{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:46:27Z","timestamp":1792518387084,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["R08002"],"award-info":[{"award-number":["R08002"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201020113"],"award-info":[{"award-number":["202201020113"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001712"],"award-info":[{"award-number":["82001712"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271823"],"award-info":[{"award-number":["82271823"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2019M663308"],"award-info":[{"award-number":["2019M663308"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011007"],"award-info":[{"award-number":["2021A1515011007"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515011295"],"award-info":[{"award-number":["2020A1515011295"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.kint.2024.06.025","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T11:37:11Z","timestamp":1722253031000},"page":"625-639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["The mechanosensitive ion channel Piezo1 contributes to podocyte cytoskeleton remodeling and development of proteinuria in lupus nephritis"],"prefix":"10.1016","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-0359","authenticated-orcid":false,"given":"Rong","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbao","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeying","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaohuan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2024.06.025_bib1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2215\/CJN.06720615","article-title":"Clinical-morphological features and outcomes of lupus podocytopathy","volume":"11","author":"Hu","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.06.025_bib2","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1093\/rheumatology\/ket491","article-title":"Podocyte involvement in lupus nephritis based on the 2003 ISN\/RPS system: a large cohort study from a single centre","volume":"53","author":"Wang","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.kint.2024.06.025_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7326\/M14-1030","article-title":"Multitarget therapy for induction treatment of lupus nephritis: a randomized trial","volume":"162","author":"Liu","year":"2015","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.kint.2024.06.025_bib4","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1016\/S0140-6736(21)00578-X","article-title":"Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial","volume":"397","author":"Rovin","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2024.06.025_bib5","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.147789","article-title":"Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis","volume":"6","author":"Bhargava","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2024.06.025_bib6","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1172\/JCI99507","article-title":"CaMK4 compromises podocyte function in autoimmune and nonautoimmune kidney disease","volume":"128","author":"Maeda","year":"2018","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2024.06.025_bib7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/s41419-022-05179-9","article-title":"CD36 aggravates podocyte injury by activating NLRP3 inflammasome and inhibiting autophagy in lupus nephritis","volume":"13","author":"Lv","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.kint.2024.06.025_bib8","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1016\/j.ymthe.2022.04.024","article-title":"Targeting tissue-resident memory CD8(+) T cells in the kidney is a potential therapeutic strategy to ameliorate podocyte injury and glomerulosclerosis","volume":"30","author":"Li","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.kint.2024.06.025_bib9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1002\/art.40863","article-title":"Pim-1 as a therapeutic target in lupus nephritis","volume":"71","author":"Fu","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.kint.2024.06.025_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.05.014","article-title":"Pathogenesis of lupus nephritis: RIP3 dependent necroptosis and NLRP3 inflammasome activation","volume":"103","author":"Guo","year":"2019","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.kint.2024.06.025_bib11","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1002\/art.40155","article-title":"Podocyte activation of NLRP3 inflammasomes contributes to the development of proteinuria in lupus nephritis","volume":"69","author":"Fu","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.kint.2024.06.025_bib12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.kint.2024.06.025_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nature13701","article-title":"Piezo1 integration of vascular architecture with physiological force","volume":"515","author":"Li","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.kint.2024.06.025_bib14","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.celrep.2015.09.072","article-title":"Piezo1 in smooth muscle cells is involved in hypertension-dependent arterial remodeling","volume":"13","author":"Retailleau","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2024.06.025_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41586-019-1485-8","article-title":"Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity","volume":"573","author":"Solis","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.kint.2024.06.025_bib16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/ard-2022-223428","article-title":"Piezo1-mediated mechanotransduction promotes entheseal pathological new bone formation in ankylosing spondylitis","volume":"82","author":"Chen","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.kint.2024.06.025_bib17","doi-asserted-by":"crossref","first-page":"R250","DOI":"10.1016\/j.cub.2017.01.048","article-title":"Piezo channels","volume":"27","author":"Parpaite","year":"2017","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2024.06.025_bib18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41572-020-0196-7","article-title":"Podocytopathies","volume":"6","author":"Kopp","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.kint.2024.06.025_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1149336","article-title":"Mechanosensitive Piezo1 protein as a novel regulator in macrophages and macrophage-mediated inflammatory diseases","volume":"14","author":"Tang","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.kint.2024.06.025_bib20","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nm.2411","article-title":"Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis","volume":"17","author":"Wei","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2024.06.025_bib21","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13045-017-0418-y","article-title":"Paxillin: a