39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1309\/9KWEA4W9Y94D1AEE","article-title":"Immunohistochemical analysis for cytokeratin 7, KIT, and PAX2: value in the differential diagnosis of chromophobe cell carcinoma","volume":"127","author":"Memeo","year":"2007","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.kint.2018.01.025_bib40","first-page":"4092","article-title":"Expression of Pax-2 in human renal cell carcinoma and growth inhibition by antisense oligonucleotides","volume":"55","author":"Gnarra","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.kint.2018.01.025_bib41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1172\/JCI118811","article-title":"The PAX2 tanscription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations","volume":"98","author":"Winyard","year":"1996","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.01.025_bib42","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.canlet.2008.02.016","article-title":"In\u00a0vivo validation of PAX2 as a target for renal cancer therapy","volume":"265","author":"Hueber","year":"2008","journal-title":"Cancer Lett"},{"key":"10.1016\/j.kint.2018.01.025_bib43","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/sj.ki.5000136","article-title":"PAX2 inactivation enhances cisplatin-induced apoptosis in renal carcinoma cells","volume":"69","author":"Hueber","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.01.025_bib44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.01.025_bib45","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2018.01.025_bib46","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1681\/ASN.2013040398","article-title":"Strategies targeting cAMP signaling in the treatment of polycystic kidney disease","volume":"25","author":"Torres","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib47","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.01.025_bib48","doi-asserted-by":"crossref","first-page":"iv15","DOI":"10.1093\/ndt\/gfu017","article-title":"Renal replacement therapy for autosomal dominant polycystic kidney disease (ADPKD) in Europe: prevalence and survival\u2013an analysis of data from the ERA-EDTA Registry","volume":"29 Suppl 4","author":"Spithoven","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2018.01.025_bib49","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","article-title":"Tolvaptan in patients with autosomal dominant polycystic kidney disease","volume":"367","author":"Torres","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.01.025_bib50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-med-050913-022838","article-title":"Vasopressin receptor antagonists, heart failure, and polycystic kidney disease","volume":"66","author":"Torres","year":"2015","journal-title":"Ann Rev Med"},{"key":"10.1016\/j.kint.2018.01.025_bib51","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1056\/NEJMoa1710030","article-title":"Tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"377","author":"Torres","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.01.025_bib52","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1006\/dbio.2000.9618","article-title":"Reduced Pax2 gene dosage increases apoptosis and slows the progression of renal cystic disease","volume":"219","author":"Ostrom","year":"2000","journal-title":"Dev Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib53","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1093\/hmg\/ddl428","article-title":"Pax2 gene dosage influences cystogenesis in autosomal dominant polycystic kidney disease","volume":"15","author":"Stayner","year":"2006","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2018.01.025_bib54","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1126\/science.184.4139.868","article-title":"Chromatin structure: a repeating unit of histones and DNA","volume":"184","author":"Kornberg","year":"1974","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.01.025_bib55","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/38444","article-title":"Crystal structure of the nucleosome core particle at 2.8 A resolution","volume":"389","author":"Luger","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.kint.2018.01.025_bib56","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.cell.2007.01.033","article-title":"The mammalian epigenome","volume":"128","author":"Bernstein","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.kint.2018.01.025_bib58","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib59","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"Bannister","year":"2011","journal-title":"Cell Res"},{"key":"10.1016\/j.kint.2018.01.025_bib60","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1126\/science.1063127","article-title":"Translating the histone code","volume":"293","author":"Jenuwein","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.01.025_bib61","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.semcdb.2015.07.007","article-title":"Pax factors in transcription and epigenetic remodelling","volume":"44","author":"Mayran","year":"2015","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib62","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.devcel.2007.09.004","article-title":"The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex","volume":"13","author":"Patel","year":"2007","journal-title":"Dev Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib63","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1074\/jbc.M109663200","article-title":"Phosphorylation of Pax2 by the c-Jun N-terminal kinase and enhanced Pax2-dependent transcription activation","volume":"277","author":"Cai","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.01.025_bib64","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1093\/emboj\/cdg536","article-title":"Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation","volume":"22","author":"Cai","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2018.01.025_bib65","doi-asserted-by":"crossref","first-page":"20395","DOI":"10.1074\/jbc.M701574200","article-title":"PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex","volume":"282","author":"Cho","year":"2007","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.01.025_bib66","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ydbio.2015.01.005","article-title":"Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms","volume":"399","author":"Ranghini","year":"2015","journal-title":"Dev Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib67","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1126\/science.1187942","article-title":"PTIP promotes chromatin changes critical for immunoglobulin class switch recombination","volume":"329","author":"Daniel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.01.025_bib68","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1128\/MCB.00990-10","article-title":"Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus","volume":"31","author":"Schwab","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib69","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1093\/emboj\/19.10.2292","article-title":"Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family","volume":"19","author":"Eberhard","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2018.01.025_bib70","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2011.11.007","article-title":"Epigenetic mechanisms of Groucho\/Grg\/TLE mediated transcriptional repression","volume":"45","author":"Patel","year":"2012","journal-title":"Mol Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib71","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.1074\/jbc.M114.607424","article-title":"The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor","volume":"290","author":"Abraham","year":"2015","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.01.025_bib72","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00467-013-2603-8","article-title":"Mechanisms of gene activation and repression by Pax proteins in the developing kidney","volume":"29","author":"Patel","year":"2014","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2018.01.025_bib73","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd2132","article-title":"Drugs, their targets and the nature and number of drug targets","volume":"5","author":"Imming","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.kint.2018.01.025_bib74","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0092-8674(95)90518-9","article-title":"Crystal structure of a paired domain-DNA complex at 2.5 A resolution reveals structural basis for Pax developmental mutations","volume":"80","author":"Xu","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib75","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(01)00410-5","article-title":"Structural studies of Ets-1\/Pax5 complex formation on DNA","volume":"8","author":"Garvie","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.kint.2018.01.025_bib76","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1101\/gad.13.10.1263","article-title":"Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding","volume":"13","author":"Xu","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2018.01.025_bib77","doi-asserted-by":"crossref","first-page":"8355","DOI":"10.1016\/S0021-9258(17)37201-0","article-title":"Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes","volume":"269","author":"Epstein","year":"1994","journal-title":"J\u00a0Biol Chem"},{"issue":"Pt 2","key":"10.1016\/j.kint.2018.01.025_bib78","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1042\/bj3370253","article-title":"Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter","volume":"337","author":"Pellizzari","year":"1999","journal-title":"Biochem J"},{"key":"10.1016\/j.kint.2018.01.025_bib79","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/acschembio.6b00782","article-title":"Inhibition of Pax2 transcription activation with a small molecule that targets the DNA binding domain","volume":"12","author":"Grimley","year":"2017","journal-title":"ACS Chem Biol"},{"key":"10.1016\/j.kint.2018.01.025_bib80","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nm.4343","article-title":"Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice","volume":"23","author":"Harlander","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2018.01.025_bib81","doi-asserted-by":"crossref","first-page":"9226","DOI":"10.1073\/pnas.1100629108","article-title":"Repair of injured proximal tubule does not involve specialized progenitors","volume":"108","author":"Humphreys","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.01.025_bib82","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1046\/j.1523-1755.1999.00663.x","article-title":"Re-expression of the developmental gene Pax-2 during experimental acute tubular necrosis in mice 1","volume":"56","author":"Imgrund","year":"1999","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818301418?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818301418?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:50:54Z","timestamp":1758761454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253818301418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S0085253818301418"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2018.01.025","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are Pax proteins potential therapeutic targets in kidney disease and cancer?","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2018.01.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}