{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:51:02Z","timestamp":1792651862393,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["387509280"],"award-info":[{"award-number":["387509280"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1350"],"award-info":[{"award-number":["SFB 1350"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.kint.2021.02.035","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T07:41:01Z","timestamp":1615275661000},"page":"122-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Inhibition of transforming growth factor \u03b21 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice"],"prefix":"10.1016","volume":"100","author":[{"given":"Michaela A.A.","family":"Fuchs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina A.E.","family":"Broeker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schrankl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolai","family":"Burzlaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Willam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Kurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2021.02.035_bib1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MNH.0b013e328344c3d4","article-title":"Mechanisms of fibrosis: the role of the pericyte","volume":"20","author":"Schrimpf","year":"2011","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2021.02.035_bib2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/ki.2015.51","article-title":"Renal fibrosis is not reduced by blocking transforming growth factor-\u03b2 signaling in matrix-producing interstitial cells","volume":"88","author":"Neelisetty","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1369\/0022155419849388","article-title":"Extracellular matrix in kidney fibrosis: more than just a scaffold","volume":"67","author":"B\u00fclow","year":"2019","journal-title":"J\u00a0Histochem Cytochem"},{"key":"10.1016\/j.kint.2021.02.035_bib4","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev-physiol-022516-034227","article-title":"Mechanisms of renal fibrosis","volume":"80","author":"Humphreys","year":"2018","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.kint.2021.02.035_bib5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/ki.1997.387","article-title":"The interstitial response to renal injury: fibroblast\u2013like cells show phenotypic changes and have reduced potential for erythropoietin gene expression","volume":"52","author":"Maxwell","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib6","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1681\/ASN.2013010030","article-title":"Plasticity of renal erythropoietin-producing cells governs fibrosis","volume":"24","author":"Souma","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib7","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2011111078","article-title":"Mechanisms of anemia in CKD","volume":"23","author":"Babitt","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ki.1985.109","article-title":"Anemia of end-stage renal disease (ESRD)","volume":"28","author":"Eschbach","year":"1985","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.kint.2020.04.040","article-title":"Different subpopulations of kidney interstitial cells produce erythropoietin and factors supporting tissue oxygenation in response to hypoxia in\u00a0vivo","volume":"98","author":"Broeker","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib10","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","article-title":"Diverse origins of the myofibroblast\u2014implications for kidney fibrosis","volume":"11","author":"Falke","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib11","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.7150\/thno.35686","article-title":"Conditional knockout of TGF-\u03b2RII \/Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation","volume":"9","author":"Yang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.kint.2021.02.035_bib12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/path.3976","article-title":"Diverse roles of TGF-\u03b2 receptor II in renal fibrosis and inflammation in\u00a0vivo and in\u00a0vitro","volume":"227","author":"Meng","year":"2012","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.kint.2021.02.035_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00082","article-title":"TGF-\u03b2\/Smad signaling in renal fibrosis","volume":"6","author":"Meng","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.kint.2021.02.035_bib14","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1681\/ASN.2016121351","article-title":"Blocking TGF-\u03b2 and \u03b2-catenin epithelial crosstalk exacerbates CKD","volume":"28","author":"Nlandu-Khodo","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1042\/CS20180438","article-title":"Transforming growth factor \u03b2 (TGF\u03b2) and related molecules in chronic kidney disease (CKD)","volume":"133","author":"Huynh","year":"2019","journal-title":"Clin Sci"},{"key":"10.1016\/j.kint.2021.02.035_bib16","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/ki.2011.255","article-title":"Canonical Wnt\/\u03b2-catenin signaling mediates transforming growth factor-\u03b21\u2013driven podocyte injury and proteinuria","volume":"80","author":"Wang","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3390\/biom10030487","article-title":"TGF-\u03b2 Signaling","volume":"10","author":"Tzavlaki","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.kint.2021.02.035_bib18","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","article-title":"Diverse roles of TGF-\u03b2\/Smads in renal fibrosis and inflammation","volume":"7","author":"Lan","year":"2011","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.kint.2021.02.035_bib19","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000057363","article-title":"Localization of TGF-\u03b2 and its receptors in the kidney","volume":"24","author":"Ando","year":"1998","journal-title":"Miner Electrolyte Metab"},{"key":"10.1016\/j.kint.2021.02.035_bib20","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1093\/ndt\/12.4.669","article-title":"TGF-beta and glomerulonephritis: anti-inflammatory versus prosclerotic actions","volume":"12","author":"Kitamura","year":"1997","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2021.02.035_bib21","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/ki.2013.372","article-title":"Transforming growth factor-\u03b21\u2013mediated renal fibrosis