{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:38:38Z","timestamp":1792604318447,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01DK132230"],"award-info":[{"award-number":["R01DK132230"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK122986"],"award-info":[{"award-number":["R01DK122986"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56DK140315"],"award-info":[{"award-number":["R56DK140315"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112984"],"award-info":[{"award-number":["R01DK112984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK142433"],"award-info":[{"award-number":["R01DK142433"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK146470"],"award-info":[{"award-number":["R01DK146470"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.kint.2026.07.038","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:20:21Z","timestamp":1789971621000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Androgens drive SOX9 upregulation in injured proximal tubular cells"],"prefix":"10.1016","author":[{"given":"Corynne Vermillion","family":"Allison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prisha S.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Xuanyuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Stayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milon","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josie A.","family":"Silvaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Z.","family":"Karel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria C.","family":"Thorson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Sloane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena Joseph","family":"Thailammanal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh","family":"Scindia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Coss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Zepeda-Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0739-9344","authenticated-orcid":false,"given":"Reena","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhashini","family":"Bolisetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6324-7807","authenticated-orcid":false,"given":"Sandeep K.","family":"Mallipattu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6420-8703","authenticated-orcid":false,"given":"Benjamin D.","family":"Humphreys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Bajwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navjot S.","family":"Pabla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.07.038_bib1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev-physiol-052521-121841","article-title":"How many cell types are in the kidney and what do they do?","volume":"84","author":"Balzer","year":"2022","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib2","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2215\/CJN.08860813","article-title":"Homeostasis, the milieu int\u00e9rieur, and the wisdom of the nephron","volume":"9","author":"Hoenig","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib3","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2017.107","article-title":"Mitochondrial energetics in the kidney","volume":"13","author":"Bhargava","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev-med-050214-013407","article-title":"Acute kidney injury","volume":"67","author":"Zuk","year":"2016","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.kint.2026.07.038_bib5","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/S0140-6736(11)61454-2","article-title":"Acute kidney injury","volume":"380","author":"Bellomo","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.kint.2026.07.038_bib6","doi-asserted-by":"crossref","first-page":"4210","DOI":"10.1172\/JCI45161","article-title":"Cellular pathophysiology of ischemic acute kidney injury","volume":"121","author":"Bonventre","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib7","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1681\/ASN.2014030262","article-title":"Regulated cell death in AKI","volume":"25","author":"Linkermann","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib8","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nrneph.2011.13","article-title":"Acute kidney injury: what\u2019s the prognosis?","volume":"7","author":"Murugan","year":"2011","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib9","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.07.038_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41581-023-00784-z","article-title":"Differences in the epidemiology, management and outcomes of kidney disease in men and women","volume":"20","author":"Chesnaye","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib12","doi-asserted-by":"crossref","first-page":"160","DOI":"10.34067\/KID.0000000000000321","article-title":"Sex and gender differences in AKI","volume":"5","author":"Curtis","year":"2023","journal-title":"Kidney360"},{"key":"10.1016\/j.kint.2026.07.038_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.kint.2025.01.008","article-title":"The role of sex and gender in acute kidney injury-consensus statements from the 33rd Acute Disease Quality Initiative","volume":"107","author":"Soranno","year":"2025","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.semnephrol.2015.01.010","article-title":"Renal endothelial injury and microvascular dysfunction in acute kidney injury","volume":"35","author":"Kumar","year":"2015","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/sj.ki.5002312","article-title":"The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function","volume":"72","author":"Basile","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib16","article-title":"Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis","volume":"135","author":"Tiwari","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib17","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1172\/JCI200215606","article-title":"TNF-\u03b1 mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity","volume":"110","author":"Ramesh","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib18","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.semnephrol.2010.03.005","article-title":"Macrophages, dendritic cells and kidney ischemia-reperfusion injury","volume":"30","author":"Li","year":"2010","journal-title":"Semin Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib19","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41581-023-00716-x","article-title":"The importance of sex and gender in basic and clinical