{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T08:19:28Z","timestamp":1793521168985,"version":"4.5.0"},"reference-count":68,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,22]],"date-time":"2022-12-22T00:00:00Z","timestamp":1671667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.kint.2022.11.023","type":"journal-article","created":{"date-parts":[[2022,12,21]],"date-time":"2022-12-21T20:16:02Z","timestamp":1671653762000},"page":"686-701","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury"],"prefix":"10.1016","volume":"103","author":[{"given":"Leticia","family":"Cuarental","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Ribagorda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria I.","family":"Ceballos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranzazu","family":"Pintor-Chocano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol M.","family":"Carriazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Dopazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Suarez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cannata-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0255-5689","authenticated-orcid":false,"given":"Ana B.","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-9523","authenticated-orcid":false,"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria D.","family":"Sanchez-Ni\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2022.11.023_bib1","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2022.11.023_bib2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2022.11.023_bib3","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Wang","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2022.11.023_bib4","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1093\/ckj\/sfab071","article-title":"Acute kidney injury in COVID-19: multicentre prospective analysis of registry data","volume":"14","author":"Wan","year":"2021","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.kint.2022.11.023_bib5","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2022.11.023_bib6","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1681\/ASN.2010101073","article-title":"The inflammatory cytokines TWEAK and TNF\u03b1 reduce renal klotho expression through NF\u03baB","volume":"22","author":"Moreno","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"suppl 1","key":"10.1016\/j.kint.2022.11.023_bib7","doi-asserted-by":"crossref","first-page":"i54","DOI":"10.1093\/ndt\/gft342","article-title":"TWEAK and the progression of renal disease: clinical translation","volume":"29","author":"Sanz","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.11.023_bib8","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1681\/ASN.2021030383","article-title":"Bone marrow-derived RIPK3 mediates kidney inflammation in acute kidney injury","volume":"33","author":"Martin-Sanchez","year":"2022","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.11.023_bib9","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1073\/pnas.1716578115","article-title":"TWEAK and RIPK1 mediate a second wave of cell death during AKI","volume":"115","author":"Martin-Sanchez","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.11.023_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1681\/ASN.2009121311","article-title":"Klotho deficiency causes vascular calcification in chronic kidney disease","volume":"22","author":"Hu","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.11.023_bib11","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.cell.2017.10.025","article-title":"In\u00a0vivo target gene activation via CRISPR\/Cas9-mediated trans-epigenetic modulation","volume":"171","author":"Liao","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.kint.2022.11.023_bib12","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.kint.2016.10.034","article-title":"Recombinant \u03b1-Klotho may be prophylactic and therapeutic for acute to chronic kidney disease progression and uremic cardiomyopathy","volume":"91","author":"Hu","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib13","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/ki.2010.328","article-title":"Klotho deficiency is an early biomarker of renal ischemia-reperfusion injury and its replacement is protective","volume":"78","author":"Hu","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib14","first-page":"921","article-title":"Fos family members: regulation, structure and role in oncogenic transformation","volume":"15","author":"Tulchinsky","year":"2000","journal-title":"Histol Histopathol"},{"key":"10.1016\/j.kint.2022.11.023_bib15","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3389\/fmicb.2017.02686","article-title":"Hijacking of the AP-1 signaling pathway during development of ATL","volume":"8","author":"Gazon","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.kint.2022.11.023_bib16","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1038\/sj.onc.1204383","article-title":"AP-1 in cell proliferation and survival","volume":"20","author":"Shaulian","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2022.11.023_bib17","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1038\/sj.onc.1204381","article-title":"The mammalian Jun proteins: redundancy and specificity","volume":"20","author":"Mechta-Grigoriou","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2022.11.023_bib18","first-page":"7429","article-title":"Transformation by Fos proteins requires a C-terminal transactivation domain","volume":"13","author":"Wisdon","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.11.023_bib19","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1038\/s41388-020-1306-4","article-title":"The nuclear oncoprotein Fra-1: a transcription factor knocking on therapeutic applications\u2019 door","volume":"39","author":"Talotta","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2022.11.023_bib20","doi-asserted-by":"crossref","first-page":"4801","DOI":"10.1128\/MCB.05780-11","article-title":"FOSL1 is integral to establishing the maternal-fetal interface","volume":"31","author":"Kent","year":"2011","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.11.023_bib21","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1128\/MCB.01054-12","article-title":"FOSL1 controls the assembly of endothelial cells into capillary tubes by direct repression of \u03b1v and \u03b23 integrin transcription","volume":"33","author":"Evellin","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.11.023_bib22","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/cdd.2014.157","article-title":"Fra-1\/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1\/2 and