{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:27:26Z","timestamp":1790807246103,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.kint.2020.03.032","type":"journal-article","created":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T21:00:17Z","timestamp":1587762017000},"page":"673-685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Arginase 2 is a mediator of ischemia\u2013reperfusion injury in the kidney through regulation of nitrosative stress"],"prefix":"10.1016","volume":"98","author":[{"given":"Masatoshi","family":"Hara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Torisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Tomita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Tsuruya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanari","family":"Kitazono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2020.03.032_bib2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"Lameire","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2020.03.032_bib3","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1681\/ASN.2015070740","article-title":"Cellular and molecular mechanisms of AKI","volume":"27","author":"Agarwal","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.03.032_bib4","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1172\/JCI72269","article-title":"Therapeutic translation in acute kidney injury: the epithelial\/endothelial axis","volume":"124","author":"Molitoris","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2020.03.032_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0378-1119(97)00099-1","article-title":"Human type II arginase: sequence analysis and tissue-specific expression","volume":"193","author":"Morris","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.kint.2020.03.032_bib6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.acthis.2011.09.002","article-title":"Immunohistochemical study of arginase 1 and 2 in various tissues of rats","volume":"114","author":"Choi","year":"2012","journal-title":"Acta Histochem"},{"key":"10.1016\/j.kint.2020.03.032_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s00424-004-1336-8","article-title":"Localization and differential expression of arginase II in the kidney of male and female mice","volume":"449","author":"Levillain","year":"2005","journal-title":"Eur J Physiol"},{"key":"10.1016\/j.kint.2020.03.032_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tips.2015.03.006","article-title":"Arginase: an old enzyme with new tricks","volume":"36","author":"Caldwell","year":"2015","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.kint.2020.03.032_bib9","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/j.ymgme.2003.10.012","article-title":"Arginases I and II: do their functions overlap?","volume":"81","author":"Cederbaum","year":"2004","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.kint.2020.03.032_bib10","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0305-0491(95)02138-8","article-title":"Comparative properties of arginases","volume":"114","author":"Jenkinson","year":"1996","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.kint.2020.03.032_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.coph.2013.01.006","article-title":"Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease","volume":"13","author":"Li","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.kint.2020.03.032_bib12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1152\/physrev.00037.2016","article-title":"Arginase: a multifaceted enzyme important in health and disease","volume":"98","author":"Caldwell","year":"2018","journal-title":"Physiol Rev"},{"key":"10.1016\/j.kint.2020.03.032_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0378-4274(02)00508-8","article-title":"Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention","volume":"140\u2013141","author":"Vir\u00e1g","year":"2003","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.kint.2020.03.032_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042038","article-title":"Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production","volume":"7","author":"Gonon","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.03.032_bib15","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/apha.12097","article-title":"Arginase inhibition improves coronary microvascular function and reduces infarct size following ischemia-reperfusion in a rat model","volume":"208","author":"Gr\u00f6nros","year":"2013","journal-title":"Acta Physiol"},{"key":"10.1016\/j.kint.2020.03.032_bib16","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/cvr\/cvp303","article-title":"Arginase inhibition mediates cardioprotection during ischaemia-reperfusion","volume":"85","author":"Jung","year":"2010","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.kint.2020.03.032_bib17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1152\/ajpgi.00227.2006","article-title":"Liver I\/R injury is improved by the arginase inhibitor, N\u03c9-hydroxy-nor-L-arginine (nor-NOHA)","volume":"292","author":"Reid","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.kint.2020.03.032_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.niox.2008.04.002","article-title":"Arginase blockade protects against hepatic damage in warm ischemia-reperfusion","volume":"19","author":"Jeyabalan","year":"2008","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.kint.2020.03.032_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033258","article-title":"Hypoxia inducible factor 1-alpha (hif-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival","volume":"7","author":"Conde","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.03.032_bib20","doi-asserted-by":"crossref","first-page":"19685","DOI":"10.1074\/jbc.M112.446542","article-title":"Mechanism of inducible nitric-oxide synthase dimerization inhibition by novel pyrimidine