research","volume":"20","author":"Ahmed","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib20","doi-asserted-by":"crossref","first-page":"52282","DOI":"10.1074\/jbc.M407629200","article-title":"Testosterone is responsible for enhanced susceptibility of males to ischemic renal injury","volume":"279","author":"Park","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.07.038_bib21","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.celrep.2015.07.034","article-title":"Sox9 activation highlights a cellular pathway of renal repair in the acutely injured mammalian kidney","volume":"12","author":"Kumar","year":"2015","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2026.07.038_bib22","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.celrep.2015.12.071","article-title":"Sox9 positive progenitor cells play a key role in renal tubule epithelial regeneration in mice","volume":"14","author":"Kang","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2026.07.038_bib23","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.kint.2024.07.002","article-title":"Sox9 flips the switch between regeneration and fibrosis","volume":"106","author":"Humphreys","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib24","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1038\/s41467-020-15638-6","article-title":"A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury","volume":"11","author":"Kim","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2026.07.038_bib25","doi-asserted-by":"crossref","first-page":"F920","DOI":"10.1152\/ajprenal.00429.2020","article-title":"Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury","volume":"319","author":"Kim","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib26","doi-asserted-by":"crossref","DOI":"10.1126\/science.add6371","article-title":"SOX9 switch links regeneration to fibrosis at the single-cell level in mammalian kidneys","volume":"383","author":"Aggarwal","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.kint.2026.07.038_bib28","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3390\/genes12040486","article-title":"Diverse regulation but conserved function: SOX9 in vertebrate sex determination","volume":"12","author":"Vining","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.kint.2026.07.038_bib29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/ng0996-62","article-title":"Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds","volume":"14","author":"Morais da Silva","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.kint.2026.07.038_bib30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature06944","article-title":"Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer","volume":"453","author":"Sekido","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.kint.2026.07.038_bib31","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0022-3468(75)90103-7","article-title":"Surgical closure of patent ductus arteriosus in the premature infant with respiratory distress","volume":"10","author":"Coran","year":"1975","journal-title":"J Pediatr Surg"},{"key":"10.1016\/j.kint.2026.07.038_bib32","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.celrep.2014.06.055","article-title":"The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation","volume":"8","author":"Li","year":"2014","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2026.07.038_bib33","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1242\/dev.048983","article-title":"Sry: the master switch in mammalian sex determination","volume":"137","author":"Kashimada","year":"2010","journal-title":"Development"},{"key":"10.1016\/j.kint.2026.07.038_bib34","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/hmg\/ddq558","article-title":"SOX9 controls epithelial branching by activating RET effector genes during kidney development","volume":"20","author":"Reginensi","year":"2011","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.kint.2026.07.038_bib35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.gendis.2014.09.004","article-title":"The versatile functions of Sox9 in development, stem cells, and human diseases","volume":"1","author":"Jo","year":"2014","journal-title":"Genes Dis"},{"key":"10.1016\/j.kint.2026.07.038_bib36","doi-asserted-by":"crossref","first-page":"5319","DOI":"10.1038\/s41467-018-07784-9","article-title":"Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9","volume":"9","author":"Croft","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.kint.2026.07.038_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI0215518","article-title":"Evidence that fibroblasts derive from epithelium during tissue fibrosis","volume":"110","author":"Iwano","year":"2002","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib38","doi-asserted-by":"crossref","first-page":"F171","DOI":"10.1152\/ajprenal.00043.2024","article-title":"Myeloid-specific ferritin light chain deletion does not exacerbate sepsis-associated AKI","volume":"327","author":"Odum","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib39","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.kint.2024.12.008","article-title":"Resazurin dye is an in vivo sensor of kidney tubular function","volume":"107","author":"Martinez","year":"2025","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib40","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1681\/ASN.0000000000000338","article-title":"Genome-wide CRISPR screen identifies phospholipid scramblase 3 as the biological target of mitoprotective drug SS-31","volume":"35","author":"Silvaroli","year":"2024","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.113939","article-title":"Ribociclib mitigates cisplatin-associated kidney injury through retinoblastoma-1 dependent mechanisms","volume":"177","author":"Kim","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.kint.2026.07.038_bib42","doi-asserted-by":"crossref","first-page":"F426","DOI":"10.1152\/ajprenal.00147.2024","article-title":"Role of the CDKL1-SOX11 signaling axis in acute kidney injury","volume":"327","author":"Silvaroli","year":"2024","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib43","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.kint.2021.08.022","article-title":"Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition","volume":"100","author":"Bai","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib44","doi-asserted-by":"crossref","first-page":"20349","DOI":"10.1074\/jbc.M512740200","article-title":"Orchiectomy attenuates post-ischemic oxidative stress and ischemia\/reperfusion injury in mice: a role for manganese superoxide