{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T11:43:32Z","timestamp":1792928612575,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,21]],"date-time":"2024-02-21T00:00:00Z","timestamp":1708473600000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"ANR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.kint.2022.08.037","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T02:03:09Z","timestamp":1666749789000},"page":"627-637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["A Phase I\/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients"],"prefix":"10.1016","volume":"103","author":[{"given":"Aur\u00e9lie","family":"Moreau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Kervella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Bouchet-Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Braudeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Sa\u00efagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Gu\u00e9rif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Limou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Bercegeay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Streitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Sawitzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul N.","family":"Harden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Game","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Markmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian S.D.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward K.","family":"Geissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Dr\u00e9no","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Josien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Cristina","family":"Cuturi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Blancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Blancho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Branchereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Cantarovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Chapelet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Dantal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9ment","family":"Deltombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucile","family":"Figueres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Gaisne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Garandeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Giral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Gourraud-Vercel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryvonne","family":"Hourmant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"Karam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarisse","family":"Kerleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Kervella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Masset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Meurette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Ville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Moreau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Renaudin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florent","family":"Delbos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Walencik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Devis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2022.08.037_bib1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.kint.2018.05.018","article-title":"Analyses of the short- and long-term graft survival after kidney transplantation in Europe between 1986 and 2015","volume":"94","author":"Coemans","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.08.037_bib2","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1016\/S0140-6736(17)31283-7","article-title":"Strategies for long-term preservation of kidney graft function","volume":"389","author":"Wekerle","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2022.08.037_bib3","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/ki.2015.50","article-title":"Now or never? The case for cell-based immunosuppression in kidney transplantation","volume":"87","author":"Hutchinson","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.08.037_bib4","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00007890-199609150-00021","article-title":"Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, CD80dim, CD86-) prolong cardiac allograft survival in nonimmunosuppressed recipients","volume":"62","author":"Fu","year":"1996","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2022.08.037_bib5","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/1521-4141(200007)30:7<1813::AID-IMMU1813>3.0.CO;2-8","article-title":"Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survival in\u00a0vivo","volume":"30","author":"Lutz","year":"2000","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.kint.2022.08.037_bib6","doi-asserted-by":"crossref","first-page":"7018","DOI":"10.4049\/jimmunol.178.11.7018","article-title":"Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance","volume":"178","author":"Turnquist","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2022.08.037_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-6143.2004.00683.x","article-title":"Prolongation of heart allograft survival by immature dendritic cells generated from recipient type bone marrow progenitors","volume":"5","author":"Peche","year":"2005","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib8","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.4049\/jimmunol.1401423","article-title":"Combining autologous dendritic cell therapy with CD3 antibodies promotes regulatory T cells and permanent islet\u00a0allograft acceptance","volume":"193","author":"Baas","year":"2014","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2022.08.037_bib9","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1111\/ajt.12708","article-title":"Autologous dendritic cells prolong allograft survival through Tmem176b-dependent antigen cross-presentation","volume":"14","author":"Segovia","year":"2014","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib10","doi-asserted-by":"crossref","first-page":"14028","DOI":"10.1038\/mtm.2014.28","article-title":"Generation and in\u00a0vivo evaluation of IL10-treated dendritic cells in a nonhuman primate model of AAV-based gene transfer","volume":"1","author":"Moreau","year":"2014","journal-title":"Mol Ther Methods Clin Dev"},{"key":"10.1016\/j.kint.2022.08.037_bib11","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1111\/ajt.14182","article-title":"Renal allograft survival in nonhuman primates infused with donor antigen-pulsed autologous regulatory dendritic