{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:24:57Z","timestamp":1776281097204,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T00:00:00Z","timestamp":1334620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Unenhanced helical computed tomography (UHCT) has evolved into a well\u2010accepted diagnostic method in patients with suspected ureterolithiasis. UHCT not only shows stones within the lumen of the ureter, it also permits evaluation of the secondary signs associated with ureteral obstruction from stones. However, there we could find no data on how secondary signs might differ in relation to different compositions of ureteral stones. In this study, we compared the degree of secondary signs revealed by UHCT in uric acid stone formers and in patients forming calcium stones. We enrolled 117 patients with ureteral stones who underwent UHCT examination and Fourier transform infra\u2010red analysis of stone samples. Clinical data were collected as follows: age, sex, estimated glomerular filtration rate (eGFR), urine pH, and radiological data on secondary signs apparent on UHCT. The uric acid stone formers had significantly lower urine pH and eGFR in comparison to calcium stone formers, and on UHCT they also had a higher percentage of the secondary signs, including rim sign (78.9% vs. 60.2%), hydroureter (94.7% vs. 89.8%), perirenal stranding (84.2% vs. 59.2%) and kidney density difference (73.7% vs. 50.0%). The radiological difference was statistically significant for perirenal stranding (<jats:italic>p<\/jats:italic> = 0.041). In conclusion, we found that UHCT scanning reveals secondary signs to be more frequent in patients with uric acid ureteral stones than in patients with calcium stones, a tendency that might result from an acidic urine environment.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2011.11.013","type":"journal-article","created":{"date-parts":[[2012,4,18]],"date-time":"2012-04-18T03:51:01Z","timestamp":1334721061000},"page":"322-326","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of secondary signs as shown by unenhanced helical computed tomography in patients with uric acid or calcium ureteral stones"],"prefix":"10.1002","volume":"28","author":[{"given":"Yii\u2010Her","family":"Chou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Po","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010En","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei\u2010Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching\u2010Chia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Chu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Shun","family":"Juan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Ching","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,17]]},"reference":[{"issue":"556","key":"e_1_2_5_2_2","first-page":"558","article-title":"Diagnostic imaging\u2014the end of intravenous urography?","volume":"47","author":"Strohmaier W.L.","year":"2008","journal-title":"Urologe A"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.055913"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/22314006"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2511081084"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2007.054809"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-003-1937-1"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.0120"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/end.2007.0248","article-title":"Secondary signs of non\u2010enhanced CT prior to laser ureterolithotripsy: is treatment outcome predictable?","volume":"22","author":"Seitz C.","year":"2008","journal-title":"J Endourol"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2005.05520.x"},{"key":"e_1_2_5_11_2","first-page":"147","article-title":"Unenhanced multidetector CT evaluation of urinary stones and secondary signs in pediatric patients","volume":"12","author":"Akay H.","year":"2006","journal-title":"Diagn Interv Radiol"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.177.6.1771285"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.3.9051021"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65161-0"},{"key":"e_1_2_5_15_2","first-page":"182","article-title":"Decreased renal parenchymal density on unenhanced helical computed tomography for diagnosis of ureteral stone disease in emergent patients with acute flank pain","volume":"31","author":"Huang C.C.","year":"2008","journal-title":"Chang Gung Med J"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.urology.2004.03.058","article-title":"Diagnostic value of renal parenchymal density difference on unenhanced helical computed tomography scan in acutely obstructing ureteral stone disease","volume":"64","author":"Ozer C.","year":"2004","journal-title":"Urology"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2214\/ajr.176.4.1760965","article-title":"Differences of renal parenchymal attenuation for acutely obstructed and unobstructed kidneys on unenhanced helical CT: a useful secondary sign?","volume":"176","author":"Georgiades C.S.","year":"2001","journal-title":"AJR Am J Roentgenol"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.2214\/ajr.182.5.1821251","article-title":"Diagnostic value of attenuation measurements of the kidney on unenhanced helical CT of obstructive ureterolithiasis","volume":"182","author":"Goldman S.M.","year":"2004","journal-title":"AJR Am J Roentgenol"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.171.4.9762995"},{"key":"e_1_2_5_20_2","first-page":"186","article-title":"Imaging of acute urinary obstruction: non\u2010enhanced CT or KUB and US","volume":"85","author":"Grenier N.","year":"2004","journal-title":"J Radiol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000019650"},{"key":"e_1_2_5_22_2","first-page":"2","article-title":"Unenhanced helical CT of ureterolithiasis: incidence of secondary urinary tract findings","volume":"54","author":"Yaqoob J.","year":"2004","journal-title":"J Pak Med Assoc"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2342-4-2"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.10.018"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2003.50027"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002470100536"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1148\/radiol.2291020690","article-title":"The soft\u2010tissue rim sign","volume":"229","author":"Al\u2010Nakshabandi N.A.","year":"2003","journal-title":"Radiology"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-001-0655-6"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-004-2511-1"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.167.5.8911160"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2008.01.010"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X11002683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X11002683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2011.11.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T05:51:08Z","timestamp":1694670668000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2011.11.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,17]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1016\/j.kjms.2011.11.013"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2011.11.013","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,17]]}}}