{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:26:27Z","timestamp":1790011587691,"version":"4.0.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.kint.2019.11.012","type":"journal-article","created":{"date-parts":[[2019,11,26]],"date-time":"2019-11-26T02:13:55Z","timestamp":1574734435000},"page":"765-777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity"],"prefix":"10.1016","volume":"97","author":[{"given":"Hong","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiagen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Obinna N.","family":"Obianom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2019.11.012_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/bmb\/ldg032","article-title":"Hazards of heavy metal contamination","volume":"68","author":"Jarup","year":"2003","journal-title":"Br Med Bull"},{"key":"10.1016\/j.kint.2019.11.012_bib2","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1001\/jama.2013.284692","article-title":"Smoking prevalence and cigarette consumption in 187 countries, 1980-2012","volume":"311","author":"Ng","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2019.11.012_bib3","doi-asserted-by":"crossref","first-page":"9199","DOI":"10.3390\/ijerph120809199","article-title":"Additional burden of diseases associated with cadmium exposure: a case study of cadmium contaminated rice fields in Mae Sot District, Tak Province, Thailand","volume":"12","author":"Songprasert","year":"2015","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.kint.2019.11.012_bib4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0013-9351(80)90105-X","article-title":"Multispecies retention parameters for cadmium","volume":"23","author":"Thomas","year":"1980","journal-title":"Environ Res"},{"key":"10.1016\/j.kint.2019.11.012_bib5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s12011-017-0959-5","article-title":"Cadmium concentration in human autopsy tissues","volume":"179","author":"Lech","year":"2017","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.kint.2019.11.012_bib6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1007\/s00204-013-1110-9","article-title":"Cadmium and cellular signaling cascades: interactions between cell death and survival pathways","volume":"87","author":"Thevenod","year":"2013","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.kint.2019.11.012_bib7","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/ije\/dyv086","article-title":"Urinary cadmium and mortality from all causes, cancer and cardiovascular disease in the general population: systematic review and meta-analysis of cohort studies","volume":"45","author":"Larsson","year":"2016","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.kint.2019.11.012_bib8","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1080\/009841099158123","article-title":"Levels of cadmium in kidney and liver tissues among a Canadian population (province of Quebec)","volume":"56","author":"Benedetti","year":"1999","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1016\/j.kint.2019.11.012_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nrd3028","article-title":"Membrane transporters in drug development","volume":"9","author":"Giacomini","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.kint.2019.11.012_bib10","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/clpt.2012.126","article-title":"Highlights from the International Transporter Consortium second workshop","volume":"92","author":"Zamek-Gliszczynski","year":"2012","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib11","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/clpt.2013.74","article-title":"Emerging transporters of clinical importance: an update from the International Transporter Consortium","volume":"94","author":"Hillgren","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/clpt.2013.81","article-title":"In\u00a0vitro methods to support transporter evaluation in drug discovery and development","volume":"94","author":"Brouwer","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/clpt.2013.77","article-title":"Transporter studies in drug development: experience to date and follow-up on decision trees from the International Transporter Consortium","volume":"94","author":"Tweedie","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/03602532.2011.602687","article-title":"Mammalian MATE (SLC47A) transport proteins: impact on efflux of endogenous substrates and xenobiotics","volume":"43","author":"Damme","year":"2011","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.kint.2019.11.012_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1124\/dmd.107.019869","article-title":"Altered pharmacokinetics of cationic drugs caused by down-regulation of renal rat organic cation transporter 2 (Slc22a2) and rat multidrug and toxin extrusion 1 (Slc47a1) in ischemia\/reperfusion-induced acute kidney injury","volume":"36","author":"Matsuzaki","year":"2008","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.kint.2019.11.012_bib16","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0270-9295(03)00089-5","article-title":"Cisplatin nephrotoxicity","volume":"23","author":"Arany","year":"2003","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2019.11.012_bib17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/clpt.2009.139","article-title":"Contribution of organic cation transporter 2 (OCT2) to cisplatin-induced