{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T08:25:47Z","timestamp":1793175947570,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2018-024461-I"],"award-info":[{"award-number":["RYC2018-024461-I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"publisher","award":["B2017\/BMD-3686 CIFRA2-CM"],"award-info":[{"award-number":["B2017\/BMD-3686 CIFRA2-CM"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015883","name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015883","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["DTS18\/00032"],"award-info":[{"award-number":["DTS18\/00032"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PI19\/00588"],"award-info":[{"award-number":["PI19\/00588"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI18\/01366"],"award-info":[{"award-number":["PI18\/01366"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI19\/00815"],"award-info":[{"award-number":["PI19\/00815"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI21\/00251"],"award-info":[{"award-number":["PI21\/00251"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.kint.2022.02.028","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:40:53Z","timestamp":1647981653000},"page":"1200-1215","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis"],"prefix":"10.1016","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-0716","authenticated-orcid":false,"given":"Lara","family":"Vali\u00f1o-Rivas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Cuarental","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Ceballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arancha","family":"Pintor-Chocano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Vanessa","family":"Perez-Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-5689","authenticated-orcid":false,"given":"Ana B.","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Dolores","family":"Sanchez-Ni\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2022.02.028_bib1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.cytogfr.2013.05.003","article-title":"The multiple facets of the TGF-\u03b2 family cytokine growth\/differentiation factor-15\/macrophage inhibitory cytokine-1","volume":"24","author":"Unsicker","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.kint.2022.02.028_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri.2016.112","article-title":"Immunoregulation by members of the TGF\u03b2 superfamily","volume":"16","author":"Chen","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.kint.2022.02.028_bib3","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1681\/ASN.2016080919","article-title":"Growth differentiation factor-15 and risk of CKD progression","volume":"28","author":"Nair","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ndt\/gfr575","article-title":"Macrophage inhibitory cytokine-1 (MIC-1\/GDF15) and mortality in end-stage renal disease","volume":"27","author":"Breit","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.02.028_bib5","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1159\/000455907","article-title":"Association of growth differentiation factor 15 with mortality in a prospective hemodialysis cohort","volume":"7","author":"You","year":"2017","journal-title":"Cardiorenal Med"},{"key":"10.1016\/j.kint.2022.02.028_bib6","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.2337\/dc09-2174","article-title":"Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy","volume":"33","author":"Lajer","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2022.02.028_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196634","article-title":"Growth differentiation factor-15 and fibroblast growth factor-23 are associated with mortality in type 2 diabetes: an observational follow-up study","volume":"13","author":"Frimodt-M\u00f8ller","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.02.028_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0105759","article-title":"Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass","volume":"9","author":"Kahli","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.02.028_bib9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijcard.2015.06.012","article-title":"Pre-operative growth differentiation factor 15 as a novel biomarker of acute kidney injury after cardiac bypass surgery","volume":"197","author":"Guenancia","year":"2015","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.kint.2022.02.028_bib10","article-title":"Growth differentiation factor-15 levels and the risk of contrast induced nephropathy in patients with acute myocardial infarction undergoing percutaneous coronary intervention: a retrospective observation study","volume":"13","author":"Sun","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.02.028_bib11","article-title":"Growth differentiation factor-15 levels and the risk of contrast induced acute kidney injury in acute myocardial infarction patients treated invasively: a propensity-score match analysis","volume":"13","author":"Sun","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.02.028_bib12","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1681\/ASN.2019090876","article-title":"Renoprotective and immunomodulatory effects of GDF15 following AKI invoked by ischemia-reperfusion injury","volume":"31","author":"Liu","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib13","first-page":"543","article-title":"Growth differentiation factor-15\/macrophage inhibitory cytokine-1 induction after kidney and lung injury","volume":"23","author":"Zimmers","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.kint.2022.02.028_bib14","doi-asserted-by":"crossref","first-page":"F1249","DOI":"10.1152\/ajprenal.00387.2013","article-title":"Genetic deletion of growth differentiation factor 15 augments renal damage in both type 1 and type 2 models of diabetes","volume":"305","author":"Mazagova","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2022.02.028_bib15","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbrc.2018.04.061","article-title":"CST3 and GDF15 ameliorate renal fibrosis by inhibiting fibroblast growth and activation","volume":"500","author":"Kim","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2022.02.028_bib16","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/s41586-019-1911-y","article-title":"GDF15 mediates the effects of metformin on body weight and energy