{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:37:38Z","timestamp":1791488258598,"version":"4.3.4"},"reference-count":54,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"IC"},{"name":"IC"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.kint.2018.03.012","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T18:20:01Z","timestamp":1528827601000},"page":"728-740","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression"],"prefix":"10.1016","volume":"94","author":[{"given":"Tanvi","family":"Arkatkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly M.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly L.","family":"Hudkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"Alpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Rawlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun W.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2018.03.012_bib1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nri2572","article-title":"Cracking the BAFF code","volume":"9","author":"Mackay","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4049\/jimmunol.175.1.319","article-title":"deltaBAFF, a splice isoform of BAFF, opposes full-length BAFF activity in\u00a0vivo in transgenic mouse models","volume":"175","author":"Gavin","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib4","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1002\/art.11354","article-title":"B\u00a0lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations","volume":"48","author":"Stohl","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib5","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1056\/NEJMoa1610528","article-title":"Overexpression of the cytokine BAFF and autoimmunity risk","volume":"376","author":"Steri","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.03.012_bib6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0140-6736(10)61354-2","article-title":"Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial","volume":"377","author":"Navarra","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2018.03.012_bib7","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/art.30613","article-title":"A\u00a0phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus","volume":"63","author":"Furie","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1177\/0961203312465781","article-title":"Effect of belimumab treatment on renal outcomes: results from the phase 3 belimumab clinical trials in patients with SLE","volume":"22","author":"Dooley","year":"2013","journal-title":"Lupus"},{"key":"10.1016\/j.kint.2018.03.012_bib9","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1126\/science.1061965","article-title":"BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF","volume":"293","author":"Thompson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.03.012_bib10","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jaut.2015.04.007","article-title":"Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers","volume":"61","author":"Figgett","year":"2015","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.kint.2018.03.012_bib11","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.1600017","article-title":"Cutting edge: BAFF promotes autoantibody production via TACI-dependent activation of transitional B cells","volume":"196","author":"Jacobs","year":"2016","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib12","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1172\/JCI45563","article-title":"Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy","volume":"121","author":"McCarthy","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.03.012_bib13","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.20062567","article-title":"BAFF and MyD88 signals promote a lupuslike disease independent of T cells","volume":"204","author":"Groom","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(01)00130-3","article-title":"Regulation of the T-independent humoral response by TACI","volume":"14","author":"von Bulow","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2018.03.012_bib15","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1126\/science.1118948","article-title":"Divergent immunoglobulin g subclass activity\u00a0through selective Fc receptor binding","volume":"310","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.03.012_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.clim.2016.06.011","article-title":"Unraveling the immunopathogenesis of glomerular disease","volume":"169","author":"Dickinson","year":"2016","journal-title":"Clin Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.1991.tb08115.x","article-title":"The effect of antibody isotype and antigenic epitope density on the complement-fixing activity of immune complexes: a systematic study using chimaeric anti-NIP antibodies with human Fc regions","volume":"84","author":"Lucisano Valim","year":"1991","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib18","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.4049\/jimmunol.1400098","article-title":"Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation","volume":"192","author":"Jackson","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2249.2006.03251.x","article-title":"Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes","volume":"147","author":"Li","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib20","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/rheumatology\/kem112","article-title":"Fifty years of anti-ds DNA antibodies: are we approaching journey's end?","volume":"46","author":"Isenberg","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.kint.2018.03.012_bib21","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20110200","article-title":"WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity","volume":"208","author":"Becker-Herman","year":"2011","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib22","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1084\/jem.20151724","article-title":"B\u00a0cell IFN-gamma receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6","volume":"213","author":"Jackson","year":"2016","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/ard.46.6.448","article-title":"Measurement of anti-DNA antibodies: a reappraisal using five different methods","volume":"46","author":"Isenberg","year":"1987","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.kint.2018.03.012_bib24","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.immuni.2006.07.013","article-title":"Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus","volume":"25","author":"Christensen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2018.03.012_bib25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nri3190","article-title":"Integration of B cell responses through Toll-like receptors and antigen receptors","volume":"12","author":"Rawlings","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri.2017.24","article-title":"Altered B cell signalling in autoimmunity","volume":"17","author":"Rawlings","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib27","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.coi.2009.08.005","article-title":"Activating systemic autoimmunity: B's, T's, and tolls","volume":"21","author":"Shlomchik","year":"2009","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib28","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1124978","article-title":"Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication","volume":"312","author":"Pisitkun","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.kint.2018.03.012_bib29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.immuni.2007.09.009","article-title":"Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation","volume":"27","author":"Deane","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2018.03.012_bib30","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/acr.20648","article-title":"Evolution