{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:56:34Z","timestamp":1779191794349,"version":"3.51.4"},"reference-count":68,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005326","name":"Yale University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013060","name":"European Molecular Biology Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007812","name":"University of Washington","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation United States of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001117","name":"amfAR, The Foundation for AIDS Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001117","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013114","name":"Broad Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014989","name":"Chan Zuckerberg Initiative","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014989","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006733","name":"Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK020572"],"award-info":[{"award-number":["DK020572"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK069062"],"award-info":[{"award-number":["DK069062"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK092926"],"award-info":[{"award-number":["DK092926"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK083912"],"award-info":[{"award-number":["DK083912"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30 DK081943"],"award-info":[{"award-number":["P30 DK081943"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114923"],"award-info":[{"award-number":["UH3DK114923"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114908"],"award-info":[{"award-number":["UH3DK114908"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114861"],"award-info":[{"award-number":["UH3DK114861"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114915"],"award-info":[{"award-number":["UH3DK114915"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114870"],"award-info":[{"award-number":["UH3DK114870"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114933"],"award-info":[{"award-number":["UH3DK114933"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114920"],"award-info":[{"award-number":["UH3DK114920"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114937"],"award-info":[{"award-number":["UH3DK114937"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114926"],"award-info":[{"award-number":["UH3DK114926"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114866"],"award-info":[{"award-number":["UH3DK114866"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK082841"],"award-info":[{"award-number":["DK082841"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U2C DK114886"],"award-info":[{"award-number":["U2C DK114886"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["UH3DK114907"],"award-info":[{"award-number":["UH3DK114907"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.kint.2020.09.015","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T07:47:55Z","timestamp":1602143275000},"page":"1502-1518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["SARS-CoV-2 receptor networks in diabetic and COVID-19\u2013associated kidney disease"],"prefix":"10.1016","volume":"98","author":[{"given":"Rajasree","family":"Menon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar A.","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Sealfon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viji","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron K.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra L.","family":"Theesfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avinash S.","family":"Boppana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingbao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Kasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer A.","family":"Schaub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine C.","family":"Berthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Eddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chrysta C.","family":"Lienczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Dagenais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryann","family":"Sohaney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian","family":"Fermin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalita","family":"Subramanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen C.","family":"Looker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Harder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura H.","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B.","family":"Hodgin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan Z.","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane E.","family":"Wobus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1602-9425","authenticated-orcid":false,"given":"Abhijit S.","family":"Naik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga G.","family":"Troyanskaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4064-0582","authenticated-orcid":false,"given":"Matthias","family":"Kretzler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2020.09.015_bib1","doi-asserted-by":"crossref","first-page":"m1996","DOI":"10.1136\/bmj.m1996","article-title":"Characterization and clinical course of 1000 patients with coronavirus disease 2019 in New York: retrospective case series","volume":"369","author":"Argenziano","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.kint.2020.09.015_bib2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S2213-8587(20)30238-2","article-title":"COVID-19 in people with diabetes: understanding the reasons for worse outcomes","volume":"8","author":"Apicella","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.kint.2020.09.015_bib3","doi-asserted-by":"crossref","first-page":"E736","DOI":"10.1152\/ajpendo.00124.2020","article-title":"COVID-19 pandemic, corona viruses, and diabetes mellitus","volume":"318","author":"Muniyappa","year":"2020","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.kint.2020.09.015_bib4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/jgs.16472","article-title":"COVID-19 and older adults: what we know","volume":"68","author":"Shahid","year":"2020","journal-title":"J\u00a0Am Geriatr Soc"},{"key":"10.1016\/j.kint.2020.09.015_bib5","article-title":"Prevalence of underlying diseases in hospitalized patients with COVID-19: a systematic review and meta-analysis","volume":"8","author":"Emami","year":"2020","journal-title":"Arch Acad Emerg Med"},{"key":"10.1016\/j.kint.2020.09.015_bib6","doi-asserted-by":"crossref","first-page":"108132","DOI":"10.1016\/j.diabres.2020.108132","article-title":"COVID-19, diabetes mellitus and ACE2: the conundrum","volume":"162","author":"Pal","year":"2020","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.kint.2020.09.015_bib7","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1681\/ASN.2006050423","article-title":"Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes","volume":"17","author":"Ye","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.09.015_bib8","doi-asserted-by":"crossref","first-page":"bnaa011","DOI":"10.1210\/endrev\/bnaa011","article-title":"Coronavirus infections and type 2 diabetes\u2014shared pathways with therapeutic implications","volume":"41","author":"Drucker","year":"2020","journal-title":"Endocr Rev"},{"key":"10.1016\/j.kint.2020.09.015_bib9","article-title":"Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells","author":"Muus","year":"2020","journal-title":"bioRxiv"},{"issue":"10251","key":"10.1016\/j.kint.2020.09.015_bib10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0140-6736(20)31759-1","article-title":"SARS-CoV-2 