nephrotoxicity","volume":"86","author":"Filipski","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib18","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.fct.2012.03.077","article-title":"Ameliorative effects of SLC22A2 gene polymorphism 808 G\/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients","volume":"50","author":"Zhang","year":"2012","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.kint.2019.11.012_bib19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.taap.2013.08.024","article-title":"Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs)","volume":"273","author":"Li","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.kint.2019.11.012_bib20","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1021\/mp400113d","article-title":"Substrate- and cell contact-dependent inhibitor affinity of human organic cation transporter 2: studies with two classical organic cation substrates and the novel substrate cd2+","volume":"10","author":"Thevenod","year":"2013","journal-title":"Mol Pharm"},{"key":"10.1016\/j.kint.2019.11.012_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.toxlet.2011.04.005","article-title":"Renal organic cation transporters mediated cadmium-induced nephrotoxicity","volume":"204","author":"Soodvilai","year":"2011","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.kint.2019.11.012_bib22","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.taap.2016.11.007","article-title":"Multidrug and toxin extrusion proteins mediate cellular transport of cadmium","volume":"314","author":"Yang","year":"2017","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.kint.2019.11.012_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3109\/03602539709037574","article-title":"Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity","volume":"29","author":"Klaassen","year":"1997","journal-title":"Drug Metab Rev"},{"key":"10.1016\/j.kint.2019.11.012_bib24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1093\/toxsci\/kfr256","article-title":"Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells","volume":"125","author":"Jing","year":"2012","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.kint.2019.11.012_bib25","doi-asserted-by":"crossref","first-page":"14599","DOI":"10.1074\/jbc.C300063200","article-title":"Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation","volume":"278","author":"Sano","year":"2003","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.11.012_bib26","doi-asserted-by":"crossref","first-page":"26287","DOI":"10.1074\/jbc.M111.253880","article-title":"Loss of AS160 Akt substrate causes Glut4 protein to accumulate in compartments that are primed for fusion in basal adipocytes","volume":"286","author":"Brewer","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.11.012_bib27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.taap.2009.01.013","article-title":"Cadmium and cellular signaling cascades: to be or not to be?","volume":"238","author":"Thevenod","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.kint.2019.11.012_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2005.07.056","article-title":"Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation","volume":"335","author":"Kane","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2019.11.012_bib29","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.2337\/db07-0681","article-title":"Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle","volume":"56","author":"Kramer","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2019.11.012_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0896-6273(00)80709-6","article-title":"Calmodulin is the Ca2+ sensor for Ca2+ -dependent inactivation of L-type calcium channels","volume":"22","author":"Peterson","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.kint.2019.11.012_bib31","doi-asserted-by":"crossref","first-page":"F505","DOI":"10.1152\/ajprenal.90545.2008","article-title":"The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity","volume":"296","author":"Pabla","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2019.11.012_bib32","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/sj.ki.5002467","article-title":"Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity","volume":"72","author":"Prozialeck","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2019.11.012_bib33","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1172\/JCI42004","article-title":"Lipocalin 2 is essential for chronic kidney disease progression in mice and humans","volume":"120","author":"Viau","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2019.11.012_bib34","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2119\/molmed.2008.00104","article-title":"Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers)","volume":"15","author":"Benoff","year":"2009","journal-title":"Mol Med"},{"key":"10.1016\/j.kint.2019.11.012_bib35","doi-asserted-by":"crossref","first-page":"7771","DOI":"10.1128\/MCB.19.11.7771","article-title":"A\u00a0role for protein kinase Bbeta\/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes","volume":"19","author":"Hill","year":"1999","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2019.11.012_bib36","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1126\/science.292.5522.1728","article-title":"Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)","volume":"292","author":"Cho","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.kint.2019.11.012_bib37","doi-asserted-by":"crossref","first-page":"847","DOI":"10.2337\/diabetes.49.5.847","article-title":"Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats","volume":"49","author":"Kim","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2019.11.012_bib38","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1530\/JOE-13-0172","article-title":"PI3 