{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:35:13Z","timestamp":1791293713563,"version":"4.1.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019519","name":"Kasturba Medical College, Manipal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019519","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.kint.2026.03.016","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T15:43:06Z","timestamp":1777045386000},"page":"99-114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reversal of advanced diabetic kidney disease in mice treated with a monoclonal anti-VEGFR1 antibody"],"prefix":"10.1016","volume":"110","author":[{"given":"Zhonghua","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnny Eugene","family":"Croy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Heinz-Taheny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Credille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim Bikash","family":"Dey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna","family":"Jaqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Hope","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Hamang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arindam","family":"Majumdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine M.","family":"Conner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1613-2000","authenticated-orcid":false,"given":"Ina Maria","family":"Schiessl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janos","family":"Peti-Peterdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Gyarmati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin L.","family":"Duffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-371X","authenticated-orcid":false,"given":"Matthew D.","family":"Breyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.03.016_bib1","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1056\/NEJMoa2024816","article-title":"Dapagliflozin in patients with chronic kidney disease","volume":"383","author":"Heerspink","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.03.016_bib2","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.03.016_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1056\/NEJMoa2403347","article-title":"Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes","volume":"391","author":"Perkovic","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.03.016_bib4","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1056\/NEJMoa0707330","article-title":"VEGF inhibition and renal thrombotic microangiopathy","volume":"358","author":"Eremina","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.03.016_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1681\/ASN.2018080853","article-title":"Therapeutic inhibition of VEGF signaling and associated nephrotoxicities","volume":"30","author":"Estrada","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib6","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2006121304","article-title":"Interstitial vascular rarefaction and reduced VEGF\u2014a expression in human diabetic nephropathy","volume":"18","author":"Lindenmeyer","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib7","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1681\/ASN.2014010028","article-title":"Functional genomic annotation of genetic risk loci highlights inflammation and epithelial biology networks in CKD","volume":"26","author":"Ledo","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1172\/JCI17423","article-title":"Glomerular-specific alterations of VEGF\u2014a expression lead to distinct congenital and acquired renal diseases","volume":"111","author":"Eremina","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.03.016_bib9","doi-asserted-by":"crossref","first-page":"12605","DOI":"10.1074\/jbc.C300012200","article-title":"Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria","volume":"278","author":"Sugimoto","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.03.016_bib10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nrneph.2011.219","article-title":"Restoring the renal microvasculature to treat chronic kidney disease","volume":"8","author":"Long","year":"2012","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib11","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1681\/ASN.V125993","article-title":"Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes","volume":"12","author":"de Vriese","year":"2001","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib12","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.2337\/diabetes.51.10.3090","article-title":"Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody","volume":"51","author":"Flyvbjerg","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2026.03.016_bib13","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1681\/ASN.2006010064","article-title":"Blockade of vascular endothelial growth factor signaling ameliorates diabetic albuminuria in mice","volume":"17","author":"Sung","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib14","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.2337\/DB11-1655","article-title":"VEGFA protects the glomerular microvasculature in diabetes","volume":"61","author":"Sivaskandarajah","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2026.03.016_bib15","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00125-010-2034-z","article-title":"Podocyte vascular endothelial growth factor (Vegf164) overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes","volume":"54","author":"Veron","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.kint.2026.03.016_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1523-1755.2005.00405.x","article-title":"Can murine diabetic nephropathy be separated from superimposed acute renal failure?","volume":"68","author":"Tay","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.03.016_bib17","doi-asserted-by":"crossref","first-page":"108","DOI":"10.7326\/0003-4819-79-1-108","article-title":"Pancreatic islet cell carcinoma. II. Results of therapy with streptozotocin in 52 patients","volume":"79","author":"Broder","year":"1973","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.kint.2026.03.016_bib18","doi-asserted-by":"crossref","first-page":"8705","DOI":"10.1038\/s41598-023-35850-w","article-title":"Streptozotocin induces renal proximal tubular injury through p53 signaling