crossroad in pathological cell migration","volume":"10","author":"Lopez-Colome","year":"2017","journal-title":"J\u00a0Hematol Oncol"},{"key":"10.1016\/j.kint.2024.06.025_bib22","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.tcb.2006.08.006","article-title":"Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking","volume":"16","author":"Ridley","year":"2006","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.kint.2024.06.025_bib23","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature12025","article-title":"Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1","volume":"496","author":"Keestra","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.kint.2024.06.025_bib24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.kint.2017.03.010","article-title":"Rac1 activation in podocytes induces the spectrum of nephrotic syndrome","volume":"92","author":"Robins","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.06.025_bib25","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.cell.2021.01.024","article-title":"A\u00a0role of PIEZO1 in iron metabolism in mice and humans","volume":"184","author":"Ma","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.kint.2024.06.025_bib26","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1038\/s41467-021-26900-w","article-title":"Insulin-activated store-operated Ca(2+) entry via Orai1 induces podocyte actin remodeling and causes proteinuria","volume":"12","author":"Kim","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2024.06.025_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2020-000389","article-title":"Prediction of prognosis and renal outcome in lupus nephritis","volume":"7","author":"Parodis","year":"2020","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.kint.2024.06.025_bib28","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nrneph.2017.85","article-title":"Redefining lupus nephritis: clinical implications of pathophysiologic subtypes","volume":"13","author":"Yu","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2024.06.025_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152330","article-title":"Mechanosensitive Piezo1 channels mediate renal fibrosis","volume":"7","author":"Zhao","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.kint.2024.06.025_bib30","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1038\/s41467-021-23482-5","article-title":"Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing","volume":"12","author":"Atcha","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2024.06.025_bib31","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.91903","article-title":"Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells","volume":"12","author":"Liu","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.kint.2024.06.025_bib32","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2023.2281179","article-title":"Piezo1 facilitates optimal T cell activation during tumor challenge","volume":"12","author":"Abiff","year":"2023","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.kint.2024.06.025_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41551-024-01188-5","article-title":"PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes","author":"Pang","year":"2024","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.kint.2024.06.025_bib34","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/1354750X.2021.1910343","article-title":"Urine soluble urokinase plasminogen activator receptor as a potential biomarker of lupus nephritis activity","volume":"26","author":"Burcsar","year":"2021","journal-title":"Biomarkers"},{"key":"10.1016\/j.kint.2024.06.025_bib35","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.kint.2020.08.035","article-title":"Rho GTPase regulatory proteins in podocytes","volume":"99","author":"Matsuda","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.06.025_bib36","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.kint.2023.01.016","article-title":"The small GTPase regulatory protein Rac1 drives podocyte injury independent of cationic channel protein TRPC5","volume":"103","author":"Polat","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.06.025_bib37","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41419-018-0353-z","article-title":"Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice","volume":"9","author":"Lv","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.kint.2024.06.025_bib38","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1681\/ASN.2020050572","article-title":"Synaptopodin is dispensable for normal podocyte homeostasis but is protective in the context of acute podocyte injury","volume":"31","author":"Ning","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.06.025_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo1461","article-title":"Force- and cell state-dependent recruitment of Piezo1 drives focal adhesion dynamics and calcium entry","volume":"8","author":"Yao","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.kint.2024.06.025_bib40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semnephrol.2012.06.003","article-title":"Calcium regulates podocyte actin dynamics","volume":"32","author":"Greka","year":"2012","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2024.06.025_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.neuron.2020.07.025","article-title":"Piezo1-Mediated Ca(2+) activities regulate brain vascular pathfinding during development","volume":"108","author":"Liu","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.kint.2024.06.025_bib42","doi-asserted-by":"crossref","first-page":"C1013","DOI":"10.1152\/ajpcell.00599.2020","article-title":"TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells","volume":"320","author":"Lakk","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.kint.2024.06.025_bib43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ncb1400","article-title":"Synaptopodin orchestrates actin organization and cell motility via regulation of RhoA signalling","volume":"8","author":"Asanuma","year":"2006","journal-title":"Nat Cell Biol"}],"updated-by":[{"DOI":"10.1016\/j.kint.2025.05.004","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000}}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253824005295?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253824005295?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:39:43Z","timestamp":1762231183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253824005295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S0085253824005295"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2024.06.025","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The mechanosensitive ion channel Piezo1 contributes to podocyte cytoskeleton remodeling and development of proteinuria in lupus nephritis","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2024.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society of Nephrology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}