renal tropism associates with acute kidney injury","volume":"396","author":"Braun","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2020.09.015_bib11","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/path.1560","article-title":"Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways","volume":"203","author":"Ding","year":"2004","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.kint.2020.09.015_bib12","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMc2011400","article-title":"Multiorgan and renal tropism of SARS-CoV-2","author":"Puelles","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2020.09.015_bib13","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11255-020-02451-9","article-title":"Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection","volume":"52","author":"Henry","year":"2020","journal-title":"Int Urol Nephrol"},{"issue":"2018","key":"10.1016\/j.kint.2020.09.015_bib14","first-page":"20023242","article-title":"Kidney impairment is associated with in-hospital death of COVID-19 patients","volume":"2002","author":"Cheng","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib15","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1681\/ASN.2020040432","article-title":"Ultrastructural evidence for direct renal infection with SARS-CoV-2","volume":"31","author":"Farkash","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.09.015_bib16","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","article-title":"Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2","volume":"126","author":"Gheblawi","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2020.09.015_bib17","doi-asserted-by":"crossref","first-page":"14614","DOI":"10.1128\/JVI.79.23.14614-14621.2005","article-title":"ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia","volume":"79","author":"Jia","year":"2005","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.kint.2020.09.015_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pharmthera.2010.06.003","article-title":"Trilogy of ACE2: a peptidase in the renin\u2013angiotensin system, a SARS receptor, and a partner for amino acid transporters","volume":"128","author":"Kuba","year":"2010","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.kint.2020.09.015_bib19","volume":"9","author":"Guo","year":"2020","journal-title":"J\u00a0Am Heart Assoc"},{"key":"10.1016\/j.kint.2020.09.015_bib20","article-title":"Systemic analysis of tissue cells potentially vulnerable to SARS-CoV-2 infection by the protein-proofed single-cell RNA profiling of ACE2, TMPRSS2 and Furin proteases","author":"Zhou","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib21","article-title":"Relevance of enriched expression of SARS-CoV-2 binding receptor ACE2 in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients","author":"Kumar","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3390\/jpm10040146","article-title":"Impact of comorbidities on the expression of SARS-CoV-2 viral entry-related genes","volume":"10","author":"Breidenbach","year":"2020","journal-title":"J Pers Med."},{"key":"10.1016\/j.kint.2020.09.015_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.2162","article-title":"The emerging role of ACE2 in physiology and disease","volume":"212","author":"Hamming","year":"2007","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.kint.2020.09.015_bib24","article-title":"Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection","author":"Diao","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib25","doi-asserted-by":"crossref","first-page":"H1084","DOI":"10.1152\/ajpheart.00217.2020","article-title":"COVID-19, ACE2, and the cardiovascular consequences","volume":"318","author":"South","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.kint.2020.09.015_bib26","doi-asserted-by":"crossref","first-page":"11727","DOI":"10.1073\/pnas.2003138117","article-title":"Cell entry mechanisms of SARS-CoV-2","volume":"117","author":"Shang","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2020.09.015_bib27","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2020.04.035","article-title":"SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues","volume":"181","author":"Ziegler","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.09.015_bib28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.09.015_bib29","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.02232-10","article-title":"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response","volume":"85","author":"Glowacka","year":"2011","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.kint.2020.09.015_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbrc.2020.03.044","article-title":"Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses","volume":"526","author":"Qi","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2020.09.015_bib31","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1159\/000507305","article-title":"Should COVID-19 concern nephrologists? Why and to what extent? The emerging impasse of angiotensin blockade","volume":"144","author":"Perico","year":"2020","journal-title":"Nephron"},{"key":"10.1016\/j.kint.2020.09.015_bib32","article-title":"Regulation of angiotensin converting enzyme 2 (ACE2) in obesity: implications for COVID-19","author":"Al Heialy","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1084\/jem.167.1.213","article-title":"Characterization of a 280-kD protein restricted to the coated pits of the renal brush border and the epithelial cells of the yolk sac. Teratogenic effect of the specific monoclonal antibodies","volume":"167","author":"Sahali","year":"1988","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.kint.2020.09.015_bib34","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ng.3259","article-title":"Understanding multicellular function and disease with human tissue-specific networks","volume":"47","author":"Greene","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2020.09.015_bib35","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.1093\/nar\/gky408","article-title":"GIANT 2.0: genome-scale integrated analysis of gene networks in tissues","volume":"46","author":"Wong","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2020.09.015_bib36","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3390\/cells9041003","article-title":"Sofosbuvir activates EGFR-dependent pathways in hepatoma cells with implications for liver-related pathological processes","volume":"9","author":"Bojkova","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.kint.2020.09.015_bib37","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1172\/JCI7286","article-title":"Epstein-Barr virus infection of renal proximal tubule cells: possible role in chronic interstitial nephritis","volume":"104","author":"Becker","year":"1999","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2020.09.015_bib38","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1399-0012.2012.01636.x","article-title":"Immunohistochemical features of BK virus nephropathy in renal transplant recipients","volume":"26","author":"Yamanaka","year":"2012","journal-title":"Clin Transplant"},{"key":"10.1016\/j.kint.2020.09.015_bib39","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/s41586-020-2286-9","article-title":"A\u00a0SARS-CoV-2 protein interaction map reveals targets for drug