{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:15:10Z","timestamp":1787242510567,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":1462,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["La 315\/15-1"],"award-info":[{"award-number":["La 315\/15-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Fo 695\/2-1"],"award-info":[{"award-number":["Fo 695\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.kint.2018.03.006","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T09:18:32Z","timestamp":1527758312000},"page":"491-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["AMP-activated kinase is a regulator of fibroblast growth factor 23 production"],"prefix":"10.1016","volume":"94","author":[{"given":"Philipp","family":"Glosse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Feger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerim","family":"Mutig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Hirche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdallah","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed M.S.","family":"Gaballa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Hocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"F\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2018.03.006_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.kint.2017.01.015","article-title":"Kidney fibroblast growth factor 23 does not contribute to elevation of its circulating levels in uremia","volume":"92","author":"Mace","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2016.11.013","article-title":"FGF23-alphaKlotho as a paradigm for a kidney-bone network","volume":"100","author":"Kuro-O","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.kint.2018.03.006_bib3","doi-asserted-by":"crossref","first-page":"34696","DOI":"10.1038\/srep34696","article-title":"Elevation in fibroblast growth factor 23 and its value for identifying subclinical atherosclerosis in first-degree relatives of patients with diabetes","volume":"6","author":"Hu","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2018.03.006_bib4","doi-asserted-by":"crossref","first-page":"8304","DOI":"10.1038\/srep08304","article-title":"FGF23 neutralization improves bone quality and osseointegration of titanium implants in chronic kidney disease mice","volume":"5","author":"Sun","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2018.03.006_bib5","doi-asserted-by":"crossref","first-page":"36881","DOI":"10.1038\/srep36881","article-title":"Energy-dense diets increase FGF23, lead to phosphorus retention and promote vascular calcifications in rats","volume":"6","author":"Raya","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2018.03.006_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bone.2016.10.001","article-title":"Cardiac actions of fibroblast growth factor 23","volume":"100","author":"Faul","year":"2017","journal-title":"Bone"},{"key":"10.1016\/j.kint.2018.03.006_bib7","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.kint.2017.02.014","article-title":"Klotho expression in osteocytes regulates bone metabolism and controls bone formation","volume":"92","author":"Komaba","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib8","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nrneph.2013.111","article-title":"Klotho, phosphate and FGF-23 in ageing and disturbed mineral metabolism","volume":"9","author":"Kuro-O","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2018.03.006_bib9","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.03.006_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"Kuro-O","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.kint.2018.03.006_bib11","doi-asserted-by":"crossref","first-page":"F882","DOI":"10.1152\/ajprenal.00360.2010","article-title":"PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop","volume":"299","author":"Lavi-Moshayoff","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2018.03.006_bib12","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1172\/JCI29463","article-title":"Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts","volume":"116","author":"Masuyama","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.03.006_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.2015.290","article-title":"Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production","volume":"89","author":"David","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib14","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1210\/jc.2004-1039","article-title":"Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men","volume":"90","author":"Ferrari","year":"2005","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.kint.2018.03.006_bib15","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.kint.2016.05.019","article-title":"Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease","volume":"90","author":"Singh","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib16","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.mce.2014.10.007","article-title":"Regulation of FGF23 expression in IDG-SW3 osteocytes and human bone by pro-inflammatory stimuli","volume":"399","author":"Ito","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.kint.2018.03.006_bib17","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00109-015-1370-3","article-title":"NFkappaB-sensitive Orai1 expression in the regulation of FGF23 release","volume":"94","author":"Zhang","year":"2016","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.kint.2018.03.006_bib18","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1038\/ki.2013.526","article-title":"Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease","volume":"85","author":"Spichtig","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib19","doi-asserted-by":"crossref","first-page":"358086","DOI":"10.1155\/2015\/358086","article-title":"FGF23 in acute and chronic illness","volume":"2015","author":"Schnedl","year":"2015","journal-title":"Dis Markers"},{"key":"10.1016\/j.kint.2018.03.006_bib20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.kint.2016.01.016","article-title":"The