{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:54:08Z","timestamp":1788497648004,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013831","name":"Buck Institute for Research on Aging","doi-asserted-by":"publisher","award":["HF-PART-23-1422047"],"award-info":[{"award-number":["HF-PART-23-1422047"]}],"id":[{"id":"10.13039\/100013831","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032645","name":"Hevolution Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011531","name":"University of Alabama","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U24-CA210990"],"award-info":[{"award-number":["U24-CA210990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01-NS100529"],"award-info":[{"award-number":["R01-NS100529"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["U54-AG075932"],"award-info":[{"award-number":["U54-AG075932"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["T32 AG000266"],"award-info":[{"award-number":["T32 AG000266"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.kint.2026.02.024","type":"journal-article","created":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:11:31Z","timestamp":1774051891000},"page":"130-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2"],"prefix":"10.1016","volume":"110","author":[{"given":"Mikayla","family":"Hady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Tadeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desislava","family":"Stoyanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison L.","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth A.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harris","family":"Ingle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna Vadhana","family":"Ashok Kumaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin D.","family":"Ambrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Benz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9050-7977","authenticated-orcid":false,"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.02.024_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/ndt\/gfac037","article-title":"Factors associated with sex differences in the risk of kidney stones","volume":"38","author":"Ferraro","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2026.02.024_bib2","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/j.bbadis.2012.03.004","article-title":"Primary hyperoxalurias: disorders of glyoxylate detoxification","volume":"1822","author":"Salido","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.kint.2026.02.024_bib3","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa2021712","article-title":"Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1","volume":"384","author":"Garrelfs","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.02.024_bib4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/jpm11020074","article-title":"Small molecule-based enzyme inhibitors in the treatment of primary hyperoxalurias","volume":"11","author":"Moya-Garzon","year":"2021","journal-title":"J Pers Med"},{"key":"10.1016\/j.kint.2026.02.024_bib5","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/hmg\/8.11.2063","article-title":"The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II","volume":"8","author":"Cramer","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2026.02.024_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s004390000351","article-title":"Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2)","volume":"107","author":"Webster","year":"2000","journal-title":"Hum Genet"},{"key":"10.1016\/j.kint.2026.02.024_bib7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/humu.9200","article-title":"Molecular analysis of the glyoxylate reductase (GRHPR) gene and description of mutations underlying primary hyperoxaluria type 2","volume":"22","author":"Cregeen","year":"2003","journal-title":"Hum Mutat"},{"key":"10.1016\/j.kint.2026.02.024_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jmb.2006.05.018","article-title":"Structural basis of substrate specificity in human glyoxylate reductase\/hydroxypyruvate reductase","volume":"360","author":"Booth","year":"2006","journal-title":"J Mol Biol"},{"key":"10.1016\/j.kint.2026.02.024_bib9","series-title":"GeneReviews\u00ae","article-title":"Primary hyperoxaluria type 2","author":"Rumsby","year":"1993"},{"key":"10.1016\/j.kint.2026.02.024_bib10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ajhg.2010.07.023","article-title":"Mutations in DHDPSL are responsible for primary hyperoxaluria type III","volume":"87","author":"Belostotsky","year":"2010","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.kint.2026.02.024_bib11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/MOU.0000000000000709","article-title":"Future treatments for hyperoxaluria","volume":"30","author":"Burns","year":"2020","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.kint.2026.02.024_bib12","doi-asserted-by":"crossref","first-page":"18249","DOI":"10.1073\/pnas.0607218103","article-title":"Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer","volume":"103","author":"Salido","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.02.024_bib13","doi-asserted-by":"crossref","first-page":"F688","DOI":"10.1152\/ajprenal.00473.2011","article-title":"Hydroxyproline metabolism in mouse models of primary hyperoxaluria","volume":"302","author":"Knight","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.02.024_bib14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/BJ20141159","article-title":"Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria","volume":"466","author":"Summitt","year":"2015","journal-title":"Biochem J"},{"key":"10.1016\/j.kint.2026.02.024_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2019.165633","article-title":"The