{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:31:34Z","timestamp":1793309494506,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006400","name":"Alnylam Pharmaceuticals Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006400","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.kint.2026.08.025","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:53:05Z","timestamp":1790610785000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Data from the French Daily-Luma cohort suggest predictors of a lumasiran response"],"prefix":"10.1016","author":[{"given":"Vittoria","family":"Soncin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Laure","family":"Sellier Leclerc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Acquaviva-Bourdain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Loppinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Knebelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Allard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dossier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Cloarec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9828-3245","authenticated-orcid":false,"given":"Thomas","family":"Stehl\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Courbebaisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Vrillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maize","family":"Ducret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Zaloszyc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5857-1207","authenticated-orcid":false,"given":"Moglie","family":"Le Quintrec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard Martinez","family":"Casado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Krummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Rousset-Rouviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Burtey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Ryckewaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Frouget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Di Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Samaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1958-4459","authenticated-orcid":false,"given":"Emilie","family":"Cornec-Le Gall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Hanf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Monet-Didailler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Schendel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Garnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Snanoudj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Cherni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Fila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Faudeux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Mauras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Mohamadou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3460-2507","authenticated-orcid":false,"given":"Sandrine","family":"Lemoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.08.025_bib1","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1056\/NEJMra1301564","article-title":"Primary hyperoxaluria","volume":"369","author":"Cochat","year":"2013","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.08.025_bib2","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00467-022-05613-2","article-title":"Genetic assessment in primary hyperoxaluria: why it matters","volume":"38","author":"Mandrile","year":"2023","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41581-022-00661-1","article-title":"Clinical practice recommendations for primary hyperoxaluria: an expert consensus statement from ERKNet and OxalEurope","volume":"19","author":"Groothoff","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib4","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1007\/s40265-023-01976-4","article-title":"Nedosiran: first approval","volume":"83","author":"Syed","year":"2023","journal-title":"Drugs"},{"key":"10.1016\/j.kint.2026.08.025_bib5","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJMoa2021712","article-title":"Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1","volume":"384","author":"Garrelfs","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.08.025_bib6","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.gim.2021.10.024","article-title":"Phase 3 trial of lumasiran for primary hyperoxaluria type 1: a new RNAi therapeutic in infants and young children","volume":"24","author":"Sas","year":"2022","journal-title":"Genet Med"},{"key":"10.1016\/j.kint.2026.08.025_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.ajkd.2022.05.012","article-title":"Lumasiran for advanced primary hyperoxaluria type 1: phase 3 ILLUMINATE-C trial","volume":"81","author":"Michael","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.kint.2026.08.025_bib8","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.ekir.2024.12.033","article-title":"Real-life data of 2-year lumasiran use in the DAILY-LUMA cohort","volume":"10","author":"Sellier-Leclerc","year":"2024","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2026.08.025_bib9","doi-asserted-by":"crossref","DOI":"10.1093\/ckj\/sfae090","article-title":"Lumasiran treatment in pediatric patients with PH1: real-world data within a compassionate use program in Italy","volume":"17","author":"Taroni","year":"2024","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.kint.2026.08.025_bib10","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00467-021-05393-1","article-title":"The effect of lumasiran therapy for primary hyperoxaluria type 1 in small infants","volume":"37","author":"M\u00e9aux","year":"2022","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib11","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ekir.2023.10.004","article-title":"Multicenter long-term real world data on treatment with lumasiran in patients with primary hyperoxaluria type 1","volume":"9","author":"Martin-Higueras","year":"2023","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2026.08.025_bib12","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1093\/ndt\/gfaf060","article-title":"Controlled access to lumasiran in primary hyperoxaluria type 1: evaluation of a new access route for orphan drugs in the Netherlands","volume":"40","author":"Deesker","year":"2025","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2026.08.025_bib13","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00467-025-06665-w","article-title":"Variable