dipeptidyl peptidase inhibitor linagliptin and the angiotensin II receptor blocker telmisartan show renal benefit by different pathways in rats with 5\/6 nephrectomy","volume":"89","author":"Tsuprykov","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib21","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.kint.2016.12.029","article-title":"The complexity of chronic kidney disease-mineral and bone disorder across stages of chronic kidney disease","volume":"91","author":"Graciolli","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib22","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/ki.2011.47","article-title":"Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease","volume":"79","author":"Isakova","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.006_bib23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMPK signalling pathway coordinates cell growth, autophagy and metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2018.03.006_bib24","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","article-title":"AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance","volume":"66","author":"Garcia","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.kint.2018.03.006_bib25","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.tcb.2015.10.013","article-title":"AMPK: an energy-sensing pathway with multiple inputs and outputs","volume":"26","author":"Hardie","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.kint.2018.03.006_bib26","doi-asserted-by":"crossref","first-page":"860","DOI":"10.2337\/db07-0843","article-title":"AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5","volume":"57","author":"McGee","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2018.03.006_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3109\/09687681003616870","article-title":"Regulation of Na+-coupled glucose carrier SGLT1 by AMP-activated protein kinase","volume":"27","author":"Sopjani","year":"2010","journal-title":"Mol Membr Biol"},{"key":"10.1016\/j.kint.2018.03.006_bib28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1159\/000355735","article-title":"Down-regulation of the Na+-coupled phosphate transporter NaPi-IIa by AMP-activated protein kinase","volume":"37","author":"D\u00ebrmaku-Sopjani","year":"2013","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.kint.2018.03.006_bib29","doi-asserted-by":"crossref","first-page":"26159","DOI":"10.1074\/jbc.M606045200","article-title":"AMP-activated kinase inhibits the epithelial Na+ channel through functional regulation of the ubiquitin ligase Nedd4-2","volume":"281","author":"Bhalla","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.03.006_bib30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00424-009-0660-4","article-title":"AMPK controls epithelial Na(+) channels through Nedd4-2 and causes an epithelial phenotype when mutated","volume":"458","author":"Alma\u00e7a","year":"2009","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2018.03.006_bib31","doi-asserted-by":"crossref","first-page":"1531392","DOI":"10.1155\/2016\/1531392","article-title":"AMP-activated protein kinase attenuates high salt-induced activation of epithelial sodium channels (ENaC) in human umbilical vein endothelial cells","volume":"2016","author":"Zheng","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.kint.2018.03.006_bib32","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1096\/fj.12-208132","article-title":"AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation","volume":"26","author":"F\u00f6ller","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2018.03.006_bib33","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1159\/000354472","article-title":"AMPK\u03b11-sensitivity of Orai1 and Ca(2+) entry in T-lymphocytes","volume":"32","author":"Bhavsar","year":"2013","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.kint.2018.03.006_bib34","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ceca.2016.11.005","article-title":"Store operated calcium entry: from concept to structural mechanisms","volume":"63","author":"Stathopulos","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.kint.2018.03.006_bib35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ceca.2016.12.009","article-title":"TRPC1, Orai1, and STIM1 in SOCE: friends in tight spaces","volume":"63","author":"Ambudkar","year":"2017","journal-title":"Cell Calcium"},{"key":"10.1016\/j.kint.2018.03.006_bib36","doi-asserted-by":"crossref","first-page":"4393","DOI":"10.1172\/JCI46122","article-title":"FGF23 induces left ventricular hypertrophy","volume":"121","author":"Faul","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.03.006_bib37","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","article-title":"AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"52","author":"Zhang","year":"2008","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2018.03.006_bib38","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.cmet.2015.09.002","article-title":"Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy","volume":"22","author":"Grabner","year":"2015","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2018.03.006_bib39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.bbrc.2008.09.057","article-title":"AMPKalpha2 counteracts the development of cardiac hypertrophy induced by isoproterenol","volume":"376","author":"Zarrinpashneh","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2018.03.006_bib40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1161\/HYPERTENSIONAHA.113.02619","article-title":"Metformin protects against systolic overload-induced heart failure independent of AMP-activated protein kinase \u03b12","volume":"63","author":"Xu","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2018.03.006_bib41","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1161\/CIRCULATIONAHA.108.844506","article-title":"Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease","volume":"119","author":"Guti\u00e9rrez","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2018.03.006_bib42","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/MNH.0000000000000349","article-title":"Role