{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T05:39:19Z","timestamp":1768455559576,"version":"3.49.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.kint.2019.06.020","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T19:39:32Z","timestamp":1564601972000},"page":"1308-1319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced\u00a0kidney fibrosis"],"prefix":"10.1016","volume":"96","author":[{"given":"Xiaohan","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan P.","family":"Rudemiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiafa","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie R.","family":"Privratsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babita","family":"Madan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Virshup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven D.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2019.06.020_bib1","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1172\/JCI72267","article-title":"Cellular and molecular mechanisms in kidney fibrosis","volume":"124","author":"Duffield","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.06.020_bib2","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1681\/ASN.2016080902","article-title":"Tubule-derived Wnts are required for fibroblast activation and kidney fibrosis","volume":"28","author":"Zhou","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib3","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1681\/ASN.2017080903","article-title":"Fibroblast-specific beta-catenin signaling dictates the outcome of AKI","volume":"29","author":"Zhou","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.devcel.2009.06.016","article-title":"Wnt\/beta-catenin signaling: components, mechanisms, and diseases","volume":"17","author":"MacDonald","year":"2009","journal-title":"Dev Cell"},{"key":"10.1016\/j.kint.2019.06.020_bib5","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1681\/ASN.2010101079","article-title":"Targeted inhibition of beta-catenin\/CBP signaling ameliorates renal interstitial fibrosis","volume":"22","author":"Hao","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib6","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2019.06.020_bib7","doi-asserted-by":"crossref","first-page":"14309","DOI":"10.1073\/pnas.1001520107","article-title":"Inhibition of Wnt\/beta-catenin\/CREB binding protein (CBP) signaling reverses pulmonary fibrosis","volume":"107","author":"Henderson","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2019.06.020_bib8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1681\/ASN.2008060566","article-title":"Wnt\/beta-catenin signaling promotes renal interstitial fibrosis","volume":"20","author":"He","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib9","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2019.06.020_bib10","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1002\/j.1460-2075.1993.tb06225.x","article-title":"Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein","volume":"12","author":"van den Heuvel","year":"1993","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2019.06.020_bib11","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.1242\/jcs.072132","article-title":"WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification","volume":"123","author":"Coombs","year":"2010","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2019.06.020_bib12","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1126\/science.1222879","article-title":"Structural basis of Wnt recognition by Frizzled","volume":"337","author":"Janda","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.kint.2019.06.020_bib13","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.kint.2016.01.017","article-title":"Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis","volume":"89","author":"Madan","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.020_bib14","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0002-9440(10)63292-0","article-title":"Blockade of CCR2 ameliorates progressive fibrosis in kidney","volume":"165","author":"Kitagawa","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2019.06.020_bib15","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","article-title":"Macrophage diversity in renal injury and repair","volume":"118","author":"Ricardo","year":"2008","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.06.020_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1681\/ASN.2017040391","article-title":"Wnt\/beta-catenin-promoted macrophage alternative activation contributes to kidney fibrosis","volume":"29","author":"Feng","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib17","doi-asserted-by":"crossref","first-page":"R1456","DOI":"10.1152\/ajpregu.00620.2005","article-title":"TNF-alpha neutralization ameliorates obstruction-induced renal fibrosis and dysfunction","volume":"292","author":"Meldrum","year":"2007","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.kint.2019.06.020_bib18","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1172\/JCI61368","article-title":"Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis","volume":"124","author":"Zhang","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.06.020_bib19","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1073\/pnas.0912228107","article-title":"Macrophage Wnt7b is critical for kidney repair and regeneration","volume":"107","author":"Lin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2019.06.020_bib20","first-page":"183","article-title":"Macrophages in kidney injury, inflammation, and fibrosis","volume":"30","author":"Cao","year":"2015","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.kint.2019.06.020_bib21","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1681\/ASN.2004110949","article-title":"Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis","volume":"16","author":"Surendran","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib22","doi-asserted-by":"crossref","first-page":"24665","DOI":"10.1074\/jbc.M109.091256","article-title":"Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt\/beta-catenin signaling","volume":"285","author":"He","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.06.020_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1523-1755.2001.030002587.x","article-title":"PAI-1 deficiency attenuates the fibrogenic response to ureteral obstruction","volume":"60","author":"Oda","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.020_bib24","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1681\/ASN.V1261173","article-title":"Obstructive nephropathy in the mouse: progressive fibrosis correlates with tubulointerstitial chemokine expression and accumulation of CC chemokine receptor 2- and 5-positive leukocytes","volume":"12","author":"Vielhauer","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib25","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.4049\/jimmunol.0901473","article-title":"Bone