{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:31:28Z","timestamp":1789536688957,"version":"build-2803163510"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2502500\/2022YFC2502501"],"award-info":[{"award-number":["2022YFC2502500\/2022YFC2502501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030023"],"award-info":[{"award-number":["82030023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20279"],"award-info":[{"award-number":["U22A20279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82300778"],"award-info":[{"award-number":["82300778"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["CYB23281"],"award-info":[{"award-number":["CYB23281"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012459","name":"Chongqing Graduate Student Research Innovation Project","doi-asserted-by":"publisher","award":["CYB240287"],"award-info":[{"award-number":["CYB240287"]}],"id":[{"id":"10.13039\/501100012459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.kint.2025.03.025","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T19:04:09Z","timestamp":1745262249000},"page":"90-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Single-cell analysis of proximal tubular cells with different DNA content reveals functional heterogeneity in the acute kidney injury to chronic kidney disease transition"],"prefix":"10.1016","volume":"108","author":[{"given":"Fugang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qigang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachuan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangli","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiqin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengying","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjing","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaozong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2025.03.025_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"Lameire","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2025.03.025_bib2","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1016\/S0140-6736(15)60126-X","article-title":"International Society of Nephrology's 0by25 initiative for acute kidney injury (zero preventable deaths by 2025): a human rights case for nephrology","volume":"385","author":"Mehta","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2025.03.025_bib3","doi-asserted-by":"crossref","first-page":"F304","DOI":"10.1152\/ajprenal.00017.2020","article-title":"A two-stage bilateral ischemia-reperfusion injury-induced AKI to CKD transition model in mice","volume":"319","author":"Zhang","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2025.03.025_bib4","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jama.2009.1322","article-title":"Chronic dialysis and death among survivors of acute kidney injury requiring dialysis","volume":"302","author":"Wald","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2025.03.025_bib5","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0002-9440(10)62276-6","article-title":"Isolation of renal progenitor cells from adult human kidney","volume":"166","author":"Bussolati","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2025.03.025_bib6","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.stem.2008.01.014","article-title":"Intrinsic epithelial cells repair the kidney after injury","volume":"2","author":"Humphreys","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"suppl 1","key":"10.1016\/j.kint.2025.03.025_bib7","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1097\/01.ASN.0000067652.51441.21","article-title":"Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure","volume":"14","author":"Bonventre","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib9","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nm.2144","article-title":"Epithelial cell cycle arrest in G2\/M mediates kidney fibrosis after injury","volume":"16","author":"Yang","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2025.03.025_bib10","doi-asserted-by":"crossref","first-page":"e01718","DOI":"10.1128\/JVI.01718-17","article-title":"Polyploidy and mitotic cell death are two distinct HIV-1 Vpr-driven outcomes in renal tubule epithelial cells","volume":"92","author":"Payne","year":"2018","journal-title":"J Virol"},{"key":"10.1016\/j.kint.2025.03.025_bib11","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1038\/ki.2008.303","article-title":"HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells","volume":"74","author":"Rosenstiel","year":"2008","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.03.025_bib12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41575-020-0284-x","article-title":"Polyploidy in liver development, homeostasis and disease","volume":"17","author":"Donne","year":"2020","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.kint.2025.03.025_bib13","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41467-021-24543-5","article-title":"Single-nucleus RNA-seq2 reveals functional crosstalk between liver zonation and ploidy","volume":"12","author":"Richter","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2025.03.025_bib14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.2021010697","article-title":"Single-cell analysis of ploidy and the transcriptome reveals functional and spatial divergency in murine megakaryopoiesis","volume":"138","author":"Sun","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.kint.2025.03.025_bib15","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1038\/s41467-018-03753-4","article-title":"Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury","volume":"9","author":"Lazzeri","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2025.03.025_bib16","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrneph.2012.290","article-title":"Renal progenitors: an evolutionary conserved strategy for kidney regeneration","volume":"9","author":"Romagnani","year":"2013","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib17","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1101\/gad.1952710","article-title":"Error-prone polyploid mitosis during normal Drosophila development","volume":"24","author":"Fox","year":"2010","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2025.03.025_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/nature09414","article-title":"The ploidy conveyor of mature hepatocytes as a source of genetic