{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:42:36Z","timestamp":1792464156665,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,25]],"date-time":"2018-09-25T00:00:00Z","timestamp":1537833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme (FP7) of the European Commission","doi-asserted-by":"publisher","award":["305499"],"award-info":[{"award-number":["305499"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C32\/17\/049"],"award-info":[{"award-number":["C32\/17\/049"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.kint.2018.08.027","type":"journal-article","created":{"date-parts":[[2018,11,3]],"date-time":"2018-11-03T02:47:50Z","timestamp":1541213270000},"page":"188-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":159,"title":["Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation"],"prefix":"10.1016","volume":"95","author":[{"given":"Saleh","family":"Yazdani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Callemeyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Gazut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Lerut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette","family":"de Loor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line","family":"Heylen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Saison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Koenig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Thaunat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieven","family":"Thorrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Kuypers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Sprangers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure-H\u00e9l\u00e8ne","family":"No\u00ebl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leentje","family":"Van Lommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans","family":"Schuit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Essig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Gwinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Anglicheau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Marquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Naesens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2018.08.027_bib1","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1681\/ASN.2015070781","article-title":"Effect of immunosuppressive drugs on humoral allosensitization after kidney transplant","volume":"27","author":"Thaunat","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.08.027_bib2","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra0902927","article-title":"Rejection of the kidney allograft","volume":"363","author":"Nankivell","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.08.027_bib3","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrneph.2012.81","article-title":"The impact of donor-specific anti-HLA antibodies on late kidney allograft failure","volume":"8","author":"Loupy","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2018.08.027_bib4","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1600-6143.2008.02519.x","article-title":"Identifying specific causes of kidney allograft loss","volume":"9","author":"El-Zoghby","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib5","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence","volume":"12","author":"Sellares","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/TP.0000000000000183","article-title":"The histology of kidney transplant failure: a long-term follow-up study","volume":"98","author":"Naesens","year":"2014","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2018.08.027_bib7","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1056\/NEJMoa1612567","article-title":"IgG endopeptidase in highly sensitized patients undergoing transplantation","volume":"377","author":"Jordan","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2018.08.027_bib8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2741\/4334","article-title":"Rational clinical trial design for antibody mediated renal allograft injury","volume":"20","author":"Sandal","year":"2015","journal-title":"Front Biosci (Landmark Ed)"},{"key":"10.1016\/j.kint.2018.08.027_bib9","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.transproceed.2015.11.028","article-title":"Complement inhibition for prevention and treatment of antibody-mediated rejection in renal allograft recipients","volume":"48","author":"Jordan","year":"2016","journal-title":"Transplant Proc"},{"key":"10.1016\/j.kint.2018.08.027_bib10","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1111\/ajt.14001","article-title":"Eculizumab therapy for chronic antibody-mediated injury in kidney transplant recipients: a pilot randomized controlled trial","volume":"17","author":"Kulkarni","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib11","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1681\/ASN.2017050589","article-title":"Complement-activating anti-HLA antibodies in kidney transplantation: allograft gene expression profiling and response to treatment","volume":"29","author":"Lefaucheur","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2018.08.027_bib12","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/ki.2013.300","article-title":"Antibody-mediated rejection, T cell-mediated rejection, and the injury-repair response: new insights from the Genome Canada studies of kidney transplant biopsies","volume":"85","author":"Halloran","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.08.027_bib13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.kint.2018.08.027_bib14","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2018.08.027_bib15","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat Methods"},{"key":"10.1016\/j.kint.2018.08.027_bib16","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1073\/pnas.0609692104","article-title":"Identification, activation, and selective in\u00a0vivo ablation of mouse NK cells via NKp46","volume":"104","author":"Walzer","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2018.08.027_bib17","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib18","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/j.1600-6143.2011.03970.x","article-title":"Interpreting NK cell transcripts versus T cell transcripts in renal transplant biopsies","volume":"12","author":"Hidalgo","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib19","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1111\/ajt.12465","article-title":"Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: an international prospective study (INTERCOM)","volume":"13","author":"Halloran","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib20","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.116.022907","article-title":"Gene expression profiling for the identification and classification of antibody-mediated heart rejection","volume":"135","author":"Loupy","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2018.08.027_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1600-6143.2011.03836.x","article-title":"A\u00a0novel pathway of chronic allograft rejection mediated by NK cells and alloantibody","volume":"12","author":"Hirohashi","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib22","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.humimm.2012.07.330","article-title":"Role