{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:34:52Z","timestamp":1792650892207,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.kint.2019.06.022","type":"journal-article","created":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T19:58:12Z","timestamp":1564689492000},"page":"95-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["The acute kidney injury to chronic kidney disease\u00a0transition in a mouse model of\u00a0acute\u00a0cardiorenal syndrome emphasizes the\u00a0role\u00a0of\u00a0inflammation"],"prefix":"10.1016","volume":"97","author":[{"given":"Katsuyuki","family":"Matsushita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-9218","authenticated-orcid":false,"given":"Turgay","family":"Saritas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahaba B.","family":"Eiwaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"McClellan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Coe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Z.","family":"Ferdaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn Y.","family":"Sakai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"McCormick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-1812","authenticated-orcid":false,"given":"Michael P.","family":"Hutchens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2019.06.022_bib1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/ki.2011.379","article-title":"Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis","volume":"81","author":"Coca","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.022_bib2","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2215\/CJN.02440213","article-title":"Association between AKI and long-term renal and cardiovascular outcomes in United States veterans","volume":"9","author":"Chawla","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/ki.2011.405","article-title":"Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury","volume":"81","author":"Bucaloiu","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.022_bib4","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.1016\/j.jelectrocard.2007.06.023","article-title":"Global public health problem of sudden cardiac death","volume":"40","author":"Mehra","year":"2007","journal-title":"J\u00a0Electrocardiol"},{"key":"10.1016\/j.kint.2019.06.022_bib5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000313745","article-title":"Cardiorenal syndromes: an executive summary from the consensus conference of the Acute Dialysis Quality Initiative (ADQI)","volume":"165","author":"Ronco","year":"2010","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1053\/j.ajkd.2014.09.008","article-title":"Acute kidney injury and prognosis after cardiopulmonary bypass: a meta-analysis of cohort studies","volume":"65","author":"Pickering","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2019.06.022_bib7","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1186\/cc9960","article-title":"Clinical accuracy of RIFLE and Acute Kidney Injury Network (AKIN) criteria for acute kidney injury in patients undergoing cardiac surgery","volume":"15","author":"Englberger","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.kint.2019.06.022_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069998","article-title":"Incidence and mortality of acute kidney injury after myocardial infarction: a comparison between KDIGO and RIFLE criteria","volume":"8","author":"Rodrigues","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2019.06.022_bib9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13054-015-0900-2","article-title":"Acute kidney injury after cardiac arrest","volume":"19","author":"Tujjar","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.kint.2019.06.022_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1001\/archinternmed.2010.514","article-title":"The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death","volume":"171","author":"Ishani","year":"2011","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.kint.2019.06.022_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/CIRCULATIONAHA.110.970160","article-title":"Associations between acute kidney injury and cardiovascular and renal outcomes after coronary angiography","volume":"123","author":"James","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2019.06.022_bib12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1681\/ASN.2007080837","article-title":"Acute kidney injury increases risk of ESRD among elderly","volume":"20","author":"Ishani","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib13","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/archinte.168.6.609","article-title":"Long-term risk of mortality and end-stage renal disease among the elderly after small increases in serum creatinine level during hospitalization for acute myocardial infarction","volume":"168","author":"Newsome","year":"2008","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.kint.2019.06.022_bib14","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/S0140-6736(10)61271-8","article-title":"Glomerular filtration rate, proteinuria, and the incidence and consequences of acute kidney injury: a cohort study","volume":"376","author":"James","year":"2010","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.kint.2019.06.022_bib15","article-title":"Chronic kidney disease progression and cardiovascular outcomes following cardiac catheterization\u2014a population-controlled study","volume":"5","author":"Brown","year":"2016","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.kint.2019.06.022_bib16","doi-asserted-by":"crossref","first-page":"R145","DOI":"10.1186\/cc12824","article-title":"Five-year