{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:09:40Z","timestamp":1772986180351,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2013,9,10]],"date-time":"2013-09-10T00:00:00Z","timestamp":1378771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":869,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Terlipressin, an analogue of vasopressin, is frequently used for the management of esophageal varices bleeding and hepatorenal syndrome. Terlipressin therapy in portal hypertensive patients is frequently associated with hyponatremia, but is rarely accompanied with serious neurological manifestations. A 39\u2010year\u2010old female with pancreatic neuroendocrine tumor, liver metastasis, main portal vein thrombosis, and a history of esophageal varices presented to the emergency room because of hematemesis. Terlipressin was given with a loading dose of 2\u2009mg followed by 1\u2009mg every 6\u2009hours. After a total of 6\u2009mg terlipressin injection, she suffered from acute delirium. Pertinent examinations showed there was no gross brain lesion by computed tomography, whereas her serum sodium level dropped from baseline (136\u2009mmol\/L) to 116\u2009mmol\/L with a serum osmolality of 256\u2009mOsm\/kg. At that time, urine sodium and urine osmolality were 142\u2009mmol\/L and 488\u2009mOsm\/kg, respectively. Under the tentative diagnosis of terlipressin\u2010induced hyponatremic encephalopathy, terlipressin was withheld and hypertonic saline infusion was given. Within 12\u2009hours, her serum sodium level recovered to 130\u2009mmol\/L and she gradually regained her cognitive functions. Although symptomatic hyponatremic encephalopathy is a rare complication of terlipressin treatment, close monitoring of serum electrolyte level is warranted in patients receiving terlipressin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2013.08.003","type":"journal-article","created":{"date-parts":[[2013,9,9]],"date-time":"2013-09-09T23:46:01Z","timestamp":1378770361000},"page":"691-694","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Terlipressin\u2010induced hyponatremic encephalopathy in a noncirrhotic patient"],"prefix":"10.1002","volume":"29","author":[{"given":"Yao\u2010Kuang","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daw\u2010Yang","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie S.W.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang\u2010Jyh","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Tzong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Chuan","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,10]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0901512"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-010-9725-8"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-008-0118-7"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23893"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058006"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v111.pm8898643"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000098028"},{"key":"e_1_2_4_9_2","first-page":"390","article-title":"Double\u2010blind randomized multicenter study comparing the efficacy and safety of 10\u2010day to 5\u2010day terlipressin treatment of bleeding esophageal varices","volume":"56","author":"Bruha R.","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200609000-00026"},{"issue":"1","key":"e_1_2_4_11_2","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/j.amjmed.2006.05.009","article-title":"Influence of hypoxia and sex on hyponatremic encephalopathy","volume":"119","author":"Arieff A.I.","year":"2006","journal-title":"Am J 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