{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:47:35Z","timestamp":1784422055005,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.kint.2021.08.026","type":"journal-article","created":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T23:18:50Z","timestamp":1632352730000},"page":"106-118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effect of disease progression on the podocyte cell cycle in Alport Syndrome"],"prefix":"10.1016","volume":"101","author":[{"given":"Camille Nicolas","family":"Frank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astgik","family":"Petrosyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geremy","family":"Clair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger E.","family":"De Filippo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Cravedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin V.","family":"Lemley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Perin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2021.08.026_bib1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1523-1755.1998.00044.x","article-title":"Progression of glomerular diseases: is the podocyte the culprit?","volume":"54","author":"Kriz","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib2","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1046\/j.1523-1755.2002.00269.x","article-title":"Podocytopenia and disease severity in IgA nephropathy","volume":"61","author":"Lemley","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib3","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1681\/ASN.2005010055","article-title":"Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene","volume":"16","author":"Wharram","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib4","doi-asserted-by":"crossref","first-page":"F1385","DOI":"10.1152\/ajprenal.00099.2016","article-title":"Glomerular pathology and the progression of chronic kidney disease","volume":"310","author":"Lemley","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.08.026_bib5","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1681\/ASN.2014030278","article-title":"A potential role for mechanical forces in the detachment of podocytes and the progression of CKD","volume":"26","author":"Kriz","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1159\/000188546","article-title":"Mitosis and the presence of binucleate cells among glomerular podocytes in diseased human kidneys","volume":"70","author":"Nagata","year":"1995","journal-title":"Nephron"},{"key":"10.1016\/j.kint.2021.08.026_bib7","doi-asserted-by":"crossref","first-page":"F40","DOI":"10.1152\/ajprenal.00404.2002","article-title":"Urinary excretion of viable podocytes in health and renal disease","volume":"285","author":"Vogelmann","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.08.026_bib8","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1046\/j.1523-1755.2000.00213.x","article-title":"Differential expression of cyclin-dependent kinase inhibitors in human glomerular disease: role in podocyte proliferation and maturation","volume":"58","author":"Shankland","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib9","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1681\/ASN.2005050488","article-title":"Podocyte hypertrophy, \u201cadaptation,\u201d and \u201cdecompensation\u201d associated with glomerular enlargement and glomerulosclerosis in the aging rat: prevention by calorie restriction","volume":"16","author":"Wiggins","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1242\/dev.084111","article-title":"Visualization of cell cycle in mouse embryos with Fucci2 reporter directed by Rosa26 promoter","volume":"140","author":"Abe","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.kint.2021.08.026_bib11","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.4161\/15384101.2015.945381","article-title":"Fucci2a: a bicistronic cell cycle reporter that allows Cre mediated tissue specific expression in mice","volume":"13","author":"Mort","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/j.kint.2021.08.026_bib12","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.kint.2017.12.018","article-title":"Alport syndrome: a unified classification of genetic disorders of collagen IV \u03b1345: a position paper of the Alport Syndrome Classification Working Group","volume":"93","author":"Kashtan","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib13","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1681\/ASN.2011030243","article-title":"Injection of amniotic fluid stem cells delays progression of renal fibrosis","volume":"23","author":"Sedrakyan","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib14","doi-asserted-by":"crossref","first-page":"11414","DOI":"10.1038\/s41598-020-67588-0","article-title":"Glomerular endothelial cell heterogeneity in Alport syndrome","volume":"10","author":"Soloyan","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2021.08.026_bib15","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1097\/01.ASN.0000130562.90255.8F","article-title":"Mouse model of X-linked Alport syndrome","volume":"15","author":"Rheault","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081812","article-title":"A novel source of cultured podocytes","volume":"8","author":"Da Sacco","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2021.08.026_bib17","doi-asserted-by":"crossref","first-page":"F1573","DOI":"10.1152\/ajprenal.00423.2006","article-title":"Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin","volume":"292","author":"Takano","year":"2007","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.08.026_bib18","doi-asserted-by":"crossref","first-page":"210","DOI":"10.23876\/j.krcp.2018.37.3.210","article-title":"Puromycin aminonucleoside triggers apoptosis in podocytes by inducing endoplasmic reticulum stress","volume":"37","author":"Min","year":"2018","journal-title":"Kidney Res Clin Pract"},{"key":"10.1016\/j.kint.2021.08.026_bib19","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1007\/s00216-018-1493-9","article-title":"Benchtop-compatible sample processing workflow for proteome profiling of <100mammalian cells","volume":"411","author":"Xu","year":"2019","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.kint.2021.08.026_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.matbio.2016.08.005","article-title":"Collagen IV diseases: a focus on the glomerular basement membrane in Alport syndrome","volume":"57\u201358","author":"Cosgrove","year":"2017","journal-title":"Matrix Biol"},{"key":"10.1016\/j.kint.2021.08.026_bib21","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.ajpath.2013.06.015","article-title":"\u03b11\u03b21 integrin\/Rac1-dependent mesangial invasion of glomerular capillaries in Alport syndrome","volume":"183","author":"Zallocchi","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2021.08.026_bib22","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.matbio.2018.04.008","article-title":"Alport syndrome and Pierson syndrome: diseases of the glomerular basement membrane","volume":"71\u201372","author":"Funk","year":"2018","journal-title":"Matrix Biol"},{"key":"10.1016\/j.kint.2021.08.026_bib23","doi-asserted-by":"crossref","first-page":"E4446","DOI":"10.1073\/pnas.1314000110","article-title":"Cell-cycle regulation of formin-mediated actin cable assembly","volume":"110","author":"Miao","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2021.08.026_bib24","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/onc.2009.112","article-title":"c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry","volume":"28","author":"Morrish","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2021.08.026_bib25","doi-asserted-by":"crossref","first-page":"36267","DOI":"10.1074\/jbc.M110.141606","article-title":"Myc-dependent