variation","volume":"467","author":"Duncan","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.kint.2025.03.025_bib19","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.1038\/s41467-022-33110-5","article-title":"Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease","volume":"13","author":"De Chiara","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2025.03.025_bib20","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.kint.2023.07.006","article-title":"Tubular cell transcriptional intermediary factor 1\u03b3 deficiency exacerbates kidney injury-induced tubular cell polyploidy and fibrosis","volume":"104","author":"Yuan","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.03.025_bib21","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.kint.2023.08.016","article-title":"Imbalanced lipid homeostasis caused by membrane \u03b1Klotho deficiency contributes to the acute kidney injury to chronic kidney disease transition","volume":"104","author":"Wang","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.03.025_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025746","article-title":"KAP degradation by calpain is associated with CK2 phosphorylation and provides a novel mechanism for cyclosporine A-induced proximal tubule injury","volume":"6","author":"Tornavaca","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2025.03.025_bib23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13578-023-01041-3","article-title":"Integrated single-nucleus sequencing and spatial architecture analysis identified distinct injured-proximal tubular types in calculi rats","volume":"13","author":"Wang","year":"2023","journal-title":"Cell Biosci"},{"key":"10.1016\/j.kint.2025.03.025_bib24","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.cmet.2019.10.004","article-title":"Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4(+) T cell metabolic rewiring","volume":"30","author":"Pucino","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.kint.2025.03.025_bib25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13578-024-01203-x","article-title":"XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions","volume":"14","author":"Sun","year":"2024","journal-title":"Cell Biosci"},{"key":"10.1016\/j.kint.2025.03.025_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102781","article-title":"Nox4 as a novel therapeutic target for diabetic vascular complications","volume":"64","author":"Wang","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.kint.2025.03.025_bib27","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41592-019-0535-3","article-title":"Supervised classification enables rapid annotation of cell atlases","volume":"16","author":"Pliner","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.kint.2025.03.025_bib28","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1681\/ASN.2020010052","article-title":"Single-cell profiling of AKI in a murine model reveals novel transcriptional signatures, profibrotic phenotype, and epithelial-to-stromal crosstalk","volume":"31","author":"Rudman-Melnick","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib29","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1681\/ASN.2020081143","article-title":"Single-nucleus RNA sequencing identifies new classes of proximal tubular epithelial cells in kidney fibrosis","volume":"32","author":"Lu","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib30","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1038\/s41467-022-31772-9","article-title":"Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration","volume":"13","author":"Balzer","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2025.03.025_bib31","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2025.03.025_bib32","doi-asserted-by":"crossref","first-page":"C849","DOI":"10.1152\/ajpcell.00081.2023","article-title":"Polyploid tubular cells initiate a TGF-\u03b21 controlled loop that sustains polyploidization and fibrosis after acute kidney injury","volume":"325","author":"De Chiara","year":"2023","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.kint.2025.03.025_bib33","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/mt.2008.76","article-title":"Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection","volume":"16","author":"Zincarelli","year":"2008","journal-title":"Mol Ther"},{"key":"10.1016\/j.kint.2025.03.025_bib34","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/mt.2010.71","article-title":"Combined paracrine and endocrine AAV9 mediated expression of hepatocyte growth factor for the treatment of renal fibrosis","volume":"18","author":"Schievenbusch","year":"2010","journal-title":"Mol Ther"},{"key":"10.1016\/j.kint.2025.03.025_bib35","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.kint.2022.07.003","article-title":"Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1","volume":"102","author":"Airik","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.03.025_bib36","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1681\/ASN.0000000000000057","article-title":"Lineage tracing and single-nucleus multiomics reveal novel features of adaptive and maladaptive repair after acute kidney injury","volume":"34","author":"Gerhardt","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2026684118","article-title":"Single-nuclear transcriptomics reveals diversity of proximal tubule cell states in a dynamic response to acute kidney injury","volume":"118","author":"Gerhardt","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2025.03.025_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-01790-6","article-title":"Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis","volume":"11","author":"Bais","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2025.03.025_bib39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13073-019-0615-0","article-title":"Single-cell analysis reveals congruence between kidney organoids and human fetal kidney","volume":"11","author":"Combes","year":"2019","journal-title":"Genome Med"},{"key":"10.1016\/j.kint.2025.03.025_bib40","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/ndt\/gfac290","article-title":"TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment","volume":"38","author":"Abdelmageed","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2025.03.025_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241411617","article-title":"Cell profiling of acute kidney injury to chronic kidney disease reveals novel oxidative stress characteristics in the failed repair of proximal