dismutase","volume":"281","author":"Kim","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.07.038_bib45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1681\/ASN.2021081150","article-title":"Spatially resolved transcriptomic analysis of acute kidney injury in a female murine model","volume":"33","author":"Dixon","year":"2022","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib46","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.kint.2026.07.038_bib47","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1172\/JCI45586","article-title":"Inhibition of PKC\u03b4 reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer","volume":"121","author":"Pabla","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib48","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1042\/CS20200168","article-title":"Sex diversity in proximal tubule and endothelial gene expression in mice with ischemic acute kidney injury","volume":"134","author":"Vi\u00f1as","year":"2020","journal-title":"Clin Sci"},{"key":"10.1016\/j.kint.2026.07.038_bib49","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.kint.2023.02.026","article-title":"Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury","volume":"103","author":"Kim","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib50","doi-asserted-by":"crossref","first-page":"16328","DOI":"10.1074\/jbc.RA120.015110","article-title":"SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells","volume":"295","author":"Kim","year":"2020","journal-title":"J Biol Chem"},{"key":"10.1016\/j.kint.2026.07.038_bib51","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.1681\/ASN.2020010052","article-title":"Single-cell profiling of AKI in a murine model reveals novel transcriptional signatures, profibrotic phenotype, and epithelial-to-stromal crosstalk","volume":"31","author":"Rudman-Melnick","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib52","doi-asserted-by":"crossref","first-page":"F629","DOI":"10.1152\/ajprenal.00260.2021","article-title":"Role of the renal androgen receptor in sex differences in ammonia metabolism","volume":"321","author":"Harris","year":"2021","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib53","doi-asserted-by":"crossref","first-page":"F922","DOI":"10.1152\/ajprenal.00560.2019","article-title":"Testosterone modulates renal ammonia metabolism","volume":"318","author":"Harris","year":"2020","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib54","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1159\/000088171","article-title":"Differential gender differences in ischemic and nephrotoxic acute renal failure","volume":"25","author":"Wei","year":"2005","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.kint.2026.07.038_bib55","doi-asserted-by":"crossref","first-page":"F395","DOI":"10.1152\/ajprenal.00454.2015","article-title":"Low-dose testosterone protects against renal ischemia-reperfusion injury by increasing renal IL-10-to-TNF-\u03b1 ratio and attenuating T-cell infiltration","volume":"311","author":"Patil","year":"2016","journal-title":"Am J Physiol Renal Physiol"},{"key":"10.1016\/j.kint.2026.07.038_bib56","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa2215025","article-title":"Cardiovascular safety of testosterone-replacement therapy","volume":"389","author":"Lincoff","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.07.038_bib57","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1001\/jama.2013.8638","article-title":"Androgen deprivation therapy and risk of acute kidney injury in patients with prostate cancer","volume":"310","author":"Lapi","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.kint.2026.07.038_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111610","article-title":"Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair","volume":"41","author":"Ide","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.kint.2026.07.038_bib59","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s44321-025-00233-3","article-title":"SOX9-dependent fibrosis drives renal function in nephronophthisis","volume":"17","author":"Patel","year":"2025","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.kint.2026.07.038_bib60","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.kint.2022.08.036","article-title":"Myofibroblast depletion reduces kidney cyst growth and fibrosis in autosomal dominant polycystic kidney disease","volume":"103","author":"Dwivedi","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.07.038_bib61","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1101\/gad.233247.113","article-title":"SOX9: a stem cell transcriptional regulator of secreted niche signaling factors","volume":"28","author":"Kadaja","year":"2014","journal-title":"Genes Dev"},{"key":"10.1016\/j.kint.2026.07.038_bib62","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1172\/JCI66022","article-title":"Sox9 and programming of liver and pancreatic progenitors","volume":"123","author":"Kawaguchi","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.07.038_bib63","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1126\/science.aas9408","article-title":"Sex reversal following deletion of a single distal enhancer of Sox9","volume":"360","author":"Gonen","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.kint.2026.07.038_bib64","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/j.devcel.2023.08.010","article-title":"Direct androgen receptor control of sexually dimorphic gene expression in the mammalian kidney","volume":"58","author":"Xiong","year":"2023","journal-title":"Dev Cell"},{"key":"10.1016\/j.kint.2026.07.038_bib65","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.kint.2023.02.026","article-title":"Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury","volume":"103","author":"Kim","year":"2023","journal-title":"Kidney Int"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382600791X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S008525382600791X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:53:06Z","timestamp":1792601586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S008525382600791X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"alternative-id":["S008525382600791X"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.07.038","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Androgens drive SOX9 upregulation in injured proximal tubular cells","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.07.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Society of Nephrology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}