{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T01:21:23Z","timestamp":1790126483816,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T00:00:00Z","timestamp":1727827200000},"content-version":"vor","delay-in-days":1462,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK068306"],"award-info":[{"award-number":["R01-DK068306"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HA 6908\/2-1"],"award-info":[{"award-number":["HA 6908\/2-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SH 849\/1-2"],"award-info":[{"award-number":["SH 849\/1-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BE 3910\/8-1"],"award-info":[{"award-number":["BE 3910\/8-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008799","name":"Stiftung f\u00fcr Pathobiochemie und Molekulare Diagnostik","doi-asserted-by":"publisher","award":["246781735"],"award-info":[{"award-number":["246781735"]}],"id":[{"id":"10.13039\/501100008799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008799","name":"Stiftung f\u00fcr Pathobiochemie und Molekulare Diagnostik","doi-asserted-by":"publisher","award":["BE 3910\/9-1"],"award-info":[{"award-number":["BE 3910\/9-1"]}],"id":[{"id":"10.13039\/501100008799","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2016_A52"],"award-info":[{"award-number":["2016_A52"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM1903G"],"award-info":[{"award-number":["01GM1903G"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GM1903I"],"award-info":[{"award-number":["01GM1903I"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016129","name":"SICB Division of Animal Behavior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008678","name":"Universit\u00e4t Leipzig","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008678","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003390","name":"Fritz Thyssen Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.kint.2020.05.027","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T19:24:13Z","timestamp":1591298653000},"page":"958-969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Novel nephronophthisis-associated variants reveal functional importance of MAPKBP1 dimerization for centriolar recruitment"],"prefix":"10.1016","volume":"98","author":[{"given":"Ria","family":"Sch\u00f6nauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Ertel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Nemitz-Kliemchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nydia","family":"Panitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Hantmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela A.","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirlee","family":"Shril","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khurrum","family":"Shahzad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Sandford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Saunier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Benmerah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bergmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friedhelm","family":"Hildebrandt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Halbritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2020.05.027_bib1","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ajhg.2016.12.011","article-title":"Mutations in MAPKBP1 cause juvenile or late-onset cilia-independent nephronophthisis","volume":"100","author":"Macia","year":"2017","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.kint.2020.05.027_bib2","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1681\/ASN.2017111200","article-title":"NPHP1 (nephrocystin-1) gene deletions cause adult-onset ESRD","volume":"29","author":"Snoek","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.027_bib3","series-title":"GeneReviews\u00ae: Nephronophthisis","author":"Stokman","year":"1993"},{"key":"10.1016\/j.kint.2020.05.027_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cell.2012.06.028","article-title":"Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling","volume":"150","author":"Chaki","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.05.027_bib5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0014-5793(99)01084-4","article-title":"A\u00a0novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1","volume":"457","author":"Koyano","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1016\/j.kint.2020.05.027_bib6","doi-asserted-by":"crossref","first-page":"29213","DOI":"10.1074\/jbc.M112.355545","article-title":"The c-Jun N-terminal kinase (JNK)-binding protein (JNKBP1) acts as a negative regulator of NOD2 protein signaling by inhibiting its oligomerization process","volume":"287","author":"Lecat","year":"2012","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.05.027_bib7","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1074\/jbc.M112.422055","article-title":"Identification and analysis of a novel dimerization domain shared by various members of c-Jun N-terminal kinase (JNK) scaffold proteins","volume":"288","author":"Cohen-Katsenelson","year":"2013","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.05.027_bib8","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.cellbi.2009.01.003","article-title":"JNK-binding protein 1 regulates NF-kappaB activation through TRAF2 and TAK1","volume":"33","author":"Yamaguchi","year":"2009","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.kint.2020.05.027_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature09327","article-title":"Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations","volume":"467","author":"Bilg\u00fcvar","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.kint.2020.05.027_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1091\/mbc.e09-06-0512","article-title":"A\u00a0novel c-Jun N-terminal kinase (JNK)-binding protein WDR62 is recruited to stress granules and mediates a nonclassical JNK