{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:57:26Z","timestamp":1793692646037,"version":"4.5.1"},"reference-count":74,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006727","name":"University of Kansas Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006729","name":"School of Medicine, University of Kansas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK106912"],"award-info":[{"award-number":["P30DK106912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30GM122731"],"award-info":[{"award-number":["P30GM122731"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK103033"],"award-info":[{"award-number":["R01DK103033"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK108433"],"award-info":[{"award-number":["R01DK108433"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54HD090216"],"award-info":[{"award-number":["U54HD090216"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.kint.2022.04.034","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T22:18:27Z","timestamp":1653603507000},"page":"577-591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner"],"prefix":"10.1016","volume":"102","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane M.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Kavanaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tana S.","family":"Pottorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailey A.","family":"Allard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon T.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph T.","family":"Cornelius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aakriti","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine I.","family":"Swenson-Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Fields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele T.","family":"Pritchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhulika","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad","family":"Slawson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-7669","authenticated-orcid":false,"given":"Darren P.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Calvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4619-4376","authenticated-orcid":false,"given":"Pamela V.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2022.04.034_bib1","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1681\/ASN.2018050493","article-title":"Prevalence estimates of polycystic kidney and liver disease by population sequencing","volume":"29","author":"Lanktree","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib2","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1056\/NEJMoa1205511","article-title":"Tolvaptan in patients with autosomal dominant polycystic kidney disease","volume":"367","author":"Torres","year":"2012","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2022.04.034_bib3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s40265-019-1056-1","article-title":"Tolvaptan: a review in autosomal dominant polycystic kidney disease","volume":"79","author":"Blair","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.kint.2022.04.034_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ncpneph0070","article-title":"Mechanisms of disease: autosomal dominant and recessive polycystic kidney diseases","volume":"2","author":"Torres","year":"2006","journal-title":"Nat Clin Pract Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib5","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1681\/ASN.2012111089","article-title":"Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations","volume":"24","author":"Freedman","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib6","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1172\/JCI67273","article-title":"Altered trafficking and stability of polycystins underlie polycystic kidney disease","volume":"124","author":"Cai","year":"2014","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2022.04.034_bib7","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1038\/s41467-019-12067-y","article-title":"Ciliary exclusion of polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model","volume":"10","author":"Walker","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2022.04.034_bib8","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.celrep.2016.10.018","article-title":"Role for the IFT-A complex in selective transport to the primary cilium","volume":"17","author":"Fu","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2022.04.034_bib9","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1101\/gad.1966210","article-title":"TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia","volume":"24","author":"Mukhopadhyay","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2022.04.034_bib10","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1083\/jcb.201110049","article-title":"The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking","volume":"197","author":"Liem","year":"2012","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib11","doi-asserted-by":"crossref","first-page":"F541","DOI":"10.1152\/ajprenal.00273.2001","article-title":"Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium","volume":"282","author":"Yoder","year":"2002","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2022.04.034_bib12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1681\/ASN.2011080829","article-title":"Disruption of IFT complex A causes cystic kidneys without mitotic spindle misorientation","volume":"23","author":"Jonassen","year":"2012","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib13","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.0836980100","article-title":"Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease","volume":"100","author":"Lin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.04.034_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ng.756","article-title":"TTC21B contributes both causal and modifying alleles across the ciliopathy spectrum","volume":"43","author":"Davis","year":"2011","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2022.04.034_bib15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3389\/fped.2017.00287","article-title":"Many genes-one disease? genetics of nephronophthisis (NPHP) and NPHP-associated disorders","volume":"5","author":"Srivastava","year":"2017","journal-title":"Front Pediatr"},{"key":"10.1016\/j.kint.2022.04.034_bib16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/ng.105","article-title":"THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia","volume":"40","author":"Tran","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2022.04.034_bib17","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.1011410108","article-title":"Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components","volume":"108","author":"Qin","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.04.034_bib18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.cellbio.23.090506.123249","article-title":"Cilia and developmental signaling","volume":"23","author":"Eggenschwiler","year":"2007","journal-title":"Annu Rev Cell Dev Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib19","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/ng.2715","article-title":"Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease","volume":"45","author":"Ma","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2022.04.034_bib20","doi-asserted-by":"crossref","first-page":"e98615","DOI":"10.15252\/embj.201798615","article-title":"Cilia-localized LKB1 regulates chemokine signaling, macrophage recruitment, and tissue homeostasis in the