of AMP-activated protein kinase in kidney tubular transport, metabolism, and disease","volume":"26","author":"Rajani","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2018.03.006_bib43","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/MNH.0b013e3283562390","article-title":"AMP-activated protein kinase regulation of kidney tubular transport","volume":"21","author":"Pastor-Soler","year":"2012","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2018.03.006_bib44","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1073\/pnas.1011498108","article-title":"Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis","volume":"108","author":"Takiar","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.03.006_bib45","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1001\/jama.2011.826","article-title":"Fibroblast growth factor 23 and risks of mortality and end-stage renal disease in patients with chronic kidney disease","volume":"305","author":"Isakova","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2018.03.006_bib46","first-page":"453","article-title":"ADAM17, a new player in the pathogenesis of chronic kidney disease-mineral and bone disorder","volume":"27","author":"Perna","year":"2017","journal-title":"J\u00a0Ren Nutr"},{"key":"10.1016\/j.kint.2018.03.006_bib47","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ceca.2012.05.005","article-title":"Regulation of Orai1\/STIM1 by the kinases SGK1 and AMPK","volume":"52","author":"Lang","year":"2012","journal-title":"Cell Calcium"},{"key":"10.1016\/j.kint.2018.03.006_bib48","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1160\/TH13-02-0176","article-title":"Regulation of STIM1\/Orai1-dependent Ca2+ signalling in platelets","volume":"110","author":"Lang","year":"2013","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.kint.2018.03.006_bib49","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1096\/fj.10-178210","article-title":"Stimulation of Ca2+-channel Orai1\/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1)","volume":"25","author":"Eylenstein","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2018.03.006_bib50","doi-asserted-by":"crossref","first-page":"F1308","DOI":"10.1152\/ajprenal.00423.2010","article-title":"AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells","volume":"299","author":"Alzamora","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2018.03.006_bib51","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.mce.2016.07.035","article-title":"Fgf23 and parathyroid hormone signaling interact in kidney and bone","volume":"436","author":"Andrukhova","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.kint.2018.03.006_bib52","doi-asserted-by":"crossref","first-page":"28265","DOI":"10.1074\/jbc.M202527200","article-title":"Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway","volume":"277","author":"Yamashita","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.03.006_bib53","doi-asserted-by":"crossref","first-page":"17559","DOI":"10.1074\/jbc.H117.806901","article-title":"In search of regulatory circuits that control the biological activity of vitamin D","volume":"292","author":"Christakos","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.03.006_bib54","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00424-012-1180-1","article-title":"Downregulation of the renal outer medullary K(+) channel ROMK by the AMP-activated protein kinase","volume":"465","author":"Siraskar","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2018.03.006_bib55","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.kint.2018.03.006_bib56","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1038\/s41598-017-05226-y","article-title":"The production of fibroblast growth factor 23 is controlled by TGF-\u03b22","volume":"7","author":"Feger","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2018.03.006_bib57","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1042\/bst0310216","article-title":"Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models","volume":"31","author":"Viollet","year":"2003","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.kint.2018.03.006_bib58","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000331722","article-title":"EMD638683, a novel SGK inhibitor with antihypertensive potency","volume":"28","author":"Ackermann","year":"2011","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.kint.2018.03.006_bib59","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/HYPERTENSIONAHA.110.163972","article-title":"Endothelin-converting enzyme\/neutral endopeptidase inhibitor SLV338 prevents hypertensive cardiac remodeling in a blood pressure-independent manner","volume":"57","author":"Kalk","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2018.03.006_bib60","doi-asserted-by":"crossref","first-page":"30200","DOI":"10.1074\/jbc.M111.222968","article-title":"Activation of the bumetanide-sensitive Na+,K+,2Cl- cotransporter (NKCC2) is facilitated by Tamm-Horsfall protein in a chloride-sensitive manner","volume":"286","author":"Mutig","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2018.03.006_bib61","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1097\/01.ASN.0000120389.09938.21","article-title":"Kidney-specific inactivation of the megalin gene impairs trafficking of renal inorganic sodium phosphate cotransporter (NaPi-IIa)","volume":"15","author":"Bachmann","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818302448?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818302448?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:50:36Z","timestamp":1758761436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253818302448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0085253818302448"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2018.03.006","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AMP-activated kinase is a regulator of fibroblast growth factor 23 production","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2018.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}