is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b","volume":"85","author":"Wang","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1097\/BOR.0b013e32830e48e8","article-title":"Anti-transforming growth factor-beta therapy in fibrosis: recent progress and implications for systemic sclerosis","volume":"20","author":"Varga","year":"2008","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.kint.2021.02.035_bib23","doi-asserted-by":"crossref","first-page":"522","DOI":"10.2337\/diab.45.4.522","article-title":"Neutralization of TGF-\u03b2 by anti-TGF-\u03b2 antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice","volume":"45","author":"Sharma","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2021.02.035_bib24","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1046\/j.1523-1755.2000.00414.x","article-title":"Antibody to transforming growth factor-\u03b2 ameliorates tubular apoptosis in unilateral ureteral obstruction","volume":"58","author":"Miyajima","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib25","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1681\/ASN.2010020147","article-title":"TGF-\u03b2 receptor deletion in the renal collecting system exacerbates fibrosis","volume":"21","author":"Gewin","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nrneph.2009.74","article-title":"Fibroblast activation and myofibroblast generation in obstructive nephropathy","volume":"5","author":"Grande","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2014.00123","article-title":"Fibroblasts in fibrosis: novel roles and mediators","volume":"5","author":"Kendall","year":"2014","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.kint.2021.02.035_bib28","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2353\/ajpath.2008.080433","article-title":"Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney","volume":"173","author":"Lin","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2021.02.035_bib29","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1681\/ASN.2018020138","article-title":"Cellular origin and functional relevance of collagen I production in the kidney","volume":"29","author":"Buchtler","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/kisup.2014.6","article-title":"The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury","volume":"4","author":"Gomez","year":"2014","journal-title":"Kidney Int Suppl (2011)"},{"key":"10.1016\/j.kint.2021.02.035_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2353\/ajpath.2010.090517","article-title":"Fate tracing reveals the pericyte and not epithelial origin of myofibroblasts in kidney fibrosis","volume":"176","author":"Humphreys","year":"2010","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2021.02.035_bib32","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1681\/ASN.2019080827","article-title":"Cellular and molecular mechanisms of kidney injury in 2,8-dihydroxyadenine nephropathy","volume":"31","author":"Klinkhammer","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib34","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1681\/ASN.2014121184","article-title":"Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling","volume":"27","author":"Souma","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib35","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41586-020-2941-1","article-title":"Decoding myofibroblast origins in human kidney fibrosis","volume":"589","author":"Kuppe","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.kint.2021.02.035_bib36","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s00424-016-1829-2","article-title":"Erythropoietin production by PDGFR-\u03b2+ cells","volume":"468","author":"Gerl","year":"2016","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2021.02.035_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025839","article-title":"Isolation and characterization of renal erythropoietin-producing cells from genetically produced anemia mice","volume":"6","author":"Pan","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2021.02.035_bib38","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ki.1997.52","article-title":"Sites of erythropoietin production","volume":"51","author":"Maxwell","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib39","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/ki.1993.362","article-title":"Identification of the renal erythropoietin-producing cells using transgenic mice","volume":"44","author":"Maxwell","year":"1993","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib40","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3390\/ijms21030725","article-title":"The influence of inflammation on anemia in CKD patients","volume":"21","author":"Gluba-Brz\u00f3zka","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2021.02.035_bib41","doi-asserted-by":"crossref","first-page":"3981","DOI":"10.1172\/JCI57301","article-title":"Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice","volume":"121","author":"Asada","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2021.02.035_bib42","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1038\/ki.2009.86","article-title":"Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy","volume":"75","author":"Chevalier","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib43","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jmoldx.2011.08.002","article-title":"RNAscope: a novel in situ RNA analysis platform for formalin-fixed, paraffin-embedded tissues","volume":"14","author":"Wang","year":"2012","journal-title":"J\u00a0Mol Diagn"},{"key":"10.1016\/j.kint.2021.02.035_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192531","article-title":"A\u00a0novel approach to adenine-induced chronic kidney disease associated anemia in rodents","volume":"13","author":"Rahman","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2021.02.035_bib45","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3390\/cells8070721","article-title":"Primary human fibroblasts in culture switch to a myofibroblast-like phenotype independently of TGF beta","volume":"8","author":"Baranyi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.kint.2021.02.035_bib46","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/ki.2015.274","article-title":"Inducible glomerular erythropoietin production in the adult kidney","volume":"88","author":"Gerl","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib47","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1182\/blood.V100.2.560","article-title":"Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable","volume":"100","author":"Lev\u00e9en","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.kint.2021.02.035_bib48","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A\u00a0global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis."