{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:30:55Z","timestamp":1793395855782,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003837","name":"Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016925","name":"The Takeda Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidney-international.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney International"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.kint.2026.08.029","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:10:22Z","timestamp":1790687422000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Podocyte GIT1 and GIT2 ArfGAPs cooperatively sustain the ARHGEF7-Cdc42 axis and glomerular permselectivity"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1492-6157","authenticated-orcid":false,"given":"Jun","family":"Matsuda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maho","family":"Tokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Asano-Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Miyakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamine","family":"Aoudjit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire E.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-4124","authenticated-orcid":false,"given":"Tomoko","family":"Takano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.kint.2026.08.029_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ki.2009.424","article-title":"Proteinuria: an enzymatic disease of the podocyte?","volume":"77","author":"Mundel","year":"2010","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.029_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1681\/ASN.2018020139","article-title":"Morphological processes of foot process effacement in puromycin aminonucleoside nephrosis revealed by FIB\/SEM tomography","volume":"30","author":"Ichimura","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00441-017-2590-3","article-title":"New structural insights into podocyte biology","volume":"369","author":"Grahammer","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.kint.2026.08.029_bib4","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.tcb.2007.06.006","article-title":"Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton","volume":"17","author":"Faul","year":"2007","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib5","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.kint.2017.12.028","article-title":"Actin dynamics at focal adhesions: a common endpoint and putative therapeutic target for proteinuric kidney diseases","volume":"93","author":"Sever","year":"2018","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.029_bib6","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.3390\/cells9071700","article-title":"Regulation of the actin cytoskeleton in podocytes","volume":"9","author":"Blaine","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.kint.2026.08.029_bib7","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.kint.2026.08.029_bib8","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0092-8674(04)00003-0","article-title":"Rho and Rac take center stage","volume":"116","author":"Burridge","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.kint.2026.08.029_bib9","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.3390\/cells10071831","article-title":"The RHO family GTPases: mechanisms of regulation and signaling","volume":"10","author":"Mosaddeghzadeh","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.kint.2026.08.029_bib10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1139\/cjpp-2013-0135","article-title":"Role of Rho-GTPases and their regulatory proteins in glomerular podocyte function","volume":"91","author":"Mouawad","year":"2013","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.kint.2026.08.029_bib11","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.kint.2020.08.035","article-title":"Rho GTPase regulatory proteins in podocytes","volume":"99","author":"Matsuda","year":"2021","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.029_bib12","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.3390\/ijms22073656","article-title":"Role of Rho GTPase interacting proteins in subcellular compartments of podocytes","volume":"22","author":"Asano-Matsuda","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2026.08.029_bib13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nrm2476","article-title":"Mammalian Rho GTPases: new insights into their functions from in vivo studies","volume":"9","author":"Heasman","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.kint.2017.03.010","article-title":"Rac1 activation in podocytes induces the spectrum of nephrotic syndrome","volume":"92","author":"Robins","year":"2017","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.029_bib15","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1128\/MCB.00730-13","article-title":"Rac1 activation in podocytes induces rapid foot process effacement and proteinuria","volume":"33","author":"Yu","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib16","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1681\/ASN.2011121206","article-title":"Podocyte-specific loss of Cdc42 leads to congenital nephropathy","volume":"23","author":"Scott","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib17","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/ki.2013.175","article-title":"Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury","volume":"84","author":"Blattner","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.kint.2026.08.029_bib18","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1172\/JCI69134","article-title":"ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling","volume":"123","author":"Gee","year":"2013","journal-title":"J Clin Invest"},{"key":"10.1016\/j.kint.2026.08.029_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1136\/jmedgenet-2012-101442","article-title":"ARHGDIA: a novel gene implicated in nephrotic syndrome","volume":"50","author":"Gupta","year":"2013","journal-title":"J Med Genet"},{"key":"10.1016\/j.kint.2026.08.029_bib20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/21541248.2015.1113353","article-title":"Disease-causing mutations of RhoGDIalpha induce Rac1 hyperactivation in podocytes","volume":"7","author":"Auguste","year":"2016","journal-title":"Small GTPases"},{"key":"10.1016\/j.kint.2026.08.029_bib21","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1681\/ASN.2019090982","article-title":"ARHGEF7 (beta-PIX) is required for the maintenance of podocyte architecture and glomerular function","volume":"31","author":"Matsuda","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib22","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1681\/ASN.0000000614","article-title":"Rac1 suppression by the focal adhesion protein GIT ArfGAP2 and podocyte protection","volume":"36","author":"Shimada","year":"2025","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1369\/jhc.7A7207.2007","article-title":"Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues","volume":"55","author":"Schmalzigaug","year":"2007","journal-title":"J Histochem Cytochem"},{"key":"10.1016\/j.kint.2026.08.029_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1161\/ATVBAHA.113.302689","article-title":"G-protein-coupled receptor-2-interacting protein-1 is required for endothelial cell directional migration and tumor angiogenesis via cortactin-dependent lamellipodia formation","volume":"34","author":"Majumder","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nm.2330","article-title":"GIT1 is associated with ADHD in humans and ADHD-like behaviors in mice","volume":"17","author":"Won","year":"2011","journal-title":"Nat Med"},{"key":"10.1016\/j.kint.2026.08.029_bib26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1186\/s12864-018-4713-y","article-title":"CLICK: one-step generation of conditional knockout mice","volume":"19","author":"Miyasaka","year":"2018","journal-title":"BMC