of complement and NK cells in antibody mediated rejection","volume":"73","author":"Akiyoshi","year":"2012","journal-title":"Hum Immunol"},{"key":"10.1016\/j.kint.2018.08.027_bib23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s12026-014-8493-4","article-title":"NK cells after transplantation: friend or foe","volume":"58","author":"Hadad","year":"2014","journal-title":"Immunol Res"},{"key":"10.1016\/j.kint.2018.08.027_bib24","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/TP.0000000000000665","article-title":"Natural killer cells mediate long-term kidney allograft injury","volume":"99","author":"Zhang","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2018.08.027_bib25","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/TP.0000000000000757","article-title":"The role of natural killer cells in humoral rejection","volume":"99","author":"Resch","year":"2015","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2018.08.027_bib26","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.kint.2016.02.030","article-title":"Natural killer cells play a critical role in mediating inflammation and graft failure during antibody-mediated rejection of kidney allografts","volume":"89","author":"Kohei","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.08.027_bib27","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3389\/fimmu.2016.00585","article-title":"The impact of HLA class I-specific killer cell immunoglobulin-like receptors on antibody-dependent natural killer cell-mediated cytotoxicity and organ allograft rejection","volume":"7","author":"Rajalingam","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2018.08.027_bib28","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1111\/ajt.13115","article-title":"The molecular landscape of antibody-mediated kidney transplant rejection: evidence for NK involvement through CD16a Fc receptors","volume":"15","author":"Venner","year":"2015","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib29","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/ki.2015.276","article-title":"Clinical and molecular significance of microvascular inflammation in transplant kidney biopsies","volume":"89","author":"Gupta","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2018.08.027_bib30","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1111\/tri.12726","article-title":"Compartment-specific expression of natural killer cell markers in renal transplantation: immune profile in acute rejection","volume":"29","author":"Dos Santos","year":"2016","journal-title":"Transpl Int"},{"key":"10.1016\/j.kint.2018.08.027_bib31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fimmu.2016.00288","article-title":"Antibody-dependent NK cell activation is associated with late kidney allograft dysfunction and the complement-independent alloreactive potential of donor-specific antibodies","volume":"7","author":"Legris","year":"2016","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2018.08.027_bib32","doi-asserted-by":"crossref","first-page":"e102","DOI":"10.1097\/TP.0000000000001586","article-title":"Evidence for CD16a-mediated NK cell stimulation in antibody-mediated kidney transplant rejection","volume":"101","author":"Parkes","year":"2017","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2018.08.027_bib33","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1111\/ajt.12438","article-title":"Kidney intragraft donor-specific antibodies as determinant of antibody-mediated lesions and poor graft outcome","volume":"13","author":"Bachelet","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib34","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/j.1600-6143.2011.03621.x","article-title":"KIR-ligand mismatches are associated with reduced long-term graft survival in HLA-compatible kidney transplantation","volume":"11","author":"van Bergen","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib35","doi-asserted-by":"crossref","first-page":"e0180831","DOI":"10.1371\/journal.pone.0180831","article-title":"KIR and their HLA class I ligands: two more pieces towards completing the puzzle of chronic rejection and graft loss in kidney transplantation","volume":"12","author":"Littera","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2018.08.027_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/nri.2016.34","article-title":"Emerging insights into natural killer cells in human peripheral tissues","volume":"16","author":"Bjorkstrom","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2018.08.027_bib37","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.ekir.2018.02.012","article-title":"Multicolor flow cytometry and cytokine analysis provides enhanced information on kidney transplant biopsies","volume":"3","author":"Muczynski","year":"2018","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2018.08.027_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/ajt.14107","article-title":"The Banff 2015 Kidney Meeting Report: current challenges in rejection classification and prospects for adopting molecular pathology","volume":"17","author":"Loupy","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/ajt.14625","article-title":"The Banff 2017 Kidney Meeting Report: revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials","volume":"18","author":"Haas","year":"2018","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib40","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1172\/JCI41789","article-title":"A\u00a0molecular classifier for predicting future graft loss in late kidney transplant biopsies","volume":"120","author":"Einecke","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2018.08.027_bib41","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/ajt.12079","article-title":"Molecular diagnosis of T cell-mediated rejection in human kidney transplant biopsies","volume":"13","author":"Reeve","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2018.08.027_bib42","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.kint.2018.08.027_bib43","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fmolb.2016.00026","article-title":"biosigner: a new method for the discovery of significant molecular signatures from omics data","volume":"3","author":"Rinaudo","year":"2016","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.kint.2018.08.027_bib44","doi-asserted-by":"crossref","first-page":"e6098","DOI":"10.1371\/journal.pone.0006098","article-title":"Deconvolution of blood microarray data identifies cellular activation patterns in systemic lupus erythematosus","volume":"4","author":"Abbas","year":"2009","journal-title":"PLoS One"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818306306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253818306306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:51:35Z","timestamp":1758761495000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253818306306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0085253818306306"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2018.08.027","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural killer cell infiltration is discriminative for antibody-mediated rejection and predicts outcome after kidney transplantation","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2018.08.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}