{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:10:10Z","timestamp":1781763010342,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R41DK136452"],"award-info":[{"award-number":["1R41DK136452"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UH3TR003288"],"award-info":[{"award-number":["UH3TR003288"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK117914"],"award-info":[{"award-number":["R01DK117914"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GR3933\/1-1"],"award-info":[{"award-number":["GR3933\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1140"],"award-info":[{"award-number":["CRC 1140"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["SPP1395"],"award-info":[{"award-number":["SPP1395"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["EXC 22167-390884018"],"award-info":[{"award-number":["EXC 22167-390884018"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["CRC 1453"],"award-info":[{"award-number":["CRC 1453"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["431984000-S1"],"award-info":[{"award-number":["431984000-S1"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["256073931-Z02"],"award-info":[{"award-number":["256073931-Z02"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["CRC1160"],"award-info":[{"award-number":["CRC1160"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21OC0066381"],"award-info":[{"award-number":["NNF21OC0066381"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["441891347- S1"],"award-info":[{"award-number":["441891347- S1"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["CRC1479"],"award-info":[{"award-number":["CRC1479"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["CRC\/TRR167"],"award-info":[{"award-number":["CRC\/TRR167"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["259373024-Z01"],"award-info":[{"award-number":["259373024-Z01"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"European Federation of Pharmaceutical Industries and Associations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001742","name":"United States-Israel Binational Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001742","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008871","name":"Juvenile Diabetes Research Foundation United States of America","doi-asserted-by":"publisher","award":["KFO201"],"award-info":[{"award-number":["KFO201"]}],"id":[{"id":"10.13039\/100008871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031688","name":"Pfizer Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["UPTAKE- 01EK2105D"],"award-info":[{"award-number":["UPTAKE- 01EK2105D"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["STOP-FSGS- 01GM1901C"],"award-info":[{"award-number":["STOP-FSGS- 01GM1901C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["HU 1016\/8-2"],"award-info":[{"award-number":["HU 1016\/8-2"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["HU 1016\/ 12-1"],"award-info":[{"award-number":["HU 1016\/ 12-1"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208080139"],"award-info":[{"award-number":["202208080139"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CRC1192"],"award-info":[{"award-number":["CRC1192"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.kint.2024.08.021","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T22:37:38Z","timestamp":1725057458000},"page":"856-869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity"],"prefix":"10.1016","volume":"106","author":[{"given":"Florian","family":"Grahammer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Dumoulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramila E.","family":"Gulieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoxian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurgazy","family":"Sulaimanov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Sandner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomke","family":"Cordts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhijeet","family":"Todkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Moulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfried","family":"Reichardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Puelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6351","authenticated-orcid":false,"given":"Rafael","family":"Kramann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin S.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hauke","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Boerries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Walz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-5062","authenticated-orcid":false,"given":"Tobias B.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2024.08.021_bib1","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2024.08.021_bib2","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","article-title":"Autosomal dominant polycystic kidney disease: the changing face of clinical management","volume":"385","author":"Ong","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2024.08.021_bib3","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"Hildebrandt","year":"2011","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2024.08.021_bib4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.molmed.2011.06.003","article-title":"mTOR signaling in polycystic kidney disease","volume":"17","author":"Ibraghimov-Beskrovnaya","year":"2011","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.kint.2024.08.021_bib5","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2024.08.021_bib6","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1172\/JCI41531","article-title":"Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease","volume":"120","author":"Qin","year":"2010","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.kint.2024.08.021_bib7","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/ncb2117","article-title":"Primary cilia regulate mTORC1 activity and cell size through Lkb1","volume":"12","author":"Boehlke","year":"2010","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2024.08.021_bib8","doi-asserted-by":"crossref","first-page":"E2817","DOI":"10.1073\/pnas.1402352111","article-title":"mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress","volume":"111","author":"Grahammer","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl 1","key":"10.1016\/j.kint.2024.08.021_bib9","doi-asserted-by":"crossref","first-page":"i9","DOI":"10.1093\/ndt\/gft491","article-title":"mTOR controls kidney epithelia in health and disease","volume":"29","author":"Grahammer","year":"2014","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2024.08.021_bib10","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/ki.2010.457","article-title":"mTOR and rapamycin in the kidney: signaling and therapeutic implications beyond immunosuppression","volume":"79","author":"Huber","year":"2011","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2024.08.021_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/nrneph.2016.108","article-title":"Roles of mTOR complexes in the kidney: implications for renal disease and transplantation","volume":"12","author":"Fantus","year":"2016","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1681\/ASN.2004080660","article-title":"Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease","volume":"16","author":"Tao","year":"2005","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib13","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1681\/ASN.2009040421","article-title":"Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1","volume":"21","author":"Shillingford","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJMoa0907419","article-title":"Sirolimus and kidney growth in autosomal dominant polycystic kidney disease","volume":"363","author":"Serra","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2024.08.021_bib15","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1056\/NEJMoa1003491","article-title":"Everolimus in patients with autosomal dominant polycystic kidney disease","volume":"363","author":"Walz","year":"2010","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2024.08.021_bib16","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2008.10.002","article-title":"Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy","volume":"8","author":"Bentzinger","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2024.08.021_bib17","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1097\/01.ASN.0000016444.90348.50","article-title":"Epithelial-specific