risk of end-stage renal disease among intensive care patients surviving dialysis-requiring acute kidney injury: a nationwide cohort study","volume":"17","author":"Gammelager","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.kint.2019.06.022_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/ALN.0000000000001400","article-title":"Rapid occurrence of chronic kidney disease in patients experiencing reversible acute kidney injury after cardiac surgery","volume":"126","author":"Legouis","year":"2017","journal-title":"Anesthesiology"},{"key":"10.1016\/j.kint.2019.06.022_bib18","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1681\/ASN.2015070832","article-title":"Bridging translation by improving preclinical study design in AKI","volume":"26","author":"de Caestecker","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib19","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1681\/ASN.2015101109","article-title":"Models of human AKI: resemblance, reproducibility, and return on investment","volume":"26","author":"Nath","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib20","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.2215\/CJN.06820617","article-title":"Overcoming translational barriers in acute kidney injury: a report from an NIDDK workshop","volume":"13","author":"Zuk","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib21","doi-asserted-by":"crossref","first-page":"F629","DOI":"10.1152\/ajprenal.00573.2016","article-title":"Determination of renal function and injury using near-infrared fluorimetry in experimental cardiorenal syndrome","volume":"312","author":"Ikeda","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.022_bib22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s13054-015-1049-8","article-title":"Estrogen administered after cardiac arrest and cardiopulmonary resuscitation ameliorates acute kidney injury in a sex- and age-specific manner","volume":"19","author":"Ikeda","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.kint.2019.06.022_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099910","article-title":"Estrogen-mediated renoprotection following cardiac arrest and cardiopulmonary resuscitation is robust to GPR30 gene deletion","volume":"9","author":"Hutchens","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2019.06.022_bib24","doi-asserted-by":"crossref","first-page":"F377","DOI":"10.1152\/ajprenal.00354.2011","article-title":"Estrogen protects renal endothelial barrier function from ischemia-reperfusion in\u00a0vitro and in\u00a0vivo","volume":"303","author":"Hutchens","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.022_bib25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/ALN.0b013e3181c98da9","article-title":"Estrogen is renoprotective via a non-receptor dependent mechanism after cardiac arrest in vivo","volume":"112","author":"Hutchens","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.kint.2019.06.022_bib26","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1681\/ASN.2015030309","article-title":"Progression after AKI: understanding maladaptive repair processes to predict and identify therapeutic treatments","volume":"27","author":"Basile","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib27","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1681\/ASN.2008060566","article-title":"Wnt\/beta-catenin signaling promotes renal interstitial fibrosis","volume":"20","author":"He","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib28","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1681\/ASN.2015040449","article-title":"Sustained activation of Wnt\/\u03b2-catenin signaling drives AKI to CKD progression","volume":"27","author":"Xiao","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib29","doi-asserted-by":"crossref","first-page":"F581","DOI":"10.1152\/ajprenal.00670.2013","article-title":"Blockade of cysteine-rich protein 61 attenuates renal inflammation and fibrosis after ischemic kidney injury","volume":"307","author":"Lai","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.022_bib30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/01.TP.0000113850.34945.DC","article-title":"Cyclosporine A sensitizes the kidney to tubulointerstitial fibrosis induced by renal warm ischemia","volume":"77","author":"Ahmed","year":"2004","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2019.06.022_bib31","doi-asserted-by":"crossref","first-page":"892","DOI":"10.7150\/ijbs.11729","article-title":"Mild ischemic injury leads to long-term alterations in the kidney: amelioration by spironolactone administration","volume":"11","author":"Barrera-Chimal","year":"2015","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.kint.2019.06.022_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.urology.2012.02.054","article-title":"Ischemic postconditioning inhibits the renal fibrosis induced by ischemia-reperfusion injury in rats","volume":"80","author":"Weng","year":"2012","journal-title":"Urology"},{"key":"10.1016\/j.kint.2019.06.022_bib33","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ki.2012.20","article-title":"Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis","volume":"82","author":"Grgic","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.06.022_bib34","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1681\/ASN.2015060647","article-title":"Severity and frequency of proximal tubule injury determines renal