{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T05:13:42Z","timestamp":1782623622916,"version":"3.54.5"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004470","name":"Daewoong Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004470","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.kint.2024.01.011","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T10:46:55Z","timestamp":1707130015000},"page":"997-1019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity"],"prefix":"10.1016","volume":"105","author":[{"given":"Chaelin","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghwan","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haein","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minki","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhyeon","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Mu","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokwoo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongmin","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dohyun","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Chul","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5978-512X","authenticated-orcid":false,"given":"Hye Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Hee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Wook","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kook-Hwan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwon Wook","family":"Joo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Sup","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon Su","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0137-5261","authenticated-orcid":false,"given":"Seung Seok","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2024.01.011_bib1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/ki.2010.89","article-title":"Acute interstitial nephritis","volume":"77","author":"Praga","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12882-019-1277-2","article-title":"Effect of steroids and relevant cytokine analysis in acute tubulointerstitial nephritis","volume":"20","author":"Yun","year":"2019","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib3","doi-asserted-by":"crossref","first-page":"6109","DOI":"10.3390\/ijms22116109","article-title":"The mechanism of drug nephrotoxicity and the methods for preventing kidney damage","volume":"22","author":"Kwiatkowska","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2024.01.011_bib4","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nrneph.2010.71","article-title":"Drug-induced acute interstitial nephritis","volume":"6","author":"Perazella","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.kint.2019.07.022","article-title":"Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do?","volume":"97","author":"Perazella","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib6","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.ki.5002776","article-title":"Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis","volume":"73","author":"Gonz\u00e1lez","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib7","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1053\/j.ajkd.2014.04.027","article-title":"Biopsy-proven acute interstitial nephritis, 1993-2011: a case series","volume":"64","author":"Muriithi","year":"2014","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2024.01.011_bib8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.kint.2018.04.011","article-title":"Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016","volume":"94","author":"Xie","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib9","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0959-440X(95)80008-O","article-title":"Aminoacyl-tRNA synthetases","volume":"5","author":"Delarue","year":"1995","journal-title":"Curr Opin Struct Biol"},{"key":"10.1016\/j.kint.2024.01.011_bib10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/emmm.201100626","article-title":"Aminoacyl-tRNA synthetases in medicine and disease","volume":"5","author":"Yao","year":"2013","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.kint.2024.01.011_bib11","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","article-title":"Collagen structure and stability","volume":"78","author":"Shoulders","year":"2009","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.kint.2024.01.011_bib12","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/molecules20010573","article-title":"Halofuginone\u2014the multifaceted molecule","volume":"20","author":"Pines","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/j.kint.2024.01.011_bib13","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.3390\/biom10121625","article-title":"Recent development of aminoacyl-tRNA synthetase inhibitors for human diseases: a future perspective","volume":"10","author":"Kim","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.kint.2024.01.011_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nchembio.1158","article-title":"Essential nontranslational functions of tRNA synthetases","volume":"9","author":"Guo","year":"2013","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.kint.2024.01.011_bib15","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1096\/fj.201801344RR","article-title":"Glutamyl-prolyl-tRNA synthetase induces fibrotic extracellular matrix via both transcriptional and translational mechanisms","volume":"33","author":"Song","year":"2019","journal-title":"FASEB J"},{"key":"10.1016\/j.kint.2024.01.011_bib16","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s41419-019-2145-5","article-title":"Roles of aminoacyl-tRNA synthetases in immune regulation and immune diseases","volume":"10","author":"Nie","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.kint.2024.01.011_bib17","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/ni.3542","article-title":"Infection-specific phosphorylation of glutamyl-prolyl tRNA synthetase induces antiviral immunity","volume":"17","author":"Lee","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.kint.2024.01.011_bib18","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1126\/science.1172638","article-title":"Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response","volume":"324","author":"Sundrud","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.kint.2024.01.011_bib19","doi-asserted-by":"crossref","first-page":"e151189","DOI":"10.1172\/JCI151189","article-title":"Kidney VISTA prevents IFN-\u03b3\/IL-9 axis-mediated tubulointerstitial fibrosis after acute glomerular injury","volume":"132","author":"Kim","year":"2022","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2024.01.011_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103243","article-title":"Renal subcapsular delivery of PGE2 promotes kidney repair by activating endogenous Sox9+ stem cells","volume":"24","author":"Chen","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.kint.2024.01.011_bib21","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000183992","article-title":"Animal model of adenine-induced chronic renal failure in rats","volume":"44","author":"Yokozawa","year":"1986","journal-title":"Nephron"},{"key":"10.1016\/j.kint.2024.01.011_bib22","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1126\/science.aar2131","article-title":"Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease","volume":"360","author":"Park","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.kint.2024.01.011_bib23","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1074-7613(00)80025-4","article-title":"Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells","volume":"10","author":"Moriggl","year":"1999","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2024.01.011_bib24","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.4049\/jimmunol.2000612","article-title":"Dynamic