{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T12:59:21Z","timestamp":1793710761494,"version":"4.6.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.kint.2021.02.038","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T11:15:01Z","timestamp":1616670901000},"page":"155-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Immunofluorescence staining for immunoglobulin heavy chain\/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases"],"prefix":"10.1016","volume":"100","author":[{"given":"Samih H.","family":"Nasr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Fidler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samar M.","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin W.","family":"Koepplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie M.","family":"Altamirano-Alonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2021.02.038_bib1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/ki.2014.408","article-title":"Diagnosis of monoclonal gammopathy of renal significance","volume":"87","author":"Bridoux","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41581-018-0077-4","article-title":"The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group","volume":"15","author":"Leung","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib3","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood-2012-07-445304","article-title":"Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant","volume":"120","author":"Leung","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.kint.2021.02.038_bib4","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1182\/blood-2013-05-495929","article-title":"How I treat monoclonal gammopathy of renal significance (MGRS)","volume":"122","author":"Fermand","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.kint.2021.02.038_bib5","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1373\/clinchem.2009.123828","article-title":"Assessment of monoclonal gammopathies by nephelometric measurement of individual immunoglobulin kappa\/lambda ratios","volume":"55","author":"Bradwell","year":"2009","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2021.02.038_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/leu.2012.159","article-title":"Prognostic utility of intact immunoglobulin Ig'\u03ba\/Ig'\u03bb ratios in multiple myeloma patients","volume":"27","author":"Bradwell","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.kint.2021.02.038_bib7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/leu.2012.197","article-title":"Immunoglobulin heavy\/light chain ratios improve paraprotein detection and monitoring, identify residual disease and correlate with survival in multiple myeloma patients","volume":"27","author":"Ludwig","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.kint.2021.02.038_bib8","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.ekir.2018.07.008","article-title":"Paraffin immunofluorescence: a valuable ancillary technique in renal pathology","volume":"3","author":"Nasr","year":"2018","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2021.02.038_bib9","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1681\/ASN.V1271482","article-title":"Renal monoclonal immunoglobulin deposition disease: the disease spectrum","volume":"12","author":"Lin","year":"2001","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib10","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1093\/ndt\/gfz176","article-title":"Proliferative glomerulonephritis with monoclonal immunoglobulin deposits: a nephrologist perspective","volume":"36","author":"Bridoux","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2021.02.038_bib11","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/PAS.0000000000000605","article-title":"IgG subclass staining in routine renal biopsy material","volume":"40","author":"Hemminger","year":"2016","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.kint.2021.02.038_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/s10157-016-1275-7","article-title":"Clinicopathological significance of monoclonal IgA deposition in patients with IgA nephropathy","volume":"21","author":"Nagae","year":"2017","journal-title":"Clin Exp Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.kint.2016.02.001","article-title":"The clinicopathologic characteristics and outcome of atypical anti-glomerular basement membrane nephritis","volume":"89","author":"Nasr","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib14","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.kint.2020.02.025","article-title":"DNAJB9-positive monotypic fibrillary glomerulonephritis is not associated with monoclonal gammopathy in the vast majority of patients","volume":"98","author":"Said","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib15","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.ekir.2017.07.008","article-title":"Membranous glomerulopathy with light chain-restricted deposits: a clinicopathological analysis of 28 cases","volume":"2","author":"Best Rocha","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2021.02.038_bib16","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ekir.2016.08.012","article-title":"Clinicopathologic features of membranous-like glomerulopathy with masked IgG kappa deposits","volume":"1","author":"Larsen","year":"2016","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2021.02.038_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1053\/j.ajkd.2015.08.016","article-title":"Amyloidosis associated with a truncated immunoglobulin heavy chain undetectable by immunostaining","volume":"66","author":"Manabe","year":"2015","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2021.02.038_bib18","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/ki.1996.116","article-title":"Increased