{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:23:21Z","timestamp":1791411801124,"version":"4.3.3"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","award":["NCT01858532"],"award-info":[{"award-number":["NCT01858532"]}],"id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003803","name":"University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001547","name":"China Medical Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.kint.2023.08.014","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:40:35Z","timestamp":1693442435000},"page":"1219-1226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Post hoc analysis of the SONAR trial indicates that the endothelin receptor antagonist atrasentan is associated with less pain in patients with type 2 diabetes and chronic kidney disease"],"prefix":"10.1016","volume":"104","author":[{"given":"Kam Wa","family":"Chan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. David","family":"Smeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-3143","authenticated-orcid":false,"given":"Meir","family":"Schechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Jongs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Vart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald E.","family":"Kohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron T.","family":"Gansevoort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Liew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6862-1941","authenticated-orcid":false,"given":"Sydney C.W.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-5301","authenticated-orcid":false,"given":"Christoph","family":"Wanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"de Zeeuw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3126-3730","authenticated-orcid":false,"given":"Hiddo J.L.","family":"Heerspink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2023.08.014_bib1","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2337\/dc11-1108","article-title":"Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K","volume":"34","author":"Abbott","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2023.08.014_bib2","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/j.pain.0000000000001744","article-title":"Diabetic polyneuropathy and pain, prevalence, and patient characteristics: a cross-sectional questionnaire study of 5,514 patients with recently diagnosed type 2 diabetes","volume":"161","author":"Gylfadottir","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.kint.2023.08.014_bib3","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.2337\/dc05-2228","article-title":"The prevalence, severity, and impact of painful diabetic peripheral neuropathy in type 2 diabetes","volume":"29","author":"Davies","year":"2006","journal-title":"Diabetes Care"},{"key":"10.1016\/j.kint.2023.08.014_bib4","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/j.1464-5491.2010.02971.x","article-title":"Prevalence of pain and association with quality of life, depression and glycaemic control in patients with diabetes","volume":"27","author":"Bair","year":"2010","journal-title":"Diabet Med"},{"key":"10.1016\/j.kint.2023.08.014_bib5","doi-asserted-by":"crossref","first-page":"917","DOI":"10.2215\/CJN.05180418","article-title":"Clinical pharmacology considerations in pain management in patients with advanced kidney failure","volume":"14","author":"Davison","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.08.014_bib6","first-page":"231","article-title":"Advances in understanding nociception and neuropathic pain","volume":"265","author":"St John Smith","year":"2018","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.kint.2023.08.014_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204054","article-title":"A\u00a0comparison of chronic pain with and without neuropathic characteristics in a Hong Kong Chinese population: an analysis of pain related outcomes and patient help seeking behaviour","volume":"13","author":"Wong","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2023.08.014_bib8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.kint.2021.03.041","article-title":"The prevalence of pain among patients with chronic kidney disease using systematic review and meta-analysis","volume":"100","author":"Lambourg","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.08.014_bib9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.2215\/CJN.00820207","article-title":"Pain, sleep disturbance, and quality of life in patients with chronic kidney disease","volume":"2","author":"Cohen","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.08.014_bib10","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1053\/j.ajkd.2004.12.021","article-title":"Quality of life in chronic kidney disease (CKD): a cross-sectional analysis in the Renal Research Institute-CKD study","volume":"45","author":"Perlman","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2023.08.014_bib11","doi-asserted-by":"crossref","first-page":"e241","DOI":"10.1111\/j.1464-5491.2012.03689.x","article-title":"Health-related quality of life and glycaemic control in patients with type 2 diabetes mellitus in Singapore","volume":"29","author":"Shim","year":"2012","journal-title":"Diabet Med"},{"key":"10.1016\/j.kint.2023.08.014_bib12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/HYPERTENSIONAHA.114.05105","article-title":"Use of nonsteroidal anti-inflammatory drugs and risk of chronic kidney disease in subjects with hypertension: nationwide longitudinal cohort study","volume":"66","author":"Hsu","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2023.08.014_bib13","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s40266-020-00824-4","article-title":"Short-course systemic and topical non-steroidal anti-inflammatory drugs: impact on adverse renal events in older adults with co-morbid disease","volume":"38","author":"Lim","year":"2021","journal-title":"Drugs Aging"},{"key":"10.1016\/j.kint.2023.08.014_bib14","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s40122-020-00233-w","article-title":"Burden of renal events associated with nonsteroidal anti-inflammatory drugs in patients with osteoarthritis and chronic low back pain: a retrospective database study","volume":"10","author":"Katsuno","year":"2021","journal-title":"Pain Ther"},{"key":"10.1016\/j.kint.2023.08.014_bib15","doi-asserted-by":"crossref","first-page":"21730","DOI":"10.18632\/aging.103978","article-title":"Frailty modifies the association between opioid use and mortality in chronic kidney disease patients with diabetes: a population-based cohort study","volume":"12","author":"Lee","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.kint.2023.08.014_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A\u00a0novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.kint.2023.08.014_bib17","first-page":"531","article-title":"Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain","volume":"7","author":"Smith","year":"2014","journal-title":"J\u00a0Pain Res"},{"key":"10.1016\/j.kint.2023.08.014_bib18","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/HYPERTENSIONAHA.119.12105","article-title":"Endothelin: 