{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:36:33Z","timestamp":1793050593830,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T00:00:00Z","timestamp":1768953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","award":["R35-HL171421"],"award-info":[{"award-number":["R35-HL171421"]}],"id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","award":["R01-AG074552"],"award-info":[{"award-number":["R01-AG074552"]}],"id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007270","name":"University of Michigan","doi-asserted-by":"publisher","award":["R01HL163870"],"award-info":[{"award-number":["R01HL163870"]}],"id":[{"id":"10.13039\/100007270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.kint.2026.01.004","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T00:19:21Z","timestamp":1769127561000},"page":"725-737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Heat shock protein 70s are modifiers of endothelial function in Fabry disease"],"prefix":"10.1016","volume":"109","author":[{"given":"Rakesh","family":"Verma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Cleuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vania","family":"Hinkovska-Galcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilka","family":"Decker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ginsburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Shayman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.01.004_bib1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1750-1172-5-30","article-title":"Fabry disease","volume":"5","author":"Germain","year":"2010","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.kint.2026.01.004_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/genes15010037","article-title":"Fabry disease in women: genetic basis, available biomarkers, and clinical manifestations","volume":"15","author":"Izhar","year":"2023","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.kint.2026.01.004_bib3","article-title":"Comment: why are females with Fabry disease affected?","volume":"21","author":"Beck","year":"2019","journal-title":"Mol Genet Metab Rep"},{"key":"10.1016\/j.kint.2026.01.004_bib4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/cge.14102","article-title":"Challenging the traditional approach for interpreting genetic variants: lessons from Fabry disease","volume":"101","author":"Germain","year":"2022","journal-title":"Clin Genet"},{"key":"10.1016\/j.kint.2026.01.004_bib5","doi-asserted-by":"crossref","first-page":"8273","DOI":"10.3390\/ijms25158273","article-title":"Inflammation, oxidative stress, and endothelial dysfunction in the pathogenesis of vascular damage: unraveling novel cardiovascular risk factors in Fabry disease","volume":"25","author":"Faro","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2026.01.004_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/01.ASN.0000043901.45141.D4","article-title":"Fabry disease in mice is associated with age-dependent susceptibility to vascular thrombosis","volume":"14","author":"Eitzman","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.01.004_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1161\/01.CIR.0000154550.15963.80","article-title":"\u03b1-Galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency","volume":"111","author":"Bodary","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2026.01.004_bib8","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1440-1681.2008.04984.x","article-title":"Vascular dysfunction in the \u03b1-galactosidase A-knockout mouse is an endothelial cell-, plasma membrane-based defect","volume":"35","author":"Park","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"10.1016\/j.kint.2026.01.004_bib9","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1681\/ASN.2008111190","article-title":"Decreased nitric oxide bioavailability in a mouse model of Fabry disease","volume":"20","author":"Shu","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.01.004_bib10","doi-asserted-by":"crossref","first-page":"20960","DOI":"10.1074\/jbc.M702436200","article-title":"Caveolin-associated accumulation of globotriaosylceramide in the vascular endothelium of \u03b1-galactosidase A null mice","volume":"282","author":"Shu","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.01.004_bib11","doi-asserted-by":"crossref","first-page":"23618","DOI":"10.1073\/pnas.1912409116","article-title":"The in vivo endothelial cell translatome is highly heterogeneous across vascular beds","volume":"116","author":"Cleuren","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.01.004_bib12","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.01.004_bib13","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"4","author":"Percie du Sert","year":"2020","journal-title":"BMJ Open Sci"},{"key":"10.1016\/j.kint.2026.01.004_bib14","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1182\/blood-2014-02-554501","article-title":"Murine coagulation factor VIII is synthesized in endothelial cells","volume":"123","author":"Everett","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.kint.2026.01.004_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.kint.2026.01.004_bib16","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2026.01.004_bib17","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ymgme.2018.10.007","article-title":"Dissociation of globotriaosylceramide and impaired endothelial function in \u03b1-galactosidase-A deficient EA.hy926 cells","volume":"125","author":"Kaissarian","year":"2018","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.kint.2026.01.004_bib18","doi-asserted-by":"crossref","first-page":"20210","DOI":"10.1073\/pnas.1910942116","article-title":"Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods","volume":"116","author":"Eroglu","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.01.004_bib19","doi-asserted-by":"crossref","first-page":"9371","DOI":"10.1038\/s41598-017-09907-6","article-title":"Exosomes from high glucose-treated glomerular endothelial cells trigger the epithelial-mesenchymal transition and dysfunction of podocytes","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2026.01.004_bib20","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/humu.23611","article-title":"Exploring genetic modifiers of Gaucher disease: the next horizon","volume":"39","author":"Davidson","year":"2018","journal-title":"Hum Mutat"},{"key":"10.1016\/j.kint.2026.01.004_bib21","doi-asserted-by":"crossref","first-page":"17394","DOI":"10.1073\/pnas.0704998104","article-title":"Molecular imaging of membrane interfaces reveals mode of \u03b2-glucosidase activation by saposin C","volume":"104","author":"Alattia","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.01.004_bib22","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.cell.2007.10.018","article-title":"LIMP-2 