of disease burden over five years in a multicenter inception systemic lupus erythematosus cohort","volume":"64","author":"Urowitz","year":"2012","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.kint.2018.03.012_bib31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.immuni.2004.05.010","article-title":"Excess BAFF rescues self-reactive B cells from peripheral deletion and allows them to enter forbidden follicular and marginal zone niches","volume":"20","author":"Thien","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2018.03.012_bib32","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S1074-7613(04)00079-2","article-title":"Reduced competitiveness of autoantigen-engaged B cells due to increased dependence on BAFF","volume":"20","author":"Lesley","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2018.03.012_bib33","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/intimm\/dxm011","article-title":"The role of BLyS\/BLyS receptors in anti-chromatin B cell regulation","volume":"19","author":"Hondowicz","year":"2007","journal-title":"Int Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib34","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.4049\/jimmunol.178.12.7531","article-title":"TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells","volume":"178","author":"Treml","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib35","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.4049\/jimmunol.179.4.2282","article-title":"TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens","volume":"179","author":"Mantchev","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib36","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood-2014-05-575845","article-title":"Differential induction of plasma cells by isoforms of human TACI","volume":"125","author":"Garcia-Carmona","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.kint.2018.03.012_bib37","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jaci.2009.03.019","article-title":"Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells","volume":"123","author":"Ozcan","year":"2009","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib38","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.4049\/jimmunol.1402425","article-title":"Cell-intrinsic expression of TLR9 in autoreactive B cells constrains BCR\/TLR7-dependent responses","volume":"194","author":"Nundel","year":"2015","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib39","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1084\/jem.20130505","article-title":"Local BLyS production by T follicular cells mediates retention of high affinity B cells during affinity maturation","volume":"211","author":"Goenka","year":"2014","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib40","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1084\/jem.20030495","article-title":"Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice","volume":"198","author":"Rahman","year":"2003","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/art.1780330505","article-title":"Measurement of increases in anti-double-stranded DNA antibody levels as a predictor of disease exacerbation in systemic lupus erythematosus. A long-term, prospective study","volume":"33","author":"ter Borg","year":"1990","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib42","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1084\/jem.126.4.607","article-title":"Immunological studies concerning the nephritis of systemic lupus erythematosus","volume":"126","author":"Koffler","year":"1967","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib43","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/ki.1995.341","article-title":"Human IgG anti-DNA antibodies deposit in kidneys and induce proteinuria in SCID mice","volume":"48","author":"Ehrenstein","year":"1995","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.012_bib44","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1046\/j.1523-1755.2003.00178.x","article-title":"Nephritogenic autoantibodies but absence of nephritis in Il-12p35-deficient mice with pristane-induced lupus","volume":"64","author":"Calvani","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.03.012_bib45","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1136\/ard.62.6.556","article-title":"Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis","volume":"62","author":"Alba","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.kint.2018.03.012_bib46","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/BF02231577","article-title":"Anti-Sm: its predictive value in systemic lupus erythematosus","volume":"12","author":"Janwityanuchit","year":"1993","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.kint.2018.03.012_bib47","first-page":"1495","article-title":"Multiple autoantibodies form the glomerular immune deposits in patients with systemic lupus erythematosus","volume":"30","author":"Mannik","year":"2003","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.kint.2018.03.012_bib48","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1002\/art.23673","article-title":"Abetimus sodium for renal flare in systemic lupus erythematosus: results of a randomized, controlled phase III trial","volume":"58","author":"Cardiel","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib49","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1084\/jem.20040168","article-title":"Short-lived plasmablasts and long-lived plasma cells contribute to chronic humoral autoimmunity in NZB\/W mice","volume":"199","author":"Hoyer","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2018.03.012_bib50","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1073\/pnas.1001074107","article-title":"Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis","volume":"107","author":"Huang","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.03.012_bib51","doi-asserted-by":"crossref","first-page":"494","DOI":"10.3389\/fimmu.2013.00494","article-title":"Long-lived plasma cells in autoimmunity: lessons from B-cell depleting therapy","volume":"4","author":"Mahevas","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2018.03.012_bib52","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1002\/art.22211","article-title":"B\u00a0cell depletion therapy in systemic lupus erythematosus: effect on autoantibody and antimicrobial antibody profiles","volume":"54","author":"Cambridge","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib53","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/art.34359","article-title":"Efficacy and safety of rituximab in patients with active proliferative lupus nephritis: the Lupus Nephritis Assessment with Rituximab study","volume":"64","author":"Rovin","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2018.03.012_bib54","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1073\/pnas.0400937101","article-title":"Recognition of single-stranded RNA viruses by Toll-like receptor 7","volume":"101","author":"Lund","year":"2004","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818302527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818302527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:50:01Z","timestamp":1758761401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253818302527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":54,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0085253818302527"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2018.03.012","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2018.03.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}