prognosis","volume":"27","author":"Takaori","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib35","doi-asserted-by":"crossref","first-page":"F87","DOI":"10.1152\/ajprenal.00026.2003","article-title":"Acute renal failure after whole body ischemia is characterized by inflammation and T cell-mediated injury","volume":"285","author":"Burne-Taney","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.022_bib36","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1101\/gr.6.4.300","article-title":"A\u00a0tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation","volume":"6","author":"Siracusa","year":"1996","journal-title":"Genome Res"},{"key":"10.1016\/j.kint.2019.06.022_bib37","first-page":"225","article-title":"A\u00a0Turkish patient of typical Loeys-Dietz syndrome with a TGFBR2 mutation","volume":"21","author":"Tug","year":"2010","journal-title":"Genet Couns"},{"key":"10.1016\/j.kint.2019.06.022_bib38","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1074\/jbc.M209256200","article-title":"Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein","volume":"278","author":"Isogai","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.06.022_bib39","doi-asserted-by":"crossref","first-page":"8655","DOI":"10.1074\/jbc.M110.174037","article-title":"Klotho inhibits transforming growth factor-\u03b21 (TGF-\u03b21) signaling and suppresses renal fibrosis and cancer metastasis in mice","volume":"286","author":"Doi","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.06.022_bib40","doi-asserted-by":"crossref","first-page":"F1210","DOI":"10.1152\/ajprenal.00660.2011","article-title":"PTEN loss defines a TGF-\u03b2-induced tubule phenotype of failed differentiation and JNK signaling during renal fibrosis","volume":"302","author":"Lan","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.06.022_bib41","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2353\/ajpath.2009.080295","article-title":"Inhibition of autoregulated TGFbeta signaling simultaneously enhances proliferation and differentiation of kidney epithelium and promotes repair following renal ischemia","volume":"174","author":"Geng","year":"2009","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.kint.2019.06.022_bib42","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122130","article-title":"Glomerular filtrate proteins in acute cardiorenal syndrome","volume":"4","author":"Wakasaki","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2019.06.022_bib43","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJMoa012689","article-title":"Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest","volume":"346","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2019.06.022_bib44","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1007\/s00134-013-3043-4","article-title":"Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort","volume":"39","author":"Lemiale","year":"2013","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.kint.2019.06.022_bib45","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1093\/ndt\/gfp225","article-title":"Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats","volume":"24","author":"Schock-Kusch","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2019.06.022_bib46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1681\/ASN.2009060615","article-title":"Distinct macrophage phenotypes contribute to kidney injury and repair","volume":"22","author":"Lee","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib47","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1681\/ASN.2014040320","article-title":"Specific macrophage subtypes influence the progression of rhabdomyolysis-induced kidney injury","volume":"26","author":"Belliere","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2019.06.022_bib48","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ckj\/sfw096","article-title":"Macrophage in chronic kidney disease","volume":"9","author":"Guiteras","year":"2016","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.kint.2019.06.022_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0071519","article-title":"Reliability of transcutaneous measurement of renal function in various strains of conscious mice","volume":"8","author":"Schock-Kusch","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2019.06.022_bib50","first-page":"1227","article-title":"Automated systematic random sampling and Cavalieri stereology of histologic sections demonstrating acute tubular necrosis after cardiac arrest and cardiopulmonary resuscitation in the mouse","volume":"33","author":"Wakasaki","year":"2018","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.kint.2019.06.022_bib51","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1038\/s41598-019-40795-0","article-title":"Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis","volume":"9","author":"Saritas","year":"2019","journal-title":"Sci Rep"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819307744?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819307744?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:54:55Z","timestamp":1758761695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253819307744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0085253819307744"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2019.06.022","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The acute kidney injury to chronic kidney disease\u00a0transition in a mouse model of\u00a0acute\u00a0cardiorenal syndrome emphasizes the\u00a0role\u00a0of\u00a0inflammation","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2019.06.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}