{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:35:04Z","timestamp":1792654504803,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003382","name":"Core Research for Evolutional Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008695","name":"Japan Foundation for Applied Enzymology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["15H05650"],"award-info":[{"award-number":["15H05650"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","award":["JPMJPR15F4"],"award-info":[{"award-number":["JPMJPR15F4"]}],"id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011327","name":"State Key Laboratory of Environmental Adaptability for Industrial Products","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17H06328"],"award-info":[{"award-number":["17H06328"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K09688"],"award-info":[{"award-number":["17K09688"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H02824"],"award-info":[{"award-number":["18H02824"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H05270"],"award-info":[{"award-number":["18H05270"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K19419"],"award-info":[{"award-number":["18K19419"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23115006"],"award-info":[{"award-number":["23115006"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25221004"],"award-info":[{"award-number":["25221004"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26111003"],"award-info":[{"award-number":["26111003"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.kint.2019.02.011","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T05:30:32Z","timestamp":1554787832000},"page":"129-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia\/reperfusion injury"],"prefix":"10.1016","volume":"96","author":[{"given":"Sho","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuo A.","family":"Susaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuhiro","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Komaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Fukagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki R.","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaomi","family":"Nangaku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2019.02.011_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.chembiol.2015.11.009","article-title":"Whole-body and whole-organ clearing and imaging techniques with single-cell resolution: toward organism-level systems biology in mammals","volume":"23","author":"Susaki","year":"2016","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.kint.2019.02.011_bib2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.cell.2014.03.042","article-title":"Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis","volume":"157","author":"Susaki","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.kint.2019.02.011_bib3","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/j.cell.2014.10.034","article-title":"Whole-body imaging with single-cell resolution by tissue decolorization","volume":"159","author":"Tainaka","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.kint.2019.02.011_bib4","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1038\/nprot.2015.085","article-title":"Advanced CUBIC protocols for whole-brain and whole-body clearing and imaging","volume":"10","author":"Susaki","year":"2015","journal-title":"Nat Protoc"},{"key":"10.1016\/j.kint.2019.02.011_bib5","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.celrep.2017.06.010","article-title":"Whole-body profiling of cancer metastasis with single-cell resolution","volume":"20","author":"Kubota","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2019.02.011_bib6","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.celrep.2018.07.056","article-title":"Chemical landscape for tissue clearing based on hydrophilic reagents","volume":"24","author":"Tainaka","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2019.02.011_bib7","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn.2928","article-title":"Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain","volume":"14","author":"Hama","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.kint.2019.02.011_bib8","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1038\/nn.4107","article-title":"ScaleS: an optical clearing palette for biological imaging","volume":"18","author":"Hama","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.kint.2019.02.011_bib9","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1038\/nprot.2012.119","article-title":"Three-dimensional imaging of solvent-cleared organs using 3DISCO","volume":"7","author":"Erturk","year":"2012","journal-title":"Nat Protoc"},{"key":"10.1016\/j.kint.2019.02.011_bib10","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.cell.2014.10.010","article-title":"iDISCO: a simple, rapid method to immunolabel large tissue samples for volume imaging","volume":"159","author":"Renier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.kint.2019.02.011_bib11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/nature12107","article-title":"Structural and molecular interrogation of intact biological systems","volume":"497","author":"Chung","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.kint.2019.02.011_bib12","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/nprot.2014.123","article-title":"Advanced CLARITY for rapid and high-resolution imaging of intact tissues","volume":"9","author":"Tomer","year":"2014","journal-title":"Nat Protoc"},{"key":"10.1016\/j.kint.2019.02.011_bib13","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.neuron.2014.12.039","article-title":"Visualizing whole-brain activity and development at the single-cell level using light-sheet microscopy","volume":"85","author":"Keller","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.kint.2019.02.011_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.kint.2019.02.011_bib15","doi-asserted-by":"crossref","first-page":"e0182072","DOI":"10.1371\/journal.pone.0182072","article-title":"Quantification of sympathetic hyperinnervation and denervation after myocardial infarction by three-dimensional assessment of the cardiac sympathetic network in cleared transparent murine hearts","volume":"12","author":"Yokoyama","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2019.02.011_bib16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1172\/JCI39778","article-title":"Heart failure causes cholinergic transdifferentiation of cardiac sympathetic nerves via gp130-signaling cytokines in rodents","volume":"120","author":"Kanazawa","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.02.011_bib17","first-page":"471","article-title":"Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure","volume":"33","author":"Merlet","year":"1992","journal-title":"J\u00a0Nucl Med"},{"key":"10.1016\/j.kint.2019.02.011_bib18","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1161\/01.RES.0000269828.62250.ab","article-title":"Cardiac sympathetic rejuvenation: a link between nerve function and cardiac hypertrophy","volume":"100","author":"Kimura","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2019.02.011_bib19","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1161\/01.CIR.88.3.1299","article-title":"Cardiac noradrenergic nerve terminal abnormalities in dogs with experimental congestive heart failure","volume":"88","author":"Himura","year":"1993","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2019.02.011_bib20","doi-asserted-by":"crossref","first-page":"H363","DOI":"10.1152\/ajpheart.00319.2001","article-title":"Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF","volume":"282","author":"Qin","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.kint.2019.02.011_bib21","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1093\/ndt\/gfq139","article-title":"Renal denervation reduces glomerular injury by suppressing NAD(P)H oxidase activity in Dahl salt-sensitive rats","volume":"25","author":"Nagasu","year":"2010","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2019.02.011_bib22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1161\/CIRCULATIONAHA.111.064097","article-title":"Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation","volume":"125","author":"Rafiq","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2019.02.011_bib23","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI83658","article-title":"Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through alpha7nAChR+ splenocytes","volume":"126","author":"Inoue","year":"2016","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.02.011_bib24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.4526","article-title":"C1 neurons mediate a stress-induced anti-inflammatory reflex in mice","volume":"20","author":"Abe","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.kint.2019.02.011_bib25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/ki.2014.287","article-title":"Origin of myofibroblasts and cellular events triggering fibrosis","volume":"87","author":"Mack","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.02.011_bib26","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.02.011_bib27","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41593-018-0109-1","article-title":"A\u00a0three-dimensional single-cell-resolution whole-brain atlas using CUBIC-X expansion microscopy and tissue clearing","volume":"21","author":"Murakami","year":"2018","journal-title":"Nat Neurosci"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819302303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819302303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:52:34Z","timestamp":1758761554000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253819302303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0085253819302303"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2019.02.011","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive three-dimensional analysis (CUBIC-kidney) visualizes abnormal renal sympathetic nerves after ischemia\/reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2019.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}