{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:30:25Z","timestamp":1793503825366,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100008272","name":"Novartis Pharmaceuticals Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008897","name":"Janssen Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000975","name":"Kidney Health Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000975","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001027","name":"Department of Health and Ageing, Australian Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","award":["2009965"],"award-info":[{"award-number":["2009965"]}],"id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004943","name":"Department of Human Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004943","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["P01 HL045522"],"award-info":[{"award-number":["P01 HL045522"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01 EB015611"],"award-info":[{"award-number":["R01 EB015611"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01 HL140681"],"award-info":[{"award-number":["R01 HL140681"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HL109282"],"award-info":[{"award-number":["R01HL109282"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HL109284"],"award-info":[{"award-number":["R01HL109284"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HL109301"],"award-info":[{"award-number":["R01HL109301"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HL109315"],"award-info":[{"award-number":["R01HL109315"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01HL109319"],"award-info":[{"award-number":["R01HL109319"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R37 MH059490"],"award-info":[{"award-number":["R37 MH059490"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01HL41642"],"award-info":[{"award-number":["U01HL41642"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01HL41652"],"award-info":[{"award-number":["U01HL41652"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01HL41654"],"award-info":[{"award-number":["U01HL41654"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01HL65520"],"award-info":[{"award-number":["U01HL65520"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01HL65521"],"award-info":[{"award-number":["U01HL65521"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1101320"],"award-info":[{"award-number":["APP1101320"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009947","name":"Merck Sharp and Dohme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010230","name":"Queensland Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012188","name":"Pratt Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N92019D00027"],"award-info":[{"award-number":["75N92019D00027"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N92019D00028"],"award-info":[{"award-number":["75N92019D00028"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N92019D00029"],"award-info":[{"award-number":["75N92019D00029"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["75N92019D00030"],"award-info":[{"award-number":["75N92019D00030"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["C06 RR020547"],"award-info":[{"award-number":["C06 RR020547"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK107532"],"award-info":[{"award-number":["R01DK107532"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012698","name":"Jack Brockhoff Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.kint.2022.06.023","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T04:43:19Z","timestamp":1657946599000},"page":"1154-1166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Lipidomic profiling in the Strong Heart Study identified American Indians at risk of chronic kidney disease"],"prefix":"10.1016","volume":"102","author":[{"given":"Wenjie","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habtamu B.","family":"Beyene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Kuokkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhong","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna J.","family":"Magliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Umans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley A.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Michailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa T.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara V.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Fiehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blangero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Meikle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2022.06.023_bib1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.ackd.2008.01.011","article-title":"Reducing the burden of chronic kidney disease among American Indians","volume":"15","author":"Narva","year":"2008","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.kint.2022.06.023_bib2","series-title":"2007 USRDS Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States","year":"2007"},{"key":"10.1016\/j.kint.2022.06.023_bib3","article-title":"Diabetes mellitus and hypertension: key risk factors for kidney disease","volume":"94","author":"Lea","year":"2002","journal-title":"J\u00a0Natl Med Assoc"},{"key":"10.1016\/j.kint.2022.06.023_bib4","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1681\/ASN.2005060638","article-title":"Obesity and risk for chronic renal failure","volume":"17","author":"Ejerblad","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1681\/ASN.2012050460","article-title":"Central body fat distribution associates with unfavorable renal hemodynamics independent of body mass index","volume":"24","author":"Kwakernaak","year":"2013","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000243716","article-title":"Effect of community characteristics on familial clustering of end-stage renal disease","volume":"30","author":"Song","year":"2009","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib7","first-page":"28s","article-title":"Race and kidney disease: role of social and