repurposing","volume":"583","author":"Gordon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.kint.2020.09.015_bib40","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.09.015_bib41","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2020.04.003","article-title":"Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China","volume":"98","author":"Su","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.09.015_bib42","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.HYP.0000060689.38912.CB","article-title":"Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy","volume":"41","author":"Tikellis","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2020.09.015_bib43","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ki.2012.83","article-title":"Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice","volume":"82","author":"Nadarajah","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.09.015_bib44","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1161\/01.HYP.0000126192.27644.76","article-title":"Increased ACE 2 and decreased ace protein in renal tubules from diabetic mice","volume":"43","author":"Ye","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2020.09.015_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/2a7b69d2-a049-448e-b584-51e4c1e8a50d","article-title":"Effect of insulin on ACE2 activity and kidney function in the non-obese diabetic mouse","volume":"9","author":"Riera","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2020.09.015_bib46","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.mce.2008.09.020","article-title":"The sweeter side of ACE2: Physiological evidence for a role in diabetes","volume":"302","author":"Bindom","year":"2009","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.kint.2020.09.015_bib47","doi-asserted-by":"crossref","first-page":"F1","DOI":"10.1152\/ajprenal.00531.2013","article-title":"Renin-angiotensin system within the diabetic podocyte","volume":"308","author":"M\u00e1rquez","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2020.09.015_bib48","article-title":"SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography","author":"Klein","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib49","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.cell.2020.04.004","article-title":"Inhibition of SARS-CoV-2 infections in engineered human tissues using clinical-grade soluble human ACE2","volume":"181","author":"Monteil","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.kint.2020.09.015_bib50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.kint.2017.08.013","article-title":"A\u00a0molecular morphometric approach to diabetic kidney disease can link structure to function and outcome","volume":"93","author":"Nair","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.09.015_bib51","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.2337\/db06-0477","article-title":"Modular activation of nuclear factor-\u03baB transcriptional programs in human diabetic nephropathy","volume":"55","author":"Schmid","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2020.09.015_bib52","article-title":"SARS-CoV-2 activates lung epithelia cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients by single-cell sequencing","author":"Chen","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib53","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2020.09.015_bib54","article-title":"The effect of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on death and severity of disease in patients with coronavirus disease 2019 (COVID-19): a meta-analysis","author":"Ghosal","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.kint.2020.09.015_bib55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ehjcvp\/pvaa021","article-title":"Speculation is not evidence: antihypertensive therapy and COVID-19","volume":"6","author":"de Simone","year":"2020","journal-title":"Eur Heart J Cardiovasc Pharmacother"},{"issue":"25","key":"10.1016\/j.kint.2020.09.015_bib56","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMoa2007621","article-title":"Cardiovascular disease, drug therapy, and mortality in Covid-19","volume":"382","author":"Mehra","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2020.09.015_bib57","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1056\/NEJMoa2006923","article-title":"Renin-angiotensin-aldosterone system blockers and the risk of Covid-19","volume":"382","author":"Mancia","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2020.09.015_bib58","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa2008975","article-title":"Renin-angiotensin-aldosterone system inhibitors and risk of Covid-19","volume":"382","author":"Reynolds","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2020.09.015_bib59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5527\/wjn.v4.i1.74","article-title":"ACE and ACE2 in kidney disease","volume":"4","author":"Mizuiri","year":"2015","journal-title":"World J Nephrol"},{"key":"10.1016\/j.kint.2020.09.015_bib60","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.2337\/dc20-0643","article-title":"Exploring diseases\/traits and blood proteins causally related to expression of ACE2, the putative receptor of SARS-CoV-2: a Mendelian randomization analysis highlights tentative relevance of diabetes-related traits","volume":"43","author":"Rao","year":"2020","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2020.09.015_bib61","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/ki.2008.497","article-title":"Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease","volume":"74","author":"Reich","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2020.09.015_bib62","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2020.09.015_bib63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s11684-020-0754-0","article-title":"Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection","volume":"14","author":"Zou","year":"2020","journal-title":"Front Med"},{"issue":"6220","key":"10.1016\/j.kint.2020.09.015_bib64","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.kint.2020.09.015_bib65","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.133267","article-title":"Single cell transcriptomics identifies focal segmental glomerulosclerosis remission endothelial biomarker","volume":"5","author":"Menon","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2020.09.015_bib66","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/s41590-019-0398-x","article-title":"The immune cell landscape in kidneys of patients with lupus nephritis","volume":"20","author":"Arazi","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.kint.2020.09.015_bib67","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1681\/ASN.2018020125","article-title":"Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response","volume":"29","author":"Wu","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2020.09.015_bib68","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/nn.4353","article-title":"Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder","volume":"19","author":"Krishnan","year":"2016","journal-title":"Nat Neurosci"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820311133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253820311133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:54:51Z","timestamp":1777474491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253820311133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0085253820311133"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2020.09.015","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.09.20096511","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SARS-CoV-2 receptor networks in diabetic and COVID-19\u2013associated kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2020.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}