{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:30:11Z","timestamp":1792618211049,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["KL"],"award-info":[{"award-number":["KL"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170644"],"award-info":[{"award-number":["81170644"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002412","name":"Xi\u2019an Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000690","name":"Research Councils UK","doi-asserted-by":"publisher","award":["WZ"],"award-info":[{"award-number":["WZ"]}],"id":[{"id":"10.13039\/501100000690","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J006742\/1"],"award-info":[{"award-number":["MR\/J006742\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/L020254\/1"],"award-info":[{"award-number":["MR\/L020254\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.kint.2019.01.039","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T17:02:27Z","timestamp":1551718947000},"page":"117-128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["The C5a\/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"96","author":[{"given":"Qi","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiju","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Qiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Sacks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuding","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2019.01.039_bib1","doi-asserted-by":"crossref","first-page":"F1078","DOI":"10.1152\/ajprenal.00017.2010","article-title":"Acute kidney injury: a springboard for progression in chronic kidney disease","volume":"298","author":"Venkatachalam","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.01.039_bib2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","article-title":"Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond","volume":"28","author":"Zhao","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.kint.2019.01.039_bib3","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1681\/ASN.2010080793","article-title":"Mechanisms of tubulointerstitial fibrosis","volume":"21","author":"Zeisberg","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib4","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm.3299","article-title":"The origin of scar-forming kidney myofibroblasts","volume":"19","author":"Eddy","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2019.01.039_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2613.2011.00764.x","article-title":"Fibroblasts and myofibroblasts in renal fibrosis","volume":"92","author":"Meran","year":"2011","journal-title":"Int J Exp Pathol"},{"key":"10.1016\/j.kint.2019.01.039_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/nm.3218","article-title":"Origin and function of myofibroblasts in kidney fibrosis","volume":"19","author":"LeBleu","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2019.01.039_bib7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/nrneph.2011.149","article-title":"Cellular and molecular mechanisms of renal fibrosis","volume":"7","author":"Liu","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib8","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1172\/JCI72267","article-title":"Cellular and molecular mechanisms in kidney fibrosis","volume":"124","author":"Duffield","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.01.039_bib9","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrneph.2014.114","article-title":"Inflammatory processes in renal fibrosis","volume":"10","author":"Meng","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1096\/fj.05-4747com","article-title":"Local extravascular pool of C3 is a determinant of postischemic acute renal failure","volume":"20","author":"Farrar","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2019.01.039_bib11","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nri3225","article-title":"The role of complement in the early immune response to transplantation","volume":"12","author":"Sacks","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2019.01.039_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fmed.2017.00066","article-title":"Complement in kidney transplantation","volume":"4","author":"Cernoch","year":"2017","journal-title":"Front Med"},{"key":"10.1016\/j.kint.2019.01.039_bib13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.smim.2013.04.013","article-title":"Anaphylatoxins in organ transplantation","volume":"25","author":"Li","year":"2013","journal-title":"Semin Immunol"},{"key":"10.1016\/j.kint.2019.01.039_bib14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.imbio.2011.07.016","article-title":"The new face of anaphylatoxins in immune regulation","volume":"217","author":"Zhou","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.kint.2019.01.039_bib15","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol Immunol"},{"key":"10.1016\/j.kint.2019.01.039_bib16","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1681\/ASN.2011111072","article-title":"C3a and C5a promote renal ischemia-reperfusion injury","volume":"23","author":"Peng","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib17","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1681\/ASN.2009090977","article-title":"Deficiency of C5aR prolongs renal allograft survival","volume":"21","author":"Li","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib18","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1681\/ASN.2007111267","article-title":"Complement 5a receptor inhibition improves renal allograft survival","volume":"19","author":"Gueler","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib19","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1038\/ni.1920","article-title":"The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection","volume":"11","author":"Satoh","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.kint.2019.01.039_bib20","doi-asserted-by":"crossref","first-page":"15919","DOI":"10.1073\/pnas.1312197110","article-title":"Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival","volume":"110","author":"Cieslewicz","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2019.01.039_bib21","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.kint.2017.09.033","article-title":"Renal tubule injury: a driving force toward chronic kidney disease","volume":"93","author":"Liu","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.01.039_bib22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.kint.2016.04.023","article-title":"The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis","volume":"90","author":"Choudhry","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.01.039_bib23","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1177\/0022034516643065","article-title":"Pulp fibroblasts control nerve regeneration through complement activation","volume":"95","author":"Chmilewsky","year":"2016","journal-title":"J\u00a0Dent Res"},{"key":"10.1016\/j.kint.2019.01.039_bib24","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1096\/fj.201500044","article-title":"Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis","volume":"30","author":"Gu","year":"2016","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2019.01.039_bib25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1093\/ndt\/gfx336","article-title":"Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy","volume":"33","author":"Yiu","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2019.01.039_bib26","doi-asserted-by":"crossref","first-page":"F35","DOI":"10.1152\/ajprenal.00060.2017","article-title":"Complement C5a receptors C5L2 and C5aR in renal fibrosis","volume":"314","author":"Martin","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.01.039_bib27","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1681\/ASN.2013020152","article-title":"Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy","volume":"25","author":"Lech","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib28","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ki.2015.295","article-title":"Proximal tubule-derived colony stimulating factor-1 mediates polarization of renal macrophages and dendritic cells, and recovery in acute kidney injury","volume":"88","author":"Wang","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.01.039_bib29","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/sj.ki.5002275","article-title":"Ex\u00a0vivo programmed macrophages ameliorate experimental chronic inflammatory renal disease","volume":"72","author":"Wang","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.01.039_bib30","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1681\/ASN.2017040391","article-title":"Wnt\/beta-catenin-promoted macrophage alternative activation contributes to kidney fibrosis","volume":"29","author":"Feng","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.01.039_bib31","first-page":"183","article-title":"Macrophages in kidney injury, inflammation, and fibrosis","volume":"30","author":"Cao","year":"2015","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.kint.2019.01.039_bib32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/383086a0","article-title":"The C5a chemoattractant receptor mediates mucosal defence to infection","volume":"383","author":"Hopken","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.kint.2019.01.039_bib33","doi-asserted-by":"crossref","DOI":"10.1172\/JCI8621","article-title":"Predominant role for C5b-9 in renal ischemia\/reperfusion injury","volume":"105","author":"Zhou","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.01.039_bib34","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1124\/mol.65.4.868","article-title":"Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes: relationships between structures and activity","volume":"65","author":"March","year":"2004","journal-title":"Mol Pharmacol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819301917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819301917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:27:13Z","timestamp":1778664433000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253819301917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0085253819301917"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2019.01.039","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The C5a\/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2019.01.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}