{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:09:03Z","timestamp":1793329743972,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001866","name":"Fonds National de la Recherche Luxembourg","doi-asserted-by":"publisher","award":["6903109"],"award-info":[{"award-number":["6903109"]}],"id":[{"id":"10.13039\/501100001866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R21 DK106584"],"award-info":[{"award-number":["R21 DK106584"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["NV17-29786A"],"award-info":[{"award-number":["NV17-29786A"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["310030-189044"],"award-info":[{"award-number":["310030-189044"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Centre of Competence in Research"},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["31003A_152829"],"award-info":[{"award-number":["31003A_152829"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["33IC30_166785\/1"],"award-info":[{"award-number":["33IC30_166785\/1"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001463","name":"American Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001463","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.kint.2020.04.038","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T03:45:32Z","timestamp":1590119132000},"page":"717-731","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":150,"title":["Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutations\u00a0in UMOD and MUC1"],"prefix":"10.1016","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1178-7980","authenticated-orcid":false,"given":"Eric","family":"Olinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendrah","family":"Kidd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Dufour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrica","family":"Belge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Bonny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantinos","family":"Deltas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3566-3950","authenticated-orcid":false,"given":"Nathalie","family":"Demoulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1668-1800","authenticated-orcid":false,"given":"Thomas","family":"Fehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Fuster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9170-1579","authenticated-orcid":false,"given":"Daniel P.","family":"Gale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9242-7148","authenticated-orcid":false,"given":"Eric","family":"Goffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate\u0159ina","family":"Hoda\u0148ov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uyen","family":"Huynh-Do","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kistler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-1989","authenticated-orcid":false,"given":"Johann","family":"Morelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Papagregoriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Pirson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sandford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Sayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8714-2332","authenticated-orcid":false,"given":"Roser","family":"Torra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Venzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Venzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"\u017divn\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Greka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Dahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Rampoldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Kmoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-5273","authenticated-orcid":false,"suffix":"Sr.","given":"Anthony J.","family":"Bleyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3744-4767","authenticated-orcid":false,"given":"Olivier","family":"Devuyst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2020.04.038_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41572-019-0109-9","article-title":"Autosomal dominant tubulointerstitial kidney disease","volume":"5","author":"Devuyst","year":"2019","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.kint.2020.04.038_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ki.2015.28","article-title":"Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management\u2014a KDIGO consensus report","volume":"88","author":"Eckardt","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib3","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1136\/jmg.39.12.882","article-title":"Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy","volume":"39","author":"Hart","year":"2002","journal-title":"J\u00a0Med Genet"},{"key":"10.1016\/j.kint.2020.04.038_bib4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrneph.2017.101","article-title":"Uromodulin: from physiology to rare and complex kidney disorders","volume":"13","author":"Devuyst","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/ng.2543","article-title":"Mutations causing medullary cystic kidney disease type 1 lie in a large VNTR in MUC1 missed by massively parallel sequencing","volume":"45","author":"Kirby","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.04.038_bib6","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1681\/ASN.2018030245","article-title":"Biallelic expression of mucin-1 in autosomal dominant tubulointerstitial kidney disease: implications for nongenetic disease recognition","volume":"29","author":"Knaup","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib7","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1681\/ASN.2018020180","article-title":"Noninvasive immunohistochemical diagnosis and novel MUC1 mutations causing autosomal dominant tubulointerstitial kidney disease","volume":"29","author":"Zivna","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2215\/CJN.06380613","article-title":"Variable clinical presentation of an MUC1 mutation causing medullary cystic kidney disease type 1","volume":"9","author":"Bleyer","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib9","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1046\/j.1523-1755.2003.00903.x","article-title":"Atypical familial juvenile hyperuricemic nephropathy associated with a hepatocyte nuclear factor-1beta gene mutation","volume":"63","author":"Bingham","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ki.2011.225","article-title":"Diagnosis, management, and prognosis of HNF1B nephropathy in adulthood","volume":"80","author":"Faguer","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib11","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.ajhg.2009.07.010","article-title":"Dominant renin gene mutations associated with early-onset hyperuricemia, anemia, and chronic kidney failure","volume":"85","author":"Zivna","year":"2009","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.kint.2020.04.038_bib12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.ajhg.2016.05.028","article-title":"Heterozygous loss-of-function SEC61A1 mutations cause autosomal-dominant tubulo-interstitial and glomerulocystic kidney disease with