{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:10:53Z","timestamp":1772986253806,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T00:00:00Z","timestamp":1396483200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":664,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council Taiwan","doi-asserted-by":"publisher","award":["NSC 93-2320-B-037-031"],"award-info":[{"award-number":["NSC 93-2320-B-037-031"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University, Taiwan","doi-asserted-by":"crossref","award":["KMU-M-110014"],"award-info":[{"award-number":["KMU-M-110014"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Toona sinensis<\/jats:italic>\n                      (TS) leaves are used as a vegetable and in traditional Chinese medicine. However,\n                      <jats:italic>in\u2009vivo<\/jats:italic>\n                      experiments regarding the anti\u2010inflammatory function of TS leaves have not previously been conducted. The aim of this study was to investigate the potential role of TS leaf extract (TSL) in the prevention of sepsis\u2010induced lung injury\n                      <jats:italic>in\u2009vivo<\/jats:italic>\n                      and on macrophage activation\n                      <jats:italic>in\u2009vitro<\/jats:italic>\n                      . The results showed that oral gavage pretreatment with TSL in rats for 30 days improved the survival of cecal ligation and puncture\u2010induced sepsis, potentially by attenuating sepsis\u2010induced histological lung damage rather than inflammatory cell infiltration. Furthermore, we demonstrated that pretreatment with TSL attenuated the lipopolysaccharide (LPS)\u2010induced expression of inducible nitric oxide synthase, thereby inhibiting nitric oxide production and release in murine macrophage\u2010like RAW 264.7 cells. Interestingly, TSL did not affect the LPS\u2010induced release of other cytokines (e.g., tumor necrosis factor \u03b1 and interleukin 1\u03b2) but increased LPS\u2010induced heme\u2010oxygenase\u20101 expression. In conclusion, the study provides preliminary data for TSL on cecal ligation and puncture\u2010induced sepsis. The beneficial impact of TSL needs extensive study to get solid evidence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2014.02.013","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T06:45:14Z","timestamp":1396507514000},"page":"279-285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>Toona sinensis<\/i>\n                    leaf aqueous extract displays activity against sepsis in both\n                    <i>in\u2009vitro<\/i>\n                    and\n                    <i>in\u2009vivo<\/i>\n                    models"],"prefix":"10.1002","volume":"30","author":[{"given":"Chih\u2010Jen","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung\u2010Chia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee\u2010Jean","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Shyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao\u2010Chuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.016"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043632"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000194725.48928.3A"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-5-593"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199604000-00023"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200005043421806"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aes401"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141670"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.06.041"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.12.023"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/1467-8748.00169"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.01.020"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X02000223"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.07.003"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2011.06.017"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2012.03.068"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1607-551X(09)70433-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.12.023"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.048"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061823"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.08.026"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2008.01007.x"},{"key":"e_1_2_5_24_2","first-page":"306","article-title":"Studies on the chemical components and biological activities of edible plants in Korea (I). Phenolic compounds from the leaves of Cedrela sinensis A","volume":"37","author":"Park J.C.","year":"1993","journal-title":"Juss Yakhak Hoeji"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.05.022"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(80)90037-2"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000158117.15446.5a"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/22.12.1077"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01795308"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00501913"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1092320409"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2011.01.001"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318270e3ee"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000191414.94461.7e"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.03.008"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.2.471"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.2.499"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.110.171462"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/15353702-0322805-26"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1656"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2012.08.038"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342603"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60242"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1860"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14000667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14000667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2014.02.013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.kjms.2014.02.013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2014.02.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:30:44Z","timestamp":1772965844000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2014.02.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,3]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["10.1016\/j.kjms.2014.02.013"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2014.02.013","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toona sinensis leaf aqueous extract displays activity against sepsis in both in\u00a0vitro and in\u00a0vivo models","name":"articletitle","label":"Article Title"},{"value":"The Kaohsiung Journal of Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kjms.2014.02.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}