},{"key":"10.1016\/j.kint.2021.02.035_bib49","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/gene.10046","article-title":"Conditional inactivation of the TGF-\u03b2 type II receptor using Cre:Lox","volume":"32","author":"Chytil","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.kint.2021.02.035_bib50","author":"Boneva"},{"key":"10.1016\/j.kint.2021.02.035_bib51","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1471-2369-14-116","article-title":"A\u00a0novel model of adenine-induced tubulointerstitial nephropathy in mice","volume":"14","author":"Jia","year":"2013","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib52","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1681\/ASN.2017111179","article-title":"Glycine amidinotransferase (GATM), renal Fanconi syndrome, and kidney failure","volume":"29","author":"Reichold","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib53","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.ajpath.2012.07.010","article-title":"Selective stabilization of HIF-1\u03b1 in renal tubular cells by 2-oxoglutarate analogues","volume":"181","author":"Schley","year":"2012","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2021.02.035_bib54","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1093\/ndt\/gfr379","article-title":"The protective effect of prolyl-hydroxylase inhibition against renal ischaemia requires application prior to ischaemia but is superior to EPO treatment","volume":"27","author":"Wang","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2021.02.035_bib55","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.kint.2021.02.035_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1517\/13543784.2011.566861","article-title":"HIF prolyl hydroxylase inhibitors for anemia","volume":"20","author":"Muchnik","year":"2011","journal-title":"Expert Opin Investig Drugs"},{"key":"10.1016\/j.kint.2021.02.035_bib57","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ki.2009.460","article-title":"Hypoxia-inducible factor-2\u03b1\u2013expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization","volume":"77","author":"Paliege","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.035_bib58","doi-asserted-by":"crossref","first-page":"17892","DOI":"10.1073\/pnas.0906070106","article-title":"CD4+ T cells control the differentiation of Gr1+ monocytes into fibrocytes","volume":"106","author":"Niedermeier","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2021.02.035_bib59","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.3389\/fphys.2020.01093","article-title":"MicroRNA-140-5p mediates renal fibrosis through TGF-\u03b21\/Smad signaling pathway by directly targeting TGFBR1","volume":"11","author":"Liao","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.kint.2021.02.035_bib60","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1093\/embo-reports\/kve064","article-title":"A\u00a0highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent","volume":"2","author":"Vooijs","year":"2001","journal-title":"EMBO Rep"},{"key":"10.1016\/j.kint.2021.02.035_bib61","doi-asserted-by":"crossref","first-page":"776","DOI":"10.3390\/ijms18040776","article-title":"MMP-2 and 9 in chronic kidney disease","volume":"18","author":"Cheng","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2021.02.035_bib62","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1093\/emboj\/20.7.1663","article-title":"Abnormal angiogenesis but intact hematopoietic potential in TGF-\u03b2 type I receptor-deficient mice","volume":"20","author":"Larsson","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2021.02.035_bib63","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1681\/ASN.2015040422","article-title":"MicroRNA-196a\/b mitigate renal fibrosis\u00a0by targeting TGF-\u03b2 receptor 2","volume":"27","author":"Meng","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.035_bib64","first-page":"3810","article-title":"Hypoxia promotes fibrogenesis in\u00a0vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition","volume":"117","author":"Higgins","year":"2007","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2021.02.035_bib65","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.34067\/KID.0001302020","article-title":"Hypoxia-inducible factor and oxygen biology in the kidney","volume":"1","author":"Sugahara","year":"2020","journal-title":"Kidney360"},{"issue":"suppl 1","key":"10.1016\/j.kint.2021.02.035_bib66","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1186\/1755-1536-5-S1-S16","article-title":"Hypoxia-inducible factor signaling in the development of kidney fibrosis","volume":"5","author":"Haase","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1016\/j.kint.2021.02.035_bib67","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1182\/blood.V79.8.1987.1987","article-title":"Effect of inflammatory cytokines on hypoxia-induced erythropoietin production","volume":"79","author":"Faquin","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.kint.2021.02.035_bib68","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jmb.2003.12.023","article-title":"A\u00a0cross-talk between hypoxia and TGF-beta orchestrates erythropoietin gene regulation through SP1 and Smads","volume":"336","author":"S\u00e1nchez-Elsner","year":"2004","journal-title":"J\u00a0Mol Biol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821002787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821002787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:54:33Z","timestamp":1777474473000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253821002787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0085253821002787"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2021.02.035","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of transforming growth factor \u03b21 signaling in resident interstitial cells attenuates profibrotic gene expression and preserves erythropoietin production during experimental kidney fibrosis in mice","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2021.02.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}