{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:02:18Z","timestamp":1793847738414,"version":"4.6.1"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK099532"],"award-info":[{"award-number":["RO1DK099532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK40703"],"award-info":[{"award-number":["RO1DK40703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO1DK51050"],"award-info":[{"award-number":["RO1DK51050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["PR161045"],"award-info":[{"award-number":["PR161045"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001353","name":"National Kidney Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001353","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.kint.2020.05.049","type":"journal-article","created":{"date-parts":[[2020,6,28]],"date-time":"2020-06-28T13:04:27Z","timestamp":1593349467000},"page":"1225-1241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease"],"prefix":"10.1016","volume":"98","author":[{"given":"Lina","family":"Shao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"El-Jouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanwu","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janani","family":"Ramesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhe Shantha","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Devendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Dorschel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Barrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azadeh","family":"Tabari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Haque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyas","family":"Yambayev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amresh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas Ranjan","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"McDonough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Furuichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Xifaras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3115-5000","authenticated-orcid":false,"given":"Tzongshi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami Mohammad","family":"Alhayaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Miyabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amrendra K.","family":"Ajay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2020.05.049_bib1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/snep.2001.20929","article-title":"The genetics and physiology of polycystic kidney disease","volume":"21","author":"Calvet","year":"2001","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib2","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1097\/01.ASN.0000141055.57643.E0","article-title":"Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease","volume":"15","author":"Pazour","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib3","doi-asserted-by":"crossref","first-page":"a028191","DOI":"10.1101\/cshperspect.a028191","article-title":"Ciliopathies","volume":"9","author":"Braun","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib4","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","article-title":"Bending the MDCK cell primary cilium increases intracellular calcium","volume":"184","author":"Praetorius","year":"2001","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/bies.20069","article-title":"Polycystins and mechanosensation in renal and nodal cilia","volume":"26","author":"Nauli","year":"2004","journal-title":"Bioessays"},{"key":"10.1016\/j.kint.2020.05.049_bib6","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.05.049_bib7","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/CIRCULATIONAHA.107.710111","article-title":"Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1","volume":"117","author":"Nauli","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2020.05.049_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature12833","article-title":"Primary cilia are specialized calcium signalling organelles","volume":"504","author":"Delling","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.kint.2020.05.049_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nature17426","article-title":"Primary cilia are not calcium-responsive mechanosensors","volume":"531","author":"Delling","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.kint.2020.05.049_bib10","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.cell.2016.09.048","article-title":"The structure of the polycystic kidney disease channel PKD2 in lipid nanodiscs","volume":"167","author":"Shen","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.05.049_bib11","doi-asserted-by":"crossref","first-page":"e48336","DOI":"10.15252\/embr.201948336","article-title":"The ion channel function of polycystin-1 in the polycystin-1\/polycystin-2 complex","volume":"20","author":"Wang","year":"2019","journal-title":"EMBO Rep"},{"key":"10.1016\/j.kint.2020.05.049_bib12","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1083\/jcb.141.4.993","article-title":"Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons","volume":"141","author":"Cole","year":"1998","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"Pazour","year":"2000","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib14","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.cub.2007.08.034","article-title":"Disruption of intraflagellar transport in adult mice leads to obesity and slow-onset cystic kidney disease","volume":"17","author":"Davenport","year":"2007","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.050054","article-title":"Cilia in vertebrate development and disease","volume":"139","author":"Oh","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.kint.2020.05.049_bib16","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ng.2715","article-title":"Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease","volume":"45","author":"Ma","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.05.049_bib17","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nature04117","article-title":"Vertebrate smoothened functions at the primary cilium","volume":"437","author":"Corbit","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.kint.2020.05.049_bib18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/ncb1670","article-title":"Kif3a constrains beta-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms","volume":"10","author":"Corbit","year":"2008","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib19","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1016\/j.cub.2005.09.012","article-title":"PDGFR\u03b1\u03b1 signaling is regulated through the primary cilium in fibroblasts","volume":"15","author":"Schneider","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib20","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ncb2259","article-title":"Subcellular spatial regulation of canonical Wnt signalling at the primary cilium","volume":"13","author":"Lancaster","year":"2011","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1126\/science.1139740","article-title":"Patched1 regulates Hedgehog signaling at the primary cilium","volume":"317","author":"Rohatgi","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.kint.2020.05.049_bib22","doi-asserted-by":"crossref","first-page":"8143","DOI":"10.1074\/jbc.274.12.8143","article-title":"Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3","volume":"274","author":"Dai","year":"1999","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.05.049_bib23","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.cell.2011.05.030","article-title":"A\u00a0role for the primary cilium in Notch signaling and epidermal differentiation during skin development","volume":"145","author":"Ezratty","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.05.049_bib24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cub.2009.11.072","article-title":"Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation","volume":"20","author":"Besschetnova","year":"2010","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib25","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2353\/ajpath.2010.090658","article-title":"Hepato-renal