activation","volume":"13","author":"Nakai","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2026.03.016_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006502","article-title":"Signal transduction by vascular endothelial growth factor receptors","volume":"2","author":"Koch","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.kint.2026.03.016_bib20","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20210565","article-title":"Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance","volume":"219","author":"Karaman","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.kint.2026.03.016_bib21","doi-asserted-by":"crossref","first-page":"9349","DOI":"10.1073\/pnas.95.16.9349","article-title":"Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice","volume":"95","author":"Hiratsuka","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.03.016_bib22","doi-asserted-by":"crossref","first-page":"H153","DOI":"10.1152\/ajpheart.00254.2003","article-title":"Model of competitive binding of vascular endothelial growth factor and placental growth factor to VEGF receptors on endothelial cells","volume":"286","author":"Mac Gabhann","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.kint.2026.03.016_bib23","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1681\/ASN.2017040385","article-title":"Progressive renal disease established by renin-coding adeno-associated virus-driven hypertension in diverse diabetic models","volume":"29","author":"Harlan","year":"2018","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib24","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1681\/ASN.2009070721","article-title":"Mouse models of diabetic nephropathy","volume":"20","author":"Brosius","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib25","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1681\/ASN.2006070798","article-title":"Endothelial nitric oxide synthase deficiency produces accelerated nephropathy in diabetic mice","volume":"17","author":"Zhao","year":"2006","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib26","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1182\/blood-2004-01-0226","article-title":"Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo","volume":"104","author":"Wang","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.kint.2026.03.016_bib27","doi-asserted-by":"crossref","first-page":"6573","DOI":"10.1158\/1078-0432.CCR-06-0831","article-title":"Anti-vascular endothelial growth factor receptor-1 antagonist antibody as a therapeutic agent for cancer","volume":"12","author":"Wu","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.kint.2026.03.016_bib28","doi-asserted-by":"crossref","first-page":"5523","DOI":"10.18632\/oncotarget.27148","article-title":"Anti-VEGFR2 therapy delays growth of preclinical pediatric tumor models and enhances anti-tumor activity of chemotherapy","volume":"10","author":"Lowery","year":"2019","journal-title":"Oncotarget"},{"key":"10.1016\/j.kint.2026.03.016_bib29","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jimmun\/vkae057","article-title":"Quantitative detection of the HVEM-BTLA checkpoint receptor cis-complex in human lymphocytes","volume":"214","author":"Atwell","year":"2025","journal-title":"J Immunol"},{"key":"10.1016\/j.kint.2026.03.016_bib30","doi-asserted-by":"crossref","first-page":"F951","DOI":"10.1152\/ajprenal.00443.2016","article-title":"Role of TGF-alpha in the progression of diabetic kidney disease","volume":"312","author":"Heuer","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.03.016_bib31","first-page":"357","article-title":"Specific creatinine determination in laboratory animals using the new enzymatic test kit \"Creatinine-PAP.\"","volume":"25","author":"Jung","year":"1987","journal-title":"J Clin Chem Clin Biochem"},{"key":"10.1016\/j.kint.2026.03.016_bib32","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/sj.ki.5001988","article-title":"Plasma creatinine determination in mice and rats: an enzymatic method compares favorably with a high-performance liquid chromatography assay","volume":"71","author":"Keppler","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.03.016_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1177\/0192623318761348","article-title":"Use of severity grades to characterize histopathologic changes","volume":"46","author":"Schafer","year":"2018","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.kint.2026.03.016_bib34","doi-asserted-by":"crossref","first-page":"F783","DOI":"10.1152\/ajprenal.00279.2012","article-title":"Transcutaneous measurement of renal function in conscious mice","volume":"303","author":"Schreiber","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.03.016_bib35","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1681\/ASN.2012010017","article-title":"Loss of the endothelial glycocalyx links albuminuria and vascular dysfunction","volume":"23","author":"Salmon","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/10618600.1996.10474713","article-title":"a language for data analysis and graphics","volume":"5","author":"Ihaka","year":"1996","journal-title":"J Comput Graph Stat"},{"key":"10.1016\/j.kint.2026.03.016_bib37","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol"},{"key":"10.1016\/j.kint.2026.03.016_bib38","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1006094117427","article-title":"Monoclonal antibodies targeting the VEGF receptor-2 (Flk1\/KDR) as an anti-angiogenic therapeutic strategy","volume":"17","author":"Witte","year":"1998","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.kint.2026.03.016_bib39","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nm731","article-title":"Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1","volume":"8","author":"Luttun","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2026.03.016_bib40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2353\/ajpath.2007.060610","article-title":"Lack of endothelial nitric-oxide synthase leads to progressive focal renal injury","volume":"170","author":"Forbes","year":"2007","journal-title":"Am J Path"},{"key":"10.1016\/j.kint.2026.03.016_bib41","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1172\/JCI94518","article-title":"Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms","volume":"128","author":"Zhao","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.03.016_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2023.100305","article-title":"Effects of dipeptidyl peptidase-4 inhibitor and angiotensin-converting enzyme inhibitor