{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:55:37Z","timestamp":1793379337553,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030-188499"],"award-info":[{"award-number":["310030-188499"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.kint.2021.11.016","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T02:04:23Z","timestamp":1637805863000},"page":"563-573","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes"],"prefix":"10.1016","volume":"101","author":[{"given":"Camille","family":"Ansermet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Centeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohan","family":"Bignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Pradervand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Menin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Gachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari AI.","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri","family":"Firsov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2021.11.016_bib1","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1007\/s00424-020-02361-w","article-title":"Glucose transporters in the kidney in health and disease","volume":"472","author":"Vallon","year":"2020","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.kint.2021.11.016_bib2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1464-5491.2009.02894.x","article-title":"Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications","volume":"27","author":"Gerich","year":"2010","journal-title":"Diabet Med"},{"key":"10.1016\/j.kint.2021.11.016_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.cbpb.2005.11.007","article-title":"Contribution of intestine and kidney to glucose fluxes in different nutritional states in rat","volume":"143","author":"Mithieux","year":"2006","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.kint.2021.11.016_bib4","first-page":"49","article-title":"Diabetic kidney disease: world wide difference of prevalence and risk factors","volume":"5","author":"Gheith","year":"2016","journal-title":"J\u00a0Nephropharmacol"},{"key":"10.1016\/j.kint.2021.11.016_bib5","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41581-018-0048-9","article-title":"Circadian rhythms and the kidney","volume":"14","author":"Firsov","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2021.11.016_bib6","doi-asserted-by":"crossref","first-page":"16089","DOI":"10.1038\/s41598-019-52682-9","article-title":"The intrinsic circadian clock in podocytes controls glomerular filtration rate","volume":"9","author":"Ansermet","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2021.11.016_bib7","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/HYPERTENSIONAHA.112.190892","article-title":"The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes","volume":"59","author":"Stow","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2021.11.016_bib8","doi-asserted-by":"crossref","first-page":"16523","DOI":"10.1073\/pnas.0904890106","article-title":"Molecular clock is involved in predictive circadian adjustment of renal function","volume":"106","author":"Zuber","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2021.11.016_bib9","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1681\/ASN.2015091055","article-title":"Nephron-specific deletion of circadian clock gene Bmal1 alters the plasma and renal metabolome and impairs drug disposition","volume":"27","author":"Nikolaeva","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.11.016_bib10","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1681\/ASN.2013060641","article-title":"Local renal circadian clocks control fluid-electrolyte homeostasis and BP","volume":"25","author":"Tokonami","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2021.11.016_bib11","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.kint.2019.09.032","article-title":"The circadian clock is disrupted in mice with adenine-induced tubulointerstitial nephropathy","volume":"97","author":"Motohashi","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.11.016_bib12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1097\/JOM.0b013e3182a299c9","article-title":"Association between shiftwork and glomerular filtration rate in police officers","volume":"55","author":"Charles","year":"2013","journal-title":"J\u00a0Occup Environ Med"},{"key":"10.1016\/j.kint.2021.11.016_bib13","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/oem.51.9.638","article-title":"Increased albumin excretion in industrial workers due to shift work rather than to prolonged exposure to low concentrations of chlorinated hydrocarbons","volume":"51","author":"Boogaard","year":"1994","journal-title":"Occup Environ Med"},{"key":"10.1016\/j.kint.2021.11.016_bib14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.5213\/inj.1938236.118","article-title":"Influence of circadian disruption associated with artificial light at night on micturition patterns in shift workers","volume":"23","author":"Kim","year":"2019","journal-title":"Int Neurourol J"},{"key":"10.1016\/j.kint.2021.11.016_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40557-018-0279-z","article-title":"The association between shift work and chronic kidney disease in manual labor workers using data from the Korea National Health and Nutrition Examination Survey (KNHANES 2011-2014)","volume":"30","author":"Uhm","year":"2018","journal-title":"Ann Occup Environ Med"},{"key":"10.1016\/j.kint.2021.11.016_bib16","doi-asserted-by":"crossref","first-page":"F933","DOI":"10.1152\/ajprenal.00197.2014","article-title":"Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells","volume":"309","author":"Solocinski","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.11.016_bib17","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1046\/j.1523-1755.2000.07710.x","article-title":"Cell cycle regulation in diabetic nephropathy","volume":"77","author":"Wolf","year":"2000","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.kint.2021.11.016_bib18","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1152\/ajprenal.00252.2014","article-title":"Theobromine increases NAD(+)\/Sirt-1 activity and protects the kidney under diabetic conditions","volume":"308","author":"Papadimitriou","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"issue":"suppl 1","key":"10.1016\/j.kint.2021.11.016_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/dom.12521","article-title":"The molecular clock as a metabolic rheostat","volume":"17","author":"Perelis","year":"2015","journal-title":"Diabetes Obes Metab"},{"key":"10.1016\/j.kint.2021.11.016_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007369","article-title":"mTOR signaling regulates central and peripheral circadian clock function","volume":"14","author":"Ramanathan","year":"2018","journal-title":"PLoS Genet"},{"key":"10.1016\/j.kint.2021.11.016_bib21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.bbrc.2005.12.012","article-title":"Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice","volume":"340","author":"Sakaguchi","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2021.11.016_bib22","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1172\/JCI44774","article-title":"Role of mTOR in podocyte function and diabetic nephropathy in humans and