Cre\/lox recombination in the developing kidney and genitourinary tract","volume":"13","author":"Shao","year":"2002","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib18","doi-asserted-by":"crossref","first-page":"5286","DOI":"10.1073\/pnas.0836980100","article-title":"Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease","volume":"100","author":"Lin","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2024.08.021_bib19","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1097\/01.ASN.0000144204.01352.86","article-title":"A\u00a0functional floxed allele of Pkd1 that can be conditionally inactivated in\u00a0vivo","volume":"15","author":"Piontek","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/12703","article-title":"Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety","volume":"23","author":"Tronche","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2024.08.021_bib21","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ygeno.2012.08.003","article-title":"A\u00a0single-sample microarray normalization method to facilitate personalized-medicine workflows","volume":"100","author":"Piccolo","year":"2012","journal-title":"Genomics"},{"key":"10.1016\/j.kint.2024.08.021_bib22","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/1471-2105-10-161","article-title":"GAGE: generally applicable gene set enrichment for pathway analysis","volume":"10","author":"Luo","year":"2009","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.kint.2024.08.021_bib23","doi-asserted-by":"crossref","first-page":"D793","DOI":"10.1093\/nar\/gks1055","article-title":"The ConsensusPathDB interaction database: 2013 update","volume":"41","author":"Kamburov","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2024.08.021_bib24","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/nm.2941","article-title":"Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma","volume":"18","author":"Kwong","year":"2012","journal-title":"Nat Med"},{"issue":"suppl 1","key":"10.1016\/j.kint.2024.08.021_bib25","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/gb-2008-9-s1-s4","article-title":"GeneMANIA: a real-time multiple association network integration algorithm for predicting gene function","volume":"9","author":"Mostafavi","year":"2008","journal-title":"Genome Biol"},{"key":"10.1016\/j.kint.2024.08.021_bib26","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2024.08.021_bib27","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1038\/s41588-022-01202-z","article-title":"Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease","volume":"54","author":"Xu","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2024.08.021_bib28","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.stem.2024.03.005","article-title":"Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease","volume":"31","author":"Vishy","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.kint.2024.08.021_bib29","doi-asserted-by":"crossref","first-page":"8715","DOI":"10.1038\/ncomms9715","article-title":"Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids","volume":"6","author":"Freedman","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2024.08.021_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003053","article-title":"Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4alpha as a disease modifier","volume":"8","author":"Menezes","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.kint.2024.08.021_bib31","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2024.08.021_bib32","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s13059-017-1349-1","article-title":"xCell: digitally portraying the tissue cellular heterogeneity landscape","volume":"18","author":"Aran","year":"2017","journal-title":"Genome Biol"},{"key":"10.1016\/j.kint.2024.08.021_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/path.2734","article-title":"Elevated TGFbeta-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease","volume":"222","author":"Hassane","year":"2010","journal-title":"J\u00a0Pathol"},{"key":"10.1016\/j.kint.2024.08.021_bib34","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1038\/ncomms5527","article-title":"TRIP13 promotes error-prone nonhomologous end joining and induces chemoresistance in head and neck cancer","volume":"5","author":"Banerjee","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2024.08.021_bib35","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1158\/1535-7163.1427.3.11","article-title":"Specific inhibition of cyclin-dependent kinase 4\/6 by PD 0332991 and associated antitumor activity in human tumor xenografts","volume":"3","author":"Fry","year":"2004","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.kint.2024.08.021_bib36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1056\/NEJMoa1505270","article-title":"Palbociclib in hormone-receptor-positive advanced breast cancer","volume":"373","author":"Turner","year":"2015","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.kint.2024.08.021_bib37","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1038\/nmat4994","article-title":"Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease","volume":"16","author":"Cruz","year":"2017","journal-title":"Nat Mater"},{"key":"10.1016\/j.kint.2024.08.021_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2004652","article-title":"Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer","volume":"6","author":"Niederst","year":"2013","journal-title":"Sci Signaling"},{"key":"10.1016\/j.kint.2024.08.021_bib39","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1126\/science.1254721","article-title":"Patient-derived models of acquired resistance can identify effective drug combinations for cancer","volume":"346","author":"Crystal","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.kint.2024.08.021_bib40","doi-asserted-by":"crossref","first-page":"6958","DOI":"10.1158\/1078-0432.CCR-17-0803","article-title":"Combined CDK4\/6 and mTOR inhibition is synergistic against glioblastoma via multiple mechanisms","volume":"23","author":"Olmez","year":"2017","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.kint.2024.08.021_bib41","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(15)00613-0","volume":"17","author":"Cristofanilli","year":"2016","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.kint.2024.08.021_bib42","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1634\/theoncologist.2016-0097","article-title":"Palbociclib in combination with fulvestrant in women with hormone receptor-positive\/HER2-negative advanced metastatic breast cancer: detailed safety analysis from a multicenter, randomized, placebo-controlled, phase III study (PALOMA-3)","volume":"21","author":"Verma","year":"2016","journal-title":"Oncologist"},{"key":"10.1016\/j.kint.2024.08.021_bib43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2215\/CJN.02650313","article-title":"Low-dose rapamycin (sirolimus) effects in autosomal dominant polycystic kidney disease: an open-label randomized controlled pilot study","volume":"9","author":"Braun","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2024.08.021_bib44","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1016\/j.transproceed.2012.06.073","article-title":"Sirolimus produced S-shaped effect on adult polycystic kidneys after 2-year treatment","volume":"44","author":"Soliman","year":"2012","journal-title":"Transplant Proc"},{"key":"10.1016\/j.kint.2024.08.021_bib45","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1681\/ASN.2009121302","article-title":"Sirolimus therapy to halt the progression of ADPKD","volume":"21","author":"Perico","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253824006276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253824006276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T23:20:55Z","timestamp":1778714455000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253824006276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S0085253824006276"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2024.08.021","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2024.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}