kidney","volume":"37","author":"Viau","year":"2018","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2022.04.034_bib21","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.kint.2020.05.049","article-title":"Genetic reduction of cilium-length by targeting intraflagellar transport 88 protein impedes kidney and liver cysts formation in mouse models of autosomal polycystic kidney disease","volume":"98","author":"Shao","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.04.034_bib22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.cub.2019.01.054","article-title":"Tulp3 is a ciliary trafficking gene that regulates polycystic kidney disease","volume":"29","author":"Legue","year":"2019","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib23","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.cub.2019.01.047","article-title":"Tulp3 regulates renal cystogenesis by trafficking of cystoproteins to cilia","volume":"29","author":"Hwang","year":"2019","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib24","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1681\/ASN.2013101126","article-title":"A\u00a0homozygous missense mutation in the ciliary gene TTC21B causes familial FSGS","volume":"25","author":"Huynh Cong","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib25","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/ana.24964","article-title":"The genetic landscape of familial congenital hydrocephalus","volume":"81","author":"Shaheen","year":"2017","journal-title":"Ann Neurol"},{"key":"10.1016\/j.kint.2022.04.034_bib26","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1038\/s41436-020-0761-1","article-title":"The morbid genome of ciliopathies: an update","volume":"22","author":"Shamseldin","year":"2020","journal-title":"Genet Med"},{"key":"10.1016\/j.kint.2022.04.034_bib27","doi-asserted-by":"crossref","first-page":"6369","DOI":"10.1096\/fj.201902611R","article-title":"Genetic interaction of mammalian IFT-A paralogs regulates cilia disassembly, ciliary entry of membrane protein, Hedgehog signaling, and embryogenesis","volume":"34","author":"Wang","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2022.04.034_bib28","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1681\/ASN.2013070735","article-title":"Downregulating hedgehog signaling reduces renal cystogenic potential of mouse models","volume":"25","author":"Tran","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib29","first-page":"789","article-title":"Dysfunction of intraflagellar transport-A causes hyperphagia-induced obesity and metabolic syndrome","volume":"9","author":"Jacobs","year":"2016","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.kint.2022.04.034_bib30","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1038\/nm1675","article-title":"A\u00a0critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1","volume":"13","author":"Piontek","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2022.04.034_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF01463929","article-title":"Antigen retrieval in cryostat tissue sections and cultured cells by treatment with sodium dodecyl sulfate (SDS)","volume":"105","author":"Brown","year":"1996","journal-title":"Histochem Cell Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib32","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/bs.mcb.2019.04.008","article-title":"Analysis of primary cilia in renal tissue and cells","volume":"153","author":"Silva","year":"2019","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib33","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1038\/s41598-018-23341-2","article-title":"Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human autosomal dominant polycystic kidney disease cells","volume":"8","author":"Silva","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.04.034_bib34","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ydbio.2009.08.023","article-title":"Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain","volume":"335","author":"Stottmann","year":"2009","journal-title":"Dev Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib35","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1038\/srep02937","article-title":"Direct confocal acquisition of fluorescence from X-gal staining on thick tissue sections","volume":"3","author":"Levitsky","year":"2013","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.04.034_bib36","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"Pazour","year":"2000","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00467-011-1941-7","article-title":"Ciliogenesis in normal human kidney development and post-natal life","volume":"27","author":"Saraga-Babic","year":"2012","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib38","doi-asserted-by":"crossref","first-page":"4257","DOI":"10.1172\/JCI64313","article-title":"Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity","volume":"122","author":"Hopp","year":"2012","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2022.04.034_bib39","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1093\/hmg\/ddr338","article-title":"Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways","volume":"20","author":"Takakura","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2022.04.034_bib40","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"cAMP stimulates the in\u00a0vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway","volume":"57","author":"Yamaguchi","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.04.034_bib41","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.04.034_bib42","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1073\/pnas.1103816108","article-title":"Polycystin-1 regulates STAT activity by a dual mechanism","volume":"108","author":"Talbot","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.04.034_bib43","doi-asserted-by":"crossref","first-page":"40419","DOI":"10.1074\/jbc.M405079200","article-title":"Calcium restriction allows cAMP activation of the B-Raf\/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype","volume":"279","author":"Yamaguchi","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2022.04.034_bib44","doi-asserted-by":"crossref","first-page":"e113","DOI":"10.1016\/j.ddmec.2013.03.001","article-title":"STAT3 signaling in polycystic kidney disease","volume":"10","author":"Weimbs","year":"2013","journal-title":"Drug Discov Today Dis Mech"},{"key":"10.1016\/j.kint.2022.04.034_bib45","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1681\/ASN.2013091026","article-title":"The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation","volume":"25","author":"Talbot","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.04.034_bib46","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"Rowe","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2022.04.034_bib47","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.cmet.2019.09.012","article-title":"Ketosis ameliorates renal cyst growth in polycystic kidney disease","volume":"30","author":"Torres","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2022.04.034_bib48","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.ebiom.2019.08.041","article-title":"Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney disease","volume":"47","author":"Leonhard","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.kint.2022.04.034_bib49","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41467-018-03036-y","article-title":"Lkb1 deficiency confers glutamine dependency in polycystic kidney disease","volume":"9","author":"Flowers","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2022.04.034_bib50","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev-biochem-060608-102511","article-title":"Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic disease","volume":"80","author":"Hart","year":"2011","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.kint.2022.04.034_bib51","doi-asserted-by":"crossref","first-page":"14719","DOI":"10.1074\/jbc.M113.525790","article-title":"Altering O-linked beta-N-acetylglucosamine cycling disrupts mitochondrial function","volume":"289","author":"Tan","year":"2014","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2022.04.034_bib52","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.isci.2019.01.031","article-title":"O-GlcNAcylation regulates primary ciliary length by promoting microtubule disassembly","volume":"12","author":"Tian","year":"2019","journal-title":"iScience"},{"key":"10.1016\/j.kint.2022.04.034_bib53","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1007\/s13238-020-00746-2","article-title":"O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis","volume":"11","author":"Yu","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.kint.2022.04.034_bib54","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000750","article-title":"Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway","volume":"3","author":"Gerakopoulos","year":"2020","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.kint.2022.04.034_bib55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fphys.2014.00072","article-title":"Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells","volume":"5","author":"Upadhyay","year":"2014","journal-title":"Front Physiol"},{"key":"10.1016\/j.kint.2022.04.034_bib56","doi-asserted-by":"crossref","first-page":"jcs213496","DOI":"10.1242\/jcs.213496","article-title":"The cilium as a force sensor-myth versus reality","volume":"132","author":"Ferreira","year":"2019","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2022.04.034_bib57","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cub.2009.11.072","article-title":"Identification of signaling pathways regulating primary cilium length and flow-mediated adaptation","volume":"20","author":"Besschetnova","year":"2010","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2022.04.034_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00232-002-1042-4","article-title":"Removal of the MDCK cell primary cilium abolishes flow sensing","volume":"191","author":"Praetorius","year":"2003","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib60","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00232-002-1055-z","article-title":"Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells","volume":"191","author":"Praetorius","year":"2003","journal-title":"J\u00a0Membr Biol"},{"key":"10.1016\/j.kint.2022.04.034_bib61","doi-asserted-by":"crossref","first-page":"e33183","DOI":"10.7554\/eLife.33183","article-title":"Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium","volume":"7","author":"Liu","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.kint.2022.04.034_bib62","first-page":"15","article-title":"Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia","volume":"54","author":"Torres-Perez","year":"2020","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.kint.2022.04.034_bib63","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1091\/mbc.e16-11-0813","article-title":"Intraflagellar transport-A complex mediates ciliary entry and retrograde trafficking of ciliary G protein-coupled receptors","volume":"28","author":"Hirano","year":"2017","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.kint.2022.04.034_bib64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbrc.2018.12.109","article-title":"TULP3 is required for localization of membrane-associated proteins ARL13B and INPP5E to primary cilia","volume":"509","author":"Han","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.kint.2022.04.034_bib65","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00018-012-0980-y","article-title":"Primary cilia elongation in response to interleukin-1 mediates the inflammatory response","volume":"69","author":"Wann","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.kint.2022.04.034_bib66","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.joca.2019.03.003","article-title":"Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation","volume":"27","author":"Fu","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.kint.2022.04.034_bib67","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.lfs.2009.01.007","article-title":"Evidence of O-linked N-acetylglucosamine in diabetic nephropathy","volume":"84","author":"Degrell","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.kint.2022.04.034_bib68","doi-asserted-by":"crossref","first-page":"F1172","DOI":"10.1152\/ajprenal.00545.2015","article-title":"Role of O-linked N-acetylglucosamine modification in diabetic nephropathy","volume":"311","author":"Gellai","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2022.04.034_bib69","doi-asserted-by":"crossref","first-page":"12749","DOI":"10.1074\/jbc.RA118.001746","article-title":"O-GlcNAcylation reduces proximal tubule protein reabsorption and promotes proteinuria in spontaneously hypertensive rats","volume":"293","author":"Silva-Aguiar","year":"2018","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2022.04.034_bib70","doi-asserted-by":"crossref","first-page":"118121","DOI":"10.1016\/j.lfs.2020.118121","article-title":"OGT knockdown counteracts high phosphate-induced vascular calcification in chronic kidney disease through autophagy activation by downregulating YAP","volume":"261","author":"Xu","year":"2020","journal-title":"Life Sci"},{"key":"10.1016\/j.kint.2022.04.034_bib71","doi-asserted-by":"crossref","first-page":"165556","DOI":"10.1016\/j.bbadis.2019.165556","article-title":"O-GlcNAcylation of RAF1 increases its stabilization and induces the renal fibrosis","volume":"1866","author":"Feng","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.kint.2022.04.034_bib72","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.freeradbiomed.2016.12.032","article-title":"Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats","volume":"103","author":"Hu","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.kint.2022.04.034_bib73","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3389\/fendo.2018.00599","article-title":"O-GlcNAc as an integrator of signaling pathways","volume":"9","author":"Ong","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.kint.2022.04.034_bib74","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1681\/ASN.V7102142","article-title":"Linkage, clinical features, and prognosis of autosomal dominant polycystic kidney disease types 1 and 2","volume":"7","author":"Torra","year":"1996","journal-title":"J\u00a0Am Soc Nephrol"}],"updated-by":[{"DOI":"10.1016\/j.kint.2022.11.015","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000}},{"DOI":"10.1016\/j.kint.2023.04.001","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000}}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822003878?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822003878?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:58:37Z","timestamp":1788231517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822003878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S0085253822003878"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2022.04.034","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742175705.793593702","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.04.26.061796","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ttc21b deficiency attenuates autosomal dominant polycystic kidney disease in a kidney tubular- and maturation-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2022.04.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}