mice","volume":"121","author":"Godel","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2021.11.016_bib23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1080\/15548627.2015.1049799","article-title":"Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis","volume":"11","author":"Lenoir","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.kint.2021.11.016_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mce.2017.12.012","article-title":"The mTOR promotes oxidative stress-induced apoptosis of mesangial cells in diabetic nephropathy","volume":"473","author":"Lu","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.kint.2021.11.016_bib25","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0009-9120(72)80014-6","article-title":"The rapid determination of urinary titratable acid and ammonium and evaluation of freezing as a method of preservation","volume":"5","author":"Chan","year":"1972","journal-title":"Clin Biochem"},{"key":"10.1016\/j.kint.2021.11.016_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/ki.2009.501","article-title":"Major contribution of tubular secretion to creatinine clearance in mice","volume":"77","author":"Eisner","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.11.016_bib27","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2021.11.016_bib28","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"10.1016\/j.kint.2021.11.016_bib29","doi-asserted-by":"crossref","first-page":"382","DOI":"10.2337\/diacare.24.2.382","article-title":"Renal gluconeogenesis: its importance in human glucose homeostasis","volume":"24","author":"Gerich","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2021.11.016_bib30","doi-asserted-by":"crossref","unstructured":"Legouis D, Faivre A, Cipp\u00e0 PE, et\u00a0al. Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism. Nephrol Dial Transplant. Published online November 28, 2020. https:\/\/doi.org\/10.1093\/ndt\/gfaa302.","DOI":"10.1093\/ndt\/gfaa302"},{"key":"10.1016\/j.kint.2021.11.016_bib31","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/nm.2214","article-title":"Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis","volume":"16","author":"Zhang","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2021.11.016_bib32","article-title":"Interaction of ApoA-IV with NR4A1 and NR1D1 represses G6Pase and PEPCK transcription: nuclear receptor-mediated downregulation of hepatic gluconeogenesis in mice and a human hepatocyte cell line","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2021.11.016_bib33","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2015803118","article-title":"Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms","volume":"118","author":"Weger","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2021.11.016_bib34","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/j.cmet.2017.04.006","article-title":"PPAR\u03b4 promotes running endurance by preserving glucose","volume":"25","author":"Fan","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2021.11.016_bib35","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1111\/j.1523-1755.2005.00218.x","article-title":"Circadian clock genes directly regulate expression of the Na(+)\/H(+) exchanger NHE3 in the kidney","volume":"67","author":"Saifur Rohman","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2021.11.016_bib36","doi-asserted-by":"crossref","first-page":"F419","DOI":"10.1152\/ajprenal.00497.2018","article-title":"Effect of renal tubule-specific knockdown of the Na(+)\/H(+) exchanger NHE3 in Akita diabetic mice","volume":"317","author":"Onishi","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.11.016_bib37","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1177\/0748730403018003007","article-title":"Peripheral circadian oscillators in mammals: time and food","volume":"18","author":"Schibler","year":"2003","journal-title":"J\u00a0Biol Rhythms"},{"key":"10.1016\/j.kint.2021.11.016_bib38","doi-asserted-by":"crossref","first-page":"F89","DOI":"10.1152\/ajprenal.00028.2017","article-title":"High dietary sodium causes dyssynchrony of the renal molecular clock in rats","volume":"314","author":"Speed","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2021.11.016_bib39","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3109\/07420528.2012.699127","article-title":"Low-carbohydrate, high-protein diet affects rhythmic expression of gluconeogenic regulatory and circadian clock genes in mouse peripheral tissues","volume":"29","author":"Oishi","year":"2012","journal-title":"Chronobiol Int"},{"key":"10.1016\/j.kint.2021.11.016_bib40","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1161\/ATVBAHA.109.190140","article-title":"Ketogenic diet disrupts the circadian clock and increases hypofibrinolytic risk by inducing expression of plasminogen activator inhibitor-1","volume":"29","author":"Oishi","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2021.11.016_bib41","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1210\/en.2011-1794","article-title":"Differential entrainment of peripheral clocks in the rat by glucocorticoid and feeding","volume":"153","author":"Sujino","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.kint.2021.11.016_bib42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5271\/sjweh.3759","article-title":"The effect of shift work on eating habits: a systematic review","volume":"45","author":"Souza","year":"2019","journal-title":"Scand J Work Environ Health"},{"key":"10.1016\/j.kint.2021.11.016_bib43","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4162\/nrp.2010.4.1.51","article-title":"The effects of internet addiction on the lifestyle and dietary behavior of Korean adolescents","volume":"4","author":"Kim","year":"2010","journal-title":"Nutr Res Pract"},{"key":"10.1016\/j.kint.2021.11.016_bib44","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1152\/physiolgenomics.00091.2018","article-title":"Clock gene expression is altered in veterans with sleep apnea","volume":"51","author":"Canales","year":"2019","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.kint.2021.11.016_bib45","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MNH.0000000000000611","article-title":"Circadian rhythms of mineral metabolism in chronic kidney disease-mineral bone disorder","volume":"29","author":"Egstrand","year":"2020","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2021.11.016_bib46","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.bbrc.2018.05.056","article-title":"Effect of cisplatin on the clock genes expression in the liver, heart and kidney","volume":"501","author":"Cao","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2021.11.016_bib47","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.tem.2020.10.005","article-title":"Time for novel strategies to mitigate cardiometabolic risk in shift workers","volume":"31","author":"Schilperoort","year":"2020","journal-title":"Trends Endocrinol Metab"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821010814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253821010814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:01:03Z","timestamp":1758762063000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253821010814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S0085253821010814"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2021.11.016","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysfunction of the circadian clock in the kidney tubule leads to enhanced kidney gluconeogenesis and exacerbated hyperglycemia in diabetes","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2021.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}