environmental factors","volume":"94","author":"Nzerue","year":"2002","journal-title":"J\u00a0Natl Med Assoc"},{"key":"10.1016\/j.kint.2022.06.023_bib8","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/IJNRD.S101808","article-title":"Dyslipidemia in patients with chronic kidney disease: etiology and management","volume":"10","author":"Mikolasevic","year":"2017","journal-title":"Int J Nephrol Renovasc Dis"},{"key":"10.1016\/j.kint.2022.06.023_bib9","doi-asserted-by":"crossref","first-page":"S145","DOI":"10.1681\/ASN.2005121320","article-title":"Lipids and renal disease","volume":"17","author":"Trevisan","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib10","first-page":"419","article-title":"Plasma lipidomic profiling identifies a novel complex lipid signature associated with ischemic stroke in chronic kidney disease","volume":"6","author":"Afshinnia","year":"2020","journal-title":"J\u00a0Transl Sci"},{"key":"10.1016\/j.kint.2022.06.023_bib11","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.130317","article-title":"Increased lipogenesis and impaired \u03b2-oxidation predict type 2 diabetic kidney disease progression in American Indians","volume":"4","author":"Afshinnia","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2022.06.023_bib12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1681\/ASN.2017030350","article-title":"Impaired \u03b2-oxidation and altered complex lipid fatty acid partitioning with advancing CKD","volume":"29","author":"Afshinnia","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.semnephrol.2018.01.004","article-title":"Lipidomics and biomarker discovery in kidney disease","volume":"38","author":"Afshinnia","year":"2018","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib14","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1093\/bioinformatics\/btz114","article-title":"Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease","volume":"35","author":"Ma","year":"2019","journal-title":"Bioinformatics"},{"key":"10.1016\/j.kint.2022.06.023_bib15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ekir.2016.08.007","article-title":"Lipidomic signature of progression of chronic kidney disease in the Chronic Renal Insufficiency Cohort","volume":"1","author":"Afshinnia","year":"2016","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2022.06.023_bib16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1194\/jlr.M055624","article-title":"Top-down lipidomics of low density lipoprotein reveal altered lipid profiles in advanced chronic kidney disease","volume":"56","author":"Reis","year":"2015","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.kint.2022.06.023_bib17","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1681\/ASN.2009111132","article-title":"Metabolite profiling identifies markers of uremia","volume":"21","author":"Rhee","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib18","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1021\/acs.jproteome.6b00956","article-title":"Combined clinical phenotype and lipidomic analysis reveals the impact of chronic kidney disease on lipid metabolism","volume":"16","author":"Chen","year":"2017","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.kint.2022.06.023_bib19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/oby.21448","article-title":"Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight\/obesity in humans","volume":"24","author":"Tonks","year":"2016","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.kint.2022.06.023_bib20","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3390\/metabo11090646","article-title":"Lipidomic signatures of changes in adiposity: a large prospective study of 5849 adults from the Australian Diabetes, Obesity and Lifestyle Study","volume":"11","author":"Beyene","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/j.kint.2022.06.023_bib21","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/oby.20598","article-title":"Plasma dihydroceramide species associate with waist circumference in Mexican American families","volume":"22","author":"Mamtani","year":"2014","journal-title":"Obesity"},{"key":"10.1016\/j.kint.2022.06.023_bib22","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1210\/jc.2015-4133","article-title":"Specific metabolic profiles and their relationship to insulin resistance in recent-onset type 1 and type 2 diabetes","volume":"101","author":"Knebel","year":"2016","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"suppl 1","key":"10.1016\/j.kint.2022.06.023_bib23","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1186\/1755-8794-6-S1-S12","article-title":"Integrated lipidomics and transcriptomic analysis of peripheral blood reveals significantly enriched pathways in type 2 diabetes mellitus","volume":"6","author":"Zhao","year":"2013","journal-title":"BMC Med Genom"},{"key":"10.1016\/j.kint.2022.06.023_bib24","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.2337\/dc21-0451","article-title":"Longitudinal plasma lipidome and risk of type 2 diabetes in a large sample of American Indians with normal fasting glucose: the Strong Heart Family Study","volume":"44","author":"Miao","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2022.06.023_bib25","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2337\/dc14-2033","article-title":"Novel metabolic markers for the risk of diabetes development in American Indians","volume":"38","author":"Zhao","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2022.06.023_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074341","article-title":"Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes","volume":"8","author":"Meikle","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.06.023_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006261","article-title":"Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients","volume":"4","author":"Graessler","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.06.023_bib28","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1161\/HYPERTENSIONAHA.113.01396","article-title":"Plasma