balance","volume":"578","author":"Coll","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.kint.2022.02.028_bib17","doi-asserted-by":"crossref","first-page":"F1329","DOI":"10.1152\/ajprenal.00487.2016","article-title":"Downregulation of kidney protective factors by inflammation: role of transcription factors and epigenetic mechanisms","volume":"311","author":"Ruiz-Andres","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2022.02.028_bib18","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNF\u03b1 reduce renal klotho expression through NF\u03baB","volume":"22","author":"Moreno","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41581-018-0078-3","article-title":"The Klotho proteins in health and disease","volume":"15","author":"Kuro-o","year":"2019","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib20","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1093\/ndt\/gfx376","article-title":"Albumin downregulates Klotho in tubular cells","volume":"33","author":"Fernandez-Fernandez","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.02.028_bib21","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1128\/MCB.20.10.3742-3751.2000","article-title":"Characterization of growth-differentiation factor 15, a transforming growth factor \u03b2 superfamily member induced following liver injury","volume":"20","author":"Hsiao","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.02.028_bib22","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1053\/j.gastro.2006.09.015","article-title":"Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia","volume":"131","author":"Baek","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.kint.2022.02.028_bib23","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1681\/ASN.2004121089","article-title":"Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury","volume":"16","author":"Fang","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.2353\/ajpath.2006.050634","article-title":"Attenuation of folic acid-induced renal inflammatory injury in platelet-activating factor receptor-deficient mice","volume":"168","author":"Doi","year":"2006","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2022.02.028_bib25","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1681\/ASN.2005070690","article-title":"Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity","volume":"17","author":"Ortega","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib26","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1681\/ASN.2015080898","article-title":"Mitogen-activated protein kinase 14 promotes AKI","volume":"28","author":"Ortiz","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib27","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.1716578115","article-title":"TWEAK and RIPK1 mediate a second wave of cell death during AKI","volume":"115","author":"Martin-Sanchez","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.02.028_bib28","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ki.2015.332","article-title":"The inflammatory cytokine TWEAK decreases PGC-1\u03b1 expression and mitochondrial function in acute kidney injury","volume":"89","author":"Ruiz-Andres","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.02.028_bib29","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1038\/ki.2011.475","article-title":"TWEAK (tumor necrosis factor\u2013like weak inducer of apoptosis) activates CXCL16 expression during renal tubulointerstitial inflammation","volume":"81","author":"Izquierdo","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.02.028_bib30","doi-asserted-by":"crossref","first-page":"e8955","DOI":"10.1371\/journal.pone.0008955","article-title":"TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21","volume":"5","author":"Sanz","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.02.028_bib31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1681\/ASN.2007050577","article-title":"The cytokine TWEAK modulates renal tubulointerstitial inflammation","volume":"19","author":"Sanz","year":"2008","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib32","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/ndt\/gfy367","article-title":"MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells","volume":"34","author":"Vali\u00f1o-Rivas","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.02.028_bib33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11255-013-0520-1","article-title":"Unilateral ureteral obstruction: beyond obstruction","volume":"46","author":"Ucero","year":"2014","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib34","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.bbadis.2013.05.032","article-title":"TNF-related weak inducer of apoptosis (TWEAK) promotes kidney fibrosis and Ras-dependent proliferation of cultured renal fibroblast","volume":"1832","author":"Ucero","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.kint.2022.02.028_bib35","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/nm1677","article-title":"Tumor-induced anorexia and weight loss are mediated by the TGF-\u03b2 superfamily cytokine MIC-1","volume":"13","author":"Johnen","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2022.02.028_bib36","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/ndt\/gfy020","article-title":"Increased urinary osmolyte excretion indicates chronic kidney disease severity and progression rate","volume":"33","author":"Gil","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.02.028_bib37","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00109-017-1594-5","article-title":"Urine metabolomics insight into acute kidney injury point to oxidative stress disruptions in energy generation and H2S availability","volume":"95","author":"Martin-Lorenzo","year":"2017","journal-title":"J\u00a0Mol Med (Berl)"},{"key":"10.1016\/j.kint.2022.02.028_bib38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/path.5132","article-title":"CCL20 blockade increases the severity of nephrotoxic folic acid-induced acute kidney injury","volume":"246","author":"Gonz\u00e1lez-Guerrero","year":"2018","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.kint.2022.02.028_bib39","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ndt\/gfz169","article-title":"Loss of NLRP6 expression increases the severity of acute kidney