TGF\u03b2 expression","volume":"22","author":"Bakiri","year":"2015","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.kint.2022.11.023_bib23","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/sj.onc.1208312","article-title":"FRA-1 expression level regulates proliferation and invasiveness of breast cancer cells","volume":"24","author":"Belguise","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2022.11.023_bib24","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.jtv.2021.08.006","article-title":"MiR-15a-5p targets FOSL1 to inhibit proliferation and promote apoptosis of keratinocytes via MAPK\/ERK pathway","volume":"30","author":"Meng","year":"2021","journal-title":"J\u00a0Tissue Viability"},{"key":"10.1016\/j.kint.2022.11.023_bib25","doi-asserted-by":"crossref","first-page":"14677","DOI":"10.1038\/s41598-021-94072-0","article-title":"The role of FOSL1 in stem-like cell reprogramming processes","volume":"11","author":"Pecce","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.11.023_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.scr.2017.12.004","article-title":"Fosl1 overexpression directly activates trophoblast-specific gene expression programs in embryonic stem cells","volume":"26","author":"Lee","year":"2018","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.kint.2022.11.023_bib27","article-title":"All for one and FOSL1 for all: FOSL1 at the crossroads of lung and pancreatic cancer driven by mutant KRAS","volume":"4","author":"Vallejo","year":"2017","journal-title":"Mol Cell Oncol"},{"key":"10.1016\/j.kint.2022.11.023_bib28","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s11033-019-05123-9","article-title":"Expression and function of FRA1 protein in tumors","volume":"47","author":"Jiang","year":"2020","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.kint.2022.11.023_bib29","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.3389\/fimmu.2017.01793","article-title":"The Fos-related antigen 1-JUNB\/activator protein 1 transcription complex, a downstream target of signal transducer and activator of transcription 3, induces T helper 17 differentiation and promotes experimental autoimmune arthritis","volume":"8","author":"Moon","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2022.11.023_bib30","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1172\/JCI96832","article-title":"Transcription factor Fra-1 targets arginase-1 to enhance macrophage-mediated inflammation in arthritis","volume":"129","author":"Hannemann","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2022.11.023_bib31","doi-asserted-by":"crossref","first-page":"701675","DOI":"10.3389\/fimmu.2021.701675","article-title":"The transcription factor FRA-1\/AP-1 controls lipocalin-2 expression and inflammation in sepsis model","volume":"12","author":"Cao","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2022.11.023_bib32","first-page":"158","article-title":"Differential expression of c-jun, c-fos and hsp 70 mRNAs after folic acid and ischemia-reperfusion injury: effect of antioxidant treatment","volume":"2","author":"Bardella","year":"1994","journal-title":"Exp Nephrol"},{"key":"10.1016\/j.kint.2022.11.023_bib33","doi-asserted-by":"crossref","first-page":"8389","DOI":"10.1016\/S0021-9258(18)83194-5","article-title":"Sequential protooncogene expression in regenerating kidney following acute renal injury","volume":"264","author":"Cowley","year":"1989","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2022.11.023_bib34","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1038\/sj.emboj.7600282","article-title":"The Fos-related antigen Fra-1 is an activator of bone matrix formation","volume":"23","author":"Eferl","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.kint.2022.11.023_bib35","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ki.2012.224","article-title":"Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia","volume":"82","author":"Park","year":"2012","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmet.2011.03.001","article-title":"AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure","volume":"13","author":"Gurley","year":"2011","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2022.11.023_bib37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ndt\/gfz169","article-title":"Loss of NLRP6 expression increases the severity of acute kidney injury","volume":"35","author":"Vali\u00f1o-Rivas","year":"2020","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.11.023_bib38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1681\/ASN.2015080898","article-title":"Mitogen-activated protein kinase 14 promotes AKI","volume":"28","author":"Ortiz","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2022.11.023_bib39","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/ndt\/gfy367","article-title":"MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells","volume":"34","author":"Vali\u00f1o-Rivas","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2022.11.023_bib40","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/08860229009087124","article-title":"Folate nephropathy occurring during cytotoxic chemotherapy with high-dose folinic acid and 5-fluorouracil","volume":"12","author":"Metz-Kurschel","year":"1990","journal-title":"Ren Fail"},{"key":"10.1016\/j.kint.2022.11.023_bib41","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.kint.2022.02.028","article-title":"Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis","volume":"101","author":"Vali\u00f1o-Rivas","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib42","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.kint.2022.11.023_bib43","doi-asserted-by":"crossref","first-page":"W212","DOI":"10.1093\/nar\/gkz446","article-title":"ChEA3: transcription factor enrichment analysis by orthogonal omics integration","volume":"47","author":"Keenan","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2022.11.023_bib44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.kint.2022.11.023_bib45","unstructured":"Bhuva D, Smyth G, Garnham A. msigdb: An Experiment Hub Package for the Molecular Signatures Database (MSigDB). R package version 1.2.0, 2021. https:\/\/bioconductor.org\/packages\/release\/data\/experiment\/manuals\/msigdb\/man\/msigdb.pdf"},{"key":"10.1016\/j.kint.2022.11.023_bib46","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1083\/jcb.107.4.1359","article-title":"Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis","volume":"107","author":"Haverty","year":"1988","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.kint.2022.11.023_bib47","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1038\/sj.ki.5001866","article-title":"Cytokine