marrow Ly6Chigh monocytes are selectively recruited to injured kidney and differentiate into functionally distinct populations","volume":"183","author":"Lin","year":"2009","journal-title":"J\u00a0Immunol"},{"issue":"119","key":"10.1016\/j.kint.2019.06.020_bib26","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1038\/ki.2010.418","article-title":"Mechanistic connection between inflammation and fibrosis","author":"Lee","year":"2010","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.kint.2019.06.020_bib27","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/01.ASN.0000120371.09769.80","article-title":"Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis","volume":"15","author":"Wada","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10787-017-0317-4","article-title":"CCR2 contributes to the recruitment of monocytes and leads to kidney inflammation and fibrosis development","volume":"26","author":"Braga","year":"2018","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.kint.2019.06.020_bib29","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.4049\/jimmunol.0902572","article-title":"Beta-catenin signaling mediates CD4 expression on mature CD8+ T cells","volume":"185","author":"Schenkel","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2019.06.020_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1681\/ASN.2010121257","article-title":"Lineage specification of parietal epithelial cells requires beta-catenin\/Wnt signaling","volume":"23","author":"Grouls","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"pii","key":"10.1016\/j.kint.2019.06.020_bib31","article-title":"Wnt signaling in mammalian development: lessons from mouse genetics","volume":"4","author":"Wang","year":"2012","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.kint.2019.06.020_bib32","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1530\/REP-17-0436","article-title":"Regulation of porcupine-dependent Wnt signaling is essential for uterine development and function","volume":"155","author":"Farah","year":"2018","journal-title":"Reproduction (Cambridge, England)"},{"key":"10.1016\/j.kint.2019.06.020_bib33","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00109-017-1606-5","article-title":"Beta-arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1\/beta-catenin signaling in mice","volume":"96","author":"Xu","year":"2018","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.kint.2019.06.020_bib34","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1681\/ASN.2016121351","article-title":"Blocking TGF-beta and beta-catenin epithelial crosstalk exacerbates CKD","volume":"28","author":"Nlandu-Khodo","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib35","doi-asserted-by":"crossref","first-page":"F1641","DOI":"10.1152\/ajprenal.00460.2012","article-title":"Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling","volume":"303","author":"Satoh","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.020_bib36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.ki.5001521","article-title":"Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice","volume":"70","author":"Ninichuk","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.020_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1159\/000257514","article-title":"Bone marrow mononuclear cells attenuate interstitial fibrosis and stimulate the repair of tubular epithelial cells after unilateral ureteral obstruction","volume":"24","author":"Barreira","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.kint.2019.06.020_bib38","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.kint.2018.11.021","article-title":"Wnt\/beta-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome","volume":"95","author":"Zhao","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.020_bib39","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.kint.2017.12.017","article-title":"Activated renal tubular Wnt\/beta-catenin signaling triggers renal inflammation during overload proteinuria","volume":"93","author":"Wong","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.020_bib40","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1681\/ASN.2010020147","article-title":"TGF-beta receptor deletion in the renal collecting system exacerbates fibrosis","volume":"21","author":"Gewin","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib41","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/biolre\/iox119","article-title":"Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility","volume":"97","author":"Farah","year":"2017","journal-title":"Biol Reprod"},{"key":"10.1016\/j.kint.2019.06.020_bib42","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1159\/000096859","article-title":"Reduction of renal fibrosis as a result of liposome encapsulated clodronate induced macrophage depletion after unilateral ureteral obstruction in rats","volume":"105","author":"Sung","year":"2007","journal-title":"Nephron Exp Nephrol"},{"key":"10.1016\/j.kint.2019.06.020_bib43","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.molmed.2011.07.009","article-title":"Metchnikoff's policemen: macrophages in development, homeostasis and regeneration","volume":"17","author":"Stefater","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.kint.2019.06.020_bib44","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.kint.2019.06.020_bib45","doi-asserted-by":"crossref","first-page":"13096","DOI":"10.1038\/ncomms13096","article-title":"Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury","volume":"7","author":"Saha","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2019.06.020_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0092159","article-title":"Porcupine is not required\u00a0for the production of the majority of Wnts from primary\u00a0human astrocytes and CD8+ T cells","volume":"9","author":"Richards","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2019.06.020_bib47","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1681\/ASN.2015060683","article-title":"Competing actions of type 1 angiotensin II receptors expressed on T lymphocytes and kidney epithelium during cisplatin-induced AKI","volume":"27","author":"Zhang","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819307720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819307720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:54:25Z","timestamp":1758761665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253819307720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0085253819307720"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2019.06.020","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced\u00a0kidney fibrosis","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2019.06.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}