{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:49:13Z","timestamp":1785894553766,"version":"3.56.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.kint.2023.09.033","type":"journal-article","created":{"date-parts":[[2023,10,31]],"date-time":"2023-10-31T22:31:07Z","timestamp":1698791467000},"page":"338-346","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Unveiling a new era with liquid chromatography coupled with mass spectrometry to enhance parathyroid hormone measurement in patients with chronic kidney disease"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0947-2226","authenticated-orcid":false,"given":"Etienne","family":"Cavalier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Farr\u00e9-Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Lukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Sophie","family":"Gendebien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Massonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Goff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Bouquegneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Delatour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1480-5761","authenticated-orcid":false,"given":"Pierre","family":"Delanaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2023.09.033_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","article-title":"KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD)","volume":"7","year":"2017","journal-title":"Kidney Int Suppl (2011)"},{"key":"10.1016\/j.kint.2023.09.033_bib2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cca.2020.12.022","article-title":"The path to the standardization of PTH: is this a realistic possibility? A position paper of the IFCC C-BM","volume":"515","author":"Cavalier","year":"2021","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.kint.2023.09.033_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cca.2016.10.016","article-title":"Perspective and priorities for improvement of parathyroid hormone (PTH) measurement\u2014a view from the IFCC Working Group for PTH","volume":"467","author":"Sturgeon","year":"2017","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.kint.2023.09.033_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.ki.5001606","article-title":"Inter-method variability in PTH measurement: implication for the care of CKD patients","volume":"70","author":"Souberbielle","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.09.033_bib5","doi-asserted-by":"crossref","first-page":"13141","DOI":"10.1016\/S0021-9258(18)98816-2","article-title":"Mutational analysis of the receptor-activating region of human parathyroid hormone","volume":"266","author":"Gardella","year":"1991","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2023.09.033_bib6","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1172\/JCI110053","article-title":"Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes","volume":"67","author":"Segre","year":"1981","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2023.09.033_bib7","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1210\/jcem-63-5-1075","article-title":"Calcium-dependent release of carboxyl-terminal fragments of parathyroid hormone by hyperplastic human parathyroid tissue in\u00a0vitro","volume":"63","author":"Hanley","year":"1986","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.kint.2023.09.033_bib8","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1210\/endo-104-6-1778","article-title":"Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood","volume":"104","author":"Mayer","year":"1979","journal-title":"Endocrinology"},{"key":"10.1016\/j.kint.2023.09.033_bib9","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/eje.0.1490301","article-title":"Large carboxy-terminal parathyroid hormone (PTH) fragment with a relatively longer half-life than 1-84 PTH is secreted directly from the parathyroid gland in humans","volume":"149","author":"Yamashita","year":"2003","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.kint.2023.09.033_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s00268-004-7489-y","article-title":"Sequential changes in plasma intact and whole parathyroid hormone levels during parathyroidectomy for secondary hyperparathyroidism","volume":"29","author":"Yamashita","year":"2005","journal-title":"World J Surg"},{"key":"10.1016\/j.kint.2023.09.033_bib11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1210\/endo-117-1-127","article-title":"Metabolism of radioiodinated carboxy-terminal fragments of bovine parathyroid hormone in normal and anephric rats","volume":"117","author":"D\u2019amour","year":"1985","journal-title":"Endocrinology"},{"issue":"suppl 102","key":"10.1016\/j.kint.2023.09.033_bib12","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1038\/sj.ki.5001599","article-title":"Circulating PTH molecular forms: what we know and what we don\u2019t","volume":"70","author":"D\u2019Amour","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.09.033_bib13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/clinchem\/hvab013","article-title":"Chemical characterization and quantification of circulating intact PTH and PTH fragments by high-resolution mass spectrometry in chronic renal failure","volume":"67","author":"Kritmetapak","year":"2021","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2023.09.033_bib14","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/clinchem\/44.4.805","article-title":"A\u00a0non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples","volume":"44","author":"Lepage","year":"1998","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2023.09.033_bib15","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1210\/jcem.84.11.6236","article-title":"A\u00a0novel immunoradiometric assay detects full-length human PTH but not amino-terminally truncated fragments: implications for PTH measurements in renal failure","volume":"84","author":"John","year":"1999","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.kint.2023.09.033_bib16","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1359\/jbmr.2001.16.4.605","article-title":"Development