pathology in Pkd2ws25\/\u2212 mice, an animal model of autosomal dominant polycystic kidney disease","volume":"176","author":"Stroope","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2020.05.049_bib26","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33183","article-title":"Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium","volume":"7","author":"Liu","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.kint.2020.05.049_bib27","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1091\/mbc.e10-12-0994","article-title":"Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins","volume":"22","author":"Larkins","year":"2011","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.kint.2020.05.049_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/1eee5a30-6970-4b13-8369-a3158b79a426","article-title":"Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells","volume":"8","author":"Boehlke","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.05.049_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140378","article-title":"A\u00a0cilia independent role of Ift88\/Polaris during cell migration","volume":"10","author":"Boehlke","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.05.049_bib30","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/0092-8674(79)90219-8","article-title":"Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40","volume":"18","author":"Tucker","year":"1979","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.05.049_bib31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-679X(08)94007-3","article-title":"Primary cilia and the cell cycle","volume":"94","author":"Plotnikova","year":"2009","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib32","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ncb1326","article-title":"Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2","volume":"7","author":"Li","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","article-title":"PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2","volume":"109","author":"Bhunia","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.05.049_bib34","doi-asserted-by":"crossref","first-page":"10786","DOI":"10.1038\/ncomms10786","article-title":"mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex","volume":"7","author":"Pema","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2020.05.049_bib35","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1073\/pnas.1011498108","article-title":"Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis","volume":"108","author":"Takiar","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2020.05.049_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95874","article-title":"Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD","volume":"3","author":"Li","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2020.05.049_bib37","doi-asserted-by":"crossref","first-page":"7161","DOI":"10.1038\/s41598-017-07300-x","article-title":"Metformin inhibits cyst formation in a zebrafish model of polycystin-2 deficiency","volume":"7","author":"Chang","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2020.05.049_bib38","first-page":"1591","article-title":"Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin","volume":"466","author":"Mekahli","year":"2014","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2020.05.049_bib39","doi-asserted-by":"crossref","first-page":"55984","DOI":"10.18632\/oncotarget.18995","article-title":"Hyperosmotic stress stimulates autophagy via polycystin-2","volume":"8","author":"Pe\u00f1a-Oyarzun","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.kint.2020.05.049_bib40","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1128\/MCB.25.20.9063-9072.2005","article-title":"Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination","volume":"25","author":"Hino","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib41","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1074\/jbc.M508778200","article-title":"Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase","volume":"281","author":"Taurin","year":"2006","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.05.049_bib42","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","article-title":"Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling","volume":"17","author":"Lal","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2020.05.049_bib43","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1681\/ASN.2009030271","article-title":"Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin","volume":"20","author":"Kim","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib44","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1681\/ASN.2011030277","article-title":"c-Met and NF-\u03baB-dependent overexpression of Wnt7a and -7b and Pax2 promotes cystogenesis in polycystic kidney disease","volume":"23","author":"Qin","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib45","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/ki.2011.56","article-title":"T-cell factor\/\u03b2-catenin activity is suppressed in two different models of autosomal dominant polycystic kidney disease","volume":"80","author":"Miller","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.05.049_bib46","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","article-title":"Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks","volume":"18","author":"Song","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2020.05.049_bib47","doi-asserted-by":"crossref","first-page":"20883","DOI":"10.1074\/jbc.M117.809517","article-title":"The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts","volume":"292","author":"Shi","year":"2017","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2020.05.049_bib48","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/ncb3363","article-title":"The polycystin complex mediates Wnt\/Ca(2+) signalling","volume":"18","author":"Kim","year":"2016","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2020.05.049_bib49","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1681\/ASN.2010010127","article-title":"Aberrant regulation of planar cell polarity in polycystic kidney disease","volume":"21","author":"Luyten","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib50","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1681\/ASN.2006020136","article-title":"Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease","volume":"17","author":"Smith","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib51","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1681\/ASN.2008101105","article-title":"Renal primary cilia lengthen after acute tubular necrosis","volume":"20","author":"Verghese","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.05.049_bib52","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1186\/s13104-019-4738-6","article-title":"Renal epithelial cells retain primary cilia during human acute renal allograft rejection injury","volume":"12","author":"Verghese","year":"2019","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.kint.2020.05.049_bib53","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1002\/dvdy.21515","article-title":"The Oak Ridge Polycystic Kidney mouse: modeling ciliopathies of mice and men","volume":"237","author":"Lehman","year":"2008","journal-title":"Dev Dyn"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820307018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820307018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:59:25Z","timestamp":1758761965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253820307018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["S0085253820307018"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2020.05.049","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.738222017.793576667","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic reduction of cilium length by targeting intraflagellar transport 88 protein impedes kidney and liver cyst formation in mouse models of autosomal polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2020.05.049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}