Genomics"},{"key":"10.1016\/j.kint.2026.08.029_bib27","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/gene.10164","article-title":"Podocyte-specific expression of cre recombinase in transgenic mice","volume":"35","author":"Moeller","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.kint.2026.08.029_bib28","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-21634-1","article-title":"CdGAP maintains podocyte function and modulates focal adhesions in a Src kinase-dependent manner","volume":"12","author":"Matsuda","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2026.08.029_bib29","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1681\/ASN.2013080859","article-title":"Estimating podocyte number and density using a single histologic section","volume":"25","author":"Venkatareddy","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib30","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1681\/ASN.2010111146","article-title":"Activation of RhoA in podocytes induces focal segmental glomerulosclerosis","volume":"22","author":"Zhu","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.kint.2026.08.029_bib31","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ajpath.2014.05.005","article-title":"Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria","volume":"184","author":"Kumagai","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.kint.2026.08.029_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-11553-x","article-title":"Structured illumination microscopy and automatized image processing as a rapid diagnostic tool for podocyte effacement","volume":"7","author":"Siegerist","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.kint.2026.08.029_bib33","first-page":"1820","article-title":"PTP1B promotes focal complex maturation, lamellar persistence and directional migration","volume":"126","author":"Burdisso","year":"2013","journal-title":"J Cell Sci"},{"key":"10.1016\/j.kint.2026.08.029_bib34","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1523\/JNEUROSCI.4828-12.2013","article-title":"GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1","volume":"33","author":"Goto","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.kint.2026.08.029_bib35","doi-asserted-by":"crossref","first-page":"8150","DOI":"10.1128\/JVI.72.10.8150-8157.1998","article-title":"Development of a self-inactivating lentivirus vector","volume":"72","author":"Miyoshi","year":"1998","journal-title":"J Virol"},{"key":"10.1016\/j.kint.2026.08.029_bib36","doi-asserted-by":"crossref","first-page":"479","DOI":"10.3390\/ijms19020479","article-title":"The role of trio, a Rho guanine nucleotide exchange factor, in glomerular podocytes","volume":"19","author":"Maier","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.kint.2026.08.029_bib37","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.kint.2026.08.029_bib38","first-page":"280","article-title":"Arf GAPs: a family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex","volume":"10","author":"Vitali","year":"2019","journal-title":"Small GTPases"},{"key":"10.1016\/j.kint.2026.08.029_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neulet.2009.04.037","article-title":"Impaired fear response in mice lacking GIT1","volume":"458","author":"Schmalzigaug","year":"2009","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.kint.2026.08.029_bib40","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1161\/CIRCULATIONAHA.108.823997","article-title":"G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development","volume":"119","author":"Pang","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.kint.2026.08.029_bib41","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1093\/ndt\/gfw021","article-title":"Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease","volume":"31","author":"Tian","year":"2016","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.kint.2026.08.029_bib42","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1083\/jcb.144.6.1235","article-title":"Rho GTPases control polarity, protrusion, and adhesion during cell movement","volume":"144","author":"Nobes","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib43","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/j.cub.2006.10.026","article-title":"Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migration","volume":"16","author":"Osmani","year":"2006","journal-title":"Curr Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003380","article-title":"Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development","volume":"9","author":"Reginensi","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.kint.2026.08.029_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.51","article-title":"Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp\/stress fibers\/YAP pathway","volume":"7","author":"Huang","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.kint.2026.08.029_bib46","doi-asserted-by":"crossref","first-page":"6582","DOI":"10.1128\/MCB.22.18.6582-6591.2002","article-title":"Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells","volume":"22","author":"Itoh","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib47","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0014-5793(03)00853-6","article-title":"The Cbl proteins are binding partners for the Cool\/Pix family of p21-activated kinase-binding proteins","volume":"550","author":"Flanders","year":"2003","journal-title":"FEBS Lett"},{"key":"10.1016\/j.kint.2026.08.029_bib48","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.1038\/sj.onc.1209329","article-title":"Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix","volume":"25","author":"Schmidt","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.kint.2026.08.029_bib49","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1056\/NEJMoa1109122","article-title":"INF2 mutations in Charcot-Marie-Tooth disease with glomerulopathy","volume":"365","author":"Boyer","year":"2011","journal-title":"N Engl J Med"},{"key":"10.1016\/j.kint.2026.08.029_bib50","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/ncb1234","article-title":"An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells","volume":"7","author":"Nishiya","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.kint.2026.08.029_bib51","article-title":"ARF6 mediates nephrin tyrosine phosphorylation-induced podocyte cellular dynamics","volume":"12","author":"Lin","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.kint.2026.08.029_bib52","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.fob.2015.08.005","article-title":"GIT2 deficiency attenuates concanavalin A-induced hepatitis in mice","volume":"5","author":"Hao","year":"2015","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.kint.2026.08.029_bib53","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1128\/MCB.00507-07","article-title":"AlphaPIX Rho GTPase guanine nucleotide exchange factor regulates lymphocyte functions and antigen receptor signaling","volume":"28","author":"Missy","year":"2008","journal-title":"Mol Cell Biol"}],"container-title":["Kidney International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826008215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0085253826008215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:42:45Z","timestamp":1793392965000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0085253826008215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":53,"alternative-id":["S0085253826008215"],"URL":"https:\/\/doi.org\/10.1016\/j.kint.2026.08.029","relation":{},"ISSN":["0085-2538"],"issn-type":[{"value":"0085-2538","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Podocyte GIT1 and GIT2 ArfGAPs cooperatively sustain the ARHGEF7-Cdc42 axis and glomerular permselectivity","name":"articletitle","label":"Article Title"},{"value":"Kidney International","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kint.2026.08.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of the International Society of Nephrology.","name":"copyright","label":"Copyright"}]}}