cells","volume":"17","author":"Ezzelarab","year":"2017","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib12","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1111\/ajt.12310","article-title":"Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates","volume":"13","author":"Ezzelarab","year":"2013","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib13","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1136\/annrheumdis-2015-208456","article-title":"Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis","volume":"76","author":"Bell","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.kint.2022.08.037_bib14","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa9301","article-title":"Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients","volume":"7","author":"Benham","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.kint.2022.08.037_bib15","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.2337\/dc11-0472","article-title":"Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients","volume":"34","author":"Giannoukakis","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2022.08.037_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/ecco-jcc\/jjv144","article-title":"Intraperitoneal administration of autologous tolerogenic dendritic cells for refractory Crohn's disease: a phase I study","volume":"9","author":"Jauregui-Amezaga","year":"2015","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.kint.2022.08.037_bib17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/S2213-8587(20)30104-2","article-title":"Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes","volume":"8","author":"Nikolic","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"10.1016\/j.kint.2022.08.037_bib18","doi-asserted-by":"crossref","first-page":"8463","DOI":"10.1073\/pnas.1820039116","article-title":"Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial","volume":"116","author":"Zubizarreta","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.08.037_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fimmu.2018.00274","article-title":"Tolerogenic dendritic cells in solid organ transplantation: where do we stand?","volume":"9","author":"Marin","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2022.08.037_bib20","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1096\/fj.08-128173","article-title":"Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates","volume":"23","author":"Moreau","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2022.08.037_bib21","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.cmet.2019.11.011","article-title":"Human tolerogenic dendritic cells regulate immune responses through lactate synthesis","volume":"30","author":"Marin","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2022.08.037_bib22","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1097\/TP.0000000000003315","article-title":"Preclinical assessment of autologous tolerogenic dendritic cells from end-stage renal disease patients","volume":"105","author":"Bouchet-Delbos","year":"2021","journal-title":"Transplantation"},{"key":"10.1016\/j.kint.2022.08.037_bib23","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(20)30167-7","article-title":"Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1\/2A trials","volume":"395","author":"Sawitzki","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2022.08.037_bib24","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1093\/clinchem\/48.9.1589","article-title":"Analytical requirements for measuring monocytic human lymphocyte antigen DR by flow cytometry: application to the monitoring of patients with septic shock","volume":"48","author":"Monneret","year":"2002","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2022.08.037_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2047-1440-2-17","article-title":"Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study","volume":"2","author":"Streitz","year":"2013","journal-title":"Transplant Res"},{"key":"10.1016\/j.kint.2022.08.037_bib26","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/cyto.a.22855","article-title":"Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol","volume":"89","author":"Kverneland","year":"2016","journal-title":"Cytometry A"},{"key":"10.1016\/j.kint.2022.08.037_bib27","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1111\/j.1600-6143.2008.02377.x","article-title":"The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation","volume":"8","author":"Bluestone","year":"2008","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib28","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1600-6143.2009.02581.x","article-title":"Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring","volume":"9","author":"Knechtle","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/j.1600-6143.2008.02492.x","article-title":"Two hundred living donor kidney transplantations under alemtuzumab induction and tacrolimus monotherapy: 3-year follow-up","volume":"9","author":"Tan","year":"2009","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib30","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1111\/ajt.16395","article-title":"Feasibility, long-term safety, and immune monitoring of regulatory T cell therapy in living donor kidney transplant recipients","volume":"21","author":"Harden","year":"2021","journal-title":"Am J Transplant"},{"key":"10.1016\/j.kint.2022.08.037_bib31","doi-asserted-by":"crossref","first-page":"m3734","DOI":"10.1136\/bmj.m3734","article-title":"Regulatory T cells for minimising immune suppression in kidney transplantation: phase I\/IIa clinical trial","volume":"371","author":"Roemhild","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.kint.2022.08.037_bib32","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1111\/ajt.16393","article-title":"Donor-derived regulatory dendritic cell infusion results in host cell cross-dressing and T cell subset changes in prospective living donor liver transplant recipients","volume":"21","author":"Macedo","year":"2021","journal-title":"Am J Transplant"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822008456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822008456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:06:05Z","timestamp":1758762365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822008456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0085253822008456"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2022.08.037","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742386784.793598765","asserted-by":"object"}]},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Phase I\/IIa study of autologous tolerogenic dendritic cells immunotherapy in kidney transplant recipients","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2022.08.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}