{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:40:30Z","timestamp":1760834430287,"version":"build-2065373602"},"reference-count":11,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.kint.2025.08.001","type":"journal-article","created":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T09:47:39Z","timestamp":1760694459000},"page":"735-737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The coming of age for polycystic kidney disease"],"prefix":"10.1016","volume":"108","author":[{"given":"Uyen A.","family":"Tran","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6440-7975","authenticated-orcid":false,"given":"Oliver","family":"Wessely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2025.08.001_bib1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"Lopez-Otin","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.kint.2025.08.001_bib2","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/nm.4000","article-title":"Cellular senescence in aging and age-related disease: from mechanisms to therapy","volume":"21","author":"Childs","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2025.08.001_bib3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/HYPERTENSIONAHA.120.14594","article-title":"Cellular senescence: a new player in kidney injury","volume":"76","author":"Li","year":"2020","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2025.08.001_bib4","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.kint.2025.05.027","article-title":"Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease","volume":"108","author":"Mao","year":"2025","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2025.08.001_bib5","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(15)60907-2","article-title":"Autosomal dominant polycystic kidney disease: the changing face of clinical management","volume":"385","author":"Ong","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2025.08.001_bib6","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1152\/physrev.00018.2024","article-title":"Physiologic mechanisms underlying polycystic kidney disease","volume":"105","author":"Boletta","year":"2025","journal-title":"Physiol Rev"},{"key":"10.1016\/j.kint.2025.08.001_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(98)03495-3","article-title":"Comparison of phenotypes of polycystic kidney disease types 1 and 2","volume":"353","author":"Hateboer","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2025.08.001_bib8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1471-2369-8-12","article-title":"p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression: roscovitine augments p21 levels","volume":"8","author":"Park","year":"2007","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.kint.2025.08.001_bib9","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","article-title":"Senescence and cancer\u2014role and therapeutic opportunities","volume":"19","author":"Schmitt","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.kint.2025.08.001_bib10","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1111\/febs.16350","article-title":"Targeting cellular senescence with senotherapeutics: senolytics and senomorphics","volume":"290","author":"Zhang","year":"2023","journal-title":"FEBS J"},{"key":"10.1016\/j.kint.2025.08.001_bib11","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1038\/s41418-024-01393-4","article-title":"AKR1B1-dependent fructose metabolism enhances malignancy of cancer cells","volume":"31","author":"Zhao","year":"2024","journal-title":"Cell Death Differ"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253825006465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253825006465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:18:14Z","timestamp":1760825894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253825006465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0085253825006465"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2025.08.001","relation":{},"ISSN":["0085-2538"],"issn-type":[{"type":"print","value":"0085-2538"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The coming of age for polycystic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2025.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2025.05.027","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 International Society of Nephrology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}