mitochondrial generation of acetyl-CoA contributes to fatty acid biosynthesis and histone acetylation during cell cycle entry","volume":"285","author":"Morrish","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2021.08.026_bib26","doi-asserted-by":"crossref","first-page":"6673","DOI":"10.1073\/pnas.89.15.6673","article-title":"NADPH-dependent beta-oxidation of unsaturated fatty acids with double bonds extending from odd-numbered carbon atoms","volume":"89","author":"Smeland","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2021.08.026_bib27","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1681\/ASN.2009020132","article-title":"Renal progenitor cells contribute to hyperplastic lesions of podocytopathies and crescentic glomerulonephritis","volume":"20","author":"Smeets","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.08.026_bib28","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.2144\/01306rv01","article-title":"Biological methods for cell-cycle synchronization of mammalian cells","volume":"30","author":"Davis","year":"2001","journal-title":"Biotechniques"},{"key":"10.1016\/j.kint.2021.08.026_bib29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.celrep.2014.03.020","article-title":"Fly-FUCCI: a versatile tool for studying cell proliferation in complex tissues","volume":"7","author":"Zielke","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2021.08.026_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108202","article-title":"Human Fucci pancreatic beta cell lines: new tools to study beta cell cycle and terminal differentiation","volume":"9","author":"Carlier","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2021.08.026_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23214","article-title":"Tracking neural crest cell cycle progression in vivo","volume":"56","author":"Rajan","year":"2018","journal-title":"Genesis"},{"key":"10.1016\/j.kint.2021.08.026_bib32","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/s41467-018-03753-4","article-title":"Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury","volume":"9","author":"Lazzeri","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2021.08.026_bib33","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.kint.2017.05.017","article-title":"Accelerated podocyte detachment and progressive podocyte loss from glomeruli with age in Alport syndrome","volume":"92","author":"Ding","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99271","article-title":"mTOR-mediated podocyte hypertrophy regulates glomerular integrity in mice and humans","volume":"4","author":"Puelles","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2021.08.026_bib35","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1080\/15384101.2016.1191710","article-title":"Cell cycle re-entry sensitizes podocytes to injury induced death","volume":"15","author":"Hagen","year":"2016","journal-title":"Cell Cycle"},{"key":"10.1016\/j.kint.2021.08.026_bib36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41419-019-1480-x","article-title":"Inhibiting 4E-BP1 re-activation represses podocyte cell cycle re-entry and apoptosis induced by adriamycin","volume":"10","author":"Li","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.kint.2021.08.026_bib37","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/path.4193","article-title":"Podocyte loss involves MDM2-driven mitotic catastrophe: MDM2 in adriamycin nephropathy","volume":"230","author":"Mulay","year":"2013","journal-title":"J Pathol"},{"key":"10.1016\/j.kint.2021.08.026_bib38","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MNH.0000000000000311","article-title":"Can podocytes be regenerated in adults?","volume":"26","author":"Shankland","year":"2017","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2021.08.026_bib39","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/sj.ki.5002222","article-title":"The spectrum of podocytopathies: a unifying view of glomerular diseases","volume":"71","author":"Wiggins","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cub.2009.07.069","article-title":"Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening","volume":"19","author":"Klein","year":"2009","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2021.08.026_bib41","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41556-018-0107-2","article-title":"Regulation of cell cycle progression by cell-cell and cell-matrix forces","volume":"20","author":"Uroz","year":"2018","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2021.08.026_bib42","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ki.2011.231","article-title":"Pdlim2 is a novel actin-regulating protein of podocyte foot processes","volume":"80","author":"Sistani","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib43","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neo.2014.04.006","article-title":"Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the \u03b21-integrin-RhoA signaling axis","volume":"16","author":"Deevi","year":"2014","journal-title":"Neoplasia"},{"key":"10.1016\/j.kint.2021.08.026_bib44","doi-asserted-by":"crossref","first-page":"20180227","DOI":"10.1098\/rstb.2018.0227","article-title":"Connections between the cell cycle, cell adhesion and the cytoskeleton","volume":"374","author":"Jones","year":"2019","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"10.1016\/j.kint.2021.08.026_bib45","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1080\/15384101.2015.1090068","article-title":"Metabolic control of the cell cycle","volume":"14","author":"Kalucka","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.kint.2021.08.026_bib46","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/nature22797","article-title":"The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival","volume":"546","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.kint.2021.08.026_bib47","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.tips.2018.12.004","article-title":"Targeting cancer cell dormancy","volume":"40","author":"Recasens","year":"2019","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.kint.2021.08.026_bib48","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1523-1755.2005.00161.x","article-title":"Limitation of podocyte proliferation improves renal function in experimental crescentic glomerulonephritis","volume":"67","author":"Griffin","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.08.026_bib49","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.1038\/s41598-020-65352-y","article-title":"Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis","volume":"10","author":"Miesen","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2021.08.026_bib50","doi-asserted-by":"crossref","first-page":"14898","DOI":"10.1038\/s41598-020-71950-7","article-title":"Connectivity mapping of glomerular proteins identifies dimethylaminoparthenolide as a new inhibitor of diabetic kidney disease","volume":"10","author":"Klein","year":"2020","journal-title":"Sci. Rep"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821008619?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821008619?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:00:29Z","timestamp":1758762029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253821008619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S0085253821008619"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2021.08.026","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.740870064.793588886","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of disease progression on the podocyte cell cycle in Alport Syndrome","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2021.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}