30 years from discovery to therapy","volume":"74","author":"Barton","year":"2019","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2023.08.014_bib19","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1523\/JNEUROSCI.21-03-00999.2001","article-title":"Expression and localization of endothelin receptors: implications for the involvement of peripheral glia in nociception","volume":"21","author":"Pomonis","year":"2001","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.kint.2023.08.014_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.npep.2007.12.001","article-title":"Endothelin-1-induced pain and hyperalgesia: a review of pathophysiology, clinical manifestations and future therapeutic options","volume":"42","author":"Hans","year":"2008","journal-title":"Neuropeptides"},{"key":"10.1016\/j.kint.2023.08.014_bib21","first-page":"4","article-title":"Endothelin receptors and pain","volume":"10","author":"Khodorova","year":"2009","journal-title":"J\u00a0Pain"},{"key":"10.1016\/j.kint.2023.08.014_bib22","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1681\/ASN.2013080830","article-title":"The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy","volume":"25","author":"de Zeeuw","year":"2014","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.08.014_bib23","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1681\/ASN.2008050482","article-title":"Avosentan reduces albumin excretion in diabetics with macroalbuminuria","volume":"20","author":"Wenzel","year":"2009","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.08.014_bib24","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/S0140-6736(23)00569-X","article-title":"Sparsentan in patients with IgA nephropathy: a prespecified interim analysis from a randomised, double-blind, active-controlled clinical trial","volume":"401","author":"Heerspink","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2023.08.014_bib25","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0140-6736(19)30772-X","article-title":"Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial","volume":"393","author":"Heerspink","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2023.08.014_bib26","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/dom.13245","article-title":"Rationale and protocol of the Study Of diabetic Nephropathy with AtRasentan (SONAR) trial: a clinical trial design novel to diabetic nephropathy","volume":"20","author":"Heerspink","year":"2018","journal-title":"Diabetes Obes Metab"},{"issue":"suppl 1","key":"10.1016\/j.kint.2023.08.014_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40266-019-00661-0","article-title":"Safety of topical non-steroidal anti-inflammatory drugs in osteoarthritis: outcomes of a systematic review and meta-analysis","volume":"36","author":"Honvo","year":"2019","journal-title":"Drugs Aging"},{"key":"10.1016\/j.kint.2023.08.014_bib28","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/ije\/dyu222","article-title":"Modelling recurrent events: a tutorial for analysis in epidemiology","volume":"44","author":"Amorim","year":"2015","journal-title":"Int J Epidemiol"},{"key":"10.1016\/j.kint.2023.08.014_bib29","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","article-title":"A\u00a0proportional hazards model for the subdistribution of a competing risk","volume":"94","author":"Fine","year":"1999","journal-title":"J\u00a0Am Stat Assoc"},{"key":"10.1016\/j.kint.2023.08.014_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.2215\/CJN.13101019","article-title":"Identifying outcomes important to patients with glomerular disease and their caregivers","volume":"15","author":"Carter","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.08.014_bib31","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1097\/00004872-199009000-00004","article-title":"Regional haemodynamic effects of endothelin-1 in rat and man: unexpected adverse reaction","volume":"8","author":"Dahl\u00f6f","year":"1990","journal-title":"J\u00a0Hypertens"},{"key":"10.1016\/j.kint.2023.08.014_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.pain.2007.08.008","article-title":"Endothelin 1 activates and sensitizes human C-nociceptors","volume":"137","author":"Namer","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.kint.2023.08.014_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0304-3959(98)00098-0","article-title":"Articular nociception induced by endothelin-1, carrageenan and LPS in naive and previously inflamed knee-joints in the rat: inhibition by endothelin receptor antagonists","volume":"77","author":"De-Melo","year":"1998","journal-title":"Pain"},{"issue":"suppl 1","key":"10.1016\/j.kint.2023.08.014_bib34","doi-asserted-by":"crossref","first-page":"S518","DOI":"10.1097\/00005344-199800001-00149","article-title":"Effects of endothelin-1 on inflammatory incapacitation of the rat knee joint","volume":"31","author":"De-Melo","year":"1998","journal-title":"J\u00a0Cardiovasc Pharmacol"},{"key":"10.1016\/j.kint.2023.08.014_bib35","first-page":"250","article-title":"Endothelin-1 serum levels in women with rheumatoid arthritis","volume":"44","author":"Alvarez-Cienfuegos","year":"2019","journal-title":"Acta Reumatol Port"},{"key":"10.1016\/j.kint.2023.08.014_bib36","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.bjp.0705663","article-title":"Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice","volume":"141","author":"Piovezan","year":"2004","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.kint.2023.08.014_bib37","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.expneurol.2006.04.034","article-title":"Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes","volume":"201","author":"Berti-Mattera","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.kint.2023.08.014_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1530\/EJE-19-0523","article-title":"Endothelin-1 predicts incident diabetic peripheral neuropathy in type 2 diabetes: a cohort study","volume":"182","author":"Pek","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.kint.2023.08.014_bib39","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.18169","article-title":"Clinical characteristics of and risk factors for chronic kidney disease among adults and children: an analysis of the CURE-CKD registry","volume":"2","author":"Tuttle","year":"2019","journal-title":"JAMA Netw Open"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823006105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823006105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T05:34:08Z","timestamp":1715146448000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253823006105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["S0085253823006105"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2023.08.014","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post hoc analysis of the SONAR trial indicates that the endothelin receptor antagonist atrasentan is associated with less pain in patients with type 2 diabetes and chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2023.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}