kinase directly phosphorylates Akt1\/2 at Ser473\/474 in the insulin signal transduction pathway","volume":"220","author":"Tsuchiya","year":"2014","journal-title":"J\u00a0Endocrinol"},{"key":"10.1016\/j.kint.2019.11.012_bib39","doi-asserted-by":"crossref","first-page":"22115","DOI":"10.1074\/jbc.C200198200","article-title":"A\u00a0method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain","volume":"277","author":"Kane","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.11.012_bib40","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nrm2728","article-title":"Rab GTPases as coordinators of vesicle traffic","volume":"10","author":"Stenmark","year":"2009","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.kint.2019.11.012_bib41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/BSR20100112","article-title":"TBC proteins: GAPs for mammalian small GTPase Rab?","volume":"31","author":"Fukuda","year":"2011","journal-title":"Biosci Rep"},{"key":"10.1016\/j.kint.2019.11.012_bib42","doi-asserted-by":"crossref","first-page":"38903","DOI":"10.1074\/jbc.M405314200","article-title":"Calmodulin-mediated activation of Akt regulates survival of c-Myc-overexpressing mouse mammary carcinoma cells","volume":"279","author":"Deb","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2019.11.012_bib43","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10549-008-0097-z","article-title":"Calmodulin modulates Akt activity in human breast cancer cell lines","volume":"115","author":"Coticchia","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.kint.2019.11.012_bib44","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/BF00290889","article-title":"Stimulation of calmodulin by cadmium ion","volume":"57","author":"Suzuki","year":"1985","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.kint.2019.11.012_bib45","series-title":"Handbook on the Toxicology of Metals, Third Edition","first-page":"445","article-title":"Chapter 23: cadmium","author":"Nordberg","year":"2007"},{"key":"10.1016\/j.kint.2019.11.012_bib46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2009.04.020","article-title":"Current status of cadmium as an environmental health problem","volume":"238","author":"Jarup","year":"2009","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.kint.2019.11.012_bib47","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/009841099157773","article-title":"Dependence of cadmium-metallothionein nephrotoxicity on glutathione","volume":"57","author":"Shaikh","year":"1999","journal-title":"J\u00a0Toxicol Environ Health A"},{"key":"10.1016\/j.kint.2019.11.012_bib48","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/0272-0590(88)90255-2","article-title":"Nephrotoxicity of intravenously injected cadmium-metallothionein: critical concentration and tolerance","volume":"10","author":"Maitani","year":"1988","journal-title":"Fundam Appl Toxicol"},{"key":"10.1016\/j.kint.2019.11.012_bib49","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1007\/s00204-019-02557-9","article-title":"An integrative approach to cisplatin chronic toxicities in mice reveals importance of organic cation-transporter-dependent protein networks for renoprotection","volume":"93","author":"Hucke","year":"2019","journal-title":"Arch Toxicol"},{"key":"10.1016\/j.kint.2019.11.012_bib50","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s10534-019-00176-6","article-title":"Channels, transporters and receptors for cadmium and cadmium complexes in eukaryotic cells: myths and facts","volume":"32","author":"Thevenod","year":"2019","journal-title":"Biometals"},{"key":"10.1016\/j.kint.2019.11.012_bib51","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.3390\/ijms16011484","article-title":"Cadmium transporters in the kidney and cadmium-induced nephrotoxicity","volume":"16","author":"Yang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2019.11.012_bib52","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1124\/jpet.111.184986","article-title":"Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney","volume":"340","author":"Ito","year":"2012","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.kint.2019.11.012_bib53","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1124\/jpet.106.110346","article-title":"Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family)","volume":"319","author":"Yonezawa","year":"2006","journal-title":"J\u00a0Pharmacol Exp Ther"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819311536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253819311536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:55:29Z","timestamp":1758761729000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253819311536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0085253819311536"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2019.11.012","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium exposure enhances organic cation transporter 2 trafficking to the kidney membrane and exacerbates cisplatin nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2019.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}