{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:53:01Z","timestamp":1788871981431,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T00:00:00Z","timestamp":1349481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that MMP had an additive effect on the formation of recurrent nasal polyp. We also investigated the association between the functional promoter polymorphism of MMPs and the intensity of labeling index. Expressions of MMP\u20102 and MMP\u20109 were assessed via immunohistochemical staining and compared between different groups, including recurrent nasal polyps, nonrecurrent nasal polyps, and control nasal mucosa. Two promoter functional single\u2010nucleotide polymorphisms (rs3918242 for MMP\u20109 and rs243865 for MMP\u20102) were selected to correlate with staining intensity. Expression of MMP\u20109 was significantly enhanced in gland for recurrent nasal polyp (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016) and nonrecurrent nasal polyp (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) compared to the control. MMP\u20102 positivity was significantly increased in surface epithelium for recurrent nasal polyp (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) compared to the control (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.061). However, there was no significant difference in MMP\u20109 and MMP\u20102 expressions between recurrent and nonrecurrent nasal polyps. Genetic polymorphism of MMP\u20102 and MMP\u20109 functional promoters was not associated with the intensity of labeling index. These results suggested that up\u2010regulation of MMP\u20109 in gland and MMP\u20102 in surface epithelium was characteristic of both recurrent and nonrecurrent nasal polyps. Pathogenesis of recurrent nasal polyps may involve a mechanism other than MMP.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2012.08.004","type":"journal-article","created":{"date-parts":[[2012,10,6]],"date-time":"2012-10-06T20:45:43Z","timestamp":1349556343000},"page":"26-31","source":"Crossref","is-referenced-by-count":10,"title":["Expression of matrix metalloproteinase\u20102 and matrix metalloproteinase\u20109 in recurrent chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1002","volume":"29","author":[{"given":"Ling\u2010Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Yu","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Yin","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Feng","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.6.f151"},{"key":"e_1_2_6_3_2","first-page":"1345","article-title":"Dynamics of matrix turnover during pathologic remodeling of the extracellular matrix","volume":"148","author":"Stetler\u2010Stevenson W.G.","year":"1996","journal-title":"Am J Pathol"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68680-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)71480-4"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)36670-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114867"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)89580-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199602)166:2<413::AID-JCP20>3.0.CO;2-A"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.26.15580"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100448997"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.3.9070604"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9708080"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70018-1"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489509133351"},{"key":"e_1_2_6_16_2","first-page":"97","article-title":"EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists","volume":"45","author":"Fokkens W.","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2350-11-85"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.8.852"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH771>3.0.CO;2-W"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2003.18.1.97"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480410017152"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.02.023"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.012411.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150674.30237.3f"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01255.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.04.032"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1398-9995.2003.00364.x"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199103000-00015"},{"key":"e_1_2_6_29_2","doi-asserted-by":"crossref","first-page":"25454","DOI":"10.1016\/S0021-9258(18)47272-9","article-title":"Expression of gelatinase A, a mediator of extracellular matrix remodeling, by tracheal gland serous cells in culture and in\u2009vivo","volume":"269","author":"Tournier J.M.","year":"1994","journal-title":"J Biol Chem"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.136.6.1363"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119024"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-6519(08)75116-1"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.07.011"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.14.1788"},{"key":"e_1_2_6_35_2","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.atherosclerosis.2009.05.028","article-title":"The \u20101562C\/T MMP\u20109 promoter polymorphism does not predict MMP\u20109 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients","volume":"207","author":"Maqbool A.","year":"2009","journal-title":"Atherosclerosis"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02990939"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X12002057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X12002057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2012.08.004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.kjms.2012.08.004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2012.08.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T08:06:08Z","timestamp":1694678768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2012.08.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,6]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1016\/j.kjms.2012.08.004"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2012.08.004","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,6]]}}}