treatment response to lumasiran in pediatric patients with primary hyperoxaluria type 1","volume":"40","author":"Saffe","year":"2025","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib14","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.kint.2023.01.029","article-title":"Glycolate oxidase inhibition by lumasiran varies between patients with primary hyperoxaluria type 1","volume":"103","author":"Garrelfs","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.025_bib15","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1681\/ASN.2021060729","article-title":"Endogenous oxalate production in primary hyperoxaluria type 1 patients","volume":"32","author":"Garrelfs","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404007203","article-title":"Molecular aetiology of primary hyperoxaluria and its implications for clinical management","volume":"6","author":"Danpure","year":"2004","journal-title":"Expert Rev Mol Med"},{"key":"10.1016\/j.kint.2026.08.025_bib17","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1002\/humu.21021","article-title":"Primary hyperoxaluria type 1: update and additional mutation analysis of the AGXT gene","volume":"30","author":"Williams","year":"2009","journal-title":"Hum Mutat"},{"key":"10.1016\/j.kint.2026.08.025_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/ki.2014.222","article-title":"Data from a large European study indicate that the outcome of primary hyperoxaluria type 1 correlates with the AGXT mutation type","volume":"86","author":"Mandrile","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.025_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/ki.2009.435","article-title":"Genotype-phenotype correlation in primary hyperoxaluria type 1: The p.Gly170Arg AGXT mutation is associated with a better outcome","volume":"77","author":"Harambat","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.025_bib20","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.ekir.2024.07.026","article-title":"Intrafamilial disease heterogeneity in primary hyperoxaluria type 1","volume":"9","author":"Deesker","year":"2024","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.kint.2026.08.025_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","article-title":"New equations to estimate GFR in children with CKD","volume":"20","author":"Schwartz","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","article-title":"A new equation to estimate glomerular filtration rate","volume":"150","author":"Levey","year":"2009","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.kint.2026.08.025_bib23","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fpsyg.2017.00456","article-title":"Repeated measures correlation","volume":"8","author":"Bakdash","year":"2017","journal-title":"Front Psychol"},{"key":"10.1016\/j.kint.2026.08.025_bib24","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.kint.2025.12.029","article-title":"Primary hyperoxaluria(s): from trials to real-life data and pipeline therapies","volume":"109","author":"Bacchetta","year":"2026","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.025_bib25","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1681\/ASN.2020121793","article-title":"High oxalate concentrations correlate with increased risk for sudden cardiac death in dialysis patients","volume":"32","author":"Pfau","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1684\/ndt.2025.108","article-title":"Fine-tuning circulating oxalate levels to improve transplant strategies in primary hyperoxaluria: What is the ideal threshold in pediatrics?","volume":"21","author":"Makosso Afiavi","year":"2025","journal-title":"Nephrol Ther"},{"key":"10.1016\/j.kint.2026.08.025_bib27","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1007\/s40620-025-02325-2","article-title":"Lumasiran at birth changes the trajectory of primary hyperoxaluria type 1: same disease, different outcomes in two affected siblings","volume":"38","author":"Peruzzi","year":"2025","journal-title":"J. Nephrol"},{"key":"10.1016\/j.kint.2026.08.025_bib28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/j.1523-1755.2004.00796.x","article-title":"Clinical implications of mutation analysis in primary hyperoxaluria type 1","volume":"66","author":"Van Woerden","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.025_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/ckj\/sfae099","article-title":"Primary hyperoxaluria in adults and children: a nationwide cohort highlights a persistent diagnostic delay","volume":"17","author":"Pszczolinski","year":"2024","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.kint.2026.08.025_bib30","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1093\/advances\/nmab033","article-title":"Vitamin B-6-induced neuropathy: exploring the mechanisms of pyridoxine toxicity","volume":"12","author":"Hadtstein","year":"2021","journal-title":"Adv Nutr"},{"key":"10.1016\/j.kint.2026.08.025_bib31","series-title":"Tolerable Upper Intake Levels for Vitamins and Minerals","year":"2006"},{"key":"10.1016\/j.kint.2026.08.025_bib32","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJMc2312941","article-title":"Lumasiran, isolated kidney transplantation, and continued vigilance","volume":"390","author":"Bacchetta","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.08.025_bib33","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/ndt\/gfag004","article-title":"Don\u2019t think that combined liver kidney transplant can solve everything in primary hyperoxaluria type 1","volume":"41","author":"Lemoine","year":"2026","journal-title":"Nephrol Dial Transplant"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826008148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826008148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:52:03Z","timestamp":1793307123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253826008148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"alternative-id":["S0085253826008148"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.08.025","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Data from the French Daily-Luma cohort suggest predictors of a lumasiran response","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.08.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}