anemia","volume":"99","author":"Bolar","year":"2016","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.kint.2020.04.038_bib13","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1056\/NEJMoa1806891","article-title":"Diagnostic utility of exome sequencing for kidney disease","volume":"380","author":"Groopman","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2020.04.038_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s12882-018-1107-y","article-title":"Autosomal dominant tubulointerstitial kidney disease-UMOD is the most frequent non polycystic genetic kidney disease","volume":"19","author":"Gast","year":"2018","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib15","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1053\/j.ajkd.2018.03.019","article-title":"Autosomal dominant tubulointerstitial kidney disease: clinical presentation of patients with ADTKD-UMOD and ADTKD-MUC1","volume":"72","author":"Ayasreh","year":"2018","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2020.04.038_bib16","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.1038\/s41598-017-07804-6","article-title":"Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations","volume":"7","author":"Trudu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2020.04.038_bib17","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1093\/hmg\/ddq205","article-title":"A\u00a0transgenic mouse model for uromodulin-associated kidney diseases shows specific tubulo-interstitial damage, urinary concentrating defect and renal failure","volume":"19","author":"Bernascone","year":"2010","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2020.04.038_bib18","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1172\/JCI93817","article-title":"Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis","volume":"127","author":"Johnson","year":"2017","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2020.04.038_bib19","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2019.07.002","article-title":"Small molecule targets TMED9 and promotes lysosomal degradation to reverse proteinopathy","volume":"178","author":"Dvela-Levitt","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.04.038_bib20","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.2215\/CJN.01220211","article-title":"Phenotype and outcome in hereditary tubulointerstitial nephritis secondary to UMOD mutations","volume":"6","author":"Boll\u00e9e","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1093\/ndt\/gft345","article-title":"Determination of uromodulin in human urine: influence of storage and processing","volume":"29","author":"Youhanna","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2020.04.038_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2215\/CJN.04230415","article-title":"Associations of urinary uromodulin with clinical characteristics and markers of tubular function in the general population","volume":"11","author":"Pruijm","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib23","doi-asserted-by":"crossref","first-page":"62","DOI":"10.2215\/CJN.04770415","article-title":"Clinical, genetic, and urinary factors associated with uromodulin excretion","volume":"11","author":"Troyanov","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib24","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1681\/ASN.2013070781","article-title":"Common variants in UMOD associate with urinary uromodulin levels: a meta-analysis","volume":"25","author":"Olden","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1053\/j.ajkd.2004.08.021","article-title":"Uromodulin storage diseases: clinical aspects and mechanisms","volume":"44","author":"Scolari","year":"2004","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2020.04.038_bib26","doi-asserted-by":"crossref","first-page":"F1062","DOI":"10.1152\/ajprenal.00233.2017","article-title":"Tamm-Horsfall protein\/uromodulin deficiency elicits tubular compensatory responses leading to hypertension and hyperuricemia","volume":"314","author":"Liu","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2020.04.038_bib27","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1097\/01.ASN.0000092147.83480.B5","article-title":"A\u00a0cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin","volume":"14","author":"Dahan","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib28","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.kint.2017.10.016","article-title":"Simultaneous sequencing of 37 genes identified causative mutations in the majority of children with renal tubulopathies","volume":"93","author":"Ashton","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib29","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.kint.2019.08.027","article-title":"High-throughput sequencing contributes to the diagnosis of tubulopathies and familial hypercalcemia hypocalciuria in adults","volume":"96","author":"Hureaux","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jmoldx.2016.03.003","article-title":"Development and validation of a mass spectrometry-based assay for the molecular diagnosis of mucin-1 kidney disease","volume":"18","author":"Blumenstiel","year":"2016","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.kint.2020.04.038_bib31","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/gim.2015.30","article-title":"Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology","volume":"17","author":"Richards","year":"2015","journal-title":"Genet Med"},{"key":"10.1016\/j.kint.2020.04.038_bib32","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1091\/mbc.e08-08-0876","article-title":"Analysis of uromodulin polymerization provides new insights into the mechanisms regulating ZP domain-mediated protein assembly","volume":"20","author":"Schaeffer","year":"2009","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.kint.2020.04.038_bib33","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1097\/01.ASN.0000092147.83480.B5","article-title":"A\u00a0cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin","volume":"14","author":"Dahan","year":"2003","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.04.038_bib34","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1523-1755.2004.00845.x","article-title":"Mutations in the uromodulin gene decrease urinary excretion of Tamm-Horsfall protein","volume":"66","author":"Bleyer","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.04.038_bib35","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/ki.2014.202","article-title":"The HNF1B score is a simple tool to select patients for HNF1B gene analysis","volume":"86","author":"Faguer","year":"2014","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820305391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820305391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:57:30Z","timestamp":1758761850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253820305391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S0085253820305391"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2020.04.038","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical and genetic spectra of autosomal dominant tubulointerstitial kidney disease due to mutations\u00a0in UMOD and MUC1","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2020.04.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}