{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:09:33Z","timestamp":1787314173692,"version":"build-2736575974"},"reference-count":17,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007464","name":"Torsten S\u00f6derbergs Stiftelse","doi-asserted-by":"publisher","award":["M64\/21"],"award-info":[{"award-number":["M64\/21"]}],"id":[{"id":"10.13039\/100007464","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["311-8.03.03.02-147635"],"award-info":[{"award-number":["311-8.03.03.02-147635"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007952","name":"Eva Luise und Horst K\u00f6hler Stiftung","doi-asserted-by":"publisher","award":["2019_KollegSE.04"],"award-info":[{"award-number":["2019_KollegSE.04"]}],"id":[{"id":"10.13039\/501100007952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["BMBF01GM1901E"],"award-info":[{"award-number":["BMBF01GM1901E"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ZX1917B"],"award-info":[{"award-number":["01ZX1917B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.kint.2023.03.013","type":"journal-article","created":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T11:30:34Z","timestamp":1679916634000},"page":"1120-1130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Deep learning\u2013based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies"],"prefix":"10.1016","volume":"103","author":[{"given":"David","family":"Unnersj\u00f6-Jess","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linus","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"H\u00f6hne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"German","family":"Sergei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash","family":"Fatehi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Witasp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Wernerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Patrakka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Hoyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schermer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Bozek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Benzing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2023.03.013_bib1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMra1808786","article-title":"Insights into glomerular filtration and albuminuria","volume":"384","author":"Benzing","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2023.03.013_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.94137","article-title":"Injury-induced actin cytoskeleton reorganization in podocytes revealed by super-resolution microscopy","volume":"2","author":"Suleiman","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2023.03.013_bib3","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ki.2015.308","article-title":"Super-resolution stimulated emission depletion imaging of slit diaphragm proteins in optically cleared kidney tissue","volume":"89","author":"Unnersj\u00f6-Jess","year":"2016","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.03.013_bib4","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.kint.2020.10.039","article-title":"A fast and simple clearing and swelling protocol for 3D in-situ imaging of the kidney across scales","volume":"99","author":"Unnersj\u00f6-Jess","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.03.013_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fmed.2019.00037","article-title":"New views of the glomerulus: advanced microscopy for advanced diagnosis","volume":"6","author":"Pullman","year":"2019","journal-title":"Front Med"},{"key":"10.1016\/j.kint.2023.03.013_bib6","doi-asserted-by":"crossref","first-page":"11473","DOI":"10.1038\/s41598-017-11553-x","article-title":"Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement","volume":"7","author":"Siegerist","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2023.03.013_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s42255-020-0204-y","article-title":"A molecular mechanism explaining albuminuria in kidney disease","volume":"2","author":"Butt","year":"2020","journal-title":"Nat Metab"},{"key":"10.1016\/j.kint.2023.03.013_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1681\/ASN.2020050597","article-title":"Deep learning\u2013based segmentation and quantification in experimental kidney histopathology","volume":"32","author":"Bouteldja","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.03.013_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.kint.2020.07.044","article-title":"Development and evaluation of deep learning\u2013based segmentation of histologic structures in the kidney cortex with multiple histologic stains","volume":"99","author":"Jayapandian","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.03.013_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.144779","article-title":"Deep learning-based molecular morphometrics for kidney biopsies","volume":"6","author":"Zimmermann","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2023.03.013_bib17","doi-asserted-by":"crossref","unstructured":"Ronneberger O, Fischer P, Brox T. U-Net: convolutional networks for biomedical image segmentation. In: Navab N, Hornegger J, Wells W, Frangi A, eds. Medical Image Computing and Computer-Assisted Intervention \u2013 MICCAI 2015. Lecture Notes in Computer Science. 2015;9351. Springer, Cham. https:\/\/doi.org\/10.1007\/978-3-319-24574-4_28","DOI":"10.1007\/978-3-319-24574-4_28"},{"key":"10.1016\/j.kint.2023.03.013_bib14","author":"De Brabandere"},{"key":"10.1016\/j.kint.2023.03.013_bib16","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-40450-4_41","article-title":"BIRCH meets coresets for k-means clustering","author":"Fichtenberger","year":"2013"},{"key":"10.1016\/j.kint.2023.03.013_bib15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.34067\/KID.0005882021","article-title":"Three-dimensional super-resolved imaging of paraffin-embedded kidney samples","volume":"3","author":"Unnersj\u00f6-Jess","year":"2021","journal-title":"Kidney360"},{"key":"10.1016\/j.kint.2023.03.013_bib11","author":"McInnes"},{"key":"10.1016\/j.kint.2023.03.013_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1681\/ASN.2020060858","article-title":"Super-resolution imaging of the filtration barrier suggests a role for podocin R229Q in genetic predisposition to glomerular disease","volume":"33","author":"Butt","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.03.013_bib13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1681\/ASN.2017030270","article-title":"Opposing roles of dendritic cell subsets in experimental GN","volume":"29","author":"Br\u00e4hler","year":"2018","journal-title":"J Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823001801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823001801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:55:02Z","timestamp":1777474502000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253823001801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S0085253823001801"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2023.03.013","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deep learning\u2013based segmentation and quantification of podocyte foot process morphology suggests differential patterns of foot process effacement across kidney pathologies","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2023.03.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}