{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T19:45:21Z","timestamp":1790019921620,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,20]],"date-time":"2012-01-20T00:00:00Z","timestamp":1327017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Health, Executive Yuan, R.O.C. (Taiwan)","award":["DOH100-TD-C-111-002"],"award-info":[{"award-number":["DOH100-TD-C-111-002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Isocitrate dehydrogenase (IDH) encodes a nicotinamide adenine dinucleotide phosphate+\u2010dependent enzyme for oxidative decarboxylation of isocitrate and has an essential role in the tricarboxylic acid cycle. Mutations of IDH1 and IDH2 have been identified in patients with glioma, leukemia, and other cancers. However, the incidence of IDH mutations in acute myeloid leukemia in Taiwan is much lower than that reported in Western countries. The reason for the difference is unknown and its clinical implications remain unclear. Acute lymphoblastic leukemia (ALL) is a heterogenous hematopoietic malignancy. Oral squamous cell carcinoma (OSCC) results from chronic carcinogen exposures and is highly prevalent in trucking workers, especially in southern Taiwan. Subtypes of both diseases require specific treatments, and molecular markers for developing tailored treatments are limited. High\u2010resolution melting (HRM) analysis is now a widely used\u2009methodology for rapid, accurate, and low\u2010cost mutation scanning. In this study, 90 adults with\u2009OSC and 31 children with ALL were scanned by HRM analysis for IDH1 and IDH2 mutation hot spots. In ALL, the allele frequency was 3.23% in both IDH1 and IDH2. In OSCC, the allele frequency was 2.22% in IDH2. A synonymous mutation over pG313 (c.939A\u2009&gt;\u2009G) of IDH2 was found in both pediatric ALL and adult OSCC. Therefore, we concluded that mutations of IDH are uncommon in ALL and OSCC and are apparently not a major consideration when selecting treatment modalities.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2011.10.023","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T00:56:09Z","timestamp":1327625769000},"page":"138-144","source":"Crossref","is-referenced-by-count":13,"title":["Isocitrate dehydrogenase mutation hot spots in acute lymphoblastic leukemia and oral 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