injury","volume":"35","author":"Vali\u00f1o-Rivas","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.02.028_bib40","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1083\/jcb.107.4.1359","article-title":"Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis","volume":"107","author":"Haverty","year":"1988","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2022.02.028_bib41","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1073\/pnas.1305538110","article-title":"Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.02.028_bib42","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1038\/emm.2017.89","article-title":"Bcl3: a regulator of NF-\u03baB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells","volume":"49","author":"Poveda","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.kint.2022.02.028_bib43","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.aar2131","article-title":"Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease","volume":"360","author":"Park","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.kint.2022.02.028_bib44","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/sj.ki.5001866","article-title":"Cytokine cooperation in renal tubular cell injury: the role of TWEAK","volume":"70","author":"Justo","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.02.028_bib45","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1681\/ASN.2009020227","article-title":"BASP1 promotes apoptosis in diabetic nephropathy","volume":"21","author":"Sanchez-Ni\u00f1o","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib46","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fendo.2020.00560","article-title":"Klotho, aging, and the failing kidney","volume":"11","author":"Buchanan","year":"2020","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.kint.2022.02.028_bib47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.2215\/CJN.02840320","article-title":"Klotho in clinical nephrology: diagnostic and therapeutic implications","volume":"16","author":"Neyra","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib48","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cell.2017.10.025","article-title":"In\u00a0vivo target gene activation via CRISPR\/Cas9-mediated trans-epigenetic modulation","volume":"171","author":"Liao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.kint.2022.02.028_bib49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s12325-019-01180-5","article-title":"Albuminuria downregulation of the anti-aging factor Klotho: the missing link potentially explaining the association of pathological albuminuria with premature death","volume":"37","author":"Fern\u00e1ndez-Fern\u00e1ndez","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.kint.2022.02.028_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1210\/endo.143.2.8657","article-title":"Mediation of unusually high concentrations of 1,25-dihydroxyvitamin D in homozygous klotho mutant mice by increased expression of renal 1alpha-hydroxylase gene","volume":"143","author":"Yoshida","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.kint.2022.02.028_bib51","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.kint.2016.04.009","article-title":"In\u00a0vivo evidence for a limited role of proximal tubular Klotho in renal phosphate handling","volume":"90","author":"Ide","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.02.028_bib52","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.3389\/fphys.2018.01494","article-title":"Fibroblast growth factor 23 expression is increased in multiple organs in mice with folic acid-induced acute kidney injury","volume":"9","author":"Egli-Spichtig","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.kint.2022.02.028_bib53","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.02.028_bib55","first-page":"1819","article-title":"Urinary growth differentiation factor-15 (GDF15) levels as a biomarker of adverse outcomes and biopsy findings in chronic kidney disease","volume":"34","author":"Perez-Gomez","year":"2021","journal-title":"J\u00a0Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1681\/ASN.2021081150","article-title":"Spatially resolved transcriptomic analysis of acute kidney injury in a female murine model","volume":"33","author":"Dixon","year":"2022","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib58","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1681\/ASN.2013111209","article-title":"The kidney is the principal organ mediating klotho effects","volume":"25","author":"Lindberg","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib59","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.02.028_bib60","doi-asserted-by":"crossref","first-page":"21968","DOI":"10.1038\/s41598-020-78936-5","article-title":"Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury","volume":"10","author":"El-Rashid","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.02.028_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/ijms20010042","article-title":"Metformin: a candidate drug for renal diseases","volume":"20","author":"Corremans","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2022.02.028_bib62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.kint.2017.12.026","article-title":"Drug repurposing in kidney disease","volume":"94","author":"Panchapakesan","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.02.028_bib63","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000481951","article-title":"Renoprotective effects of metformin","volume":"138","author":"De Broe","year":"2018","journal-title":"Nephron"},{"key":"10.1016\/j.kint.2022.02.028_bib64","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12882-017-0579-5","article-title":"Risk of acute kidney injury and survival in patients treated with metformin: an observational cohort study","volume":"18","author":"Bell","year":"2017","journal-title":"BMC Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822002101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822002101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T02:43:20Z","timestamp":1780281800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822002101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":62,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S0085253822002101"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2022.02.028","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742171974.793594843","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2022.02.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}