effects of the inactivation of hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria","volume":"1866","author":"Buchalski","year":"2020","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.kint.2026.02.024_bib16","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00726-021-03012-9","article-title":"N-propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties","volume":"53","author":"Scott","year":"2021","journal-title":"Amino Acids"},{"key":"10.1016\/j.kint.2026.02.024_bib17","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1158\/1535-7163.MCT-18-1323","article-title":"Targeting mitochondrial proline dehydrogenase with a suicide inhibitor to exploit synthetic lethal interactions with p53 upregulation and glutaminase inhibition","volume":"18","author":"Scott","year":"2019","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.kint.2026.02.024_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148733","article-title":"Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: a prevention strategy against neurodegeneration","volume":"1826","author":"Teramayi","year":"2024","journal-title":"Brain Res"},{"key":"10.1016\/j.kint.2026.02.024_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166848","article-title":"Therapeutic targeting of HYPDH\/PRODH2 with N-propargylglycine offers a hyperoxaluria treatment opportunity","volume":"1870","author":"Bons","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.kint.2026.02.024_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1177\/12.5.333","article-title":"Histochemical recognition of calcium oxalate","volume":"12","author":"Pizzolato","year":"1964","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.kint.2026.02.024_bib21","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1681\/ASN.2016030338","article-title":"An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluria","volume":"28","author":"Liebow","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.02.024_bib22","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1681\/ASN.2017040390","article-title":"Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluria","volume":"29","author":"Fargue","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.02.024_bib23","doi-asserted-by":"crossref","first-page":"2700","DOI":"10.1016\/j.bbadis.2015.09.016","article-title":"Hydroxyproline metabolism in a mouse model of primary hyperoxaluria type 3","volume":"1852","author":"Li","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.kint.2026.02.024_bib24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s42003-022-03750-w","article-title":"Two independent modes of kidney stone suppression achieved by AIM\/CD5L and KIM-1","volume":"5","author":"Matsuura","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.kint.2026.02.024_bib25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1523-1755.2002.00433.x","article-title":"Kidney injury molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury","volume":"62","author":"Han","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.02.024_bib26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11010-016-2700-7","article-title":"Kidney injury molecule-1 (KIM-1) mediates renal epithelial cell repair via ERK MAPK signaling pathway","volume":"416","author":"Zhang","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.kint.2026.02.024_bib27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/aja.1001680308","article-title":"Histochemical evaluation of mouse and rat kidneys with lectin-horseradish peroxidase conjugates","volume":"168","author":"Schulte","year":"1983","journal-title":"Am J Anat"},{"key":"10.1016\/j.kint.2026.02.024_bib28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4103\/0971-4065.111840","article-title":"Serum cystatin C as a marker of renal function in detection of early acute kidney injury","volume":"23","author":"Murty","year":"2013","journal-title":"Indian J Nephrol"},{"key":"10.1016\/j.kint.2026.02.024_bib29","article-title":"4-Hydroxy-2-oxoglutarate metabolism in a mouse model of primary hyperoxaluria type 3","volume":"39","author":"Li","year":"2024","journal-title":"Biochem Biophys Rep"},{"key":"10.1016\/j.kint.2026.02.024_bib30","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10545-016-9940-2","article-title":"Genetic cause and prevalence of hydroxyprolinemia","volume":"39","author":"Staufner","year":"2016","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.kint.2026.02.024_bib31","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00726-008-0111-0","article-title":"PRODH variants and risk for schizophrenia","volume":"35","author":"Willis","year":"2008","journal-title":"Amino Acids"},{"key":"10.1016\/j.kint.2026.02.024_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2025.110319","article-title":"Biochemical, structural, and cellular characterization of S-but-3-yn-2-ylglycine as a mechanism-based covalent inactivator of the flavoenzyme proline dehydrogenase","volume":"765","author":"Meeks","year":"2025","journal-title":"Arch Biochem Biophys"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:55:09Z","timestamp":1787172909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253826002188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0085253826002188"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.02.024","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-propargylglycine restores survival by preventing calcium oxalate stone formation, tubular injury, and kidney dysfunction in a lethal mouse model of primary hyperoxaluria type 2","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.02.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}