lipidomic profile signature of hypertension in Mexican American families: specific role of diacylglycerols","volume":"62","author":"Kulkarni","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2022.06.023_bib29","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.atherosclerosis.2015.05.037","article-title":"Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL","volume":"241","author":"Sutter","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.kint.2022.06.023_bib30","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1161\/ATVBAHA.111.234096","article-title":"Plasma lipidomic analysis of stable and unstable coronary artery disease","volume":"31","author":"Meikle","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2022.06.023_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.chembiol.2018.10.008","article-title":"High-throughput plasma lipidomics: detailed mapping of the associations with cardiometabolic risk factors","volume":"26","author":"Huynh","year":"2019","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.kint.2022.06.023_bib32","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1161\/01.CIR.99.18.2389","article-title":"Rising tide of cardiovascular disease in American Indians","volume":"99","author":"Howard","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2022.06.023_bib33","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/oxfordjournals.aje.a115757","article-title":"The Strong Heart Study: a study of cardiovascular disease in American Indians: design and methods","volume":"132","author":"Lee","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.kint.2022.06.023_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/aje\/kwf208","article-title":"Genetic and environmental contributions to cardiovascular disease risk in American Indians: the Strong Heart Family study","volume":"157","author":"North","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.kint.2022.06.023_bib35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0168-8227(02)00025-6","article-title":"The Australian Diabetes, Obesity and Lifestyle Study (AusDiab)--methods and response rates","volume":"57","author":"Dunstan","year":"2002","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.kint.2022.06.023_bib36","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1161\/01.CIR.94.9.2159","article-title":"Genetic and environmental contributions to cardiovascular risk factors in Mexican-Americans: the San Antonio Family Heart Study","volume":"94","author":"Mitchell","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2022.06.023_bib37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1753-4887.1999.tb01790.x","article-title":"Genetics of atherosclerosis risk factors in Mexican-Americans","volume":"57","author":"MacCluer","year":"1999","journal-title":"Nutr Rev"},{"key":"10.1016\/j.kint.2022.06.023_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00109-007-0273-3","article-title":"Genetics of variation in HOMA-IR and cardiovascular risk factors in Mexican-Americans","volume":"86","author":"Voruganti","year":"2008","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.kint.2022.06.023_bib39","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A\u00a0new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.kint.2022.06.023_bib40","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/EDE.0000000000000313","article-title":"The association of urine arsenic with prevalent and incident chronic kidney disease: evidence from the Strong Heart Study","volume":"26","author":"Zheng","year":"2015","journal-title":"Epidemiology"},{"key":"10.1016\/j.kint.2022.06.023_bib41","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/aje\/kwp151","article-title":"Defining incident chronic kidney disease in the research setting: the ARIC Study","volume":"170","author":"Bash","year":"2009","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.kint.2022.06.023_bib42","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"39","author":"Kidney Foundation","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2022.06.023_bib43","doi-asserted-by":"crossref","first-page":"e1041","DOI":"10.1210\/clinem\/dgaa054","article-title":"Mapping the associations of the plasma lipidome with insulin resistance and response to an oral glucose tolerance test","volume":"105","author":"Beyene","year":"2020","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.kint.2022.06.023_bib44","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11745-013-3781-7","article-title":"Variability in associations of phosphatidylcholine molecular species with metabolic syndrome in Mexican\u2013American families","volume":"48","author":"Kulkarni","year":"2013","journal-title":"Lipids"},{"key":"10.1016\/j.kint.2022.06.023_bib45","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1194\/jlr.P035808","article-title":"Plasma lipid profiling in a large population-based cohort [S]","volume":"54","author":"Weir","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.kint.2022.06.023_bib46","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A\u00a0direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J\u00a0R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.kint.2022.06.023_bib47","first-page":"1483","article-title":"Qualitative response models: a survey","volume":"19","author":"Amemiya","year":"1981","journal-title":"J\u00a0Econ Lit"},{"key":"10.1016\/j.kint.2022.06.023_bib48","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.kint.2022.06.023_bib49","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12918-016-0349-1","article-title":"DGCA: a comprehensive R package for differential gene correlation analysis","volume":"10","author":"McKenzie","year":"2016","journal-title":"BMC Syst Biol"},{"key":"10.1016\/j.kint.2022.06.023_bib50","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41598-021-04446-7","article-title":"A\u00a0multi-omics study of circulating phospholipid markers of blood