binding of polymeric lambda-IgA to cultured human mesangial cells in IgA nephropathy","volume":"49","author":"Lai","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0272-6386(88)80022-2","article-title":"The immunohistology of IgA nephropathy","volume":"12","author":"Jennette","year":"1988","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2021.02.038_bib20","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.kint.2016.10.026","article-title":"The clinicopathologic characteristics of kidney diseases related to monotypic IgA deposits","volume":"91","author":"Vignon","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib21","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/art.1780390425","article-title":"IgA multiple myeloma presenting as Henoch-Schonlein purpura\/polyarteritis nodosa overlap syndrome","volume":"39","author":"Birchmore","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.kint.2021.02.038_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5414\/CN108339","article-title":"Recurrence of monoclonal IgA lambda glomerulonephritis in kidney allograft associated with multiple myeloma","volume":"84","author":"Herrmann","year":"2015","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib23","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1681\/ASN.2009010110","article-title":"Proliferative glomerulonephritis\u00a0with monoclonal IgG deposits","volume":"20","author":"Nasr","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0002-9343(74)90852-3","article-title":"Biologic and clinical significance of cryoglobulins: a report of 86 cases","volume":"57","author":"Brouet","year":"1974","journal-title":"Am J Med"},{"key":"10.1016\/j.kint.2021.02.038_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1373\/clinchem.2007.090134","article-title":"A\u00a0critical appraisal of current practice in the detection, analysis, and reporting of cryoglobulins","volume":"54","author":"Vermeersch","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2021.02.038_bib26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/01913123.2014.952803","article-title":"The many faces of cryoglobulinemic nephropathy: a clinico-pathologic study of 47 cases with emphasis on the value of electron microscopy","volume":"38","author":"Ojemakinde","year":"2014","journal-title":"Ultrastruct Pathol"},{"key":"10.1016\/j.kint.2021.02.038_bib27","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ki.1989.84","article-title":"Renal involvement in essential mixed cryoglobulinemia","volume":"35","author":"D\u2019Amico","year":"1989","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib28","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1182\/blood-2018-09-872028","article-title":"Randall-type monoclonal immunoglobulin deposition disease: novel insights from a nationwide cohort study","volume":"133","author":"Joly","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.kint.2021.02.038_bib29","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2215\/CJN.10491012","article-title":"Renal amyloidosis: origin and clinicopathologic correlations of 474 recent cases","volume":"8","author":"Said","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib30","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.kint.2019.05.027","article-title":"The sensitivity and specificity of the routine kidney biopsy immunofluorescence panel are inferior to diagnosing renal immunoglobulin-derived amyloidosis by mass spectrometry","volume":"96","author":"Gonzalez Suarez","year":"2019","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib31","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.humpath.2007.04.013","article-title":"Clinical and histological characteristics of renal AA amyloidosis: a retrospective study of 68 cases with a special interest to amyloid-associated inflammatory response","volume":"38","author":"Verine","year":"2007","journal-title":"Hum Pathol"},{"key":"10.1016\/j.kint.2021.02.038_bib32","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/modpathol.2015.1","article-title":"Paraffin immunofluorescence in the renal pathology laboratory: more than a salvage technique","volume":"28","author":"Messias","year":"2015","journal-title":"Mod Pathol"},{"key":"10.1016\/j.kint.2021.02.038_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.kint.2018.01.028","article-title":"Proliferative glomerulonephritis with monoclonal immunoglobulin G deposits is associated with high rate of early recurrence in the allograft","volume":"94","author":"Said","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.02.038_bib34","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00467-020-04763-5","article-title":"Progression of proliferative glomerulonephritis with monoclonal IgG deposits in pediatric patients","volume":"36","author":"Miller","year":"2021","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2021.02.038_bib35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1523-1755.2004.00365.x","article-title":"Proliferative glomerulonephritis with monoclonal IgG deposits: a distinct entity mimicking immune-complex glomerulonephritis","volume":"65","author":"Nasr","year":"2004","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821002969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821002969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T00:59:32Z","timestamp":1758761972000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253821002969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0085253821002969"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2021.02.038","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunofluorescence staining for immunoglobulin heavy chain\/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2021.02.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}