activation","volume":"21","author":"Wasserman","year":"2010","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.kint.2020.05.027_bib11","doi-asserted-by":"crossref","first-page":"43708","DOI":"10.1038\/srep43708","article-title":"Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly","volume":"7","author":"Sgourdou","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2020.05.027_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fped.2017.00287","article-title":"Many genes-one disease? Genetics of nephronophthisis (NPHP) and NPHP-associated disorders","volume":"5","author":"Srivastava","year":"2018","journal-title":"Front Pediatr"},{"key":"10.1016\/j.kint.2020.05.027_bib13","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ki.2015.28","article-title":"Autosomal dominant tubulointerstitial kidney disease: diagnosis, classification, and management\u2014a KDIGO consensus report","volume":"88","author":"Eckardt","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.05.027_bib14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/ckj\/sfx149","article-title":"The European Renal Association\u2014European Dialysis and Transplant Association (ERA-EDTA) Registry Annual Report 2015: a summary","volume":"11","author":"Kramer","year":"2018","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.kint.2020.05.027_bib15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.kint.2019.01.038","article-title":"Value of renal gene panel diagnostics in adults waiting for kidney transplantation due to undetermined end-stage renal disease","volume":"96","author":"Ottlewski","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.05.027_bib16","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1242\/jcs.115.9.1825","article-title":"CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation","volume":"115","author":"Ou","year":"2002","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2020.05.027_bib17","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.devcel.2016.10.006","article-title":"Spatial control of primary ciliogenesis by subdistal appendages alters sensation-associated properties of cilia","volume":"39","author":"Mazo","year":"2016","journal-title":"Dev Cell"},{"key":"10.1016\/j.kint.2020.05.027_bib18","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1038\/ncomms5207","article-title":"Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal appendages on the mother centriole during cilia biogenesis","volume":"5","author":"Veleri","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2020.05.027_bib19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.15252\/embr.201540632","article-title":"New frontiers: discovering cilia-independent functions of cilia proteins","volume":"16","author":"Vertii","year":"2015","journal-title":"EMBO Rep"},{"key":"10.1016\/j.kint.2020.05.027_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/hmg\/ddz281","article-title":"The association of microcephaly protein WDR62 with CPAP\/IFT88 is required for cilia formation and neocortical development","volume":"29","author":"Shohayeb","year":"2020","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2020.05.027_bib21","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.neuron.2016.09.056","article-title":"Microcephaly proteins Wdr62 and Aspm define a mother centriole complex regulating centriole biogenesis, apical complex, and cell fate","volume":"92","author":"Jayaraman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.kint.2020.05.027_bib22","first-page":"527","article-title":"Opposing roles for JNK and Aurora A in regulating the association of WDR62 with spindle microtubules","volume":"128","author":"Lim","year":"2015","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2020.05.027_bib23","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/ng.662","article-title":"Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy","volume":"42","author":"Otto","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.05.027_bib24","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1038\/s41467-017-01479-3","article-title":"IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning","volume":"8","author":"Taulet","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2020.05.027_bib25","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1242\/jcs.085407","article-title":"Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein","volume":"124","author":"Kaplan","year":"2011","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2020.05.027_bib26","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1007\/s00018-017-2570-5","article-title":"Routes and machinery of primary cilium biogenesis","volume":"74","author":"Bernab\u00e9-Rubio","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.kint.2020.05.027_bib27","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/ng.3871","article-title":"Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease","volume":"49","author":"Lu","year":"2017","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.05.027_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1083\/jcb.200502088","article-title":"Stress granules and processing bodies are dynamically linked sites of mRNP remodeling","volume":"169","author":"Kedersha","year":"2005","journal-title":"J\u00a0Cell Biol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820306323?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820306323?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:27:35Z","timestamp":1778664455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253820306323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["S0085253820306323"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2020.05.027","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel nephronophthisis-associated variants reveal functional importance of MAPKBP1 dimerization for centriolar recruitment","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2020.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}