{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:37:05Z","timestamp":1792784225555,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T00:00:00Z","timestamp":1300665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund of Cancer","award":["KMU-QC-093001"],"award-info":[{"award-number":["KMU-QC-093001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Breast cancer has become the second leading cancer among females in Taiwan. Even though the etiology of breast cancer is multifactorial, oxidative stress plays an important role in the carcinogenesis. The purpose of this study was to investigate the expression of manganese superoxide dismutase (MnSOD), one of the major antioxidant enzymes that is involved against oxidative stress, in adjacent cancer\u2010free breast tissues and neoplasm tissues within the same patient. Sixty\u2010five breast cancer patients' formalin\u2010fixed tissue blocks, including ductal carcinoma\n                      <jats:italic>in situ<\/jats:italic>\n                      (DCIS) tissues, invasive ductal carcinoma (IDC) tissues, and adjacent cancer\u2010free tissues, were evaluated by immunohistochemical stain. Meanwhile, their demographic and clinical information was also collected. The combined scores of MnSOD\u2010positive cell proportion and MnSOD staining intensity were compared for different tissues within the same patient. The results showed that the mean combined scores of MnSOD expression in adjacent cancer\u2010free tissues (6.33), IDC (5.30), and DCIS (3.78) were significantly different when assessed by repeated\u2010measurement analysis of variance (\n                      <jats:italic>F<\/jats:italic>\n                      = 14.17,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Additionally, the results revealed that the distribution of strong MnSOD protein expression was 80.0%, 72.3%, and 52.3% in adjacent cancer\u2010free tissues, IDC, and DCIS, respectively. However, there was no statistically significant relationship between the expression of MnSOD and grades of breast cancer or other clinicopathologic variables. We suggest that the expression of MnSOD in neoplasm tissues, independent of the clinicopathologic characters, plays a critical role in breast cancer biology.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2010.11.003","type":"journal-article","created":{"date-parts":[[2011,4,28]],"date-time":"2011-04-28T15:06:31Z","timestamp":1304003191000},"page":"167-172","source":"Crossref","is-referenced-by-count":22,"title":["Expression of manganese superoxide dismutase in patients with breast cancer"],"prefix":"10.1002","volume":"27","author":[{"given":"Shih\u2010Meng","family":"Tsai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Feng","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu\u2010Hsien","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Wen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheau\u2010Fang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Tzu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Yin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Yu","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"e_1_2_6_2_2","unstructured":"IARC.Globocan http:\/\/globocan.iarc.fr\/factsheets\/populations\/factsheet.asp 2008 accessed 16.12.10"},{"key":"e_1_2_6_3_2","unstructured":"WHO.The world health report.2010 WHO Geneva Switzerland"},{"key":"e_1_2_6_4_2","unstructured":"Department of Health Executive Yuan Taiwan. 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