roles for IL-2-STAT5 signaling in effector and regulatory CD4+ T cell populations","volume":"205","author":"Jones","year":"2020","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.kint.2024.01.011_bib25","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ki.2014.285","article-title":"TNF receptors: signaling pathways and contribution to renal dysfunction","volume":"87","author":"Al-Lamki","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib26","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.immuni.2009.06.020","article-title":"Interleukin-17-producing \u03b3\u03b4 T cells selectively expand in response to pathogen products and environmental signals","volume":"31","author":"Martin","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2024.01.011_bib27","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.celrep.2017.05.071","article-title":"Strong TCR\u03b3\u03b4 signaling prohibits thymic development of IL-17A-secreting \u03b3\u03b4 T cells","volume":"19","author":"Sumaria","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2024.01.011_bib28","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/s41591-019-0415-5","article-title":"A\u00a0signature of circulating inflammatory proteins and development of end-stage renal disease in diabetes","volume":"25","author":"Niewczas","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2024.01.011_bib29","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1172\/JCI135716","article-title":"Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury","volume":"130","author":"Mehrotra","year":"2020","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2024.01.011_bib30","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.1073\/pnas.85.17.6528","article-title":"Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7","volume":"85","author":"Shoyab","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2024.01.011_bib31","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1681\/ASN.2019030321","article-title":"Proximal tubule-derived amphiregulin amplifies and integrates profibrotic EGF receptor signals in kidney fibrosis","volume":"30","author":"Kefaloyianni","year":"2019","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib32","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1038\/s41598-021-81726-2","article-title":"In\u00a0vivo silencing of amphiregulin by a novel effective self-assembled-micelle inhibitory RNA ameliorates renal fibrosis via inhibition of EGFR signals","volume":"11","author":"Son","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2024.01.011_bib33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/MNH.0000000000000696","article-title":"The epidermal growth factor receptor axis and kidney fibrosis","volume":"30","author":"Harris","year":"2021","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.kint.2024.01.011_bib34","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.immuni.2018.04.023","article-title":"Amphiregulin-producing pathogenic memory T helper 2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis","volume":"49","author":"Morimoto","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2024.01.011_bib35","doi-asserted-by":"crossref","first-page":"10738","DOI":"10.1073\/pnas.1802320115","article-title":"Amphiregulin-producing \u03b3\u03b4 T cells are vital for safeguarding oral barrier immune homeostasis","volume":"115","author":"Krishnan","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2024.01.011_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal change disease","volume":"12","author":"Vivarelli","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib37","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/CIRCRESAHA.119.315999","article-title":"Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis","volume":"127","author":"Wu","year":"2020","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2024.01.011_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101203","article-title":"Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response","volume":"297","author":"Jin","year":"2021","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.kint.2024.01.011_bib39","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.immuni.2018.07.011","article-title":"Lung \u03b3\u03b4 T cells mediate protective responses during neonatal influenza infection that are associated with type 2 immunity","volume":"49","author":"Guo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.kint.2024.01.011_bib40","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib41","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3389\/fphar.2018.01337","article-title":"Glutamyl-prolyl-tRNA synthetase regulates epithelial expression of mesenchymal markers and extracellular matrix proteins: implications for idiopathic pulmonary fibrosis","volume":"9","author":"Song","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.kint.2024.01.011_bib42","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12967-020-02376-y","article-title":"Antifibrotic therapy to normalize the tumor microenvironment","volume":"18","author":"Hauge","year":"2020","journal-title":"J\u00a0Transl Med"},{"key":"10.1016\/j.kint.2024.01.011_bib43","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.kint.2019.11.025","article-title":"Kidney residency of VISTA-positive macrophages accelerates repair from ischemic injury","volume":"97","author":"Park","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.01.011_bib44","article-title":"Immune cell composition in normal human kidneys","volume":"10","author":"Park","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2024.01.011_bib45","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1681\/ASN.2014111136","article-title":"Low-dose IL-17 therapy prevents and reverses diabetic nephropathy, metabolic syndrome, and associated organ fibrosis","volume":"27","author":"Mohamed","year":"2016","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.01.011_bib46","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/HYPERTENSIONAHA.113.02620","article-title":"Deficiency of the interleukin 17\/23 axis accelerates renal injury in mice with deoxycorticosterone acetate\u00a0+ angiotensin II-induced hypertension","volume":"63","author":"Krebs","year":"2014","journal-title":"Hypertension"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382400067X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382400067X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T03:33:47Z","timestamp":1716262427000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525382400067X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S008525382400067X"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2024.01.011","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamyl-prolyl-tRNA synthetase (EPRS1) drives tubulointerstitial nephritis-induced fibrosis by enhancing T cell proliferation and activity","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2024.01.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2024.02.007","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}