tubule cells","volume":"24","author":"Yu","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2025.03.025_bib42","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.7150\/ijbs.91237","article-title":"Acyloxyacyl hydrolase protects against kidney injury via inhibition of tubular CD74-macrophage crosstalk","volume":"20","author":"Wu","year":"2024","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.kint.2025.03.025_bib43","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.metabol.2019.04.013","article-title":"YY1: a novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis","volume":"96","author":"Yang","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.kint.2025.03.025_bib44","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41374-019-0331-9","article-title":"ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription","volume":"100","author":"Yao","year":"2020","journal-title":"Lab Invest"},{"key":"10.1016\/j.kint.2025.03.025_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103246","article-title":"Lactate drives epithelial-mesenchymal transition in diabetic kidney disease via the H3K14la\/KLF5 pathway","volume":"75","author":"Zhang","year":"2024","journal-title":"Redox Biol"},{"key":"10.1016\/j.kint.2025.03.025_bib46","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.kint.2020.12.031","article-title":"The proximal tubule, protein uptake, and the riddle of the segments","volume":"99","author":"Hall","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.03.025_bib47","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1038\/s41598-019-44161-y","article-title":"Gcm1 is involved in cell proliferation and fibrosis during kidney regeneration after ischemia-reperfusion injury","volume":"9","author":"Kamejima","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2025.03.025_bib48","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/15548627.2015.1135284","article-title":"The yin and yang of autophagy in acute kidney injury","volume":"12","author":"Melk","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.kint.2025.03.025_bib49","article-title":"From AKI to CKD: maladaptive repair and the underlying mechanisms","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2025.03.025_bib50","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1681\/ASN.2021010069","article-title":"Recent approaches to targeting canonical NF\u03baB signaling in the early inflammatory response to renal IRI","volume":"32","author":"Reid","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2025.03.025_bib51","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fcell.2020.00361","article-title":"Regulatory mechanisms of cell polyploidy in insects","volume":"8","author":"Ren","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.kint.2025.03.025_bib52","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.pharmthera.2018.10.013","article-title":"P53 in kidney injury and repair: mechanism and therapeutic potentials","volume":"195","author":"Tang","year":"2019","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.kint.2025.03.025_bib53","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ndt\/gfac173","article-title":"Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study","volume":"38","author":"Steinbrenner","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2025.03.025_bib54","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3390\/biomedicines11051356","article-title":"Osteopontin as a biomarker in chronic kidney disease","volume":"11","author":"Sinha","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.kint.2025.03.025_bib55","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12967-023-04279-0","article-title":"Increased expression of OPN contributes to idiopathic pulmonary fibrosis and indicates a poor prognosis","volume":"21","author":"Ji","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.kint.2025.03.025_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.109839","article-title":"Kidney fibrosis molecular mechanisms Spp1 influences fibroblast activity through transforming growth factor beta smad signaling","volume":"27","author":"Ding","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.kint.2025.03.025_bib57","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1167\/iovs.09-3420","article-title":"Impaired angiogenic response in the corneas of mice lacking osteopontin","volume":"51","author":"Fujita","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.kint.2025.03.025_bib58","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.ecoenv.2019.01.005","article-title":"Osteopontin potentiates PM-induced IL-1\u03b1 and IL-1\u03b2 production via the ERK\/JNK signaling pathway","volume":"171","author":"Wang","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"key":"10.1016\/j.kint.2025.03.025_bib59","doi-asserted-by":"crossref","DOI":"10.1002\/dvg.23529","article-title":"Epithelial-mesenchymal plasticity in kidney fibrosis","volume":"62","author":"Hadpech","year":"2024","journal-title":"Genesis"},{"key":"10.1016\/j.kint.2025.03.025_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114414","article-title":"Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-\u03b21\/p38MAPK\/Smad2\/3 pathway","volume":"280","author":"Qin","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.kint.2025.03.025_bib61","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1042\/CS20180602","article-title":"MKP2 inhibits TGF-\u03b21-induced epithelial-to-mesenchymal transition in renal tubular epithelial cells through a JNK-dependent pathway","volume":"132","author":"Li","year":"2018","journal-title":"Clin Sci (Lond)"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253825003321?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253825003321?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:40:58Z","timestamp":1762231258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253825003321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0085253825003321"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2025.03.025","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single-cell analysis of proximal tubular cells with different DNA content reveals functional heterogeneity in the acute kidney injury to chronic kidney disease transition","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2025.03.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society of Nephrology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}