pressure","volume":"12","author":"Liu","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.06.023_bib51","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.bbamem.2017.04.006","article-title":"The critical role of phosphatidylcholine and phosphatidylethanolamine metabolism in health and disease","volume":"1859","author":"van der Veen","year":"2017","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.kint.2022.06.023_bib52","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.2337\/db13-0993","article-title":"The concentration of phosphatidylethanolamine in mitochondria can modulate ATP production and glucose metabolism in mice","volume":"63","author":"van der Veen","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2022.06.023_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/tra.12230","article-title":"Phospholipid synthesis and transport in mammalian cells","volume":"16","author":"Vance","year":"2015","journal-title":"Traffic"},{"key":"10.1016\/j.kint.2022.06.023_bib54","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1474-9726.2011.00760.x","article-title":"Alterations in phosphatidylethanolamine levels affect the generation of A\u03b2","volume":"11","author":"Nesic","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.kint.2022.06.023_bib55","doi-asserted-by":"crossref","first-page":"E3976","DOI":"10.1073\/pnas.1411694111","article-title":"Phosphatidylethanolamine deficiency disrupts \u03b1-synuclein homeostasis in yeast and worm models of Parkinson disease","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.06.023_bib56","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14601","article-title":"The anticancer natural product ophiobolin A induces cytotoxicity by covalent modification of phosphatidylethanolamine","volume":"5","author":"Chidley","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.kint.2022.06.023_bib57","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.ircmb.2015.10.001","article-title":"Phosphatidylethanolamine metabolism in health and disease","volume":"321","author":"Calzada","year":"2016","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.kint.2022.06.023_bib58","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.bbalip.2015.12.017","article-title":"Berberine treatment attenuates the palmitate-mediated inhibition of glucose uptake and consumption through increased 1,2,3-triacyl-sn-glycerol synthesis and accumulation in H9c2 cardiomyocytes","volume":"1861","author":"Chang","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.kint.2022.06.023_bib59","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1128\/MCB.05893-11","article-title":"Reducing plasma membrane sphingomyelin increases insulin sensitivity","volume":"31","author":"Li","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.06.023_bib60","series-title":"Middleton's Allergy (Eighth Edition)","first-page":"139","article-title":"9: Lipid mediators of hypersensitivity and inflammation","author":"Peebles","year":"2014"},{"key":"10.1016\/j.kint.2022.06.023_bib61","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.3390\/molecules24244545","article-title":"The role of phosphatidylethanolamine adducts in modification of the activity of membrane proteins under oxidative stress","volume":"24","author":"Pohl","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.kint.2022.06.023_bib62","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nrneph.2009.184","article-title":"An update on the lipid nephrotoxicity hypothesis","volume":"5","author":"Ruan","year":"2009","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2022.06.023_bib63","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/nu11040722","article-title":"Lipid accumulation and chronic kidney disease","volume":"11","author":"Gai","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.kint.2022.06.023_bib64","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ekir.2016.12.003","article-title":"Profiling of plasma metabolites suggests altered mitochondrial fuel usage and remodeling of sphingolipid metabolism in individuals with type 2 diabetes and kidney disease","volume":"2","author":"Liu","year":"2017","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2022.06.023_bib65","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11306-011-0343-y","article-title":"Sphingomyelin is associated with kidney disease in type 1 diabetes (the FinnDiane Study)","volume":"8","author":"M\u00e4kinen","year":"2012","journal-title":"Metabolomics"},{"key":"10.1016\/j.kint.2022.06.023_bib66","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52916-w","article-title":"Lipidomic analysis reveals sphingomyelin and phosphatidylcholine species associated with renal impairment and all-cause mortality in type 1 diabetes","volume":"9","author":"Tofte","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.06.023_bib67","doi-asserted-by":"crossref","first-page":"794","DOI":"10.3389\/fphys.2020.00794","article-title":"The link between the mitochondrial fatty acid oxidation derangement and kidney injury","volume":"11","author":"Console","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.kint.2022.06.023_bib68","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev-physiol-021115-105045","article-title":"The biochemistry and physiology of mitochondrial fatty acid \u03b2-oxidation and its genetic disorders","volume":"78","author":"Houten","year":"2016","journal-title":"Annu Rev Physiol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822005361?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822005361?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:26:23Z","timestamp":1793503583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822005361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":68,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["S0085253822005361"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2022.06.023","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipidomic profiling in the Strong Heart Study identified American Indians at risk of chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2022.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}