on experimental diabetic kidney disease","volume":"104","author":"Al Tuhaifi","year":"2024","journal-title":"Lab Invest"},{"key":"10.1016\/j.kint.2026.03.016_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10456-023-09883-8","article-title":"Capillary rarefaction: a missing link in renal and cardiovascular disease?","volume":"27","author":"Steegh","year":"2024","journal-title":"Angiogenesis"},{"key":"10.1016\/j.kint.2026.03.016_bib44","doi-asserted-by":"crossref","first-page":"e90","DOI":"10.1002\/cpz1.90","article-title":"Gene set knowledge discovery with enrichr","volume":"1","author":"Xie","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.kint.2026.03.016_bib45","doi-asserted-by":"crossref","first-page":"7533","DOI":"10.1073\/pnas.90.16.7533","article-title":"Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium","volume":"90","author":"Quinn","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.03.016_bib46","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1161\/01.HYP.24.5.531","article-title":"Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study","volume":"24","author":"Gasc","year":"1994","journal-title":"Hypertension"},{"key":"10.1016\/j.kint.2026.03.016_bib47","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1152\/physrev.00055.2009","article-title":"Biology of human sodium glucose transporters","volume":"91","author":"Wright","year":"2011","journal-title":"Physiol Rev"},{"key":"10.1016\/j.kint.2026.03.016_bib48","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.2337\/diabetes.48.11.2229","article-title":"Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes","volume":"48","author":"Cooper","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.kint.2026.03.016_bib49","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1053\/j.ajkd.2006.11.039","article-title":"Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis","volume":"49","author":"Zhu","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2026.03.016_bib50","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1681\/ASN.2021070948","article-title":"Acute treatment effects on GFR in randomized clinical trials of kidney disease progression","volume":"33","author":"Neuen","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib51","doi-asserted-by":"crossref","first-page":"6216","DOI":"10.1038\/s41598-021-85693-6","article-title":"A dose-escalating toxicology study of the candidate biologic ELP-VEGF","volume":"11","author":"Waller","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2026.03.016_bib52","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ki.2014.219","article-title":"Reduced adenosine A2a receptor-mediated efferent arteriolar vasodilation contributes to diabetes-induced glomerular hyperfiltration","volume":"87","author":"Persson","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.03.016_bib53","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1681\/ASN.2019020192","article-title":"Glomerular function and structural integrity depend on hyaluronan synthesis by glomerular endothelium","volume":"30","author":"van den Berg","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.03.016_bib54","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1182\/blood-2006-04-016030","article-title":"Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes\/macrophages","volume":"108","author":"Murakami","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.kint.2026.03.016_bib55","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1172\/JCI119392","article-title":"Vascular dysfunction induced by elevated glucose levels in rats is mediated by vascular endothelial growth factor","volume":"99","author":"Tilton","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.03.016_bib56","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1007\/s00125-017-4322-3","article-title":"The VEGF-A inhibitor sFLT-1 improves renal function by reducing endothelial activation and inflammation in a mouse model of type 1 diabetes","volume":"60","author":"Bus","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.kint.2026.03.016_bib57","doi-asserted-by":"crossref","first-page":"F609","DOI":"10.1152\/ajprenal.00377.2009","article-title":"Soluble Flt-1 gene therapy ameliorates albuminuria but accelerates tubulointerstitial injury in diabetic mice","volume":"298","author":"Kosugi","year":"2010","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.03.016_bib58","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/ndt\/gfae010","article-title":"Outcomes for clinical trials involving adults with chronic kidney disease: a multinational Delphi survey involving patients, caregivers and health professionals","volume":"39","author":"Matus Gonzalez","year":"2024","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2026.03.016_bib59","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.ajkd.2019.08.007","article-title":"Change in estimated GFR and albuminuria as end points in clinical trials: a viewpoint from the FDA","volume":"75","author":"Thompson","year":"2020","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2026.03.016_bib60","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1200\/JCO.2015.65.0218","article-title":"Docetaxel as monotherapy or combined with ramucirumab or icrucumab in second-line treatment for locally advanced or metastatic urothelial carcinoma: an open-label, three-arm, randomized controlled phase II trial","volume":"34","author":"Petrylak","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.kint.2026.03.016_bib61","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10637-013-9998-8","article-title":"Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a phase 1 study","volume":"32","author":"LoRusso","year":"2014","journal-title":"Invest New Drugs"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826003066?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826003066?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:56:02Z","timestamp":1787172962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253826003066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0085253826003066"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.03.016","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reversal of advanced diabetic kidney disease in mice treated with a monoclonal anti-VEGFR1 antibody","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.04.006","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}