{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:16:05Z","timestamp":1787800565202,"version":"build-2784847793"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T00:00:00Z","timestamp":1350864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Alpha\u2010fetoprotein is a well\u2010known tumor marker in the screening and follow\u2010up of hepatocellular carcinoma. In Taiwanese society, a high prevalence of hepatitis and hepatoma and elevation of alpha\u2010fetoprotein associated with liver function impairment usually suggested clinics undertake further examination for liver or genital tumor. We report the case of 45\u2010year\u2010old man who was found to have an alpha\u2010fetoprotein\u2010producing esophageal adenocarcinoma with an initial presentation of liver function impairment and rapid elevation of alpha\u2010fetoprotein. Esophageal cancer was diagnosed via endoscope and a biopsy proved the presence of adenocarcinoma. A small endoscopic biopsy specimen failed to identify the alpha\u2010fetoprotein positive tumor cell. Esophagectomy was performed and histopathological study of surgical specimen revealed grade II adenocarcinoma with regional metastatic lymphadenopathy. Immunohistochemical study was focal positive for alpha\u2010fetoprotein. Serum alpha\u2010fetoprotein declined transiently after esophagectomy and fluctuation of alpha\u2010fetoprotein level was noted during the treatment with adjuvant chemotherapy. Finally, 19 months after the operation, the patient died due to multiple organ metastases with multiple organ failure. Thus, a small specimen for upper endoscopy may not be sufficient in the presence of alpha\u2010fetoprotein\u2010producing adenocarcinoma. Monitoring of serum alpha\u2010fetoprotein may be useful in the evaluation and follow\u2010up of esophageal alpha\u2010fetoprotein\u2010producing adenocarcinoma.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2012.08.018","type":"journal-article","created":{"date-parts":[[2012,10,22]],"date-time":"2012-10-22T23:00:20Z","timestamp":1350946820000},"page":"106-110","source":"Crossref","is-referenced-by-count":9,"title":["A case of alpha\u2010fetoprotein\u2010producing esophageal adenocarcinoma"],"prefix":"10.1002","volume":"29","author":[{"given":"Yi\u2010Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Hung","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huang\u2010Ming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng\u2010Chyang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Yi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,22]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2001.28841"},{"key":"e_1_2_4_3_2","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.5858\/2002-126-1106-PYSTOT","article-title":"Primary yolk sac tumor of the urachus","volume":"126","author":"Huang H.Y.","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_4_2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00428-003-0772-8","article-title":"Hepatoid adenocarcinoma of the urinary bladder","volume":"442","author":"Lopez\u2010Beltran A.","year":"2003","journal-title":"Virchows Arch"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-3-27"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340050181"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1582::AID-CNCR12>3.0.CO;2-A"},{"key":"e_1_2_4_8_2","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000050982","article-title":"Alpha\u2010fetoprotein\u2010producing renal cell carcinoma","volume":"67","author":"Poulakis V.","year":"2001","journal-title":"Urol Int"},{"key":"e_1_2_4_9_2","first-page":"257","article-title":"A case of alpha\u2010fetoprotein producing lung cancer","volume":"25","author":"Yamanaka A.","year":"1987","journal-title":"Nihon Kyobu Shikkan Gakkai Zasshi"},{"key":"e_1_2_4_10_2","first-page":"207","article-title":"Alpha1\u2010fetoprotein: physiology, pathology and diagnosis especially in childhood (author's transl)","volume":"189","author":"Knopfle G.","year":"1977","journal-title":"Klin Padiatr"},{"key":"e_1_2_4_11_2","first-page":"991","article-title":"Serum alpha\u2010fetoprotein in patients with neoplasms of the gastrointestinal tract","volume":"35","author":"McIntire K.R.","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_4_12_2","first-page":"593","article-title":"Diagnostic value of the analysis of alpha fetoprotein levels in malignant neoplasms of the digestive system","volume":"45","author":"Pardela M.","year":"1992","journal-title":"Wiad Lek"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910580321"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00199396"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1827.2002.01328.x"},{"key":"e_1_2_4_16_2","first-page":"2965","article-title":"AFP\u2010producing hepatoid adenocarcinoma in association with Barrett's esophagus with multiple liver metastasis responding to paclitaxel\/CDDP: a case report","volume":"25","author":"Chiba N.","year":"2005","journal-title":"Anticancer Res"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-008-9043-x"},{"key":"e_1_2_4_18_2","doi-asserted-by":"crossref","unstructured":"KurodaN OnishiK LeeGH. 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