of a novel immunoradiometric assay exclusively for biologically active whole parathyroid hormone 1-84: implications for improvement of accurate assessment of parathyroid function","volume":"16","author":"Gao","year":"2001","journal-title":"J\u00a0Bone Miner Res"},{"key":"10.1016\/j.kint.2023.09.033_bib17","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/clinchem\/hvac135","article-title":"Validation of an LC-MS\/MS method using solid-phase extraction for the quantification of 1-84 parathyroid hormone: toward a candidate reference measurement procedure","volume":"3","author":"Farr\u00e9-Segura","year":"2022","journal-title":"Clin Chem"},{"issue":"suppl 113","key":"10.1016\/j.kint.2023.09.033_bib18","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral bone disorder (CKD-MBD)","volume":"76","year":"2009","journal-title":"Kidney Int"},{"issue":"4 suppl 3","key":"10.1016\/j.kint.2023.09.033_bib19","first-page":"S1","article-title":"K\/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease","volume":"42","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2023.09.033_bib20","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1093\/ndt\/gfr535","article-title":"Interpretation of serum PTH concentrations with different kits in dialysis patients according to the KDIGO guidelines: importance of the reference (normal) values","volume":"27","author":"Cavalier","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2023.09.033_bib21","first-page":"241","article-title":"How the reference values for serum parathyroid hormone concentration are (or should be) established?","volume":"40","author":"Souberbielle","year":"2016","journal-title":"J\u00a0Endocrinal Invest"},{"key":"10.1016\/j.kint.2023.09.033_bib22","first-page":"1347","volume":"54","author":"Cavalier","year":"2016","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.kint.2023.09.033_bib23","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s40618-019-01075-w","article-title":"Parathyroid hormone reference ranges in healthy individuals classified by vitamin D status","volume":"42","author":"Yalla","year":"2019","journal-title":"J\u00a0Endocrinol Invest"},{"key":"10.1016\/j.kint.2023.09.033_bib24","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cca.2020.05.030","article-title":"Use of data mining in the establishment of age-adjusted reference intervals for parathyroid hormone","volume":"508","author":"Delgado","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.kint.2023.09.033_bib25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.2215\/CJN.01730218","article-title":"Clear the fog around parathyroid hormone assays: what do iPTH assays really measure?","volume":"13","author":"Hocher","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2023.09.033_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040242","article-title":"Measuring parathyroid hormone (PTH) in patients with oxidative stress\u2014do we need a fourth generation parathyroid hormone assay?","volume":"7","author":"Hocher","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2023.09.033_bib27","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1021\/ac051711o","article-title":"Identification of carboxyl-terminal peptide fragments of parathyroid hormone in human plasma at low-picomolar levels by mass spectrometry","volume":"78","author":"Zhang","year":"2006","journal-title":"Anal Chem"},{"key":"10.1016\/j.kint.2023.09.033_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1373\/clinchem.2009.137323","article-title":"Selected reaction monitoring-mass spectrometric immunoassay responsive to parathyroid hormone and related variants","volume":"56","author":"Lopez","year":"2010","journal-title":"Clin Chem"},{"key":"10.1016\/j.kint.2023.09.033_bib29","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/ki.2009.374","article-title":"Parathyroid hormone measurement in CKD","volume":"77","author":"Souberbielle","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2023.09.033_bib30","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1210\/jc.2009-2791","article-title":"The ratio of parathyroid hormone as measured by third- and second-generation assays as a marker for parathyroid carcinoma","volume":"95","author":"Cavalier","year":"2010","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.kint.2023.09.033_bib31","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.cca.2017.12.012","article-title":"Spurious intraoperative PTH results observed with 2nd, but not with 3rd generation PTH assays","volume":"477","author":"Cavalier","year":"2018","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.kint.2023.09.033_bib32","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1530\/eje.0.1470123","article-title":"Origin of parathyroid hormone (PTH) fragments detected by intact-PTH assays","volume":"147","author":"Nguyen-Yamamoto","year":"2002","journal-title":"Eur J Endocrinol"},{"issue":"suppl 3","key":"10.1016\/j.kint.2023.09.033_bib33","article-title":"Reversed whole PTH\/intact PTH ratio as an indicator of marked parathyroid enlargement: five case studies and a literature review","volume":"1","author":"Komaba","year":"2008","journal-title":"NDT Plus"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823007615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253823007615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T01:06:10Z","timestamp":1758762370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253823007615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0085253823007615"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2023.09.033","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling a new era with liquid chromatography coupled with mass spectrometry to enhance parathyroid hormone measurement in patients with chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2023.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}