imidazoles","volume":"27","author":"Nagpal","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.03.032_bib21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(97)00469-9","article-title":"What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in\u00a0vivo?","volume":"411","author":"Halliwell","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.kint.2020.03.032_bib22","doi-asserted-by":"crossref","first-page":"402","DOI":"10.15252\/embj.201592789","article-title":"Bax assembles into large ring-like structures remodeling the mitochondrial outer membrane in apoptosis","volume":"35","author":"Gro\u00dfe","year":"2016","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2020.03.032_bib23","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/abio.2001.5575","article-title":"Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography","volume":"303","author":"Teerlink","year":"2002","journal-title":"Anal Biochem"},{"key":"10.1016\/j.kint.2020.03.032_bib24","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.drudis.2018.01.046","article-title":"Research of novel anticancer agents targeting arginase inhibition","volume":"23","author":"Pham","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.kint.2020.03.032_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103260","article-title":"Effect of arginase inhibition on ischemia-reperfusion injury in patients with coronary artery disease with and without diabetes mellitus","volume":"9","author":"K\u00f6vamees","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.03.032_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.atherosclerosis.2010.10.044","article-title":"OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signaling","volume":"214","author":"Ryoo","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.kint.2020.03.032_bib27","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/CIRCRESAHA.115.304262","article-title":"OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase","volume":"115","author":"Pandey","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2020.03.032_bib28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.semnephrol.2004.04.002","article-title":"Nitric oxide synthesis in the kidney: isoforms, biosynthesis, and functions in health","volume":"24","author":"Kone","year":"2004","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2020.03.032_bib29","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.yjmcc.2010.12.010","article-title":"Reversal of inducible nitric oxide synthase uncoupling unmasks tolerance to ischemia\/reperfusion injury in the diabetic rat heart","volume":"50","author":"Okazaki","year":"2011","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.kint.2020.03.032_bib30","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.vph.2012.02.004","article-title":"Nitric oxide synthase uncoupling: a therapeutic target in cardiovascular diseases","volume":"57","author":"Roe","year":"2012","journal-title":"Vasc Pharmacol"},{"key":"10.1016\/j.kint.2020.03.032_bib31","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1046\/j.1523-1755.2002.00268.x","article-title":"L-arginine deficiency and supplementation in experimental acute renal failure and in human kidney transplantation","volume":"61","author":"Schramm","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.03.032_bib32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1681\/ASN.V122361","article-title":"L-arginine supplementation improves function and reduces inflammation in renal allografts","volume":"12","author":"Vos","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.03.032_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1001\/jama.295.1.58","article-title":"L-arginine therapy in acute myocardial infarction. The vascular interaction with age in myocardial infarction (VINTAGE MI) randomized clinical trial","volume":"295","author":"Schulman","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2020.03.032_bib34","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.cardiores.2004.01.025","article-title":"Critical timing of L-arginine treatment in pots-ischemic myocardial apoptosis-role of NOS isoforms","volume":"62","author":"Liang","year":"2004","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.kint.2020.03.032_bib35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.18632\/aging.100663","article-title":"Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-\u2161 and S6K1 signaling","volume":"6","author":"Xiong","year":"2014","journal-title":"Aging"},{"key":"10.1016\/j.kint.2020.03.032_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fimmu.2013.00219","article-title":"Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension","volume":"4","author":"Toque","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2020.03.032_bib37","article-title":"Kidney mass reduction leads to L-arginine metabolism-dependent blood pressure increase in mice","volume":"7","author":"Pillai","year":"2018","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.kint.2020.03.032_bib38","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/ajprenal.00352.2012","article-title":"Mouse model of ischemic acute kidney injury: technical notes and tricks","volume":"303","author":"Wei","year":"2012","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820304166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820304166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:58:33Z","timestamp":1758761913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253820304166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0085253820304166"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2020.03.032","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Arginase 2 is a mediator of ischemia\u2013reperfusion injury in the kidney through regulation of nitrosative stress","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2020.03.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}