cooperation in\u00a0renal tubular cell injury: the role of TWEAK","volume":"70","author":"Justo","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010192","article-title":"Epigenetic mechanisms regulate MHC and antigen processing molecules in human embryonic and induced pluripotent stem cells","volume":"5","author":"Su\u00e1rez-\u00c1lvarez","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2022.11.023_bib49","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ki.2015.332","article-title":"The inflammatory cytokine TWEAK decreases PGC-1\u03b1 expression and mitochondrial function in acute kidney injury","volume":"89","author":"Ruiz-Andres","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2022.11.023_bib50","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/MCB.22.2.587-598.2002","article-title":"Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently","volume":"22","author":"Young","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2022.11.023_bib51","doi-asserted-by":"crossref","first-page":"e352","DOI":"10.1038\/emm.2017.89","article-title":"Bcl3: a regulator of NF-\u03baB inducible by TWEAK in acute kidney injury with anti-inflammatory and antiapoptotic properties in tubular cells","volume":"49","author":"Poveda","year":"2017","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.kint.2022.11.023_bib52","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbadis.2016.01.006","article-title":"NF\u03baBiz protein downregulation in acute kidney injury: modulation of inflammation and survival in tubular cells","volume":"1862","author":"Poveda","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.kint.2022.11.023_bib53","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/79676","article-title":"Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1","volume":"6","author":"Jochum","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2022.11.023_bib54","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.3390\/ijms22168603","article-title":"Analysis of PPAR\u03b3 signaling activity in psoriasis","volume":"22","author":"Sobolev","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2022.11.023_bib55","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s10517-011-1208-0","article-title":"Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process","volume":"150","author":"Sobolev","year":"2011","journal-title":"Bull Exp Biol Med"},{"key":"10.1016\/j.kint.2022.11.023_bib56","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1242\/jcs.079855","article-title":"Elevated Fra-1 expression causes severe lipodystrophy","volume":"124","author":"Luther","year":"2011","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.kint.2022.11.023_bib57","doi-asserted-by":"crossref","first-page":"13143","DOI":"10.1038\/s41598-020-69735-z","article-title":"FOSL1 is a novel mediator of endotoxin\/lipopolysaccharide-induced pulmonary angiogenic signaling","volume":"10","author":"Nitkin","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2022.11.023_bib58","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2302\/kjm.2011-0009-OA","article-title":"Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease","volume":"61","author":"Takada","year":"2012","journal-title":"Keio J Med"},{"key":"10.1016\/j.kint.2022.11.023_bib59","unstructured":"Wellcome Sanger Institute. Cancer Dependency Map. Accessed August 2022. https:\/\/score.depmap.sanger.ac.uk"},{"key":"10.1016\/j.kint.2022.11.023_bib60","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2369-13-153","article-title":"The effects of a selective inhibitor of c-Fos\/activator protein-1 on endotoxin-induced acute kidney injury in mice","volume":"13","author":"Miyazaki","year":"2012","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.kint.2022.11.023_bib61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40560-015-0115-2","article-title":"T-5224, a selective inhibitor of c-Fos\/activator protein-1, improves survival by inhibiting serum high mobility group box-1 in lethal lipopolysaccharide-induced acute kidney injury model","volume":"3","author":"Ishida","year":"2015","journal-title":"J\u00a0Intensive Care"},{"key":"10.1016\/j.kint.2022.11.023_bib62","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1053\/j.gastro.2009.12.002","article-title":"Tumor necrosis factor and interferon-gamma down-regulate Klotho in mice with colitis","volume":"138","author":"Thurston","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.kint.2022.11.023_bib63","doi-asserted-by":"crossref","first-page":"560","DOI":"10.3389\/fendo.2020.00560","article-title":"Klotho, aging, and the failing kidney","volume":"11","author":"Buchanan","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.kint.2022.11.023_bib64","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1101\/gad.7.3.479","article-title":"JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers","volume":"7","author":"Deng","year":"1993","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2022.11.023_bib65","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1016\/j.yexcr.2013.04.010","article-title":"IL-4 inhibition of IL-1 induced matrix metalloproteinase-3 (MMP-3) expression in human fibroblasts involves decreased AP-1 activation via negative crosstalk involving of Jun N-terminal kinase (JNK)","volume":"319","author":"Chambers","year":"2013","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.kint.2022.11.023_bib66","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1038\/s41467-020-17205-5","article-title":"Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury","volume":"11","author":"Wilflingseder","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2022.11.023_bib67","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2022.11.023_bib68","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4049\/jimmunol.0901196","article-title":"Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB","volume":"184","author":"Takada","year":"2010","journal-title":"J\u00a0Immunol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822010870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253822010870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:04:33Z","timestamp":1758762273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253822010870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":68,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0085253822010870"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2022.11.023","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2022.11.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier, Inc., on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}