is a receptor for lysosomal mannose-6-phosphate-independent targeting of \u03b2-glucocerebrosidase","volume":"131","author":"Reczek","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.kint.2026.01.004_bib23","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s10545-012-9478-x","article-title":"Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts","volume":"35","author":"Aureli","year":"2012","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.kint.2026.01.004_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.lab.2004.03.013","article-title":"Mutations in the gene encoding cytosolic \u03b2-glucosidase in Gaucher disease","volume":"144","author":"Beutler","year":"2004","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.kint.2026.01.004_bib25","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/humu.22381","article-title":"Characterization of variants in the glucosylceramide synthase gene and their association with type 1 Gaucher disease severity","volume":"34","author":"Alfonso","year":"2013","journal-title":"Hum Mutat"},{"key":"10.1016\/j.kint.2026.01.004_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ebiom.2016.11.006","article-title":"Progranulin as a novel factor in Gaucher disease","volume":"13","author":"Choy","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/j.kint.2026.01.004_bib27","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1093\/hmg\/dds535","article-title":"ITCH regulates degradation of mutant glucocerebrosidase: implications to Gaucher disease","volume":"22","author":"Maor","year":"2013","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2026.01.004_bib28","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.1073\/pnas.0712309105","article-title":"Elevated globotriaosylsphingosine is a hallmark of Fabry disease","volume":"105","author":"Aerts","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.01.004_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ymgme.2023.107714","article-title":"Prevalence of Fabry disease in patients with chronic kidney disease: a systematic review and meta-analysis","volume":"140","author":"Linares","year":"2023","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.kint.2026.01.004_bib30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s40620-024-01908-9","article-title":"Pathogenic pathways of renal damage in Fabry nephropathy: interplay between immune cell infiltration, apoptosis and fibrosis","volume":"37","author":"Bondar","year":"2024","journal-title":"J Nephrol"},{"key":"10.1016\/j.kint.2026.01.004_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132444","article-title":"Ventricular arrhythmias and primary prevention of sudden cardiac death in Anderson-Fabry disease","volume":"415","author":"Piccolo","year":"2024","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.kint.2026.01.004_bib32","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s12325-024-03062-x","article-title":"Influence of treatment effect modifiers in Fabry disease: a systematic literature review","volume":"42","author":"Azimpour","year":"2025","journal-title":"Adv Ther"},{"issue":"suppl 2","key":"10.1016\/j.kint.2026.01.004_bib33","first-page":"1","article-title":"Glycosphingolipid mediated caveolin-1 oligomerization","author":"Shu","year":"2012","journal-title":"J Glycomics Lipidomics"},{"key":"10.1016\/j.kint.2026.01.004_bib34","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/ATVBAHA.123.319833","article-title":"Unraveling the role of sex in endothelial cell dysfunction: evidence from lineage tracing mice and cultured cells","volume":"44","author":"Shin","year":"2024","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2026.01.004_bib35","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1161\/CIRCRESAHA.122.320259","article-title":"Illuminating the mechanisms underlying sex differences in cardiovascular disease","volume":"130","author":"Reue","year":"2022","journal-title":"Circ Res"},{"key":"10.1016\/j.kint.2026.01.004_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0304551","article-title":"The short-chain fatty acid propionate prevents ox-LDL-induced coronary microvascular dysfunction by alleviating endoplasmic reticulum stress in HCMECs","volume":"19","author":"Hong","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2026.01.004_bib37","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5717913","article-title":"Reperfusion activates AP-1 and heat shock response in donor kidney parenchyma after warm ischemia","volume":"2018","author":"Reznik","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.kint.2026.01.004_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ki.2013.520","article-title":"Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease","volume":"86","author":"Shu","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.01.004_bib39","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1074\/jbc.M111.323295","article-title":"Modulation of heme\/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination","volume":"287","author":"Peng","year":"2012","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.01.004_bib40","doi-asserted-by":"crossref","first-page":"49332","DOI":"10.1074\/jbc.M304738200","article-title":"Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone\/ubiquitin ligase CHIP","volume":"278","author":"Jiang","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.01.004_bib41","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature08710","article-title":"Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology","volume":"463","author":"Kirkegaard","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.kint.2026.01.004_bib42","doi-asserted-by":"crossref","first-page":"355ra118","DOI":"10.1126\/scitranslmed.aad9823","article-title":"Heat shock protein-based therapy as a potential candidate for treating the sphingolipidoses","volume":"8","author":"Kirkegaard","year":"2016","journal-title":"Sci Transl Med"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382600013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382600013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:10:03Z","timestamp":1793049003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525382600013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S008525382600013X"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.01.004","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat shock protein 70s are modifiers of endothelial function in Fabry disease","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.01.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society of Nephrology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}